Patent application number | Description | Published |
20090088636 | APPARATUS FOR DELIVERING HIGH INTENSITY FOCUSED ULTRASOUND ENERGY TO A TREATMENT SITE INTERNAL TO A PATIENT'S BODY - An apparatus for delivering HIFU energy may include a probe with a plurality of leaves that provide a bowl-shaped HIFU therapy transducer. In once case, pins may slide within grooves in the leaves to deploy the leaves. In another case, spines may be configured to slide in a channel defined in each leaf. In other cases, a spring or a shape memory alloy may be used to deploy the leaves. In another implementation, a probe may be fitted with a flexible material that couples the HIFU therapy transducer to the probe and allows the transducer to be drawn to the side of the probe for insertion. In another implementation, a probe may have one or more inflatable bladders that form the HIFU therapy transducer. In yet another implementation, a probe may have an imaging component and a HIFU therapy transducer disposed thereon that rotate, as a unit, about a hinge. | 04-02-2009 |
20090118725 | HEMOSTATIC TISSUE TUNNEL GENERATOR FOR INSERTING TREATMENT APPARATUS INTO TISSUE OF A PATIENT - A catheter for insertion into and treatment of tissue in a patient comprises a radio frequency (RF) electrode having an elongated body that conducts electrical RF energy to a conductive tip. An insulating sleeve surrounds the elongated body. In a first mode of operation, the conductive tip is exposed outside the insulating sleeve and the RF electrode delivers RF energy that erodes the tissue of the patient and creates a tunnel through which the catheter can advance into the tissue of the patient. In a second mode of operation, the insulating sleeve and/or the RF electrode is retracted and a second treatment apparatus treats the tissue. | 05-07-2009 |
20090118729 | HEMOSTATIC SPARK EROSION TISSUE TUNNEL GENERATOR WITH INTEGRAL TREATMENT PROVIDING VARIABLE VOLUMETRIC NECROTIZATION OF TISSUE - A catheter for insertion into and treatment of tissue in a patient comprises a radio frequency (RF) electrode having an elongated body that conducts electrical RF energy to a conductive tip. An insulating sleeve surrounding the elongated body prevents leakage of RF energy from the elongated body when the catheter is being inserted into the tissue of the patient. In a first mode of operation, the conductive tip is exposed outside the insulating sleeve and the RF electrode delivers first RF energy capable of producing sparks that erode the tissue of the patient and create a tunnel through which the catheter can advance into the tissue of the patient. In a second mode of operation, the insulating sleeve is retracted to expose a portion of the RF electrode. Second RF energy is delivered to the volume of tissue around the catheter to necrotize the tissue by heating without producing sparks. | 05-07-2009 |
20090318852 | ULTRASOUND BASED COSMETIC THERAPY METHOD AND APPARATUS - A waveguide couples an acoustic source (such as an ultrasound transducer) to a custom cosmetic product (e.g., a liquid or gel-based skin care product) applied to the skin. In one exemplary embodiment, a distal surface of the waveguide is placed in contact with a relatively thin layer of skin care product that has been applied to the skin. Alternatively, the thin layer can be applied to the distal face of the waveguide, and then the waveguide placed on the skin. The custom cosmetic product has been formulated such that when ultrasound energy is directed into the custom cosmetic product via the waveguide, bubbles included or formed in the custom cosmetic product oscillate, and increase the permeability of the skin to active beneficial agents included in the custom cosmetic product. | 12-24-2009 |
20090318853 | ULTRASOUND BASED COSMETIC THERAPY METHOD AND APPARATUS - A waveguide couples an acoustic source (such as an ultrasound transducer) to a custom cosmetic product (e.g., a liquid or gel-based skin care product) applied to the skin. In one exemplary embodiment, a distal surface of the waveguide is placed in contact with a relatively thin layer of skin care product that has been applied to the skin. Alternatively, the thin layer can be applied to the distal face of the waveguide, and then the waveguide placed on the skin. The custom cosmetic product has been formulated such that when ultrasound energy is directed into the custom cosmetic product via the waveguide, bubbles included or formed in the custom cosmetic product oscillate, and increase the permeability of the skin to active beneficial agents included in the custom cosmetic product. | 12-24-2009 |
20120271222 | ULTRASOUND BASED COSMETIC THERAPY METHOD AND APPARATUS - A waveguide couples an acoustic source (such as an ultrasound transducer) to a cosmetic product (such as a liquid or gel-based skin care product) applied to the skin. In one representative embodiment, a distal surface of the waveguide is placed in contact with a relatively thin layer of skin care product that has been applied to the skin. Alternatively, the thin layer can be applied to the distal face of the waveguide, and then the waveguide placed on the skin. The cosmetic product may be formulated such that when ultrasound energy is directed into the cosmetic product via the waveguide, microspheres in the cosmetic product oscillate and increase the permeability of the skin to active beneficial agents included in the cosmetic product. | 10-25-2012 |
20140022864 | SYSTEM AND METHOD FOR FISH FINDING USING A SONAR DEVICE AND A REMOTE COMPUTING DEVICE - The present invention generally relates to a fish finding sonar system. Specifically, this invention relates to a sonar device pairing with a remote computing device to provide information to an angler about what is under the surface of the water. Embodiments of the present invention include a sonar device and a remote computing device configured to allow the sonar device to wirelessly communicate with the remote computing device and the remote computing device to connect to a database to register and receive information about real-time fishing hotspots. | 01-23-2014 |
20150085602 | SYSTEM AND METHOD FOR FINDING FISH USING A SONAR DEVICE AND A REMOTE COMPUTING SYSTEM - The present invention generally relates to a sonar fish finding system. Specifically, this invention relates to a sonar device which attaches to a fishing line and floats on the water like a fishing bubble, float, or bobber. The sonar device pairs with a wireless computing device over a Bluetooth Smart (also known as Bluetooth Low Energy) connection to provide information to a fisherman about what is under the surface of the water. In some embodiments, processing may be done on subsets of sonar data samples in order to allow for processing a complete result without requiring storage of the entire set of data samples at once. In certain embodiments of the present invention, the sonar device sends data to a remote computing system either directly or indirectly through a wireless computing device. The remote computing system also sends the wireless computing device information about both real-time fishing hotspots, and fishing hotspots predicted based on historical data and current conditions. | 03-26-2015 |
20150085614 | SYSTEM AND METHOD FOR FISH FINDING USING A SONAR DEVICE AND A REMOTE COMPUTING DEVICE - The present invention generally relates to a fish finding sonar system. Specifically, this invention relates to a sonar device pairing with a remote computing device to provide information to an angler about what is under the surface of the water. Embodiments of the present invention include a sonar device and a remote computing device configured to allow the sonar device to wirelessly communicate with the remote computing device and the remote computing device to connect to a database to register and receive information about real-time fishing hotspots. | 03-26-2015 |
Patent application number | Description | Published |
20100003724 | CHEMICALLY MODIFIED NUCLEOSIDE 5'-TRIPHOSPHATES FOR THERMALLY INITIATED AMPLIFICATION OF NUCLEIC ACID - Provided herein are methods and compositions for nucleic acid replication. These methods involve the use of 3′-substituted nucleoside 5′-triphosphates or 3′-substituted terminated primers in nucleic acid replication reactions. In certain aspects, the methods are accomplished by use of 3′-substituted NTPs and/or 3′-substituted terminated primers which provide utility in nucleic acid replication. In preferred embodiments, the NTPs and/or primers are substituted at the 3′-position with particular heat labile chemical groups such as ethers, esters or carbonate esters. | 01-07-2010 |
20110008788 | CHEMICALLY MODIFIED LIGASE COFACTORS, DONORS AND ACCEPTORS - Provided herein are methods for ligation of polynucleotides containing modified ligation components, particularly modified ligase cofactors, modified acceptors and modified donors. The methods readily applied to ligation-based assays for detection of a nucleic acid sequence where the use of the modified cofactor improves discrimination between matched and mismatched templates. Furthermore, the use of the modified ligation components reduces or eliminates the ligation in the absence of nucleic acid template. | 01-13-2011 |
20140038181 | CHEMICALLY SUBSTITUTED THERMOSENSITIVE PROBES AND COFACTORS FOR HOT START LIGATION - Provided herein are methods for ligase mediated nucleic acid replication and amplification of oligo- and probes containing substituted ligase components, particularly substituted ligase cofactors, substituted oligo- and probe acceptors, substituted oligo- and probe donors, substituted adenylated oligo- and polynucleotide donor intermediates carrying thermolabile group or groups. The substituted ligase components are not active until Hot Start activation step converts them into unsubstituted or natural ligase components, which fully support ligase reaction. The described methods are readily applied to ligation-based assays, especially utilizing Ligase Chain Reaction (LCR), for detection of a nucleic acid sequence where the use of the substituted ligase components improves an overall efficiency of LCR, increase discrimination between matched and mismatched templates and reduces or eliminates appearance of false positive signal. Furthermore, the use of the substituted ligase components reduces or eliminates the false positive signal originated from the template independent and blunt-ended ligation. | 02-06-2014 |
20140323354 | Chemically Modified Ligase Cofactors, Donors and Acceptors - Provided herein are methods for ligation of polynucleotides containing modified ligation components, particularly modified ligase cofactors, modified acceptors and modified donors. The methods readily applied to ligation-based assays for detection of a nucleic acid sequence where the use of the modified cofactor improves discrimination between matched and mismatched templates. Furthermore, the use of the modified ligation components reduces or eliminates the ligation in the absence of nucleic acid template. In addition, methods are applied to the preparation of nucleic acid libraries using modified acceptor probes and modified donor probes that reduce or eliminate probe dimerization during the ligation process. | 10-30-2014 |
Patent application number | Description | Published |
20110008215 | Modular system for radiosynthesis with multi-run capabilities and reduced risk of radiation exposure - Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components. | 01-13-2011 |
20110150714 | Modular System for Radiosynthesis with Multi-Run Capabilities and Reduced Risk of Radiation Exposure - Macro- and microfluidic devices and related technologies, and chemical processes using such devices. More specifically, the devices may be used for a fully automated synthesis of radioactive compounds for imaging, such as by positron emission tomography (PET), in an efficient, compact and safe to the operator manner. In particular, embodiments of the present invention relate to an automated, multi-run, microfluidic instrument for the multi-step synthesis of radiopharmaceuticals, such as PET probes, comprising a remote shielded mini-cell containing radiation-handing components. | 06-23-2011 |
20120107185 | Interface Between Components of a Chemistry Module Based on a Set of Movable Containers - An apparatus for carrying out a chemical synthesis and related systems and methods are disclosed. The apparatus may comprise at least one rotatable drum comprising at least one slot having at least one chemical reagent or a cartridge, and at least one system block configured to be in communication with the at least one chemical reagent. The system block may comprise at least one means for extracting reagent from the slot. The apparatus may comprise a plurality of slots and a plurality of system blocks, wherein each system block may be in communication with at least one slot of reagent or cartridge. | 05-03-2012 |
20160003791 | SYSTEM AND METHOD FOR RADIOSYNTHESIS, QUALITY CONTROL AND DOSE DISPENSING - A system and method for performing radiochemical synthesis, analysis and/or dispensing of radiopharmaceuticals using specially designed disposable components: palettes and caddies, the palette being an assembly of containers not connected with each other for direct material transfer; the caddy being a disposable component used to transfer material between containers on the palettes and/or other locations. | 01-07-2016 |
Patent application number | Description | Published |
20090318852 | ULTRASOUND BASED COSMETIC THERAPY METHOD AND APPARATUS - A waveguide couples an acoustic source (such as an ultrasound transducer) to a custom cosmetic product (e.g., a liquid or gel-based skin care product) applied to the skin. In one exemplary embodiment, a distal surface of the waveguide is placed in contact with a relatively thin layer of skin care product that has been applied to the skin. Alternatively, the thin layer can be applied to the distal face of the waveguide, and then the waveguide placed on the skin. The custom cosmetic product has been formulated such that when ultrasound energy is directed into the custom cosmetic product via the waveguide, bubbles included or formed in the custom cosmetic product oscillate, and increase the permeability of the skin to active beneficial agents included in the custom cosmetic product. | 12-24-2009 |
20090318853 | ULTRASOUND BASED COSMETIC THERAPY METHOD AND APPARATUS - A waveguide couples an acoustic source (such as an ultrasound transducer) to a custom cosmetic product (e.g., a liquid or gel-based skin care product) applied to the skin. In one exemplary embodiment, a distal surface of the waveguide is placed in contact with a relatively thin layer of skin care product that has been applied to the skin. Alternatively, the thin layer can be applied to the distal face of the waveguide, and then the waveguide placed on the skin. The custom cosmetic product has been formulated such that when ultrasound energy is directed into the custom cosmetic product via the waveguide, bubbles included or formed in the custom cosmetic product oscillate, and increase the permeability of the skin to active beneficial agents included in the custom cosmetic product. | 12-24-2009 |
20120271222 | ULTRASOUND BASED COSMETIC THERAPY METHOD AND APPARATUS - A waveguide couples an acoustic source (such as an ultrasound transducer) to a cosmetic product (such as a liquid or gel-based skin care product) applied to the skin. In one representative embodiment, a distal surface of the waveguide is placed in contact with a relatively thin layer of skin care product that has been applied to the skin. Alternatively, the thin layer can be applied to the distal face of the waveguide, and then the waveguide placed on the skin. The cosmetic product may be formulated such that when ultrasound energy is directed into the cosmetic product via the waveguide, microspheres in the cosmetic product oscillate and increase the permeability of the skin to active beneficial agents included in the cosmetic product. | 10-25-2012 |