Patent application number | Description | Published |
20110271717 | SYSTEM AND METHOD FOR CONTROL OF GLASS TRANSMITTANCE - This application relates to methods of making glass compositions, and glasses resulting from these methods. More particularly, the disclosure relates to a method of making a glass having high total solar transmittance and high light transmittance in the visible and near infrared ranges with the use of oxygen-fuel burners in a furnace. Such glass compositions are useful, for example, in glass-based solar cells. | 11-10-2011 |
20120132269 | GLASS SUBSTRATES FOR HIGH TEMPERATURE APPLICATIONS - A glass substrate may be processed at high temperatures without substantially losing its thermal-strengthening characteristics or deforming. In some examples, the glass substrate exhibits an increased annealing point and/or softening point as compared to standard glass substrates. In some examples, the glass substrate includes a relatively high amount of CaO and/or MgO, and/or a relatively low amount of Na | 05-31-2012 |
20150083200 | GLASS SUBSTRATES FOR HIGH TEMPERATURE APPLICATIONS - A glass substrate may be processed at high temperatures without substantially losing its thermal-strengthening characteristics or deforming. In some examples, the glass substrate exhibits an increased annealing point and/or softening point as compared to standard glass substrates. In some examples, the glass substrate includes a relatively high amount of CaO and/or MgO, and/or a relatively low amount of Na | 03-26-2015 |
Patent application number | Description | Published |
20140165671 | LOCK ASSEMBLY HAVING QUICK RELEASE DOUBLE FIRE PLATE - A lock assembly includes a mounting fire plate configured for attachment to the door. A first lockset includes a lockset fire plate and a first operator assembly having a first operator handle. The first operator assembly is mounted to the lockset fire plate. At least one fusible link is configured to releasably couple the lockset fire plate of the first lockset to the mounting fire plate. The at least one fusible link is configured to melt during a fire condition to release the lockset fire plate from the mounting fire plate to facilitate a separation of the first lockset including the lockset fire plate from the mounting fire plate and the door by force of gravity. | 06-19-2014 |
20140165672 | LOCK ASSEMBLY HAVING FIRE RESISTANT SPINDLE LINKAGE - A lock assembly includes an exterior operator assembly, an interior operator assembly, and a latch assembly. An outer spindle is operatively coupled to a latch assembly, is drivably coupled to the interior operator assembly, and has a longitudinal bore. A coupling mechanism is coupled to the outer spindle. A locking spindle assembly is rotatably received in the longitudinal bore, and is configured to selectively operate the coupling mechanism to couple the exterior operator assembly to the outer spindle upon actuation of a drive assembly. The locking spindle assembly has a fire compliant component made of a first material that melts during a fire to prevent operation of the latch assembly with the exterior operator assembly, and has a fire resistant component made of a second material and configured to block the longitudinal bore of the outer spindle to aid in preventing the spread of the fire through the door. | 06-19-2014 |
20140165673 | LOCK ASSEMBLY HAVING LOCK POSITION SENSOR - A lock assembly includes an exterior lockset that includes an exterior operator handle. An interior lockset includes an interior operator assembly and a control electronics module. An outer spindle is operatively coupled to a latch assembly and is drivably coupled to the interior operator assembly. A locking mechanism is operatively coupled to a drive assembly, and includes a coupling mechanism and a locking spindle assembly. The coupling mechanism is configured to selectively couple the exterior operator handle to the outer spindle. The locking spindle assembly is configured to operate the coupling mechanism to transition from a locked condition to an unlocked condition by an actuation of the drive assembly. A lock position sensor is located in the interior lockset and is communicatively coupled to the control electronics module. The lock position sensor is configured to sense whether the coupling mechanism is in the locked condition or the unlocked condition. | 06-19-2014 |
20140165674 | LOCK ASSEMBLY HAVING SECURED SETSCREW CONFIGURATION TO PREVENT UNAUTHORIZED HANDLE REMOVAL - A lock assembly includes a coupling mechanism connected to a spindle assembly. The coupling mechanism has an outer sleeve having a longitudinal interior opening that extends along a first axis. An operator handle includes a proximal lock core opening, and a distal shaft portion having an axial opening configured to receive the outer sleeve. The distal shaft portion and the outer sleeve are configured to define a through path oriented across the longitudinal interior opening of the outer sleeve. A portion of the through path at the outer sleeve is configured to threadably receive a setscrew to fasten the operator handle to the outer sleeve. A keyed lock core has a tailpiece that is positioned in the longitudinal interior opening of the outer sleeve to obstruct the through path and block access to the setscrew via the through path to prevent unauthorized removal of the operator handle. | 06-19-2014 |
20140165677 | LOCK ASSEMBLY HAVING MOTOR INSIDE INTERIOR OPERATOR HANDLE - A lock assembly includes an exterior operator assembly having an exterior operator handle. An interior operator assembly has an interior operator handle having a mounting opening. An outer spindle is operatively coupled to a latch assembly, drivably coupled to the interior operator assembly, has a longitudinal bore, and is rotatable about a first axis. A coupling mechanism is drivably coupled to the outer spindle. A locking spindle assembly is rotatably received in the longitudinal bore and rotatable about the first axis, and is configured to selectively operate the coupling mechanism to drivably couple the exterior operator assembly to the outer spindle. A motor drive assembly includes a motor having a motor shaft. The motor is positioned inside the mounting opening of the interior operator handle. The motor shaft is drivably coupled to the locking spindle assembly to operate the coupling mechanism when the motor drive assembly is actuated. | 06-19-2014 |
Patent application number | Description | Published |
20110005914 | Selective dehydrohalogenation of tertiary halogenated hydrocarbons and removal of tertiary halogenated hydrocarbon impurities from a halogenated hydrocarbon product - A process for converting a tertiary halogenated hydrocarbons in a tertiary halogenated hydrocarbon-containing stream to a corresponding unhalogenated or less-halogenated unsaturated hydrocarbon product with the release of hydrogen halide involves contacting the tertiary halogenated hydrocarbon with a sorbent-type dehydrohalogenation catalyst in a reaction zone and optionally passing a stripping gas through the reaction zone to remove vapor phase reaction products from the reaction zone. A process for removing a tertiary chlorinated hydrocarbon impurity from 1,3-dichloro-1-propene involves contacting a mixture containing the 1,3-dichloro-1-propene and the tertiary chlorinated hydrocarbon impurity with a dehydrochlorination catalyst effective to catalyze a conversion of the tertiary chlorinated hydrocarbon impurity to a corresponding unchlorinated or less-chlorinated unsaturated hydrocarbon and hydrogen chloride and distilling the 1,3-dichloro-1-propene to produce a purified cis-1,3-dichloro-1-propene fraction and a purified trans-1,3-dichloro-1-propene fraction. | 01-13-2011 |
20110268648 | PROCESS AND SYSTEM FOR PRODUCTION OF DICHLORINE - The present disclosure provides a process and a system for producing dichlorine (Cl | 11-03-2011 |
20120116122 | PROCESS FOR THE CONVERSION OF ALIPHATIC CYCLIC AMINES TO ALIPHATIC DIAMINES - The instant invention is a process for the conversion of aliphatic cyclic amines to aliphatic diamines. The process for conversion of aliphatic cyclic amines to aliphatic diamines comprises the steps of: (1) selecting one or more cyclic amines; (2) contacting said one or more cyclic amines with ammonia and hydrogen, optionally water, and optionally one or more solvents in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 120° C. to about 250° C. and a pressure in the range of from 700 to 3500 psig for a period in the range of at least one hour or more in one or more reactor systems; (3) forming a product mixture comprising one or more aliphatic diamine, optionally a portion of said one or more cyclic amines, optionally a portion of said ammonia, optionally a portion of said hydrogen, optionally water, and optionally a portion of said one or more solvents; (4) removing said product mixture from the reactor system; (5) removing at least a portion of said portion of ammonia, said portion of hydrogen, or mixture thereof from said product mixture via distillation; (6) removing at least a portion of said portion of water via distillation; (7) removing at least a portion of said portion of one or more optional solvents via distillation; (8) removing at least a portion of said portion of one or more cyclic amines; (9) thereby separating said one or more aliphatic diamines from said product mixture; and (10) thereby converting said one or more cyclic amines to one or more aliphatic diamines. | 05-10-2012 |
20120116123 | PROCESS FOR SEPARATING ONE OR MORE ALIPHATIC DIAMINES FROM REDUCTIVE AMINATION REACTION SOLVENTS AND IMPURITIES - The instant invention provides a process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities, and aliphatic diamines obtained via such a process. The process for separating one or more aliphatic diamines from reductive amination reaction solvents and impurities according to the instant invention comprises the steps of: (1) feeding one or more cycloaliphatic cyanoaldehydes, hydrogen, ammonia, and optionally one or more solvents into a continuous reductive amination reactor system; (2) contacting said one or more cycloaliphatic cyanoaldehydes, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C. and a pressure in the range of from 700 to 3500 psig; (3) thereby forming a product mixture comprising one or more cycloaliphatic diamines, optionally one or more bicyclic by-products, optionally one or more cycloaliphatic aminonitriles, optionally one or more cycloaliphatic aminoalcohols, optionally one or more oligomeric by-products, ammonia, water, hydrogen, and optionally one or more solvents; (4) removing said product mixture from the reactor system; (5) removing at least a portion of said ammonia, said hydrogen, or mixture thereof from said product mixture via distillation; (6) removing at least a portion of said water and said one or more optional solvents via distillation; (7) removing at least a portion of one or more optional bicyclic by-products via distillation; (8) removing one or more optional cycloaliphatic aminonitriles, one or more optional cycloaliphatic aminoalcohols, one or more optional oligomeric by-products via distillation; and (9) thereby separating said one or more cycloaliphatic diamines from said product mixture. | 05-10-2012 |
20120116124 | PROCESS FOR REDUCTIVE AMINATION OF ALIPHATIC CYANOALDEHYDES TO ALIPHATIC DIAMINES - The instant invention provides a process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines, and aliphatic diamines produced via such method. The process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprises the steps of: (1) providing a mixture of one or more cycloaliphatic cyanoaldehydes, optionally water, and optionally one or more solvents, wherein said one or more cycloaliphatic cyanoaldehydes are selected from the group consisting of 1,3-cyanocyclohexane carboxaldehyde, 1,4-cyanocyclohexane carboxaldehyde, mixtures thereof, and combinations thereof; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature in the range of 15 to 40° C. for a period of at least 1 minute or more, for example 5 minutes or more; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C. and a pressure in the range of from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines, wherein said one or more cycloaliphatic diamines are diamines selected from the group consisting of 1,3-bis(aminomethyl)cyclohexane, 1,4-bis(aminomethyl)cyclohexane, combinations thereof, and mixtures thereof. | 05-10-2012 |
20120123165 | CYCLOALIPHATIC DIAMINES AND METHOD OF MAKING THE SAME - The instant invention provides cycloaliphatic diamines and a method of making the same. The cycloaliphatic diamines according to the instant invention comprise the reaction product of one or more cycloaliphatic cyanoaldehydes selected from the group consisting of 1,3-cyanocyclohexane carboxaldehyde, 1,4-cyanocyclohexane carboxaldehyde, mixtures thereof, and combinations thereof, hydrogen, and ammonia fed into a continuous reductive amination reactor system; wherein the one or more cycloaliphatic cyanoaldehydes, hydrogen, and ammonia are contacted with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature in the range of from 80° C. to about 160° C. and a pressure in the range of from 700 to 3500 psig; and wherein one or more cycloaliphatic diamines are formed; and wherein said one or more cycloaliphatic diamines are selected from the group consisting of 1,3-bis(aminomethyl)cyclohexane, 1,4-bis(aminomethyl)cyclohexane, combinations thereof, and mixtures thereof. | 05-17-2012 |
20120136173 | PROCESS FOR IMPROVING THE CATALYTIC ACTIVITY OF CATALYST SYSTEMS FOR REDUCTIVE AMINATION OF ALIPHATIC CYANOALDEHYDES TO ALIPHATIC DIAMINES - The instant invention provides a process for improving catalytic activity of catalyst systems for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines. The process for improving catalytic activity of catalyst systems for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprises the steps of: (1) feeding ammonia, optionally hydrogen, and optionally one or more solvents over one or more heterogeneous metal based catalyst systems having a reduced catalytic activity for a period of greater than 1 hour at a temperature in the range of from 50° C. to 500° C.; wherein said one or more heterogeneous metal based catalyst systems have a yield of less than 90 percent based on the molar conversion of cyanoaldehydes to diamines; and (2) thereby improving the catalytic activity of said one or more heterogeneous metal based catalyst systems. | 05-31-2012 |
20130206578 | SELECTIVE DEHYDROHALOGENATION OF TERTIARY HALOGENATED HYDROCARBONS AND REMOVAL OF TERTIARY HALOGENATED HYDROCARBON IMPURITIES FROM A HALOGENATED HYDROCARBON PRODUCT - A process for converting a tertiary halogenated hydrocarbons in a tertiary halogenated hydrocarbon-containing stream to a corresponding unhalogenated or less-halogenated unsaturated hydrocarbon product with the release of hydrogen halide involves contacting the tertiary halogenated hydrocarbon with a sorbent-type dehydrohalogenation catalyst in a reaction zone and optionally passing a stripping gas through the reaction zone to remove vapor phase reaction products from the reaction zone. A process for removing a tertiary chlorinated hydrocarbon impurity from 1,3-dichloro-1-propene involves contacting a mixture containing the 1,3-dichloro--propene and the tertiary chlorinated hydrocarbon impurity with a dehydrochlorination catalyst effective to catalyze a conversion of the tertiary chlorinated hydrocarbon impurity to a corresponding unchlorinated or less-chlorinated unsaturated hydrocarbon and hydrogen chloride and distilling the 1,3-dichloro-1-propene to produce a purified cis-1,3-dichloro- 1-propene fraction and a purified trans-1,3-dichloro-1-propene fraction. | 08-15-2013 |
20130206579 | SELECTIVE DEHYDROHALOGENATION OF TERTIARY HALOGENATED HYDROCARBONS AND REMOVAL OF TERTIARY HALOGENATED HYDROCARBON IMPURITIES FROM A HALOGENATED HYDROCARBON PRODUCT - A process for converting a tertiary halogenated hydrocarbons in a tertiary halogenated hydrocarbon-containing stream to a corresponding unhalogenated or less-halogenated unsaturated hydrocarbon product with the release of hydrogen halide involves contacting the tertiary halogenated hydrocarbon with a sorbent-type dehydrohalogenation catalyst in a reaction zone and optionally passing a stripping gas through the reaction zone to remove vapor phase reaction products from the reaction zone. A process for removing a tertiary chlorinated hydrocarbon impurity from 1,3-dichloro-1-propene involves contacting a mixture containing the 1,3-dichloro-1-propene and the tertiary chlorinated hydrocarbon impurity with a dehydrochlorination catalyst effective to catalyze a conversion of the tertiary chlorinated hydrocarbon impurity to a corresponding unchlorinated or less-chlorinated unsaturated hydrocarbon and hydrogen chloride and distilling the 1,3-dichloro-1-propene to produce a purified cis-1,3-dichloro-1-propene fraction and a purified trans-1,3-dichloro-1-propene fraction. | 08-15-2013 |
Patent application number | Description | Published |
20080289166 | OPEN HEAD POWER TONG ASSEMBLY AND METHOD OF MAKING AN OPEN-HEAD POWER TONG ASSEMBLY - A method of making an open-head power tong assembly includes the steps of providing a power tong assembly that has a first case assembly and a transmission assemble. A second case assembly is provided that includes a casing having a sidewall with a plurality of supporting ribs, a base wall, and a top plate that define an interior region that is adapted to receive a pinion gear, a conversion shaft having first and second axial end portions, and an open-head tong assembly. The first case assembly is removed from the transmission assembly of the power tong assembly to expose a transmission shaft. The transmission shaft is removed to expose a transmission shaft opening. The second case is mounted to the transmission assembly such that the second axial end of the conversion shaft is engaged with the transmission shaft opening. | 11-27-2008 |
20100300251 | TONG ASSEMBLY - A tong assembly includes a case assembly having an enclosure defining an interior. A bearing assembly is disposed in the interior of the enclosure. The bearing assembly includes a first bearing member defining a first cavity and a second bearing member defining a first cavity. A tong head assembly is disposed in the interior of the enclosure of the case assembly. The tong head assembly includes a tong head engaged with an outer ring gear. The outer ring gear includes a first axial end portion, an oppositely disposed second axial end portion and a central portion. The first axial end portion is disposed in the first cavity of the first bearing member. The second axial end portion is disposed in the first cavity of the second bearing member. | 12-02-2010 |
20120103248 | WEIGHING AND DISPLAY STATION - A system for monitoring loads at well drilling and service operations includes a digital user interface. The digital interface is in electronic communication with a first pressure transducer in fluid communication with a first pad type hydraulic load sensor, a second pressure transducer in fluid communication with a second pad type hydraulic load sensor, and a third pressure transducer in fluid communication with a hydraulic diaphragm type deadline load sensor. The digital user interface module functions to monitor the hydraulic pressures experienced at each pressure transducer and functions to calculate and display a corresponding weight load in numerical and graphical form for each pressure transducer. The digital user interface is also in electronic communication with a fourth transducer in fluid communication with a hydraulic power tong unit. The digital user interface module also functions to monitor the hydraulic pressure experienced at the pressure transducer and functions to calculate and display a corresponding torque load produced by the power tongs in numerical and graphical form. | 05-03-2012 |
20120210827 | ROD TONG ASSEMBLY - A tong assembly includes a case assembly and a tong head assembly disposed in the interior of the case assembly and adapted to engage a first sucker rod. A transmission assembly engaged to a hydraulic motor and including a backup tong assembly. The backup tong assembly includes a backup tong having a first end and an oppositely disposed second end adapted to hold a second sucker rod. A load pin engaged to the second end of the backup tong and an outer casing of the transmission assembly, the load pin includes strain gages for measuring a force applied to the first end of the backup tong to output a force signal. A rotary encoder engages a shaft of the hydraulic motor and outputs a position signal when a. A controller generates an output signal based on only one of the force signal or the position signal when the force signal is greater than a predetermined value or when the position signal is within a predetermined range of values. The output signal actuates a valve to direct fluid from the hydraulic motor to a hydraulic fluid reservoir. | 08-23-2012 |
20140103641 | METHOD AND SYSTEM FOR TIGHTENING THREADED ELEMENTS AND CERTIFYING THE CONNECTIONS AND THE DEVICES FOR CONNECTING THREADED ELEMENTS - A method and system certifies a joint between a first threaded element having a first shoulder and a second threaded element having a second shoulder and the equipment used to tighten the connection. The method tightens to a first position at which the first shoulder abuts the second shoulder. Marks are made that are aligned across the first element and the second element corresponding to the first position. The connection is loosened and then tightened to a second position complying with a predetermined tightening specification. The distance beyond the marks for the first position is measured to verify that it is within acceptable tolerances. If acceptable the connection and/or the tightening equipment can be certified. | 04-17-2014 |
20140104074 | METHOD AND APPARATUS FOR CONTROLLING OIL WELL DRILL SITE SYSTEMS - A control system for a well site, the well site includes connectable elements configured for inserting down a well. An explosion hazard zone surrounds the well site. A first electronics enclosure is remote from the explosion hazard zone and houses a first electronics module. A remote electronics control module is spaced apart from the first electronics housing and a remote hydraulics module removed from the first electronics module and the hazard zone module. The control system includes a human machine interface including a display and input. A central communications module is in wireless communication with the first electronics control module, the remote electronics module, and a remote location. A processor is in one or more of the first electronics module, the communications module or the human machine interface. | 04-17-2014 |
20140105526 | TONG BEARING - A renewable bearing is for a tong including a housing and an engagement assembly. The bearing has a monolithic upper bearing element having a substantially planar upper surface and a monolithic lower bearing element having a substantially planar lower surface. The upper and lower bearing elements are configured to mount inside the housing with a substantially same outer horizontal profile as the upper bearing element. The upper bearing element and the lower bearing element define a central open area. The upper bearing element and the lower bearing element have an inner section define a radial recess opening to the central opening and for receiving the engagement assembly. The upper bearing element and the lower bearing element have outer sections that form a bearing portion radially intermediate the engagement assembly. | 04-17-2014 |
Patent application number | Description | Published |
20110065587 | EPITOPE TESTING USING SOLUBLE HLA - The present invention relates generally to a methodology for assaying the binding of a peptide to an individual, specific, soluble HLA molecule. | 03-17-2011 |
20120301871 | COMPARATIVE LIGAND MAPPING FROM MHC POSITIVE CELLS - The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be uninfected, infected, or tumorgenic. The methodology of the present invention broadly allows for these peptide ligands and their comcomittant source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorgenic versus nontumorgenic cells with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected cells. | 11-29-2012 |
20120302452 | COMPARATIVE LIGAND MAPPING FROM MHC CLASS I POSITIVE CELLS - The present invention relates generally to a methodology for the isolation, purification and identification of peptide ligands presented by MHC positive cells. In particular, the methodology of the present invention relates to the isolation, purification and identification of these peptide ligands from soluble class I and class II MHC molecules which may be uninfected, infected, or tumorgenic. The methodology of the present invention broadly allows for these peptide ligands and their comcomittant source proteins thereof to be identified and used as markers for infected versus uninfected cells and/or tumorgenic versus nontumorgenic cells with said identification being useful for marking or targeting a cell for therapeutic treatment or priming the immune response against infected cells. | 11-29-2012 |
20120329670 | EPITOPE TESTING USING SOLUBLE HLA - A methodology is provided for assaying the ability of a peptide of interest to displace an endogenously loaded peptide in a recombinantly produced, secreted, individual, soluble HLA trimolecular complex. | 12-27-2012 |
Patent application number | Description | Published |
20110250682 | FORMATION OF NEUROMUSCULAR JUNCTIONS IN A DEFINED SYSTEM - A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions. | 10-13-2011 |
20130096888 | Model and Methods for Identifying Points of Action in Electrically Active Cells - The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored. | 04-18-2013 |
20130115694 | FORMATION OF NEUROMUSCULAR JUNCTIONS IN A DEFINED SYSTEM - A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions. | 05-09-2013 |
20140206028 | Stable Electrically Active Neurons from Adult Tissue - Disclosed are compositions and methods of making stable electrically active adult neurons from adult neural tissue. The disclosed compositions can be used with microelectrode arrays in vitro to represent in vivo neural function for drug discovery and for studying neuronal degenerative diseases, neuronal development, and neuronal regeneration. | 07-24-2014 |
20140302599 | Method of Co-Culturing Mammalian Muscle Cells and Motoneurons - The invention provides a method of co-culturing mammalian muscle cells and mammalian motoneurons. The method comprises preparing one or more carriers coated with a covalently bonded monolayer of trimethoxysilylpropyl diethylenetriamine (DETA); suspending isolated fetal mammalian skeletal muscle cells in serum-free medium according to medium composition 1; suspending isolated fetal mammalian spinal motoneurons in serum-free medium according to medium composition 1; plating the suspended muscle cells onto the one or more carriers at a predetermined density and allowing the muscle cells to attach; plating the suspended motoneurons at a predetermined density onto the one or more carriers and allowing the motoneurons to attach; covering the one or more carriers with a mixture of medium composition 1 and medium composition 2; and incubating the carriers covered in the media mixture. | 10-09-2014 |
20140349884 | Synthetic Mammalian Neuromuscular Junction and Method of Making - A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions. | 11-27-2014 |
Patent application number | Description | Published |
20120122728 | Method Of Screening Drugs For Reversal Of Amyloid Beta Neurotoxicity - A method of screening a compound for effectiveness in treating amyloid beta neurotoxicity comprises culturing mammalian neurons in serum-free defined medium until the neurons are electrically functional, exposing the electrically stable neurons to amyloid beta, monitoring the exposed neurons for impairment of electrical functionality, and treating the exposed neurons with the candidate drug while monitoring their electrical activity for reversal of impairment. The invention also includes a method of identifying a mammalian neuron having a biological marker conferring predisposition to development of Alzheimer's disease, the method comprising culturing the mammalian neuron in serum-free medium until the neuron is electrically functional, exposing the electrically stable neuron to amyloid beta while monitoring for impairment of electrical functionality as an indicator of presence of said biological marker, and verifying presence of the biological marker by treating the impaired neuron with an anti-amyloidogenic compound while monitoring for return of neuron functionality. | 05-17-2012 |
20120128639 | In Vitro Production Of Oligodendrocytes From Human Umbilical Cord Stem Cells - The invention provides a method of producing oligodendrocytes by in vitro differentiation of human multi-potent progenitor cells (MLPCs). The method comprises culturing isolated MLPCs on a first surface in a serum-free defined culture medium; replacing the culture medium with serum-free culture medium supplemented with bFGF, EGF and PDGF-AA for approximately 24 hours; changing the cultured MLPCs into the supplemented serum-free culture medium further supplemented with differentiation factors norepinephrine, forskolin. and K252a; establishing a 3D environment by covering the culture with a second surface opposite and spaced apart from the first surface, so as to contain the MLPCs therebetween; and continuing to culture until a majority of the MLPCs have differentiated into oligodendrocytes. Additionally included is a method of treatment for a subject afflicted by a disease characterized by central or peripheral nervous system demyelination, the method comprising transplanting into the subject oligodendrocytes produced according to the method disclosed. | 05-24-2012 |
20140274796 | Methods, Systems, and Compositions for In Vitro Concentric Cell Culture Analog Systems - The present invention comprises methods, systems and compositions comprising concentric chamber cell culture analog devices, comprising biologically functional cells, which function similarly to in vivo conditions. | 09-18-2014 |
Patent application number | Description | Published |
20130097984 | LIGHT RIDING VEHICLE - To achieve a particular price point and/or to utilize a particular engine, riding lawn mowers may be configured with reduced size, weight, and/or power requirements, in order. A riding lawn mower may comprise a cutting deck coupled to a cutting blade, and an internal combustion engine having a displacement of less than 225 cubic centimeters. The internal combustion engine may be coupled to the cutting blade via a friction drive, wherein the friction drive is configured with a neutral bearing in order to reduce flat spotting of components of the friction drive. | 04-25-2013 |
20130097985 | LIGHT RIDING VEHICLE - To achieve a particular price point and/or to utilize a particular engine, riding lawn mowers may be configured with reduced size, weight, and/or power requirements, in order. A riding lawn mower may comprise a cutting deck coupled to a cutting blade, and an internal combustion engine having a displacement of less than 225 cubic centimeters. The internal combustion engine may be coupled to the cutting blade via a friction drive, wherein the friction drive is configured with a neutral bearing in order to reduce flat spotting of components of the friction drive. | 04-25-2013 |
20130227923 | LIGHT RIDING VEHICLE - To achieve a particular price point and/or to utilize a particular engine, riding lawn mowers may be configured with reduced size, weight, and/or power requirements, in order. A riding lawn mower may comprise a cutting deck coupled to a cutting blade, and an internal combustion engine having a displacement of less than 225 cubic centimeters. The internal combustion engine may be coupled to the cutting blade via a friction drive, wherein the friction drive is configured with a neutral bearing in order to reduce flat spotting of components of the friction drive. | 09-05-2013 |
20140080670 | LIGHT RIDING VEHICLE WITH VARIABLE FRICTION DRIVE - Riding lawn mowers may utilize friction drives configured with a variable normal force between frictional components. In a riding lawn mower, an internal combustion engine may be coupled to a differential via a friction drive, wherein the friction drive is configured with a variable normal force in order to provide improved power transfer and/or shifting performance. | 03-20-2014 |
Patent application number | Description | Published |
20080262126 | NANOCOMPOSITE METHOD OF MANUFACTURE - Disclosed are systems and methods for the formation of a polymer nanocomposite material using a high-concentration masterbatch as a source of nanocomposite filler. | 10-23-2008 |
20100122612 | Pipe Wrench - A pipe wrench or tool with an improved I-beam handle design having a ramped or tapered cross-sectional configuration, as well as an optional stronger ductile iron material. Specifically, the portion of the tool handle adjacent the jaw or tool operating portion, has wider flanges in the I-beam configuration than the flanges in the opposite end of the tool handle. Such a design adds additional strength at what are typically critical stress areas of the tool handle. The use of the present handle design, along with the use of a stronger ductile iron material, as disclosed here, provides wrenches using these features with a substantial improvement in tool strength as compared to conventional tools. | 05-20-2010 |
20120267279 | CONTAINER FOR AIR FRESHENING MATERIALS AND OTHER VOLATILES - A container for air freshening materials or other volatiles includes a receptacle or base and a cover that may be rotated from a closed position to multiple open positions while still engaged to the base to create vent passageway(s) between the cover and the base. A containment section of the base houses an air freshening material, such as a fragrance gel or potpourri, or a volatile, such as an insect repellant. The base further defines an alignment section adapted to rotationally and axially position the cover, an integrated sealing element, and an optional vent section. The alignment section includes a ramp and upper and lower locating elements coupled to the ramp. The alignment section engages at least one guide or a guide nub that extends from a depending arm of the cover. The guide or guide nub travels along the ramp from a first locating element when the cover is in a fully closed position to a second locating element when the cover is in a fully open position. In one of its multiple open positions, the cover is rotationally and axially displaced to specified height(s) above the container, allowing for fragrance or volatile material release. | 10-25-2012 |
20130327845 | AIR FRESHENER - An air freshener removably engages with a structure, such as the supporting post of a rear view mirror of a motor vehicle. The air freshener has a rigidifying core defining a central axis, and an outer portion or sleeve contacting the core that is formed from one or more fragrance loaded polymers. Together, the core and outer portion are shaped to surround a first axis perpendicular to the central axis. The ends of the air freshener are juxtaposed generally opposite one another in closed configuration, and the arm portions of the air freshener flex in directions substantially parallel to the first axis to separate the ends to open the air freshener. A breakable strap and/or connectors may be provided to join the ends together. Alternatively, one end of the air freshener may be inserted within a cavity formed in the opposite end of the air freshener. | 12-12-2013 |
Patent application number | Description | Published |
20110232349 | PROCESSING OF TITANIUM-ALUMINUM-VANADIUM ALLOYS AND PRODUCTS MADE THEREBY - A method of forming an article from an α−β titanium including, in weight percentages, from about 2.9 to about 5.0 aluminum, from about 2.0 to about 3.0 vanadium, from about 0.4 to about 2.0 iron, from about 0.2 to about 0.3 oxygen, from about 0.005 to about 0.3 carbon, from about 0.001 to about 0.02 nitrogen, and less than about 0.5 of other elements. The method comprises cold working the α−β titanium alloy. | 09-29-2011 |
20120003118 | PROCESSING OF TITANIUM-ALUMINUM-VANADIUM ALLOYS AND PRODUCTS MADE THEREBY - A method of forming an article from an α−β titanium including, in weight percentages, from about 2.9 to about 5.0 aluminum, from about 2.0 to about 3.0 vanadium, from about 0.4 to about 2.0 iron, from about 0.2 to about 0.3 oxygen, from about 0.005 to about 0.3 carbon, from about 0.001 to about 0.02 nitrogen, and less than about 0.5 of other elements. The method comprises cold working the α−β titanium alloy. | 01-05-2012 |
20120177532 | PROCESSING OF TITANIUM-ALUMINUM-VANADIUM ALLOYS AND PRODUCTS OF MADE THEREBY - A method of forming an article from an a-13 titanium including, in weight percentages, from about 2.9 to about 5.0 aluminum, from about 2.0 to about 3.0 vanadium, from about 0.4 to about 2.0 iron, from about 0.2 to about 0.3 oxygen, from about 0.005 to about 0.3 carbon, from about 0.001 to about 0.02 nitrogen, and less than about 0.5 of other elements. The method comprises cold working the α−β titanium alloy. | 07-12-2012 |
20140060138 | PROCESSING OF TITANIUM-ALUMINUM-VANADIUM ALLOYS AND PRODUCTS MADE THEREBY - A method of forming an article from an α−β titanium including, in weight percentages, from about 2.9 to about 5.0 aluminum, from about 2.0 to about 3.0 vanadium, from about 0.4 to about 2.0 iron, and from about 0.2 to about 0.3 oxygen. The method comprises cold working the α−β titanium alloy. | 03-06-2014 |
Patent application number | Description | Published |
20100111853 | ANTIBODIES THAT BIND TO IL-12 AND METHODS OF PURIFYING THE SAME - Anti-IL-12 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-12 antibodies from a sample matrix is presented. These isolated anti-IL-12 antibodies can be used in a clinical setting as well as in research and development. Pharmaceutical compositions comprising isolated anti-IL-12 antibodies are also described. | 05-06-2010 |
20100135987 | ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY - Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention. | 06-03-2010 |
20100136025 | VIRAL INACTIVATION DURING PURIFICATION OF ANTIBODIES CROSS REFERENCE TO RELATED APPLICATIONS - Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification. In a particular aspect, methods herein employ an acidification step followed by one or more chromatography steps. The chromatography steps can include one or more of the following chromatographic procedures: ion exchange chromatography, affinity chromatography, and hydrophobic interaction chromatography. | 06-03-2010 |
20100150864 | ANTIBODIES THAT BIND TO IL-18 AND METHODS OF PURIFYING THE SAME - Anti-IL-18 antibodies are disclosed herein, including antigen-binding portions thereof. One or more methods for isolating and purifying anti-IL-18 antibodies from a sample matrix is presented. These isolated anti-IL-18 antibodies can be used in a clinical setting as well as in research and development. Pharmaceutical compositions comprising isolated anti-IL-18 antibodies are also described. | 06-17-2010 |
20110206687 | Isolation And Purification Of Anti-IL-13 Antibodies Using Protein A Affinity Chromatography - Disclosed herein are methods for the isolation and purification of anti-IL-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., Protein A affinity chromatography), ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention. | 08-25-2011 |
20110301342 | APPARATUS AND PROCESS FOR PURIFICATION OF PROTEINS - The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, a depth filter, and a mixed-mode chromatography resin. A membrane adsorber or monolith may be substituted for the mixed-mode chromatography column. | 12-08-2011 |
20120264920 | PROCESSES FOR PURIFICATION OF PROTEINS - The invention is directed to a method for purifying a protein. The method involves providing a sample containing the protein, processing the sample through a capture chromatography resin, inactivating viruses in the sample, and processing through at least one depth filter and ion-exchange membrane. | 10-18-2012 |
20130195888 | ULTRAFILTRATION AND DIAFILTRATION FORMULATION METHODS FOR PROTEIN PROCESSING - Disclosed herein are methods of purifying proteins using ultrafiltration and diafiltration processes. | 08-01-2013 |
20140255423 | ISOLATION AND PURIFICATION OF ANTIBODIES USING PROTEIN A AFFINITY CHROMATOGRAPHY - Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise pH viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably Protein A affinity, ion exchange chromatography, and hydrophobic chromatography. Further, the present invention is directed toward pharmaceutical compositions comprising one or more antibodies of the present invention. | 09-11-2014 |
Patent application number | Description | Published |
20130066820 | SYSTEM AND METHOD FOR EVIDENCE-BASED DECISION BOOTSTRAPPING - The systems and methods relate to decision making processes. Data associated with a request for a decision is received. Risks associated with the request are identified. Decision queries associated with each of the identified risks are determined. Any non-standard attributes associated with each of the identified risks are identified. A confidence level threshold for each of the identified risks is determined. A decision recommendation, generated by a machine learning component, is received. The decision recommendation includes a response to each of the one or more decision queries, determined based on the exceptional attributes, if any, and a confidence level associated with the response. The confidence level is compared to the confidence level threshold. Based on the comparison, a decision path for responding to the request is determined. Decision path actions are determined based on the decision path. | 03-14-2013 |
20130110755 | SYSTEM AND METHOD FOR RENDERING DECISION SUPPORT INFORMATION TO MEDICAL WORKERS | 05-02-2013 |
20130167192 | METHOD AND SYSTEM FOR DATA PATTERN MATCHING, MASKING AND REMOVAL OF SENSITIVE DATA - Systems, methods and computer-readable media for applying policy enforcement rules to sensitive data. An unstructured data repository for storing unstructured data is maintained. A structured data repository for storing structured data is maintained. Request for information is received. The request is analyzed to determine its context. Based on the context, a policy enforcement action associated with generating a response to the request is identified. The policy enforcement action may be to remove sensitive data in generating the response to the request and/or mask sensitive data in generating a response to the request. An initial response to the request is generated by retrieving unstructured data from the unstructured data repository. Using the structured data maintained in the structured data repository, sensitive data included within the initial response is identified. The policy enforcement action is applied to the sensitive data included within the initial response to generate the response to the request. | 06-27-2013 |
20130197938 | SYSTEM AND METHOD FOR CREATING AND USING HEALTH DATA RECORD - Systems, methods and computer-readable media for creating and using a health data record. Data relating to a patient's health is received from one or more information sources. The data includes unstructured data and structured data elements. The unstructured data is parsed to identify data elements. At least some of the structured data elements and at least some of the data elements parsed from the unstructured data are normalized to create normalized data elements. A weight is assigned to the normalized data elements. The normalized data elements are mapped in accordance with an ontology. The mapped data is stored in a data repository in accordance with a data model. | 08-01-2013 |
Patent application number | Description | Published |
20090024187 | MULIT-PROGRAMMABLE TRIAL STIMULATOR - Disclosed are systems and methods which provide trial stimulators suited for use interoperatively and during patient trial. Trial stimulator embodiments provide a patient interface and/or clinician interface which appears and functions substantially the same as an interface of a pulse generator controller which will be used after a trial period. A compliance monitor feature may be provided to facilitate verifying the proper use of the trial stimulator during a trial period. A diagnostic feature may be provided to facilitate verifying proper operation of various aspects of a trial stimulator, such as electrode impedance analysis. Trial stimulators of embodiments provide stimulation to a plurality of tissues and/or areas of the body, such as spinal cord stimulation, deep brain stimulation, etcetera. Embodiments provide for multi-electrode stimulation and multi-stimulation programs. Embodiments are configured to provide active discharge of stimulation pulses as well as to utilize constant current sources in providing the stimulation pulses. | 01-22-2009 |
20110144721 | SYSTEM AND METHOD FOR PROGRAMMING AN IMPLANTABLE PULSE GENERATOR - In one embodiment, a method of programming an IPG comprises providing one or several GUI screens on the programmer device, the GUI screens comprising a master amplitude GUI control for controlling amplitudes for stimsets of a stimulation program and one or several balancing GUI controls for controlling amplitudes of each stimset of the stimulation program; communicating one or several commands from the programmer device to the IPG to change the amplitude of all stimsets of the stimulation program in response to manipulation of the master amplitude GUI control, wherein the amplitude of each stimulation set is automatically calculated by a level selected through the master amplitude GUI control and one or several calibration parameters for the respective stimulation set; and automatically recalculating the one or several calibration parameters for a respective stimulation set in response to manipulation of one of the balancing GUI controls and storing the recalculated calibration parameters. | 06-16-2011 |
20110208265 | MULTI-PROGRAMMABLE TRIAL STIMULATOR - Disclosed are systems and methods which provide trial stimulators suited for use interoperatively and during patient trial. Trial stimulator embodiments provide a patient interface and/or clinician interface which appears and functions substantially the same as an interface of a pulse generator controller which will be used after a trial period. A compliance monitor feature may be provided to facilitate verifying the proper use of the trial stimulator during a trial period. A diagnostic feature may be provided to facilitate verifying proper operation of various aspects of a trial stimulator, such as electrode impedance analysis. Trial stimulators of embodiments provide stimulation to a plurality of tissues and/or areas of the body, such as spinal cord stimulation, deep brain stimulation, etcetera. Embodiments provide for multi-electrode stimulation and multi-stimulation programs. Embodiments are configured to provide active discharge of stimulation pulses as well as to utilize constant current sources in providing the stimulation pulses. | 08-25-2011 |
20110257660 | APPARATUS FOR IMPLANTING AN ELECTRICAL STIMULATION LEAD - In one embodiment, an introducer is provided for implanting an electrical stimulation lead to enable electrical stimulation of nerve tissue. The introducer includes an outer sheath and an inner penetrator. The outer sheath may accommodate insertion of the electrical stimulation lead and may be inserted into a human body near the nerve tissue. The inner penetrator is removably housed within the outer sheath and includes an inner channel configured to accommodate a guide wire, a tip end having a shape and size substantially conforming to that of the guide wire, a body region having a shape and size substantially conforming to that of the outer sheath, and one or more transition regions substantially connecting the tip end with the body region. At least a portion of the transition regions of the inner penetrator may flex to substantially follow flexures in the guide wire during advancement of the inner penetrator. | 10-20-2011 |
20120245594 | APPARATUS FOR IMPLANTING AN ELECTRICAL STIMULATION LEAD - In one embodiment, an introducer is provided for implanting an electrical stimulation lead to enable electrical stimulation of nerve tissue. The introducer includes an outer sheath and an inner penetrator. The outer sheath may accommodate insertion of the electrical stimulation lead and may be inserted into a human body near the nerve tissue. The inner penetrator is removably housed within the outer sheath and includes an inner channel configured to accommodate a guide wire, a tip end having a shape and size substantially conforming to that of the guide wire, a body region having a shape and size substantially conforming to that of the outer sheath, and one or more transition regions substantially connecting the tip end with the body region. At least a portion of the transition regions of the inner penetrator may flex to substantially follow flexures in the guide wire during advancement of the inner penetrator. | 09-27-2012 |
20130131758 | SYSTEM AND METHOD FOR PROGRAMMING AN IMPLANTABLE PULSE GENERATOR - In one embodiment, a method of programming an IPG comprises providing one or several GUI screens on the programmer device, the GUI screens comprising a master amplitude GUI control for controlling amplitudes for stimsets of a stimulation program and one or several balancing GUI controls for controlling amplitudes of each stimset of the stimulation program; communicating one or several commands from the programmer device to the IPG to change the amplitude of all stimsets of the stimulation program in response to manipulation of the master amplitude GUI control, wherein the amplitude of each stimulation set is automatically calculated by a level selected through the master amplitude GUI control and one or several calibration parameters for the respective stimulation set; and automatically recalculating the one or several calibration parameters for a respective stimulation set in response to manipulation of one of the balancing GUI controls and storing the recalculated calibration parameters. | 05-23-2013 |