Nikolaev
Anatoly Nikolaev, Burlingame, CA US
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20100203044 | DR6 ANTAGONISTS AND USES THEREOF IN TREATING NEUROLOGICAL DISORDERS - Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue. | 08-12-2010 |
20110110942 | METHOD OF PROMOTING DENDRITIC SPINE DENSITY - The invention relates to methods of increasing density of dendritic spines as a means to retain or improve cognition and to treat disorders associated with decreased dendritic spine morphology and a psychiatric disorder such as addiction and schizophrenia or a disorder associated with impaired cognition such as autism, Lett Syndrome, Tourette Syndrome, and Fragile-X Syndrome. | 05-12-2011 |
20110223630 | METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION - Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue. | 09-15-2011 |
Anatoly J. Nikolaev, Ann Arbor, MI US
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20120076785 | METHOD FOR INHIBITING NEURODEGENERATION - Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue. | 03-29-2012 |
Andrey Nikolaev, Novgorod RU
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20140313520 | LOCATION DETERMINATION USING LIGHT SOURCES - The present disclosure relates to computer-implemented systems and methods for location determination using light sources. An example method may include receiving, by a computer including one or more processors, a location request for a device within an indoor environment. The method may also include receiving respective light source identifiers associated with one or more light sources in the indoor environment. The one or more light sources may be in communication with the device. Additionally, the method may include accessing, by the computer, a virtual map associated with the indoor environment, and the virtual map may include one or more associations between the respective light source identifiers and respective positions, within the indoor environment, of the one or more light sources. Furthermore, the method may include determining, based at least in part on the virtual map and the respective light source identifiers, a location of the device within the indoor environment. | 10-23-2014 |
Arseniy Nikolaev, Moscow RU
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20140184471 | DEVICE WITH DISPLAYS - According to a first aspect of the invention, there is provided a display assembly device comprising first and second faces, the first face arranged to present a first display and the second face arranged to present an optional second display, the device further comprising a computer system operable to run a plurality of application programs using one or more processors to execute a set of stored instructions, wherein the one or more processors is configured by the set of instructions to limit arrangements in which content is displayable on at least one of the displays as display content associated with an application program provisioned on a device infrastructure of the display assembly device. | 07-03-2014 |
Arseniy Andreevich Nikolaev, Moscow RU
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20150089636 | AUTHENTICATED RELEASE OF DATA TOWARDS A DEVICE DRIVER - A method and an electronic device for authenticating release of data towards a device driver. the device comprises a main display area, a memory module and a processor module, the processor module is for executing a display function manager that manages access to an extra display area defined outside of the main display area, storing into the memory module authentication credentials identifying software applications, executing on the processor module, that are authorized for the display function manager and receiving a request, from one of the software applications executing on the processor module, for sending data towards the display function manager. the request comprises requesting credentials from the one software application. the processor is also for verifying the requesting credentials in relation to the extra display area against the stored authentication credentials and, when the requesting credentials are verified, authorizing the release of the data towards the device driver. | 03-26-2015 |
Dmitry Nikolaev, Ulm DE
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20120038058 | VERTICALLY CONTACTED ELECTRONIC COMPONENT AND METHOD FOR PRODUCING SAME - An electronic component has at least one contact surface situated in a contact plane, at least one insulating layer disposed above the contact plane, at least one stabilizing layer disposed on the insulating layer for increasing a mechanical stability of the component, and at least one of a bonding contact and a soldering contact. The insulating layer and the stabilizing layer have at least one opening which opens in an upper side of the stabilizing layer. The upper side of the stabilizing layer is oriented away from the contact surface. The opening extends through the stabilizing layer and the insulating layer as far as the contact surface. The at least one of a bonding contact and a soldering contact extends over the stabilizing layer and touches the contact surface through the opening. | 02-16-2012 |
Evgenij Nikolaev, Moscow RU
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20080251715 | INTRODUCTION OF IONS INTO A MAGNETIC FIELD - In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage. | 10-16-2008 |
20100193679 | GUIDING CHARGED DROPLETS AND IONS IN AN ELECTROSPRAY ION SOURCE - Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter. | 08-05-2010 |
20110186728 | ION MANIPULATION CELL WITH TAILORED POTENTIAL PROFILES - An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell. | 08-04-2011 |
20120043461 | KINGDON MASS SPECTROMETER WITH CYLINDRICAL ELECTRODES - The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments. Appropriate voltages at the sheath electrode segments generate a potential distribution between the two concentric cylindrical surfaces which forms a parabolic potential well in the axial direction for orbiting ions. The ion clouds oscillating harmonically in the axial direction in this potential well induce image currents in suitable electrodes, from which the oscillation frequencies can be determined by Fourier analyses. | 02-23-2012 |
20120193529 | ION CYCLOTRON RESONANCE MEASURING CELLS WITH HARMONIC TRAPPING POTENTIAL - The invention relates to devices and methods for the acquisition of mass spectra with very high mass resolution in ion cyclotron resonance mass spectrometers and methods to produce the devices. The invention presents cylindrical ICR measuring cells with special electrode geometries to generate harmonic trapping potentials for orbiting ions up to the walls of the cell. Only a single DC trapping voltage has to be applied to create the harmonic trapping potential distribution. The sheath of the cylindrical cell is divided by longitudinal gaps into a multitude of sheath electrodes, which either have to carry layers with resistance profiles able to generate parabolic voltage profiles along the sheath electrodes, or which form sheath electrodes of varying width by parabolic gaps, able to create complicated potential distributions which are harmonic on average for orbiting ions. Orbiting ions of a given mass m/z can oscillate harmonically in axial direction with exactly the same oscillation frequency, independent of the radius of their orbit and of their axial oscillation amplitude. Ideally, the cylinders are closed by endcaps with rotationally hyperbolic form, divided into partial electrodes like in infinity cells. The ions can then be excited to their cyclotron motions by dipolar excitation fields also uniformly filling the ICR cell up to the endcaps. The ion clouds orbiting on their cyclotron trajectory are kept together for much longer periods than was possible hitherto, even if they orbit near the sheath electrodes. The image currents thus give rise to minute-long transients, from which mass spectra with ultrahigh mass resolution can be obtained. | 08-02-2012 |
Evgeny Nikolaev, Moscow RU
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20140070090 | DYNAMICALLY HARMONIZED FT-ICR CELL WITH SPECIALLY SHAPED ELECTRODES FOR COMPENSATION OF INHOMOGENEITY OF THE MAGNETIC FIELD - A method and apparatus of compensating a magnetic field inhomogeneity in a dynamically harmonized FT-ICR cell is presented, based on adding of extra electrodes into the cell, the extra electrodes being shaped in such a way that the averaged electric field created by these electrodes produces a counter force to the forces caused by the inhomogeneous magnetic field on the cycling ions. | 03-13-2014 |
20150364304 | METHODS FOR ACQUIRING AND EVALUATING MASS SPECTRA IN FOURIER TRANSFORM MASS SPECTROMETERS - The invention provides a method for acquiring a mass spectrum with a Fourier transform mass spectrometer, wherein analyte ions and additional reporter ions oscillate at mass specific frequencies in a measuring cell of the frequency mass spectrometer and interact by Coulomb forces; the image current signal induced by the reporter ion is measured; and mass signals of the analyte ions are determined from a sideband signal of the reporter ions in the frequency domain or from the instantaneous frequency of the reporter ions in the time domain. | 12-17-2015 |
Gennadi Nikolaev, Tallinn EE
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20110223258 | Ferric Phosphate Based Composition, the Preparation and Use Thereof - The invention deals with an ferric phosphate based composition, in order to obtain which 100 mass fractions of orthophosphoric acid, 10-20 mass fractions of iron(III) oxide, 5-10 mass fractions of powdery aluminium oxide and 100 mass fractions of water are mixed, whereas the reaction takes place within a temperature range of 60-70° C. and at least one nanopowder from among silver, copper or flint is added to the mixture in the amount of 0.5 mass fractions, The ferric phosphate based compositions can be used for the bio- and fire protection of timber, as an antibacterial disinfectant, as well as a rust converter for the rust-inhibiting of metals. | 09-15-2011 |
Igor Nikolaev, Offemweg 10 NL
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20130216654 | FOOD ADDITIVE COMPRISING AN AMIDASE FOR DETOXIFYING OCHRATOXIN - The present invention relates to amidase enzymes and a feed or food additive comprising the amidase enzyme capable of degrading ochratoxin. | 08-22-2013 |
Igor Nikolaev, Noordwijk NL
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20110014681 | GLUCOAMYLASE VARIANTS - The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also provides enzyme compositions comprising the variant glucoamylases; DNA constructs comprising polynucleotides encoding the variants; and methods of producing the glucoamylase variants in host cells. | 01-20-2011 |
20110020899 | GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES - The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g., starch hydrolyzing compositions); DNA constructs comprising polynucleotides encoding the variants and methods of producing the variant glucoamylases in host cells | 01-27-2011 |
20110236935 | OXIDATION PROCESS - A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD | 09-29-2011 |
20110256571 | PROTEINS - An amino acid sequence is described. The amino acid may comprise a signal sequence that is SEQ ID NO. 1a (or a variant or homologue or derivative or fragment thereof) that is expressed as a fusion protein that comprises a protein of interest. The signal sequence directs secretion of the protein of interest. The protein of interest may be a heterologous protein. Secretion of the fusion protein aids purification. | 10-20-2011 |
20120135500 | CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof. | 05-31-2012 |
20130143301 | BETA-GLUCOSIDASE I VARIANTS WITH IMPROVED PROPERTIES - The present disclosure is generally directed to enzymes and in particular beta-glucosidase variants. Also described are nucleic acids encoding beta-glucosidase variants, compositions comprising beta-glucosidase variants, methods of using beta-glucosidase variants, and methods of identifying additional useful beta-glucosidase variants. | 06-06-2013 |
20140073017 | CELLULASE COMPOSITIONS AND METHODS OF USING THE SAME FOR IMPROVED CONVERSION OF LIGNOCELLULOSIC BIOMASS INTO FERMENTABLE SUGARS - The present invention relates to compositions that can be used in hydrolyzing biomass such as compositions comprising a polypeptide having β-glucosidase activity, methods for hydrolyzing biomass material, and methods for improving the stability and saccharification efficacy of a composition comprising such β-glucosidase polypeptides and/or activity. | 03-13-2014 |
20140302585 | CELLULASE VARIANTS WITH IMPROVED EXPRESSION, ACTIVITY AND STABILITY, AND USE THEREOF - The present disclosure relates to cellulase variants. In particular the present disclosure relates to cellulase variants having improved expression, activity and/or stability. Also described are nucleic acids encoding the cellulase variants, compositions comprising the cellulase variants, and methods of use thereof. | 10-09-2014 |
20140356922 | POLYPEPTIDES HAVING GLUCOAMYLASE ACTIVITY AND METHOD OF PRODUCING THE SAME - The present invention relates to polypeptides having glucoamylase activity with improved properties and to compositions comprising these polypeptides suitable for use in the production of a food, beverage (e.g. beer), feed, or biofuel. Also described is an improved and cost-effective process for isolating glucoamylases suitable for large scale protein purification procedures. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process. | 12-04-2014 |
20150315558 | VARIANTS HAVING GLUCOAMYLASE ACTIVITY - The present invention relates to variants having glucoamylase activity with improved properties and to compositions comprising these variants suitable for use for example in the production of a food, beverage (e.g. beer), feed, biochemical, or biofuel. Also disclosed are DNA constructs encoding the variants and methods of producing the glucoamylase variants in host cells. Furthermore, different methods and uses related to glucoamylases according to the invention are disclosed, such as in a brewing process. | 11-05-2015 |
20150315560 | VARIANTS OF CELLOBIOHYDROLASES - Disclosed are a number of homologs and variants of | 11-05-2015 |
Igor Nikolaev, Galway IE
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20130090971 | METHOD AND SYSTEM FOR ALLOCATION OF RESOURCES IN AN AGILE ENVIRONMENT - A computer-implemented method is provided for optimizing allocation of resources across stories for a release within an Agile development environment. The method includes receiving (i) resource information representing a plurality of resources available for allocation to the stories, (ii) one or more story definitions, each story definition comprising a unique identifier and one or more story-level constraints corresponding to a story, (iii) release information, (iv) iteration information, and (iv) one or more optimization criteria. The method also includes generating a plurality of story-level allocation scenarios and determining one or more optimized story-level allocation scenarios from the plurality of story-level allocation scenarios. Each story-level allocation scenario satisfies the one or more story-level constraints associated with each story definition. Each optimized story-level allocation scenario optimizes assignment of iterations or allocation of resources to the stories to satisfy the one or more optimization criteria. | 04-11-2013 |
20140142998 | Method and System for Optimized Task Assignment - A computer-implemented method is provided for assigning tasks to resources. The method includes receiving one or more constraints corresponding to each of the tasks and one or more constraints corresponding to each of the resources. The method also includes receiving a value from a user defining at least one of a plurality of variables including: (i) a resource variable representing resources available for allocation to the tasks, (ii) a duration variable representing a time frame for completing the tasks, and iii) a scope variable representing one or more of the plurality of tasks requiring execution. The method further includes applying a first optimization scheme to determine a value for each undefined variable to formulate a task delivery plan and applying a second optimization scheme to determine a task for assignment to a resource. | 05-22-2014 |
Ivan Nikolaev, Prague CZ
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20160036836 | Detecting DGA-Based Malicious Software Using Network Flow Information - Detecting DGA-based malware is disclosed. In an embodiment, a number of domain name server requests originating from a particular host among a plurality of hosts is determined. The number of domain name server requests are directed to one or more domain name servers. A number of internet protocol addresses contacted by the particular host is determined. Based on the number of domain name server requests and the number of internet protocol addresses contacted existence of malware on the particular host is determined. | 02-04-2016 |
Ivan Nikolaev, Richmond Hill CA
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20150079221 | TWO STAGE INJECTION UNIT ROTARY VALVE - An injection unit for an injection molding machine includes a nozzle for dispensing melt to a mold, and a valve housing having a first port in fluid communication with the nozzle. The valve housing has a second port and a third port. A plasticizing barrel is in fluid communication with the second port. A shooting pot is in fluid communication the third port. A valve closure member is mounted in the valve housing. The valve closure member is moveable between a first position in which the first port is in fluid communication with the third port and in fluid isolation of the second port, and a second position in which the second port is in fluid communication with the third port and in fluid isolation of the first port. When in at least one of the first and second positions, fluid communication is provided between the respective ports through a gap provided between an outer surface of the closure member and an inner surface of the valve housing. | 03-19-2015 |
Ivan Petrovich Nikolaev, Moscow RU
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20120117729 | MULTIFUNCTIONAL BED - The invention relates to therapeutic-prophylactic equipment and domestic articles and can be used in the home for the care of seriously ill patients having limited mobility or being completely immobile as well as for the prophylactic treatment of temporarily immobile patients. The use of the proposed bed makes it possible to combine various methods for acting on the body, thereby making it possible to take measures for the efficient prevention and healing of a wide range of diseases. This, together with all the listed means and the interactions thereof, makes it possible to enhance and widen the healing effect and improve service quality. | 05-17-2012 |
Ivan Sergejevitsj Nikolaev, Eindhoven NL
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20120081683 | Lithographic Apparatus And Detector Apparatus - A detector including a layer of scintillation material, a layer of spacer material on the scintillation material, and a spectral purity filter layer on the spacer material. A method includes directing EUV radiation through a spectral purity filter layer, directing the EUV radiation through a spacer material layer provided beneath the spectral purity filter layer, directing the EUV onto a layer of scintillation material, and detecting scintillation radiation emitted by the scintillation material | 04-05-2012 |
Konstantin Nikolaev, Edina, MN US
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20090185315 | MAGNETIC SENSOR INCLUDING A FREE LAYER HAVING PERPENDICULAR TO THE PLANE ANISOTROPY - A magnetic sensor includes a reference layer having a first magnetization direction and a free layer assembly having an effective magnetization direction substantially perpendicular to the first magnetization direction and substantially perpendicular to a plane of each layer of the free layer assembly. A spacer layer is between the reference layer and the free layer, and a signal enhancement layer is exchange coupled to the free layer assembly on a side opposite the spacer layer. | 07-23-2009 |
20100323100 | CONTROLLING THICKNESS UNIFORMITY AND INTERFACES IN STACKS - A method of creating a stack having multiple layers of deposited film onto a substrate is discussed. The method includes depositing a first layer of a first material onto the substrate and depositing a second layer onto the first layer. Depositing the second layer includes depositing a first amount of the second material onto the first layer at a first deposition temperature selected to set the normalized diffusion activation energy of the second material. | 12-23-2010 |
20110006033 | Magnetic Device Definition with Uniform Biasing Control - A method of fabricating a magnetic device is described. A mask removing layer is formed on a layered sensing stack and a hard mask layer is formed on the mask removing layer. A first reactive ion etch is performed with a non-oxygen-based chemistry to define the hard mask layer using an imaged layer formed on the hard mask layer as a mask. A second reactive ion etch is performed with an oxygen-based chemistry to define the mask removing stop layer using the defined hard mask layer as a mask. A third reactive ion etch is performed to define the layered sensing stack using the hard mask layer as a mask. The third reactive ion etch includes an etching chemistry that performs at a lower etching rate on the hard mask layer than on the layered sensing stack. | 01-13-2011 |
20110006384 | MAGNETIC TUNNEL JUNCTION HAVING COHERENT TUNNELING STRUCTURE - A magnetic tunnel junction includes an amorphous ferromagnetic reference layer having a first reference layer side and an opposing second reference layer side. The first reference layer side has a greater concentration of boron than the second reference layer side. A magnesium oxide tunnel barrier layer is disposed on the second side of the amorphous ferromagnetic reference layer. The magnesium oxide tunnel barrier layer has a crystal structure. An amorphous ferromagnetic free layer is disposed on the magnesium oxide tunnel barrier layer. | 01-13-2011 |
20110164335 | MAGNETIC SENSOR INCLUDING A FREE LAYER HAVING PERPENDICULAR TO THE PLANE ANISOTROPY - A magnetic sensor includes a reference layer having a first magnetization direction and a free layer assembly having an effective magnetization direction substantially perpendicular to the first magnetization direction and substantially perpendicular to a plane of each layer of the free layer assembly. A spacer layer is between the reference layer and the free layer, and a signal enhancement layer is exchange coupled to the free layer assembly on a side opposite the spacer layer. | 07-07-2011 |
20110200845 | CURRENT PERPENDICULAR TO THE PLANE READER WITH IMPROVED GIANT MAGNETO-RESISTANCE - In some embodiments, a current perpendicular to the plane giant magneto-resistance (CPP GMR) read sensor may include a reference layer and/or a free layer that includes a plurality of sub-layers. For example, at least one of the reference layer or free layer may include a first ferromagnetic sub-layer, a second ferromagnetic sub-layer, and a Heusler alloy layer located between the first ferromagnetic sub-layer and the second ferromagnetic sub-layer. In some embodiments, a CPP GMR read sensor may include a current closed path (CCP) spacer layer between the reference layer and the free layer. The CCP spacer layer may include Ag and Al | 08-18-2011 |
20120217598 | MAGNETIC TUNNEL JUNCTION HAVING COHERENT TUNNELING STRUCTURE - A magnetic tunnel junction includes an amorphous ferromagnetic reference layer having a first reference layer side and an opposing second reference layer side. The first reference layer side has a greater concentration of boron than the second reference layer side. A magnesium oxide tunnel barrier layer is disposed on the second side of the amorphous ferromagnetic reference layer. The magnesium oxide tunnel barrier layer has a crystal structure. An amorphous ferromagnetic free layer is disposed on the magnesium oxide tunnel barrier layer. | 08-30-2012 |
20120295131 | Current Perpendicular to the Plane Reader with Giant Magneto-Resistance - In some embodiments, a current perpendicular to the plane giant magneto-resistance (CPP GMR) read sensor may include a reference layer and/or a free layer that includes a plurality of sub-layers. For example, at least one of the reference layer or free layer may include a first ferromagnetic sub-layer, a second ferromagnetic sub-layer, and a Heusler alloy layer located between the first ferromagnetic sub-layer and the second ferromagnetic sub-layer. In some embodiments, a CPP GMR read sensor may include a current closed path (CCP) spacer layer between the reference layer and the free layer. The CCP spacer layer may include Ag and Al | 11-22-2012 |
20130001721 | MAGNETIC TUNNEL JUNCTION HAVING COHERENT TUNNELING STRUCTURE - A magnetic tunnel junction includes an amorphous ferromagnetic reference layer having a first reference layer side and an opposing second reference layer side. The first reference layer side has a greater concentration of boron than the second reference layer side. A magnesium oxide tunnel barrier layer is disposed on the second side of the amorphous ferromagnetic reference layer. The magnesium oxide tunnel barrier layer has a crystal structure. An amorphous ferromagnetic free layer is disposed on the magnesium oxide tunnel barrier layer. | 01-03-2013 |
Konstantin Nikolaev, Bloomington, MN US
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20130288076 | STACK WITH WIDE SEED LAYER - A stack having a seed layer structure with a first part having a first cross-track width and a free layer deposited over the seed layer structure and with a second cross-track width, wherein the first cross-track width is greater than the second cross-track width. In one implementation, the seed layer structure further comprises an antiferromagnetic (AFM) layer and a synthetic antiferromagnetic (SAF) layer. In one alternate implementation, the cross-track width of the seed layer structure is substantially equal to the combined cross-track width of the free layer and cross-track width of two permanent magnets. | 10-31-2013 |
20140356648 | STACK WITH WIDE SEED LAYER - A stack having a seed layer structure with a first part having a first cross-track width and a free layer deposited over the seed layer structure and with a second cross-track width, wherein the first cross-track width is greater than the second cross-track width. In one implementation, the seed layer structure further comprises an antiferromagnetic (AFM) layer and a synthetic antiferromagnetic (SAF) layer. In one alternate implementation, the cross-track width of the seed layer structure is substantially equal to the combined cross-track width of the free layer and cross-track width of two permanent magnets. | 12-04-2014 |
20150084624 | MAGNETORESISTIVE SENSOR - Implementations disclosed herein allow a signal detected by a magnetoresistive (MR) sensor to be improved by providing for one or more alloyed layers that each include a ferromagnetic material and a refractory material. The alloyed layers are provided adjacent to a shield element or between soft magnetic layers of the sensor stack. | 03-26-2015 |
20150311430 | MAGNETORESISTIVE SENSOR - Implementations disclosed herein provide a magnetoresistive (MR) sensor including a free layer comprising a first layer of CoFeB or CoFe/CoFeB and a second layer made of an alloyed layer including a ferromagnetic material and a refractory material. An implementation of the MR sensor further includes a cap layer adjacent to the second layer wherein the cap layer does not include any tantalum. | 10-29-2015 |
20150325260 | SENSOR STACK STRUCTURE - A reader stack, such as for a magnetic storage device, the stack having a top synthetic antiferromagnetic (SAF) layer, a magnetic capping layer adjacent to the top SAF layer, an RKKY coupling layer adjacent to the magnetic capping layer opposite the top SAF layer, and a free layer adjacent to the RKKY coupling layer opposite the magnetic capping layer. Also included is a method for biasing a free layer in a reader stack by providing an exchange coupling between the free layer and a top synthetic antiferromagnetic (SAF) layer using a layer having RKKY coupling property positioned between the free layer and the top SAF layer and a magnetic capping layer between the SAF layer and the layer having RKKY coupling property. | 11-12-2015 |
20150332714 | MAGNETORESISTIVE SENSOR - Implementations disclosed herein allow a signal detected by a magnetoresistive (MR) sensor to be improved by providing for one or more alloyed layers that each includes a ferromagnetic material and a refractory material. The alloyed layers are provided adjacent to a shield element or between soft magnetic layers of the sensor stack. | 11-19-2015 |
20150369879 | MAGNETIC SENSOR ANNEALING USING A ROCKING FIELD - Implementations described and claimed herein provide a system comprising an external magnetic field generator, wherein the external field magnetic field generator is configured to rock an effective annealing magnetic field between a first positive angle and a second negative angle compared to a desired pinning field orientation in an AFM/PL structure. | 12-24-2015 |
Konstantin Rudolfovich Nikolaev, Edina, MN US
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20110019314 | MAGNETORESISTIVE DEVICE WITH ENHANCED PINNED LAYER - A magnetoresistive device includes a free layer, a separating layer, a pinned layer, and a magnetic stabilizer in close proximity to the pinned layer, wherein the magnetic stabilizer may enhance the stability of the magnetization direction of the pinned layer. | 01-27-2011 |
20120206839 | MAGNETORESISTIVE DEVICE WITH ENHANCED PINNED LAYER - A magnetoresistive device includes a free layer, a separating layer, a pinned layer, and a magnetic stabilizer in close proximity to the pinned layer, wherein the magnetic stabilizer may enhance the stability of the magnetization direction of the pinned layer. | 08-16-2012 |
Konstantin Rudolfovich Nikolaev, Bloomington, MN US
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20140160596 | DATA STORAGE DEVICE WITH VARIABLE ANISOTROPY SIDE SHIELD - Various embodiments may be generally directed to a data storage device with at least a magnetic element having a magnetic stack positioned adjacent to and separated from at least one side shield on an air bearing surface (ABS). The side shield can be configured with a predetermined anisotropy variation along a down-track direction. | 06-12-2014 |
Leonid Nikolaev, Mississauga CA
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20090217385 | Cryptographic control for mobile storage means - A system and method that regulates the various operations between computing stations and storage devices. Storage devices are the storage means that are contained upon devices that are able to have data stored upon them. Any operation that involves or may lead to the exchange or accessing of content (data) between a storage device and computing station may be regulated by means of a policy which comprise a set of rules. Rules may be defined according to specific criteria, including the type of storage device, the type of content, the attributes of the content, and other attributes associated with the storage device and/or the content. The policy will be dynamically installed upon a computing station for specific user(s) and will regulate the data operations that may take place between the computing stations and storage devices based on evaluation of the policy. Based on the evaluation of the policy, the requested operation is permitted, restricted in some areas, or denied. | 08-27-2009 |
20100058072 | CONTENT CRYPTOGRAPHIC FIREWALL SYSTEM - A system and method that regulates the various operations between computing stations and storage or content. Any operation that involves or may lead to the exchange or accessing of content (data) between storage or hosting content container and computing station may be regulated by means of a policy which comprise a set of rules. Rules may be defined according to specific criteria, including the type of storage, the type of content, the attributes of the content, and other attributes associated with the storage device and/or the content. The policy will be dynamically installed/updated upon a computing station for specific User(s) and will regulate the data operations that may take place between the computing stations and storage or content based on evaluation of the policy. Based on the evaluation of the policy, the requested operation is permitted, restricted in some areas, or denied. | 03-04-2010 |
Petr Vladimirovich Nikolaev, Moscow RU
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20120117729 | MULTIFUNCTIONAL BED - The invention relates to therapeutic-prophylactic equipment and domestic articles and can be used in the home for the care of seriously ill patients having limited mobility or being completely immobile as well as for the prophylactic treatment of temporarily immobile patients. The use of the proposed bed makes it possible to combine various methods for acting on the body, thereby making it possible to take measures for the efficient prevention and healing of a wide range of diseases. This, together with all the listed means and the interactions thereof, makes it possible to enhance and widen the healing effect and improve service quality. | 05-17-2012 |
Segei Nikolaev, Sacramento, CA US
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20130124174 | INTERNAL PARALLELISM IN A PARALLEL DISCRETE EVENT SIMULATION FOR SPACE SITUATIONAL AWARENESS - An internally parallel PDES (“IP-PDES”) system performs logical processes in parallel and further performs the internal processing of at least one logical process in parallel. Because the IP-PDES system is PDES-based, each logical process may have its processing performed in parallel with the other logical processes. The IP-PDES system allows for certain logical processes to be designated as internally parallel meaning that the logical process, referred to as an IP logical process, has its internal processing also performed in parallel. The IP-DES system allocates multiple nodes for such an IP logical process so that executable code of the IP logical process executes in parallel at the allocated nodes to simulate the occurrence of an event. Internal parallelism within a PDES may help overcome resource limitations and help speed up the overall simulation. | 05-16-2013 |
Sergei Nikolaev, Sacramento, CA US
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20130124079 | MONITORING OBJECTS ORBITING EARTH USING SATELLITE-BASED TELESCOPES - An ephemeris refinement system includes satellites with imaging devices in earth orbit to make observations of space-based objects (“target objects”) and a ground-based controller that controls the scheduling of the satellites to make the observations of the target objects and refines orbital models of the target objects. The ground-based controller determines when the target objects of interest will be near enough to a satellite for that satellite to collect an image of the target object based on an initial orbital model for the target objects. The ground-based controller directs the schedules to be uploaded to the satellites, and the satellites make observations as scheduled and download the observations to the ground-based controller. The ground-based controller then refines the initial orbital models of the target objects based on the locations of the target objects that are derived from the observations. | 05-16-2013 |
20130275036 | SCHEDULER FOR MONITORING OBJECTS ORBITING EARTH USING SATELLITE-BASED TELESCOPES - An ephemeris refinement system includes satellites with imaging devices in earth orbit to make observations of space-based objects (“target objects”) and a ground-based controller that controls the scheduling of the satellites to make the observations of the target objects and refines orbital models of the target objects. The ground-based controller determines when the target objects of interest will be near enough to a satellite for that satellite to collect an image of the target object based on an initial orbital model for the target objects. The ground-based controller directs the schedules to be uploaded to the satellites, and the satellites make observations as scheduled and download the observations to the ground-based controller. The ground-based controller then refines the initial orbital models of the target objects based on the locations of the target objects that are derived from the observations. | 10-17-2013 |
20140330544 | MODELING THE LONG-TERM EVOLUTION OF SPACE DEBRIS - A space object modeling system that models the evolution of space debris is provided. The modeling system simulates interaction of space objects at simulation times throughout a simulation period. The modeling system includes a propagator that calculates the position of each object at each simulation time based on orbital parameters. The modeling system also includes a collision detector that, for each pair of objects at each simulation time, performs a collision analysis. When the distance between objects satisfies a conjunction criterion, the modeling system calculates a local minimum distance between the pair of objects based on a curve fitting to identify a time of closest approach at the simulation times and calculating the position of the objects at the identified time. When the local minimum distance satisfies a collision criterion, the modeling system models the debris created by the collision of the pair of objects. | 11-06-2014 |
Sergei Nikolaev, San Jose, CA US
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20120192062 | SYSTEM AND METHOD TO TRANSFORM RESULTS OF CLIENT REQUESTS USING CLIENT UPLOADED PRESENTATION FORMATS - Method and apparatus to facilitate access to a network-based publication system. In an embodiment, a user or third party affiliate of a network-based publication system uploads a style sheet or other presentation format file to a database in the network-based publication system. Thereafter, the user or third party affiliate sends a request to the network-based publication system, and the publication system uses one or more of the uploaded style sheets to format the response to be transmitted back to the third party affiliate. | 07-26-2012 |
20150317290 | SYSTEM AND METHOD TO TRANSFORM RESULTS OF CLIENT REQUESTS USING CLIENT UPLOADED PRESENTATION FORMATS - Method and apparatus to facilitate access to a network-based publication system. In an embodiment, a user or third party affiliate of a network-based publication system uploads a style sheet or other presentation format file to a database in the network-based publication system. Thereafter, the user or third party affiliate sends a request to the network-based publication system, and the publication system uses one or more of the uploaded style sheets to format the response to be transmitted back to the third party affiliate. | 11-05-2015 |
Sergei (shawn) Nikolaev, Albany, CA US
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20150112782 | Methods and Systems for Unified Vault and Rewards within Real Money Applications - A virtual vault is generated and displayed for a user of a real-money application and is defined to hold in trust real-money rewards for the user. Each real-money reward is redeemable for real-world monetary value within the real-money application. The virtual vault includes respective reward graphics for the real-money rewards for the user. Upon selection of a reward graphic by the user, a determination is made as to whether or not the user is qualified to receive a real-money reward corresponding to the selected reward graphic. If the user is qualified to receive the real-money reward, the user is credited with a real-world monetary value specified by the real-money reward. Or, if the user is not qualified to receive the real-money reward, the user is notified of one or more actions required by the user in order to qualify for receipt of the real-money reward. | 04-23-2015 |
20150112783 | Methods and Systems for Cross-Platform Promotion with Real Money Applications - A notification regarding a real-money application is transmitted to a user of a second application when the user is executing the second application. The notification conveys a reward available to the user within the second application in exchange for performing a required action in the real-money application. Upon selection of a control object by the user, the real-money application is executed with reference to the user so as to provide the user with an interface to perform the required action in the real-money application. Upon determining that the user completed the required action in the real-money application, a status of the user is updated in the second application to provide the user with the reward in the second application corresponding to completion of the required action in the real-money application. | 04-23-2015 |
Valery Mikhailovich Nikolaev, Moscow RU
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20090275663 | Method for Producing a Disinfecting Agent - The invention relates to medicine, in particular to sanitary and hygiene, more specifically to methods for producing a disinfecting agent for decontaminating different types of water, including drinking water. The inventive disinfecting agent producing method by dissolving quaternary ammonium compounds in water in the presence of an active additive in the form of guanidines, consists in preparing an aqueous 1-15% guanidine solution by permanently agitating it at a temperature ranging from 30 to 90° C., in cooling the solution accompanied with a precipitation control, when the precipitation process is over, in filtering the solution by using a filter whose cell size ranges from 10 to 1 mkm and in adding the quaternary ammonium compounds into the solution in such away that the concentration thereof in said solution is equal to 0.1-3%. | 11-05-2009 |
Vassili I. Nikolaev, Redmond, WA US
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20130304944 | Device Enumeration Support - Device enumeration support techniques are described for busses that do not natively support enumeration. In one or more embodiments, an intermediate controller of a computing device is configured to interconnect and manage various hardware devices associated with the computing device. The intermediate controller may detect connection and disconnection of hardware devices in association with one or more communication busses employed by the computing device. In response to such detection, the intermediate controller may send appropriate notifications to an operating system to alert the operating system when hardware devices come and go. This enables the operating system to enumerate and denumerate hardware devices within a device configuration and power management system implemented by the operating system that facilitates interaction with the hardware devices through corresponding representations. | 11-14-2013 |
Viacheslav Nikolaev, Würzburg DE
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20080286760 | Means and Methods for the Determination of Camp In Vitro and In Vivo - The present invention relates to a chimeric peptide, comprising a cAMP binding moiety having only one cAMP binding site and at least two detectable labels, whereby the first of said two detectable labels is located at the carboxy terminus and the second of said two detectable labels is located at the amino terminus of said cAMP binding moiety. Said chimeric peptide of the invention is particularly useful in/for direct determination of cAMP concentrations) in vitro and/or in vivo. Furthermore, nucleic acid molecules encoding said chimeric proteins are described as well as vectors and host cells comprising the same. The present invention also provides methods for producing the chimeric protein of the invention and methods for identification and screening of molecules or compounds which are capable of modifying cAMP binding to the chimeric peptide of the invention or the biological and/or pharmacological function of adenylyl cyclases or phosphodiesterases. In addition, a method for cAMP determination in a sample and a method for the detection of cAMP in the living cell or tissue is described. Finally, a kit comprising the compounds of the present invention is disclosed. | 11-20-2008 |
Viacheslav Nikolaev, Wurzburg DE
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20080286760 | Means and Methods for the Determination of Camp In Vitro and In Vivo - The present invention relates to a chimeric peptide, comprising a cAMP binding moiety having only one cAMP binding site and at least two detectable labels, whereby the first of said two detectable labels is located at the carboxy terminus and the second of said two detectable labels is located at the amino terminus of said cAMP binding moiety. Said chimeric peptide of the invention is particularly useful in/for direct determination of cAMP concentrations) in vitro and/or in vivo. Furthermore, nucleic acid molecules encoding said chimeric proteins are described as well as vectors and host cells comprising the same. The present invention also provides methods for producing the chimeric protein of the invention and methods for identification and screening of molecules or compounds which are capable of modifying cAMP binding to the chimeric peptide of the invention or the biological and/or pharmacological function of adenylyl cyclases or phosphodiesterases. In addition, a method for cAMP determination in a sample and a method for the detection of cAMP in the living cell or tissue is described. Finally, a kit comprising the compounds of the present invention is disclosed. | 11-20-2008 |
20100209445 | MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING BETA1-ADRENOCEPTOR ANTIBODIES - The present invention relates to novel β-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-β-adrenergic receptor antibodies like anti-βradrenergic receptor antibodies. | 08-19-2010 |
20150038673 | MUTANT DOUBLE CYCLIZED RECEPTOR PEPTIDES INHIBITING BETA1-ADRENOCEPTOR ANTIBODIES - The present invention relates to novel β-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-.beta.-adrenergic receptor antibodies like anti-β | 02-05-2015 |
Vladimir Nikolaev, St. Petersburg RU
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20100275843 | HVPE REACTOR ARRANGEMENT - An HVPE reactor arrangement comprises a reaction chamber ( | 11-04-2010 |
Vladimir Nikolaev, Saint-Petersburg RU
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20140001486 | COMPOSITE SEMIDCONDUCTOR SUBSTRATE, SEMICONDUCTOR DEVICE, AND MANUFACTURING METHOD | 01-02-2014 |
Vsevold Valerievich Nikolaev, Zurich CH
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20120329819 | NEW CRYSTALLINE FORM OF PEMETREXED DISODIUM - The present invention relates to a new polymorphic or crystalline form of Pemetrexed Disodium, processes for its preparation and its use, in particular for the preparation of medicaments. | 12-27-2012 |
Vyacheslav Viktorovich Nikolaev, Saint-Petersburg RU
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20150041696 | VALVE DRIVE FOR ACTUATING A VALVE - A valve drive for actuating a valve comprises a main motor, a main shaft, a transmitting device comprising a nut and a spindle and adapted to transform rotational movement of the nut into a translational movement of the spindle, and driving means adapted to move the spindle, wherein the main motor is adapted to transfer rotation to the nut via the main shaft, and the spindle is adapted to open and close the valve during the translational movement of the spindle. The valve drive for actuating a valve further comprises a differential mechanism mounted between the main motor and the main shaft, said differential mechanism comprising a first input shaft connecting the differential mechanism to the main motor, and a second input shaft. The output shaft of the differential mechanism is the main shaft. | 02-12-2015 |
20150135868 | ELECTROMECHANICAL DRIVING ACTUATOR WITH DAMPING DEVICE - An electromechanical driving actuator with a damping device comprises an electric motor ( | 05-21-2015 |