Patent application number | Description | Published |
20100035815 | SKIN WOUND HEALING COMPOSITIONS AND METHODS OF USE THEREOF - A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound. | 02-11-2010 |
20110082082 | SKIN WOUND HEALING COMPOSITIONS AND METHODS OF USE THEREOF - A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 pg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed. | 04-07-2011 |
20110301090 | SKIN WOUND HEALING COMPOSITIONS AND METHODS OF USE THEREOF - A wound healing composition comprising an amount of heat shock protein effective to promote wound healing and a method thereof to apply the composition. A preferred heat shock protein is either full-length hsp90α or the middle domain plus the charged sequence of hsp90α. The composition is topically applied to skin wounds, covering the outer surface of the wound. The heat shock protein acts by promoting migration of both human epidermal keratinocyte and dermal fibroblasts to the wound in order to close, heal, and remodel the wound. | 12-08-2011 |
20120121595 | FRAGMENT OF SECRETED HEAT SHOCK PROTEIN-90ALPHA (Hsp90ALPHA) AS VACCINES OR EPITOPE FOR MONOCLONAL ANTIBODY DRUGS OR TARGET FOR SMALL MOLECULE DRUGS AGAINST A RANGE OF SOLID HUMAN TUMORS - The invention provides methods for treating HIF-1α-overexpressing human tumors, inhibiting HIF-1α-overexpressing tumor invasion and preventing tumor metastasis, and/or promoting tumor prophylaxis, using various types of inhibitors against the Hsp90α from the tumors. | 05-17-2012 |
20120329719 | Methods of use of skin wound healing compositions - A wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain. The composition includes a pharmaceutical medium to carry the polypeptide compound, such as an aqueous solution, suspension, dispersion, salve, ointment, gel, cream, lotion, spray or paste. Additionally, a method of applying a wound healing composition comprising a class of polypeptide compounds having a polypeptide chain with 5 to 120 amino acid units per chain in a concentration of from about 1 μg/ml to about 100 μg/ml for a time sufficient to heal the wound is disclosed. | 12-27-2012 |
20140199309 | FRAGMENT OF SECRETED HEAT SHOCK PROTEIN-90ALPHA (HSP90ALPHA) AS VACCINES OR EPITOPE FOR MONOCLONAL ANTIBODY DRUGS OR TARGET FOR SMALL MOLECULE DRUGS AGAINST A RANGE OF SOLID HUMAN TUMORS - The invention provides methods for treating HIF-1α-overexpressing human tumors, inhibiting HIF-1α-overexpressing tumor invasion and preventing tumor metastasis, and/or promoting tumor prophylaxis, using various types of inhibitors against the Hsp90α from the tumors. | 07-17-2014 |
Patent application number | Description | Published |
20110058055 | VIDEO STORAGE - Systems, methods, and devices for encoding video data are provided. For example, an electronic device for obtaining and encoding video may include image capture circuitry, motion-sensing circuitry, and data processing circuitry. The image capture circuitry may capture an uncompressed video frame, and the motion-sensing circuitry may detect physical motion of the electronic device. The data processing circuitry may encode the uncompressed video frame based at least in part on a quantization parameter, which the data processing circuitry may determine based at least in part on whether the motion-sensing circuitry has detected physical motion of the electronic device. | 03-10-2011 |
20120084142 | BID LANDSCAPE FORECASTING IN ONLINE ADVERTISING - Techniques are provided for advertiser bid forecasting in online advertising, including display advertising. Methods are provided in which key targeting-related user segments are determined from bidding statistics. A feature set is extracted from an impression opportunity, based at least in part on the bidding statistics. A gradient boosting descent tree technique is utilized in determining an initial bid forecasting result. A linear regression-based model is used in post-tuning to arrive at a post-tuned result. For short-term forecasting, this may be the final result. For long-term forecasting, a hybrid approach may be utilized with further processing including utilization of a publisher-specific model. | 04-05-2012 |
20120120184 | SYSTEM AND METHOD FOR PROVIDING CAMERA FUNCTIONS IN A VIDEO ENVIRONMENT - A method is provided in one example and includes receiving image data at a camera element that is provisioned at a first endpoint, which is configured to conduct a video session involving a second endpoint. The method also includes identifying an incoming request for the video session; signaling to the camera element to open a lens included within the camera element; detecting that the video session has been terminated; and signaling to the camera element to close the lens. | 05-17-2012 |
20120120270 | SYSTEM AND METHOD FOR PROVIDING ENHANCED AUDIO IN A VIDEO ENVIRONMENT - A method is provided in one example and includes receiving audio data at a microphone array that includes a plurality of microphones. The microphone array is provisioned at a first endpoint, which includes a camera element configured to capture video data associated with a video session involving the first endpoint and a second endpoint. The method also includes formatting the audio data into a time division multiplex (TDM) stream, and communicating the stream to a port for a subsequent communication over a network and to the second endpoint. | 05-17-2012 |
20130013617 | INDEXING TIMESTAMP WITH TIME ZONE VALUE - Techniques are described for processing a query to produce query results, the query specifying at least a first timestamp value. Embodiments receive the query for processing and access a database index containing a plurality of database keys. The database index contains one or more database index keys, each of which includes at least a timestamp value and a time zone value. Embodiments compare the first timestamp value specified in the query with a portion of one the database index keys to locate at least a portion of the query results. More specifically, the compared portion of the database index key excludes the time zone value. The located portion of the query results is then retrieved. | 01-10-2013 |
Patent application number | Description | Published |
20100321506 | CALIBRATION TECHNIQUES FOR CAMERA MODULES - A set of calibration procedures that can be run to assist in calibrating a camera module, such as may be intended for installation into a mobile consumer device. The procedures include lens shading calibration, white balance calibration, light source color temperature calibration, auto focus macro calibration, static defect pixel calibration, and mechanical shutter delay calibration. The light source color temperature calibration may be performed to assist in the other calibrations, each of which may generate data that can be potentially be stored in non-volatile memory on board the camera module for use during operation. | 12-23-2010 |
20130156091 | NETWORKED IMAGE/VIDEO PROCESSING SYSTEM FOR ENHANCING PHOTOS AND VIDEOS - A distributed image/video processing system is disclosed herein wherein one or more of digital image/video recorders (e.g., a digital cameras, video recorders, or smart phones, etc.) are in network communication with central network site for transmitting image or video data thereto. The recorders process their image/video data dependent upon an estimate of a measurement of network bandwidth that is available for transmitting image or video data to the central network site. | 06-20-2013 |
20130156092 | NETWORKED IMAGE/VIDEO PROCESSING SYSTEM AND NETWORK SITE THEREFOR - A distributed image/video processing system is disclosed herein wherein one or more of digital image/video recorders (e.g., a digital cameras, video recorders, or smart phones, etc.) are in network communication with central network site for transmitting image or video data thereto. The recorders process their image/video data dependent upon an estimate of a measurement of network bandwidth that is available for transmitting image or video data to the central network site. | 06-20-2013 |
20130156095 | NETWORKED IMAGE/VIDEO PROCESSING SYSTEM - A distributed image/video processing system is disclosed herein wherein one or more of digital image/video recorders (e.g., a digital cameras, video recorders, or smart phones, etc.) are in network communication with central network site for transmitting image or video data thereto. The recorders process their image/video data dependent upon an estimate of a measurement of network bandwidth that is available for transmitting image or video data to the central network site. | 06-20-2013 |
Patent application number | Description | Published |
20100048382 | TOLUENE SELECTIVE DISPROPORTIONATION CATALYST - The present invention discloses a catalyst for toluene shape selective disproportionation, comprising: a) 45 to 95 wt % of ZSM-5 molecular sieve having an average particle size of from 0.3 to 6 μm and a molar ratio of SiO | 02-25-2010 |
20100283594 | TIRE PRESSURE MONITORING SYSTEM - The present disclosure relates to a tire pressure monitoring system adapted to an automobile having a first component and a changeable second component, said tire pressure monitoring system comprising: a register for transmitting the registered code of the said automobile via a wireless manner; a relay disposed in the second component for relaying a second tire information transmitted by tire pressure transmitter for each tire in the second component, wherein when the relay receives the registered code, it attaches the registered code to the second tire information and relays the second tire information; and a receiver disposed in the first component for receiving the second tire information relaid by the relay, wherein when the registered code included in the second tire information is consistent with the registered code of said automobile stored in the receiver, the receiver processes the second tire information as the tire information of the second component of said automobile. The present invention can achieve a registration when the trailer of the truck is changed via a simple and reliable manner. | 11-11-2010 |
20110241856 | AUTOMATIC NETWORKING APPARATUS FOR VEHICLES - The present invention relates to an automatic networking apparatus for vehicles for a vehicle with a first component and a second replaceable component, and it comprises a first identity recognition module disposed on the first component and a second identity recognition module disposed on the second component. When the second identity recognition module turns into a networking mode, it transmits a low-frequency wake-up signal through a low-frequency signal transmission circuit to wake up the first identity recognition module. A low-frequency sensor circuit of the first identity recognition module is able to sense the low-frequency wake-up signal, and responds to the low-frequency wake-up signal to transmit an identity code corresponding to the first component through the high-frequency signal transmission circuit. The high-frequency signal receiving circuit of the second identity recognition module can receive the identity code of the first component and store the received identity code. In the following data transmission, the second identity recognition module can send the data with the identity code of the first component loaded with, so that a receiving apparatus of the first component identifies it. The present invention features in networking automation, simple installation, and convenient maintenance. | 10-06-2011 |
20120081155 | Dual-Mode Voltage Controlled Oscillator, Frequency Synthesizer and Wireless Receiving Device - The invention provides a dual-mode voltage-controlled oscillator (DMVCO), a frequency synthesizer and a wireless receiving device, and pertains to the technical field of integrated circuit of radio frequency wireless receiver. The DMVCO and the frequency synthesizer can operate in a wideband mode and a quadrature mode. When operating in the quadrature mode, a quadrature signal is provided for a Single Sideband Mixer of the frequency synthesizer by a quadrature coupling of a first voltage-controlled oscillator unit and a second voltage-controlled oscillator unit in the DMVCO in the overlapped frequency band so that the frequency synthesizer can cover a higher output frequency band. Therefore, the tuning range of the DMVCO of the invention is wide, and the frequency synthesizer using the DMVCO is low in power consumption, simple in structure and has good frequency spur performance. | 04-05-2012 |
20120146779 | AUTOMATIC NETWORKING APPARATUS AND SYSTEM FOR VEHICLES - A vehicle automatic networking apparatus with a first component and a second replaceable component includes a first identity recognition module on the first component and a second identity recognition module on the second component. The second module in a networking mode transmits a low frequency wake up signal through a low frequency signal transmission circuit to wake up the first module. A first identity recognition module low frequency sensor circuit senses the low frequency wake up signal, and responds by transmitting an identity code of the first component through a low frequency signal transmission circuit. A second module low frequency signal receiving circuit receives and stores the first component identity code. In a following data transmission, the second module sends data with the identity code, and a first component receiving apparatus identifies it. The first and second modules are both located rearward of a second component connection hitch. | 06-14-2012 |
20120298760 | CONTACTLESS COMMUNICATION DEVICE - A contactless communication device comprises a contactless front chip, a security chip concentrator and a security chipset. Wherein, said security chipset contains more than two security chips for storing and processing the contactless application data; said contactless front chip is used for implementing the interaction between said security chip and the external contactless field; said security chip concentrator, which is connected with the contactless front chip and with the security chip of the security chipset, is used for selecting a security chip based on the contactless application and implementing the connection between the selected security chip and the contactless front chip. The contactless communication device of the present invention is based on the application mode of multi-card for multi-use so that different providers can independently issue security chips separated from the contactless communication device, then the problems of data security, user management and so on caused by single-card for multi-use are avoided. | 11-29-2012 |
20130046372 | DELIVERY SYSTEM FOR NEW SLIDE-AND-LOCK BIOABSORBABLE STENT - A transcatheter delivery device for delivering a slide-and-lock stent to a stenosed lumen consists of an outer cannula ( | 02-21-2013 |
20130127600 | Contactless Communication Device - A contactless communication device comprises a contactless front chip, a security chip concentrator and a security chipset. Wherein, said security chipset contains more than two security chips for storing and processing the contactless application data; said contactless front chip is used for implementing the interaction between said security chip and the external contactless field; said security chip concentrator, which is connected with the contactless front chip and with the security chip of the security chipset, is used for selecting a security chip based on the contactless application and implementing the connection between the selected security chip and the contactless front chip. The contactless communication device of the present invention is based on the application mode of multi-card for multi-use so that different providers can independently issue security chips separated from the contactless communication device, then the problems of data security, user management and so on caused by single-card for multi-use are avoided. | 05-23-2013 |
20130217328 | METHOD AND APPARATUS FOR DATA TRANSMISSION - A method and an apparatus for data transmission between a contactless front element and a security element are provided. The method includes: the contactless front element transparently transmits first data obtained from a contactless identification device to the security element through a single wire connection; the security element processes the first data to generate second data; the contactless front element transparently transmits the second data obtained from the security element through the single wire connection to the contactless identification device. Compared with the prior art, the method can transmit the contactless data in real time between the contactless front element and the security element. Thus the security element can directly respond instructions sent by a proximity coupling device during simulating Proximity Integrated Circuit Card, so that the contactless front element becomes a transparent transport channel, the time order compatibility problem can be avoided, and the safety problem can be surmounted. | 08-22-2013 |
20130321139 | METHOD AND DEVICE FOR RECEIVING AND PROCESSING TIRE PRESSURE SIGNALS - The invention relates to a method and device for receiving and processing tire pressure signals. Said device comprises a first directional antenna, a second directional antenna, an amplifier, a signal converter and a micro-controller. The first directional antenna can be positioned near one of the front wheels of said vehicle, and its orientation points to another front wheel of said vehicle. The second directional antenna can be positioned near one of the rear wheels of said vehicle, said rear wheel and one of the front wheels are arranged diagonally, and the orientation of the second directional antenna points to another rear wheel of said vehicle. The amplifier can be connected to the first directional antenna and the second directional antenna to amplify the pressure signals transmitted by the transmitters and detected by the first directional antenna and the second directional antenna, respectively. The signal converter is used for converting the pressure signals in radio signal format to field strength signals. The micro-controller is used for receiving the converted field strength signals of the respective transmitters, and determining the tire positions where the respective transmitters are installed based on the magnitudes of the field strength signals of the respective transmitters. | 12-05-2013 |
20140189995 | METHODS FOR INSTALLING REACTOR COOLANT LOOP PIPING IN A NUCLEAR POWER PLANT - Method for installing reactor coolant loop (RCL) piping of a reactor coolant system (RCS) system in a pressurized water reactor (PWR) nuclear power plant by positioning the reactor vessel, steam generator, or both, into position after attaching one or more coolant pumps, surveying coolant loop piping and a plurality of nozzles on the reactor vessel, the steam generator and coolant pump casing, or a combination thereof, with a precise measurement and 3D modeling technology for positioning data, then performing weld prep machining for the coolant loop piping on the reactor vessel side, and machining for the coolant loop piping on the steam generator side and coolant pump side based on the positioning data, and installing temporary supports for coolant loop piping and finishing the fit-up and welding between the coolant loop piping and the reactor vessel, steam generator, and each coolant pump. | 07-10-2014 |
Patent application number | Description | Published |
20100166704 | Methods and compositions for inhibition of viral replication - The present invention is directed to methods and compositions that are effective in the inhibition of viral replication. In particular, the methods and compositions are effective at interfering with the activity of host cell proteins required in viral replication. For example, an embodiment of the invention is directed to inhibition of flavivirus replication wherein the replication is affected by changing the normal interactions of the host cell protein TIAR or TIA-1. | 07-01-2010 |
20100285006 | Compositions of Kinase Inhibitors and Their Use for Treatment of Cancer and Other Diseases Related to Kinases - The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof. | 11-11-2010 |
20110112180 | NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS - The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds. | 05-12-2011 |
20120252763 | NOVEL GROUP OF STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL PATHWAY INHIBITORS - The present invention relates to the use of a novel class of cancer stem cell pathway (CSCP) inhibitors; to methods of using such compounds to treat refractory, recurrent, or metastatic cancers; to methods of selective killing cancer cells by using such compounds with specific administration regimen; to methods of targeting cancer stem cells by inhibiting Stat3 pathway; to methods of using novel compounds in the treatment of conditions or disorders in a mammal related to aberrant Stat3 pathway activity; and to processes for preparing such compounds and intermediates thereof, and to the pharmaceutical composition of relevant compounds, and to the specific methods of administration of these compounds. | 10-04-2012 |
20120321622 | Compositions of Kinase Inhibitors and Their Use for Treatment of Cancer and Other Diseases Related to Kinases - The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof. | 12-20-2012 |
20130028944 | NOVEL METHODS FOR TARGETING CANCER STEM CELLS - The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof. | 01-31-2013 |
20130034591 | NOVEL COMPOUNDS AND COMPOSITIONS FOR TARGETING CANCER STEM CELLS - The invention provides naphthofuran compounds, polymorphs of naphthofuran compounds, naphthofuran compounds in particle form, purified compositions that contain one or more naphthofuran compounds, purified compositions that contain one or more naphthofuran compounds in particle form, methods of producing these naphthofuran compounds, polymorphs, purified compositions and/or particle forms, and methods of using these naphthofuran compounds, polymorphs, purified compositions and/or particle forms to treat subjects in need thereof. | 02-07-2013 |
20140275033 | INHIBITORS OF KINASES AND CANCER STEM CELLS, AND METHODS OF PREPARATION AND USE THEREOF - The invention provides novel inhibitors of cancer stem cells as well as cancer stem cell pathway kinase and other related kinases, pharmaceutical compositions and uses thereof in the treatment of cancer or a related disorder in a mammal, and methods of making such compounds and compositions. | 09-18-2014 |
20150018410 | NOVEL STAT3 PATHWAY INHIBITORS AND CANCER STEM CELL INHIBITORS - The present invention relates to a novel naphtho class of compounds as Stat3 pathway inhibitors and as cancer stem cell inhibitors; to methods of using such compounds to treat cancer; to methods of using such compounds to treat disorders in a mammal related to aberrent Stat3 pathway activity; to pharmaceutical compositions containing such compounds. | 01-15-2015 |
Patent application number | Description | Published |
20100029648 | 11-Beta HSD1 Inhibitors - This invention relates to inhibiting 11βHSD1. | 02-04-2010 |
20100035957 | Methods for the Use of Inhibitors of Cytosolic Phospholipase A2 - This invention provides methods for the use of substituted indole compounds of the general formula: | 02-11-2010 |
20100137298 | Biaryl Sulfonamides and Methods for Using Same - The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors. | 06-03-2010 |
20100203007 | NOVEL BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 08-12-2010 |
20100227859 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS - The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human. | 09-09-2010 |
20120165537 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS - Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form. | 06-28-2012 |
20120238731 | METHODS OF PREPARATION OF CONJUGATES - The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents. | 09-20-2012 |
20120244171 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. | 09-27-2012 |
20130266596 | NOVEL BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 10-10-2013 |
20130302357 | NOVEL BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 11-14-2013 |
20130302359 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. | 11-14-2013 |
20140135502 | METHODS FOR THE PREPARATION OF CHARGED CROSSLINKERS - Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form. | 05-15-2014 |
20150030616 | NOVEL BENZODIAZEPINE DERIVATIVES - The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. | 01-29-2015 |
Patent application number | Description | Published |
20090091913 | LED-based dental exam lamp with variable chromaticity - An electrically powered light source including a light emitting diode (LED) having variable chromaticity, which is adapted for use in a dental operatory. A dental operatory lamp includes a thermally conductive housing having a front directed toward the operating area and a rear away from the operating area; a generally elliptical reflector located on the rear of the thermally conductive housing; at least one heat pipe; a plurality of color LEDs projecting light toward the elliptical reflector, the plurality of LEDs being in thermal contact with the at least one heat pipe; and an optical light guide for combining light from said LEDs. Another embodiment of the lamp includes at least two user selectable light spectra, one of said spectra providing white light with color temperature in the range 4000° K-6000° K and one spectra having reduced output in the wavelength range 400-500 nm. | 04-09-2009 |
20100091507 | Directed LED Light With Reflector - A high intensity light is disclosed. A first circular lighting array having a plurality of reflectors and light emitting diodes is provided. A second circular lighting array is mounted on the first circular lighting array. The second circular lighting array has a second plurality of reflectors and light emitting diodes. Each reflector includes a tulip-shaped reflective surface having a symmetrical vertical cross section and a different symmetrical horizontal cross section. The reflective surface creates a uniform beam reflecting from a corresponding LED at horizontal angles relative to the reflective surface and a narrow beam in vertical angles relative to the reflective surface. | 04-15-2010 |
20100208487 | LED ILLUMINATION DEVICE - A device comprising a plurality of LEDs arranged in a coplanar array, the coplanar array comprising an LED at the center and LEDs positioned radially symmetrically around the LED at the center, and wherein the central axes of the LEDs are arranged to be parallel to each other; a one-piece lens array collimating light from the LEDs, the lens array comprising a plurality of coplanar lens tiles, the coplanar lens tiles comprising a lens tile at the center and lens tiles positioned radially symmetrically around the lens tile at the center, and wherein the central axis of each of the lens tiles is aligned with the central axis of a corresponding LED; and a focusing lens converging the collimated light from the lens array into a single image in a focal plane, wherein the central axis of the focusing lens is aligned with the central axis of the lens array. | 08-19-2010 |
20110222308 | LIGHT GUIDE FOR COUPLING DIFFERENTLY SHAPED LIGHT SOURCE AND RECEIVER - A light guide for interfacing between a light source having a light emitting surface with a first shape and a light receiver with a light receiving surface of a second shape. The light guide has a light emitting end having a first shape of substantially the same size as the first shape of the light emitting surface. A light receiving end has a second shape of substantially the same size as the second shape of the light receiving surface. A free form body between the light emitting end and the light receiving end causes a transition between the first and second shape. | 09-15-2011 |
20120008327 | TAILORED SIDE-EMITTER PERIMETER BEACON - An optical element for a side emitting light that emits light from a light source at side directions relative to the horizon is disclosed. The optical element has an internal recess adapted to fit over a light source. The internal recess includes a collimating surface and interior refractive surfaces. An exterior refractive surface corresponding to the interior refractive surfaces is provided. A faceted prismatic reflecting surface corresponding with the collimating surface is provided. Light at a substantially horizontal angle relative to the horizon is emitted through the interior refractive surface through the exterior reflective surface to a side direction and light at a substantially vertical angle relative to the horizon is collimated by the collimating surface and reflected by the reflecting surface in the side direction. | 01-12-2012 |
20120170302 | LED-BASED DENTAL EXAM LAMP WITH VARIABLE CHROMATICITY - An electrically powered light source including a light emitting diode (LED) having variable chromaticity, which is adapted for use in a dental operatory. A dental operatory lamp includes a thermally conductive housing having a front directed toward the operating area and a rear away from the operating area; a generally elliptical reflector located on the rear of the thermally conductive housing; at least one heat pipe; a plurality of color LEDs projecting light toward the elliptical reflector, the plurality of LEDs being in thermal contact with the at least one heat pipe; and an optical light guide for combining light from said LEDs. Another embodiment of the lamp includes at least two user selectable light spectra, one of said spectra providing white light with color temperature in the range 4000° K-6000° K and one spectra having reduced output in the wavelength range 400-500 nm. | 07-05-2012 |
20130294103 | COLOR TEMPERATURE TUNABLE LED-BASED LAMP MODULE - A light mixing and folding lamp includes an LED assembly with two or more LED chips that direct light into the ingress end of a light mixing rod. The light mixing rod is positioned to pass through an aperture in a concave second reflecting element, and mixed light emerges from the egress end of the light mixing rod, where it is directed toward a first reflecting element positioned near a focal point of the second reflecting element. The first reflecting element reflects mixed light emerging from the egress end of the light mixing rod, folding the mixed light back toward a concave reflecting surface of the second reflecting element. The second reflecting element reflects light from the first reflecting element forward, where the light emerges from the lamp directed toward a subject to be illuminated. | 11-07-2013 |
Patent application number | Description | Published |
20100131451 | DISPLAYING RESOURCES BASED ON SHARED CONTEXTS - A user data engine residing on an endpoint machine generates a current user context reflecting a specific flow of operations performed by an end-user when interacting with a software application. A context engine residing on a sever machine compares the current user context to one or more stored user contexts included in a context database and generates a similarity value based on each comparison. A resource engine identifies resources in a resource database that are associated with the stored user contexts and then generates a relevance score for each resource based on the similarity scores corresponding to the stored user contexts with which those resources are associated. The resource engine transmits a resource list reflecting the identified resources to the user data engine based on the relevance scores. The user data engine displays on a display screen of the endpoint machine information associated with resources reflected in the resource list. | 05-27-2010 |
20100131452 | DISPLAYING RESOURCES BASED ON SHARED CONTEXTS - A user data engine residing on an endpoint machine generates a current user context reflecting a specific flow of operations performed by an end-user when interacting with a software application. A context engine residing on a sever machine compares the current user context to one or more stored user contexts included in a context database and generates a similarity value based on each comparison. A resource engine identifies resources in a resource database that are associated with the stored user contexts and then generates a relevance score for each resource based on the similarity scores corresponding to the stored user contexts with which those resources are associated. The resource engine transmits a resource list reflecting the identified resources to the user data engine based on the relevance scores. The user data engine displays on a display screen of the endpoint machine information associated with resources reflected in the resource list. | 05-27-2010 |
20100131896 | MANUAL AND AUTOMATIC TECHNIQUES FOR FINDING SIMILAR USERS - A user data engine records profile data supplied by a user and usage data that is based on interactions between the user and a software application. A group data engine receives a set of user data comprising the profile data and the usage data for each user of a plurality of users. The group data engine determines a similarity value between each pair of users of the software application. The group data engine identifies groups of similar users based on the similarity values by executing one or more clustering algorithms. A user may then search for other users and groups of users of the software application and may then receive information from the users and/or groups of users that is related to use of the software application. | 05-27-2010 |
20110314415 | Method and System for Providing Custom Tooltip Messages - A computer-implemented method for providing custom tooltips to an end-user of a software application. The method includes receiving a selection of a user interface (UI) element associated with the software application; and causing a custom tooltip to be displayed on a display device in response to the selection, where the custom tooltip includes one or more custom tooltip entries associated with the selected UI element created by one or more users. | 12-22-2011 |
20130006907 | DISPLAYING RESOURCES BASED ON SHARED CONTEXTS - A user data engine residing on an endpoint machine generates a current user context reflecting a specific flow of operations performed by an end-user when interacting with a software application. A context engine residing on a sever machine compares the current user context to one or more stored user contexts included in a context database and generates a similarity value based on each comparison. A resource engine identifies resources in a resource database that are associated with the stored user contexts and then generates a relevance score for each resource based on the similarity scores corresponding to the stored user contexts with which those resources are associated. The resource engine transmits a resource list reflecting the identified resources to the user data engine based on the relevance scores. The user data engine displays on a display screen of the endpoint machine information associated with resources reflected in the resource list. | 01-03-2013 |
Patent application number | Description | Published |
20100099754 | 5,6-DIMETHYL XANTHONE-4-ACETIC ACID DERIVATIVES AND METHOD OF PREPARING THE SAME - A method of preparation of 5,6-dimethylxanthone-4-acetic acid (DMXAA) and derivatives thereof. The derivatives are represented by formula (I), wherein R represents totally 1 to 2 substitutes at 1, 2, 3, 7, and 8 position selected from a lower alkyl, halogen, CF | 04-22-2010 |
20120089104 | ANTIVIRAL TRANSDERMAL PATCH AND METHOD FOR PRODUCING THE SAME - An antiviral transdermal patch including a backing layer, a viscous polymer layer, and a protection film layer. The viscous polymer layer includes an antiviral agent, a viscous polymer, and a transdermal enhancer. The transdermal enhancer is laurocapram or a mixture thereof. The antiviral agent is a nucleoside antiviral drug with a daily delivery rate of less than 100 mg/day. The patch effectively promotes the penetration of a nucleoside antiviral agent into the blood circulation and avoids enzymolysis in the gastrointestinal tract and the first pass effect of the liver and reduces side effect of drugs, thereby inhibiting the replication of target viruses and reducing viral DNA level in the serum. A method for producing the patch is also provided. The raw materials involved in the invention are easily purchased from the market at a low cost. | 04-12-2012 |
Patent application number | Description | Published |
20100023605 | System and method for synchronizing configurations in a controller network - A method is disclosed for synchronizing configuration data. The method may include providing a controller network that includes a plurality of control modules and each control module may have registration information stored thereon. The method may include detecting a registration information change associated with a control module and receiving current configuration data from the control module, if the registration information change is detected. The method may also include creating new configuration data for each control module in the controller network based on the received current configuration data, and synchronizing the configuration of each control module with the created new configuration data. | 01-28-2010 |
20120253609 | Proportional control using state space based scheduling - A method for proportional state space based scheduling of gain within a machine includes generating a speed error value and when the speed error value is substantially nonzero producing an implement position difference value representing the amount by which an implement position differs from a position that would provide a desired machine speed. The method then converts the implement position difference value to a desired implement position command and differences the desired implement position command and a position signal indicative of the current implement position to produce an implement difference value. The implement difference value is used to generate one or more implement actuator signals | 10-04-2012 |
20120253631 | CVT control using state space based gain scheduling - An engine powered wheeled machine having improved engine over speed and under speed protection includes a parallel path transmission having a gear train with first and second transmission inputs and a transmission output, and including a hydraulic variator having a variator output driving the first transmission input, the hydraulic variator having a variator pump and a variator motor, the displacement of the variator pump being controlled by a variator actuator. The machine further includes an engine having an engine output driving the second transmission input and driving the variator pump and a controller for receiving one or more values indicative of one or more ranges of permissible engine speed, a value indicative of an actual engine speed, and a value indicative of the position of the variator actuator, with the controller being configured to control the position of the variator actuator based on state space gain mapping to maintain the engine speed within the one or more ranges of permissible engine speed. | 10-04-2012 |
20130260962 | ADAPTIVE POWER SOURCE CONTROL SYSTEM - A method of controlling a power source associated with a machine includes determining a difference between an underspeed setpoint associated with a peak power source torque and a first power source speed. The method also includes determining a torque distribution associated with the power source and at least one parasitic load receiving power from the power source. The torque distribution is based on the difference and respective torque priority values associated with the power source and the at least one parasitic load. The method further includes providing torque from the power source to the at least one parasitic load based on the torque distribution and modifying at least one of the respective torque priority values. Modifying at least one of the torque priority values reduces a difference between the underspeed set point and a second power source speed different than the first power source speed. | 10-03-2013 |
20130288856 | TORQUE CONTROL SYSTEM - A method of controlling a machine includes receiving a torque demand associated with at least one of a first parasitic load and a second parasitic load. At least the first parasitic load receives power from a power source of the machine via a transmission coupled to the power source. The method also includes providing torque from the power source to the at least one of the first and second parasitic loads in response to receiving the torque demand. In such a method wherein torque is provided to the at least one of the first and second parasitic loads based on a torque priority value associated with the at least one of the first and second parasitic loads. In addition, the torque priority value is adjustable by an operator of the machine during operation of the machine. | 10-31-2013 |
20130289836 | TRANSMISSION CONTROL SYSTEM - A method of controlling a transmission associated with a machine includes determining a torque demand associated with a parasitic load, the parasitic load receiving power from a power source of the machine via the transmission. The method also includes converting the torque demand into a corresponding torque request using a first neural network associated with a control system of the machine. The torque demand is an input of the first neural network and the torque request is an output of the first neural network. The method further includes directing the power source to provide torque to the transmission substantially equal to the torque request. | 10-31-2013 |
20140032057 | FEEDFORWARD CONTROL SYSTEM - A method of controlling a machine power source includes receiving a request indicative of desired machine implement movement. The desired movement will require a corresponding change in loading on a hydraulic pump. The method also includes determining a steady state torque required for the request, and determining a transient torque required for the request. The transient torque is based on a desired rate of implement movement associated with the request. The method further includes generating a power source fueling signal corresponding to a total torque required for the change in loading on the pump, and providing fuel to the power source based on the fueling signal prior to transmission of the change in loading on the pump to the power source. | 01-30-2014 |
20140185944 | Gradient Search For 2D/3D Map Compression - This disclosure is generally drawn to methods, systems, devices and/or apparatus related to compressing the size of engineering development maps. Specifically, some of the disclosed example methods, systems, devices and/or apparatus relate to compression of an engineering development map (e.g., kinematic map) based on a given fixed size and/or based on a given target error tolerance value using gradient search techniques. | 07-03-2014 |
20140185945 | MODIFIED DP SEARCH FOR 2D/3D MAP COMPRESSION - This disclosure is generally drawn to methods, systems, devices and/or apparatus related to compressing the size of engineering development maps. Specifically, some of the disclosed example methods, systems, devices and/or apparatus relate to compression of an engineering development map (e.g., kinematic map) based on a given fixed size and/or based on a given target error tolerance value using modified Douglas-Peucker search techniques. | 07-03-2014 |
Patent application number | Description | Published |
20080255213 | THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS - Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides having a structure | 10-16-2008 |
20090326020 | COMPOUNDS FOR TREATMENT OF CANCER - Compounds according to formula (I) are disclosed | 12-31-2009 |
20110118228 | Enzymatic production or chemical synthesis and uses for 5,7-dienes and UVB conversion products thereof - Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance. | 05-19-2011 |
20110257196 | COMPOUNDS FOR TREATMENT OF CANCER - The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer. | 10-20-2011 |
20120071524 | COMPOUNDS FOR TREATMENT OF CANCER - The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer. | 03-22-2012 |
20120258938 | Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof - Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein. | 10-11-2012 |
20130197049 | COMPOUNDS FOR TREATMENT OF CANCER - The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer. | 08-01-2013 |
20140200201 | Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof - Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance. | 07-17-2014 |
Patent application number | Description | Published |
20090294947 | CHIP PACKAGE STRUCTURE AND MANUFACTURING METHOD THEREOF - A chip package structure includes a substrate, a chip, a thermal conductive layer, a plurality of signal contacts, and a molding compound. The substrate includes a plurality of first thermal conductive vias, a connecting circuit, and a plurality of signal vias electrically connected to the connecting circuit, and the substrate has a chip disposing region. The chip is disposed on the chip disposing region of the substrate and electrically connected to the signal vias through the connecting circuit. The thermal conductive layer is disposed over the substrate, connected to the first thermal conductive vias, and located above the chip disposing region. Besides, the thermal conductive layer has first openings exposing the signal vias. The signal contacts are respectively disposed in the first openings and connected to the signal vias. The molding compound encapsulates the chip. | 12-03-2009 |
20110108973 | CHIP PACKAGE STRUCTURE AND METHOD FOR FABRICATING THE SAME - The disclosure provides a chip package structure and method for fabricating the same. The chip package structure includes at least one chip having at least one through via. At least one stress buffering structure is disposed in the through via. The stress buffering structure includes a first gasket and a second gasket. A supporting pillar has two terminals respectively connected to the first gasket and the second gasket. The cross-sectional area of the supporting pillar is smaller than areas of the first gasket and the second gasket. A buffering layer is sandwiched between the first gasket and the second gasket, surrounding a sidewall of the supporting pillar. An insulating layer is disposed on the through via, surrounding a sidewall of the stress buffering structure. | 05-12-2011 |
20110309357 | MEASURING APPARATUS - A measuring apparatus including a first chip, a first circuit layer, a first heater, a first stress sensor and a second circuit layer is provided. The first chip has a first through silicon via, a first surface and a second surface opposite to the first surface. The first circuit layer is disposed on the first surface. The first heater and the first stress sensor are disposed on the first surface and connected to the first circuit layer. The second circuit layer is disposed on the second surface. | 12-22-2011 |
Patent application number | Description | Published |
20090102842 | CLIPPING GEOMETRIES IN RAY-CASTING - A computer implemented method for creating a depth range buffer for supporting clipping geometries for ray-casting includes inputting image data, establishing a depth range buffer for specifying a start and an end point of each ray, computing a near depth of the image data corresponding to the start point of each ray, computing a far depth of the image data corresponding to the end point of each ray, clipping the volume by restricting ray-casting within the start and end points of the depth range buffer, and rendering a portion of the image data corresponding to the visible depth range. | 04-23-2009 |
20090135180 | APPARATUS AND METHOD FOR VOLUME RENDERING ON MULTIPLE GRAPHICS PROCESSING UNITS (GPUs) - A method for volume rendering a volumetric dataset with multiple graphics processing units (GPUs) coupled to a computer system, comprises building a block hierarchical structure of blocks for the volumetric dataset, the block hierarchy comprising a block sequence; partitioning the block sequence into a plurality of groups; determining a target work load for each GPU; allocating each group of the plurality to a respective GPU in accordance with the target load; rendering respective intermediate images by the respective GPUs; and compositing for a final image by blending the respective intermediate images. | 05-28-2009 |
20090284537 | FRAMEWORK FOR PROCESSING AND RENDERING LARGE VOLUME DATA - Described herein is a system and method for facilitating large volume data processing and rendering. An exemplary system includes at least one processor coupled to a first memory, wherein the processor is configured to organize the large volume data in the first memory into one or more bricks. In addition, at least one graphics processing unit (GPU) is coupled to the processor and a second memory. The GPU is configured to process at least one or more bricks transferred from the first memory to the second memory to produce intermediate processing results, and to further render the intermediate processing results. | 11-19-2009 |
20090295800 | METHOD FOR DIRECT VOLUMETRIC RENDERING OF DEFORMABLE BRICKED VOLUMES - A method for rendering a deformable object. The method includes: obtaining a 3D volumetric voxel dataset of a region, such region having therein an object to be rendered; building a tree hierarchical structure for the obtained volumetric dataset, such tree structure blocks as the nodes of a primary tree hierarchy and bricks being those blocks stored as textures in a video memory; augmenting the primary tree hierarchical structure with maximum and minimum values of the data contained within a block; creating a neighborhood tree hierarchy having for each leaf block of the neighborhood tree hierarchy a reference to the neighboring leaf blocks in the neighborhood tree hierarchy as well as references to neighboring bricks in the neighborhood tree hierarchy; updating the information about minimum and maximum in the primary tree hierarchy by saving for each block the minimum and maximum of the neighboring blocks; and rendering the leaf blocks in visibility order. | 12-03-2009 |
20130038605 | SELECTIVE FLOW VISUALIZATION OF TRACED PARTICLES - A method for tracing a plurality of virtual particles through a flow filed includes receiving a flow field. A flow domain is divided into cells. Virtual particles are defined within the flow domain and values are collected for flow properties at each cell. A histogram is generated for each cell representing the collected flow properties for that corresponding cell. The histogram includes, for each of the one or more flow properties, a plurality of bins defining ranges of property values and a count of virtual particles within that cell that exhibit those properties. The histograms for the plurality of cells are advected with respect to the flow field over time. A graphical representation of the plurality of particles within the flow domain is rendered based on the advected histograms for the plurality of cells using a graphics processor. | 02-14-2013 |
20130063436 | FLOATING VOLUME-OF-INTEREST IN MULTILAYER VOLUME RAY CASTING - A method that includes receiving vertices of a mesh, wherein the mesh represents a volume of interest (VOI) from an original volume, performing a transformation operation on the mesh, wherein the transformation operation transforms vertices of the mesh, obtaining sampling locations of the original volume using the transformed vertices, performing an inverse transformation on the transformed vertices of the mesh and the sampling locations, and performing a ray casting on the original volume to produce an image, wherein the ray casting uses the transformed vertices and a result of the inverse transformation as input. | 03-14-2013 |
20150022522 | Luggage Visualization and Virtual Unpacking - Methods and systems for luggage visualization perform virtual unpacking by visually moving an object image away from its original pose. A scanned 3D volume is segmented guided by a confidence measure to create a label volume whose voxels specify the detected object IDs. The luggage dataset and the label volume are visualized by volume rendering. Using an automatic coloring algorithm, any pair of objects whose projections are adjacent in an image are assigned distinct hues. A layered framework efficiently renders a scene mixed with packed luggage, animated unpacking objects, and already unpacked objects put aside for further inspection. A GPU is used to automatically select objects that are not blocked by others and can be unpacked. | 01-22-2015 |
Patent application number | Description | Published |
20090100304 | Hardware and Software Co-test Method for FPGA - A hardware and software co-test method for FPGA comprises the following steps of: setting up a HW/SW co-test system comprising a PC, a software part, HW/SW communication modules, a hardware accelerator for testing a DUT FPGA which is mapped with a configuration file of DUT; predefining a table of test vectors for FPGA by software part in PC; generating configuration files based on the tables of test vector for I/O module, CLB and routing matrix, and then sending the configuration file into DUT FPGA to configure the FPGA; testing DUT FPGA in terms of the tables of test vector for lo I/O module, CLB and routing matrix, and returning results to the software part; and comparing the test results with expected data in the software part, generating a test report, and during the above steps, the error cells in the FPGA are capable of being automatically positioned. | 04-16-2009 |
20120012967 | Black silicon based metal-semiconductor-metal photodetector - A black silicon based metal-semiconductor-metal photodetector includes a silicon substrate and a black silicon layer formed on the silicon substrate. An interdigitated electrode pattern structure is formed on the black silicon layer, which can be a planar or U-shaped structure. A thin potential barrier layer is deposited at the interdigitated electrode pattern structure. An Al or transparent conductive ITO thin film is deposited on the thin potential barrier layer. A passivation layer is provided on the black silicon layer. In the black silicon based metal-semiconductor-metal photodetector, the black silicon layer, as a light-sensitive area, can respond to ultraviolet, visible and near infrared light. | 01-19-2012 |
20130109402 | RESOURCES ALLOCATION METHOD AND APPARATUS FOR MULTIPLE RADIO REMOTE UNITS SHARING A CELL | 05-02-2013 |
20130153796 | Underground Annular Blowout Preventer and Assembly Process Thereof - An underground annular blowout preventer, which belongs to the technical field of underground blowout prevention, includes an upper joint and a lower joint are sleeved outside a central barrel. The lower end of the central barrel is fixedly connected with the lower joint. The lower end of the upper joint is sleeved on the inner side of the upper end of the lower joint. The upper joint is matched with the lower joint through a spline. The lower end of the upper joint can freely move relative to the lower joint along a spline pair. At least one rubber barrel is sleeved on the outer side of the upper joint. The rubber barrel can be extruded and expanded by the upper joint and the lower joint. The underground annular blowout preventer of the present invention can transmit large torque, has a simple structure, long service life, is convenient to use, and can be repeatedly used. The underground annular blowout preventer is used in coordination with a check valve of a near drill in the well drilling process, so that quick sealing of a well can be ensured, and well blowout accidents can be effectively prevented. A pipe column is lowered to seal the well and is lifted to open the well, and the inside of the drill rod is in communication with an annular space after the well is sealed, which facilitates replacement for heavy mud lubrication operations. | 06-20-2013 |
Patent application number | Description | Published |
20080299087 | Amniotic membrane preparations and purified compositions and therapy for scar reversal and inhibition - Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases. | 12-04-2008 |
20120207848 | Amniotic Membrane Preparations and Purified Compositions and Therapy for Scar Reversal and Inhibition - Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases. | 08-16-2012 |
20120207849 | Amniotic Membrane Preparations and Purified Compositions and Anti-Angiogenesis Treatment - Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases. | 08-16-2012 |
20120328690 | Amniotic Membrane Preparations and Purified Compositions and Anti-Inflammation Methods - Compositions having a combination of specific biological components have been found to exert a number of useful effects in mammalian cells, including modulating TGF β signaling, apoptosis, and proliferation of mammalian cells, as well as decreasing inflammation in mice. These components can be obtained commercially, or can be prepared from biological tissues such as placental tissues. Placental amniotic membrane (AM) preparations described herein include AM pieces, AM extracts, AM jelly, AM stroma, and mixtures of these compositions with additional components. The compositions can be used to treat various diseases, such as wound healing, inflammation and angiogenesis-related diseases. | 12-27-2012 |
Patent application number | Description | Published |
20080243943 | Method and apparatus for efficient execution of interprocedural transactional memory code while maintaining safety - In some embodiments, a method and apparatus for efficient execution of interprocedural transactional memory code while maintaining safety are presented. In this regard, a transaction agent is introduced to start a transactional memory transaction from a first procedure of a program, and to end the transaction from a second procedure of the program. Other embodiments are also disclosed and claimed. | 10-02-2008 |
20110225166 | FREQUENT ITEMSET COUNTING USING CLUSTERED PREFIXES AND INDEX SUPPORT - Techniques are provided for (2) extending SQL to support direct invocation of frequent itemset operations, (3) improving the performance of frequent itemset operations by clustering itemset combinations to more efficiently use previously produced results, and (4) making on-the-fly selection of the occurrence counting technique to use during each phase of a multiple phase frequent itemset operation. When directly invoked in an SQL statement, a frequent itemset operation may receive input from results of operations specified in the SQL statement, and provide its results directly to other operations specified in the SQL statement. By clustering itemset combinations, resources may be used more efficiently by retaining intermediate information as long as it is useful, and then discarding it to free up volatile memory. Dynamically selecting an occurrence counting technique allows a single frequent itemset operation to change the occurrence counting technique that it is using midstream, based on cost considerations and/or environmental conditions. | 09-15-2011 |
20110307876 | REGISTER MAPPING TECHNIQUES FOR EFFICIENT DYNAMIC BINARY TRANSLATION - Generally, the present disclosure provides a system and method for mapping registers from a system with more registers to a system with fewer registers. Regions may be formed that include one or more blocks of code with relatively frequent register accesses. The most frequently accessed source registers may be mapped to target registers. Each block in the region may be bounded by a prologue and at least one epilogue. The prologue may be configured to implement register mapping and the epilogue(s) may be configured to manage program flow from a block in the region to another block in the region or to a block not in the region. | 12-15-2011 |
Patent application number | Description | Published |
20110119680 | POLICY-DRIVEN SCHEMA AND SYSTEM FOR MANAGING DATA SYSTEM PIPELINES IN MULTI-TENANT MODEL - Methods and apparatus are described for managing data flows in a high-volume system. Jobs are grouped into pipelines of related tasks. A pipeline controller accepts schemas defining the jobs in a pipeline, their dependencies, and various policies for handling the data flow. Pipelines may be smoothly upgraded with versioning techniques and optional start/stop times for each pipeline. Late data or job dependencies may be handled with a number of strategies. The controller may also mediate resource usage in the system. | 05-19-2011 |
20110214064 | SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR DISPLAYING ONE OR MORE DATA SETS TO A USER - In accordance with embodiments, there are provided mechanisms and methods for displaying one or more data sets to a user. These mechanisms and methods for displaying one or more data sets to a user can enable enhanced data security, more relevant data display, reduced processing, etc. | 09-01-2011 |
20120072783 | MECHANISM FOR FACILITATING EFFICIENT ERROR HANDLING IN A NETWORK ENVIRONMENT - In accordance with embodiments, there are provided methods and systems for facilitating efficient error handling in a network environment. A method of embodiments includes receiving a validation request having configuration parameters of error dialogs relating to errors, and validating the configuration parameters and the errors. The validating includes mapping each error with a corresponding dialog. The method further includes transmitting a validating report having results of validation of the configuration parameters and the errors. The validation report is used to assign an order to each error and its corresponding dialog. | 03-22-2012 |
20130103701 | SYSTEMS AND METHODS FOR PROPAGATING A GLOBAL FILTER TO INDIVIDUAL DATASETS - A user can define a filter to applied be to one or more datasets. The filter includes a specification of a field to filter. Upon applying the filter to a dataset, if the specified field cannot be found in the dataset, a field in the dataset is selected as a default field to filter. Selecting what field in the dataset should be the default field is based on evaluating a set of rules. The default field is then filtered according to the filter criteria. | 04-25-2013 |
20130132870 | SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR TRANSIENT STORAGE OF USER INTERFACE CONFIGURATIONS - In accordance with embodiments, there are provided mechanisms and methods for the transient storage of user interface configurations. These mechanisms and methods for the transient storage of user interface configurations can provide accessibility of user interface configurations prior to such user interface configurations being saved by the respective author. The ability to provide accessibility of user interface configurations prior to such user interface configurations being saved by the respective author can enable the user interface configurations to be used in many different ways even before they are saved, such as enabling the re-use of a user interface configuration across multiple different user interfaces, enabling multiple different users to apply further configurations to the user interface, enabling future access to the user interface configuration, etc. | 05-23-2013 |
20130246399 | SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR DISPLAYING ONE OR MORE DATA SETS TO A USER - In accordance with embodiments, there are provided mechanisms and methods for displaying one or more data sets to a user. These mechanisms and methods for displaying one or more data sets to a user can enable enhanced data security, more relevant data display, reduced processing, etc. | 09-19-2013 |
Patent application number | Description | Published |
20110195972 | APPLICATION OF 2,5 -DIHYDROXYMETHYL -3,6 - DIMETHYL PYRAZINE AND ITS DERIVATES IN PHARMACY - An application of 2,5-dihydroxymethyl-3,6-dimethyl pyrazine and its derivatives in the preparation of drugs for the treatment of, prevention of, and/or protection from heart failure wherein the structural formula of the compound is as follows: | 08-11-2011 |
20130123249 | NOVEL BENZOXAZINE OXAZOLIDINONE COMPOUNDS, PREPARATION METHODS AND USES THEREOF - Novel benzoxazine oxazolidinone compounds, preparation methods and uses thereof are disclosed, which belong to the field of pharmacy. More specifically, novel benzoxazine oxazolidinone compounds represented by the following general formula (I), preparation methods and uses thereof in preparing medicament for treating infectious diseases, especially infectious diseases caused by multi-drug resistant bacteria, are disclosed. | 05-16-2013 |
20140011856 | SALT FORM OF TYROSINE KINASE INHIBITOR - Provided are acid addition salts of (Z)—N-[2-(diethylamino)ethyl]-2-methyl-7-(1,2-dihydro-5-fluoro-2-oxo-3H-indol-3-ylidene)-4,5,6,7-tetrahydro-1H-indol-3-carboxamide, wherein the salt comprising at least one of a number of salts including L-malate, hydrochloride, phosphate, L-tartrate, benzenesulfonate, sulfate, methanesulfonate, succinate, citrate, fumarate, p-toluenesulfonate, hydrobromate, L-mandelate, lactate, acetate or maleate salt. Also provided is a pharmaceutical composition comprising the salt compounds, and a method of treatment by administering a therapeutically effective amount of the salt compounds as preparation of medicaments. | 01-09-2014 |
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20110217442 | Compositions and Methods for Producing Consumables for Patients with Dysphagia - Compositions are provided that are suitable for safe consumption by a patient with dysphagia. In one embodiment, the compositions include a modified xanthan gum in an amount suitable to provide a viscous, free-flowing solution having gel-like properties. The modified xanthan gum comprises a non-pyruvylated xanthan gum, a reduced-pyruvylated xanthan gum, or a combination thereof. The composition desirably has a viscosity of greater than about 2000 cP and is characterized as having a shape retention of greater than about 50%. Also provided are methods for their preparation and use. | 09-08-2011 |
20110243923 | ORGANIC COMPOUNDS - The present invention relates to modulators of the interaction between Epstein-Barr Virus induced receptor-2 (EBi2) and cholest-5-ene-3b,7b,25-triol (7, 25-dihydroxycholesterol) (“7,25DHC”) and/or cholest-5-ene-3b, 7b-diol (7-hydroxycholesterol) (“7HC”). The modulator maybe a small chemical molecule, antibody or other therapeutic protein. Methods of medical treatment and methods of identifying modulators are also described. | 10-06-2011 |
20110274629 | Natural Polymer Blends for Use in Personal Care Products - Embodiments of the present description provide a blend for use in a personal care product having a modified xanthan gum and a galactomannan, wherein the modified xanthan gum is a non-pyruvylated xanthan gum, and the modified xanthan gum and the galactomannan are present in the blend in a ratio from about 1:99 to about 99:1 by weight. Also provided in embodiments of the present description are personal care products having blends of modified xanthan gums and galactomannans, methods for product formulation, and use thereof. | 11-10-2011 |
20130059032 | Blends for Fermented Milk Products - A stabilizing additive for compositions, e.g., fermented milk products, is disclosed comprising xanthan gum and iota-carrageenan wherein the weight percentage of the xanthan gum in the stabilizing additive is higher than the weight percentage of the iota-carrageenan. The xanthan gum can be reduced pyruvate or non-pyruvylated xanthan. The stabilizing additive can further comprise a galactomannan. The composition can further comprise starch. Also disclosed is a method for making a fermented milk product comprising adding the stabilizing additive to milk and fermenting the milk or adding the stabilizing additive to already fermented milk. Fermented milk products comprising the additive can include, e.g., yogurt, drinkable yogurt, kefir or Ymer. | 03-07-2013 |
Patent application number | Description | Published |
20120093761 | VACCINE COMPOSITIONS AND METHODS OF USE THEREOF - Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, siRNA, RNA or DNA to PAPCs or MHC class II positive cells (e.g. tumor cells). Antigens may be, for example, DNA that results in expression of the gene of interest and induction of a robust and specific immune response to the expressed protein in a subject (e.g., mammal). Antigens may also be immunogenic peptides or polypeptides that are processed and presented. In one embodiment, a nanoparticle -based method to deliver antigens in vivo as described herein includes injection of a vaccine composed of a DNA encoding at least one antigen, or at least one antigenic peptide or polypeptide conjugated to a charged dendrimer (e.g., PADRE-derivatized dendrimer) that is also conjugated to a T helper epitope (e.g., PADRE). Negatively-charged plasmids bind naturally to a positively-charged PADRE-dendrimer, while peptide or polypeptide antigens can be chemically linked to the PADRE-dendrimer if they are not negatively-charged. Alternatively, negatively-charged dendrimers may be used. The compositions, kits, vaccines and methods described herein have both prophylactic and treatment applications, i.e., can be used as a prophylactic to prevent onset of a disease or condition in a subject, as well as to treat a subject having a disease or condition. A vaccine as described herein can be used to mount an immune response against any infectious pathogen or cancer. | 04-19-2012 |