Patent application number | Description | Published |
20100099954 | Data-driven sleep coaching system - System and method for a user to monitor and/or modify his or her sleep. In one embodiment, the sleep coaching system comprises a sensor for sensing a physiological signal of a sleeping user such as an EEG, computer memory databases for storing user and sleep-related data and advice, and a processor that generates a set of advice to improve user sleep satisfaction based on the user and sleep-related data. The advice to improve user sleep satisfaction, which may be communicated to the user, may comprise a sleep coaching plan, which may include one or more sleep coaching workshops that the user may undertake. | 04-22-2010 |
20130060097 | MULTI-MODAL SLEEP SYSTEM - Systems and methods are provided for a multi-modal sleep system comprising a data processor for operating in a plurality of operating modes. The data processor may detect at least one sensor providing data to the data processor and determine a sensor type associated with each of the at least one sensor. The data processor may select a mode of operation based on the determined sensor type of the detected at least one sensor and of each of the at least one sensor. A first of the plurality of operating modes may be selected in response to determining that the at least one detected sensor includes a first sensor type or combination of sensor types. The data processor may be configured to receive data from the at least one detected sensor and process the received data according to the selected mode of operation to output a characterization of a user's sleep. | 03-07-2013 |
20130344465 | DATA-DRIVEN SLEEP COACHING SYSTEM - System and method for a user to monitor and/or modify his or her sleep. In one embodiment, the sleep coaching system comprises a sensor for sensing a physiological signal of a sleeping user such as an EEG, computer memory databases for storing user and sleep-related data and advice, and a processor that generates a set of advice to improve user sleep satisfaction based on the user and sleep-related data. The advice to improve user sleep satisfaction, which may be communicated to the user, may comprise a sleep coaching plan, which may include one or more sleep coaching workshops that the user may undertake. | 12-26-2013 |
20150051453 | MULTI-MODAL SLEEP SYSTEM - Systems and methods are provided for a multi-modal sleep system comprising a data processor for operating in a plurality of operating modes. The data processor may detect at least one sensor providing data to the data processor and determine a sensor type associated with each of the at least one sensor. The data processor may select a mode of operation based on the determined sensor type of the detected at least one sensor and of each of the at least one sensor. A first of the plurality of operating modes may be selected in response to determining that the at least one detected sensor includes a first sensor type or combination of sensor types. The data processor may be configured to receive data from the at least one detected sensor and process the received data according to the selected mode of operation to output a characterization of a user's sleep. | 02-19-2015 |
Patent application number | Description | Published |
20140369954 | D, L-CYCLIC PEPTIDE NANOTUBE REINFORCING AGENTS - The disclosed subject matter can provide a nanotube-reinforced polymer composite material comprising a plurality of nanotubes, each nanotube being formed of a plurality of cyclic peptide molecules, disposed within a polymer matrix, such as a biodegradable polymer matrix. A cyclic polymer, such as a cyclic 8-mer, composed of amino acid residues of alternating absolute configurations (D/L, R/S), can self-assemble into nanotubes useful for preparation of the composite polymer material of the invention. For example, the cyclic peptide (QL)4, wherein the glutamine and leucine residues are of opposite absolute configuration, self-assembles into nanotubes, which when formed into a reinforced polymer composite including poly(caprolactone), provides a biocompatible material of greater tensile strength and Young's modulus compared to the poly(caprolactone) material alone. The nanotubes can be prepared by a vapor equilibration technique or by a solvent-nonsolvent precipitation technique. The materials of the invention can be used for implants, stents and the like as well as for synthetic ligaments, tendons, cartilage, and bone for use in the living tissue of a patient in need thereof. For example, a spinal fusion cage comprising a PDLLA polymer matrix with a plurality of nanotubes of the invention can exhibit enhanced stiffness. | 12-18-2014 |
Patent application number | Description | Published |
20120197607 | DIMENSION REDUCTION IN PREDICTIVE MODEL DEVELOPMENT - Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. | 08-02-2012 |
20120197608 | PREDICTIVE MODEL VALIDATION - Models are generated using a variety of tools and features of a model generation platform. For example, in connection with a project in which a user generates a predictive model based on historical data about a system being modeled, the user is provided through a graphical user interface a structured sequence of model generation activities to be followed, the sequence including dimension reduction, model generation, model process validation, and model re-generation. | 08-02-2012 |
Patent application number | Description | Published |
20080207740 | Small organic molecule regulators of cell proliferation - The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. | 08-28-2008 |
20110077256 | MEDIATORS OF HEDGEHOG SIGNALING PATHWAYS, COMPOSITIONS AND USES RELATED THERETO - The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from | 03-31-2011 |
20120010178 | METHODS AND COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISORDERS - Methods, compounds and compositions for promoting motor neuron survival and the treatment of a neurodegenerative disorders such as Spinal Muscular Atrophy (SMA) are described herein. | 01-12-2012 |
20120021519 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS - The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof. | 01-26-2012 |
20130259842 | STABLE REPROGRAMMED CELLS - The present invention relates to a stable pluripotent reprogrammed cells, and compositions and methods of isolation and uses thereof, wherein the stable pluripotent reprogrammed cells is derived from a somatic cell and has undergone incomplete remodeling of the epigenome. In some embodiments, the stable reprogrammed cell is a human stable reprogrammed cell. In some embodiments, the stable reprogrammed cell has a statistically significant lower level of expression of one or any combination of Nanog, Dnmt3b, Lefty2 as compared to an induced pluripotent stem cell. In some embodiments, the stable reprogrammed cell has a statistically significant higher level of expression of one or any combination of Tdgf1, Tert or endogenous Sox2 as compared to a somatic cell from which it was derived. In some embodiments, the stable reprogrammed cell has a statistically significant faster rate of doubling as compared to an induced pluripotent stem cell (iPSC) or an embryonic stem (ES) cell. Other aspects of the invention relate to compositions comprising the reprogrammed cell, method of isolation and method of use. | 10-03-2013 |
Patent application number | Description | Published |
20110008333 | METHODS OF INHIBITING UNWANTED CELL PROLIFERATION USING HEDGEHOG ANTAGONISTS - The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein. | 01-13-2011 |
20110070645 | COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS - Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described. | 03-24-2011 |
20130023491 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE - In the invention provides for a method of stimulating or increasing β-cell replication or growth, by contacting a β-cell with an inhibitor of adenosine kinase (ADK), an inhibitor of S-Adenosylhomocysteine hydrolase (SAHH) or an activator of AMP activated protein kinase (AMPK). | 01-24-2013 |
20130190350 | Mediators of Hedgehog Signaling Pathways, Compositions and Uses Related Thereto - The present invention makes available methods and reagents for inhibiting aberrant growth states resulting from hedgehog gain-of-function, ptc loss-of-function or smoothened gain-of-function comprising contacting the cell with a hedgehog antagonist, such as a small molecule, in a sufficient amount to aberrant growth state, e.g., to agonize a normal ptc pathway or antagonize smoothened or hedgehog activity. | 07-25-2013 |
20140294855 | SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION - The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided is a method for repairing or regenerating a damaged muscle tissue of a subject. | 10-02-2014 |
20140335611 | COMPOSITIONS AND METHODS FOR PROMOTING THE GENERATION OF PDX1+ PANCREATIC CELLS - Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in Table I to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described. | 11-13-2014 |
20150119399 | BETA-CELL REPLICATION PROMOTING COMPOUNDS AND METHODS OF THEIR USE - Disclosed are methods for stimulating or increasing β-cell replication or growth, e.g., for increasing insulin secretion, and methods of treating disorders such as diabetes, as well as related compositions and formulations. | 04-30-2015 |
Patent application number | Description | Published |
20120204014 | Systems and Methods for Improving Divergent Conditional Branches - Embodiments of the present invention provide systems, methods, and computer program products for improving divergent conditional branches in code being executed by a processor. For example, in an embodiment, a method comprises detecting a conditional statement of a program being simultaneously executed by a plurality of threads, determining which threads evaluate a condition of the conditional statement as true and which threads evaluate the condition as false, pushing an identifier associated with the larger set of the threads onto a stack, executing code associated with a smaller set of the threads, and executing code associated with the larger set of the threads. | 08-09-2012 |
20130117750 | Method and System for Workitem Synchronization - Method, system, and computer program product embodiments for synchronizing workitems on one or more processors are disclosed. The embodiments include executing a barrier skip instruction by a first workitem from the group, and responsive to the executed barrier skip instruction, reconfiguring a barrier to synchronize other workitems from the group in a plurality of points in a sequence without requiring the first workitem to reach the barrier in any of the plurality of points. | 05-09-2013 |
20130155074 | SYSCALL MECHANISM FOR PROCESSOR TO PROCESSOR CALLS - Provided is a method for processing system calls from a GPU to a CPU. The method includes a GPU storing a plurality of tasks in a memory, with each task representing a function to be performed on the CPU. The method also includes generating a CPU interrupt, and processing of the stored plurality of tasks by the CPU. | 06-20-2013 |
20130159685 | CONTROL FLOW-BASED APPROACH IN IMPLEMENTING EXCEPTION HANDLING ON A GRAPHICS PROCESSING UNIT - A function in source code is processed by a compiler for execution on a graphics processing unit, wherein the function includes an exception handling structure. An exception raising block is converted into a first control flow and an exception handler block is converted into a second control flow. The first control flow includes setting an exception raised indicator and finding an exception handler to process the raised exception. The exception raised indicator remains set until an appropriate exception handler is found. The second control flow includes clearing the exception raised indicator and processing the exception. | 06-20-2013 |
20130262775 | Cache Management for Memory Operations - Embodiments of the present invention provides for the execution of threads and/or workitems on multiple processors of a heterogeneous computing system in a manner that they can share data correctly and efficiently. Disclosed method, system, and article of manufacture embodiments include, responsive to an instruction from a sequence of instructions of a work-item, determining an ordering of visibility to other work-items of one or more other data items in relation to a particular data item, and performing at least one cache operation upon at least one of the particular data item or the other data items present in any one or more cache memories in accordance with the determined ordering. The semantics of the instruction includes a memory operation upon the particular data item. | 10-03-2013 |