Patent application number | Description | Published |
20100242631 | METHOD AND SYSTEM FOR PARTICLES ANALYSIS IN MICROSTRUCTURE DEVICES BY ISOLATING PARTICLES - During the fabrication of microstructure devices, such as integrated circuits, particles may be analyzed by displacing or removing the particles from the device surface and subsequently performing an analysis process. Consequently, a well-defined measurement environment may be established after removal of the particles, which may be accomplished on the basis of nanoprobes and the like. Hence, even critical surface areas may be monitored with respect to contamination and the like on the basis of well-established analysis techniques. | 09-30-2010 |
20110241166 | Semiconductor Device Comprising a Capacitor Formed in the Contact Level - A contact level in a semiconductor device may be used for providing a capacitor that may be directly connected to a transistor, thereby providing a very space-efficient capacitor/transistor configuration. For example, superior dynamic RAM arrays may be formed on the basis of the capacitor/transistor configuration disclosed herein. | 10-06-2011 |
20110266685 | Semiconductor Device Comprising Sophisticated Conductive Elements in a Dielectric Material System Formed by Using a Barrier Layer - An efficient patterning strategy may be applied when etching through a dielectric material system on the basis of two different etch chemistries. To this end, a conductive etch stop or barrier material may be formed in the opening prior to etching through the further dielectric layer of the material system, thereby substantially preserving the initial critical dimensions and avoiding etch damage. Thus, superior contact openings, via openings and the like may be formed on the basis of well-established etch chemistries. | 11-03-2011 |
20110291170 | Semiconductor Device Comprising a Buried Capacitor Formed in the Contact Level - In a semiconductor device, capacitors may be formed so as to be in direct contact with a transistor by using a shared transistor region, such as a drain region or a source region of closely spaced transistors, as one capacitor electrode, while the other capacitor electrode is provided in the form of a buried electrode in the dielectric material of the contact level. To this end, dielectric material may be deposited so as to reliably form a void, wherein, at any appropriate manufacturing stage, a capacitor dielectric material may be provided so as to separate the capacitor electrodes. | 12-01-2011 |
20110291298 | Chip Package Including Multiple Sections for Reducing Chip Package Interaction - Thermally induced stress in a semiconductor die, i.e., in a complex metallization system thereof, may be reduced by “dividing” a package substrate into two or more substrate sections, which may have formed therebetween an appropriate stress buffer region, for instance a region of superior resiliency. In this case, the total deformation of the package substrate may be reduced, thereby also reducing the thermally induced stress forces in the complex metallization system of the semiconductor die. Hence, for a given size and complexity of a metallization system, an increased production yield and superior reliability may be achieved. | 12-01-2011 |
20110291299 | Stress Reduction in Chip Packaging by a Stress Compensation Region Formed Around the Chip - A stress compensation region that may be appropriately positioned on a package substrate may compensate for or at least significantly reduce the thermally induced mechanical stress in a sensitive metallization system of a semiconductor die, in particular during the critical reflow process. For example, a stressor ring may be formed so as to laterally surround the chip receiving portion of the package substrate, wherein the stressor ring may efficiently compensate for the thermally induced deformation in the chip receiving portion. | 12-01-2011 |
20120025862 | Test Structure for ILD Void Testing and Conduct Resistance Measurement in a Semiconductor Device - In complex semiconductor devices, the contact characteristics may be efficiently determined on the basis of a test structure which includes a combination of interconnect chain structures and a comb structure including gate electrode structures. Consequently, an increased amount of measurement information may be obtained on the basis of a reduced overall floor space of the test structure. In this manner, the complex manufacturing sequence for forming a contact level of a semiconductor device may be quantitatively estimated and monitored. | 02-02-2012 |
20120122249 | DOPANT MARKER FOR PRECISE RECESS CONTROL - A semiconductor device is formed by implanting recess markers in a material during deposition and using the recess markers during etching of the material for precise in-situ removal rate definition and removal homogeneity-over-radius definition. An embodiment includes depositing a layer of material on a substrate, implanting first and second dopants in the material at first and second predetermined times during deposition of the material, etching the material, detecting the depths of the first and second dopants during etching, calculating the removal rate of the material in situ from the depths of the first and second dopants, and determining from the removal rate a stop position for etching. Embodiments further include depositing a layer of material on a substrate, laterally implanting a first dopant and a second dopant in the material at a predetermined depth during deposition of the material, etching the material, detecting the positions and intensities of the first and second dopants during etching, and calculating lateral homogeneity of the material in situ from the intensities of the first and second dopants. Embodiments further include in situ corrective action for the removal process based on the determined removal rate and lateral homogeneity. | 05-17-2012 |
20120161327 | Shrinkage of Contact Elements and Vias in a Semiconductor Device by Incorporating Additional Tapering Material - Vertical contact structures, such as contact elements connected to semiconductor-based contact regions in device areas comprising densely-spaced gate electrode structures, are formed for given lithography and patterning capabilities by incorporating at least one additional dielectric layer of superior tapering behavior into the dielectric material system. | 06-28-2012 |
20120164836 | INTEGRATED CIRCUIT FABRICATION METHODS UTILIZING EMBEDDED HARDMASK LAYERS FOR HIGH RESOLUTION PATTERNING - Embodiments of a method for fabricating integrated circuits are provided. In one embodiment, the method includes the steps of depositing a dielectric layer over a semiconductor device, forming a plurality of trimmed hardmask structures at predetermined locations over the dielectric layer, embedding the plurality of trimmed hardmask structures in a surrounding hardmask layer, removing the plurality of trimmed hardmask structures to create a plurality of openings through the surrounding hardmask layer, and etching the dielectric layer through the plurality of openings to form a plurality of etch features therein. | 06-28-2012 |
20120193807 | DRAM CELL BASED ON CONDUCTIVE NANOCHANNEL PLATE - A capacitor is formed in nano channels in a conductive body. Embodiments include forming a source contact through a first inter layer dielectric (ILD), forming a conductive body on the first ILD, forming a second ILD on the conductive body, forming drain and gate contacts through the second ILD, conductive body, and first ILD, forming nano channels in the conductive body, forming an insulating layer in the channels, and metalizing the channels. An embodiment includes forming the nano channels by forming a mask on the second ILD, the mask having features with a pitch of 50 nanometers (nm) to 100 nm, etching the second ILD through the mask, etching the conductive body through the mask to a depth of 80% to 90% of the thickness of the conductive body, and removing the mask. | 08-02-2012 |
20120199950 | INTEGRATED CIRCUITS HAVING PLACE-EFFICIENT CAPACITORS AND METHODS FOR FABRICATING THE SAME - Integrated circuits having place-efficient capacitors and methods for fabricating the same are provided. A dielectric layer is formed overlying a conductive feature on a semiconductor substrate. A via opening is formed into the dielectric layer to expose a portion of the conductive feature. A partial opening is etched into the dielectric layer and positioned over the conductive feature. Etch resistant particles are deposited overlying the dielectric layer and in the partial opening. The dielectric layer is further etched using the etch resistant particles as an etch mask to extend the partial opening. A first conductive layer is formed overlying the extended partial opening and electrically contacting the conductive feature. A capacitor insulating layer is formed overlying the first conductive layer. A second conductive layer is formed overlying the insulating layer. | 08-09-2012 |
20120225503 | DOPANT MARKER FOR PRECISE RECESS CONTROL - A method is provided including depositing a layer of material on a substrate, during deposition of the material, at a predetermined depth, laterally implanting a first dopant and a second dopant in the material, the second dopant being different from the first dopant, etching the material, during etching, detecting the positions and intensities of the first and second dopants, and calculating lateral homogeneity of the material in situ from the intensities of the first and second dopants. | 09-06-2012 |
20120244710 | Shrinkage of Critical Dimensions in a Semiconductor Device by Selective Growth of a Mask Material - In sophisticated semiconductor devices, manufacturing techniques and etch masks may be formed on the basis of a mask layer stack which comprises an additional mask layer, which may receive an opening on the basis of lithography techniques. Thereafter, the width of the mask opening may be reduced by applying a selective deposition or growth process, which thus results in a highly uniform and well-controllable adjustment of the target width of the etch mask prior to performing the actual patterning process, for instance for forming sophisticated contact openings, via openings and the like. | 09-27-2012 |
20120267763 | INTEGRATED CIRCUITS HAVING PLACE-EFFICIENT CAPACITORS AND METHODS FOR FABRICATING THE SAME - An integrated circuit having a place-efficient capacitor includes a lower capacitor electrode having a surface area comprised of an inner surface area of a partial opening and a via opening formed in a patterned dielectric layer on a semiconductor substrate, a capacitor insulating layer overlying the lower capacitor electrode, and an upper capacitor electrode including a metal fill material filling the partial opening and the via opening and having a surface area that includes the inner surface area of the partial opening and via opening. | 10-25-2012 |
20120270342 | IN-SITU MEASUREMENT OF FEATURE DIMENSIONS - Methods and systems are provided for fabricating a semiconductor device. An exemplary method involves forming a feature of a semiconductor device in a first region of a layer of material on a semiconductor substrate and forming a test structure in a second region of the layer of material. The test structure is formed concurrently to forming the feature, and a dimension of the feature is determined using the test structure. | 10-25-2012 |
20120282712 | DOPANT MARKER FOR PRECISE RECESS CONTROL - Recess markers are implanted in a material during deposition and used during etching of the material for in-situ removal rate and removal homogeneity-over-radius definitions. An embodiment includes depositing a material on a substrate, implanting two dopants at two predetermined times, respectively, during deposition of the material, etching the material, detecting depths of the two dopants during etching, calculating the removal rate of the material in situ from the depths of the two dopants, and determining from the removal rate an etching stop position. Embodiments further include laterally implanting two dopants in a material at a predetermined depth during deposition, etching the material, detecting the positions and intensities of the two dopants during etching, and calculating lateral homogeneity of the material in situ from intensities of the dopants. Embodiments further include in situ corrective action for the removal process based on the determined removal rate and lateral homogeneity. | 11-08-2012 |
20130001654 | MASK-BASED SILICIDATION FOR FEOL DEFECTIVITY REDUCTION AND YIELD BOOST - A semiconductor device with reduced defect density is fabricated by forming localized metal silicides instead of full area silicidation. Embodiments include forming a transistor having a gate electrode and source/drain regions on a substrate, forming a masking layer with openings exposing portions of both the gate electrode and source/drain regions over the substrate, depositing metal in the openings on the exposed portions, forming silicides in the openings, and removing unreacted metal and the masking layer. | 01-03-2013 |
20140299929 | DRAM CELL BASED ON CONDUCTIVE NANOCHANNEL PLATE - A capacitor is formed in nano channels in a conductive body. Embodiments include forming a source contact through a first inter layer dielectric (ILD), forming a conductive body on the first ILD, forming a second ILD on the conductive body, forming drain and gate contacts through the second ILD, conductive body, and first ILD, forming nano channels in the conductive body, forming an insulating layer in the channels, and metalizing the channels. An embodiment includes forming the nano channels by forming a mask on the second ILD, the mask having features with a pitch of 50 nanometers (nm) to 100 nm, etching the second ILD through the mask, etching the conductive body through the mask to a depth of 80% to 90% of the thickness of the conductive body, and removing the mask. | 10-09-2014 |
Patent application number | Description | Published |
20080254451 | Compositions and Methods for Treating Schizophrenia and Related Disorders - The present invention relates, generally, to methods and compositions for detecting or treating mental disorders, such as schizophrenia. The present invention more particularly discloses the identification of human genes which can be used for the diagnosis, prevention and treatment of schizophrenia and related disorders, as well as for the screening of therapeutically active drugs. The invention further discloses specific polymorphisms or alleles of the CNTFR gene that are related to schizophrenia, as well as diagnostic tools and kits based on these markers. The invention can be used in the diagnosis of or predisposition to, detection, prevention and/or treatment of schizophrenia and related disorders. | 10-16-2008 |
20080305483 | BIALLELIC MARKERS DERIVED FROM GENOMIC REGIONS CARRYING GENES INVOLVED IN ARACHIDONIC ACID METABOLISM - The invention provides polynucleotides including biallelic markers derived from genes involved in arachidonic acid metabolism and from genomic regions flanking those genes. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. | 12-11-2008 |
20090136450 | THERAPY FOR NEUROLOGICAL DISEASES - The present invention relates to compositions and methods for treating neurological diseases in a subject. More specifically, the invention relates to combination therapies for treating such diseases, using a c-kit inhibitor and a neuroactive compound. The invention may be used against a variety of demyelinating diseases, including multiple sclerosis, in any mammalian subject, particularly human subjects, and at various stages of disease progression. | 05-28-2009 |
20090155806 | Genomic Sequence of the 5-Lipoxygenase-Activating Protein (FLAP), Polymorphic Markers Thereof and Methods for Detection of Asthma - The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway. | 06-18-2009 |
20100234236 | Novel Disease Treatment by Predicting Drug Association - The present invention relates to methods for drug repositioning. More particularly, this invention relates to methods for selecting approved drugs or combinations of approved drugs for use in new therapeutic indications. This approach is situated in a cross section between drug repositioning and disease treatment by combinations of drugs with additive or synergistic action. The invention also allows to define drugs or drug combinations for treating the unmet medical need in diseases neglected by majority of Pharma companies, such as orphan diseases. | 09-16-2010 |
20100310641 | THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. More particularly, the invention relates to combined therapies for treating said disease by affecting PMP22 expression in a subject. | 12-09-2010 |
20110269764 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF SYNAPSE FUNCTION - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate synapse function for treating said disease. | 11-03-2011 |
20120040940 | COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signaling and thyroid hormone pathway in a subject. | 02-16-2012 |
20120058992 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate angiogenesis for treating said disease. | 03-08-2012 |
20120071483 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that modulate cell stress response for treating said disease. | 03-22-2012 |
20120088744 | COMPOSITIONS FOR TREATING CMT AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. | 04-12-2012 |
20120108528 | NEW THERAPEUTIC APPROACHES FOR TREATING NEUROINFLAMMATORY CONDITIONS - The present invention relates to novel compositions which can be used for the treatment of neuroinflammation, in particular in subjects having a neurodegenerative, autoimmune, infectious, toxic or traumatic disorder. More particularly, the invention relates to combined therapies for treating neuroinflammation. The invention also discloses new methods for treating neuroinflammation pathological conditions in a subject. | 05-03-2012 |
20120270836 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder. | 10-25-2012 |
20120283114 | NEW DIAGNOSTIC TOOLS FOR ALZHEIMER DISEASE - The present invention relates to development, validation and application of new sets of biomarkers for diagnosis of Alzheimer's disease (AD) and related disorders including early diagnosis of MCI and early prodrome of AD, identification of disease sub types, prediction of their response to disease management procedures, drugs and their combinations and for monitoring response for these treatment, including validation of biomarkers for clinical trials. | 11-08-2012 |
20130085122 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS - The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination. | 04-04-2013 |
20130090307 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS - The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorder, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on Baclofen and Acamprosate combination. | 04-11-2013 |
20130217036 | NEW DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE - The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease subtypes, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder. | 08-22-2013 |
20140038927 | COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS - The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury. | 02-06-2014 |
20140080873 | TREATMENT OF CEREBRAL ISCHEMIA - The present invention relates to new compositions and methods for protecting neuronal cells from ischemic or hypoxic events. More precisely, this invention provides new combinatorial therapies that efficiently protect neuronal cells from ischemia or hypoxia. | 03-20-2014 |
20140178463 | COMPOSITIONS FOR TREATING CMT AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related disorders. | 06-26-2014 |
20140235599 | COMBINATION OF PILOCARPIN AND METHIMAZOL FOR TREATING CHARCOT-MARIETOOTH DISEASE AND RELATED DISORDERS - The present invention relates to compositions and methods for the treatment of the Charcot-Marie-Tooth disease and related peripheral neuropathies. More particularly, the invention relates to combined therapies for treating said disease by affecting simultaneously muscarinic receptor signalling and thyroid hormone pathway in a subject. | 08-21-2014 |
20140357648 | THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE - The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease and related disorders. In particular, the invention concerns compounds which, alone or in combination(s), can effectively modulate synapse function and/or angiogenesis and/or cell stress response. The invention also relates to methods of producing a drug or a drug combination for treating Alzheimer's disease and to methods of treating Alzheimer's disease or a related disorder. | 12-04-2014 |
20140371229 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE - The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder. | 12-18-2014 |
20140371277 | COMPOSITIONS FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS - The present invention relates to compositions and methods for the treatment of amyotrophic lateral sclerosis. More specifically, the present invention relates to novel combinatorial therapies for treating amyotrophic lateral sclerosis or a related disorder. | 12-18-2014 |
20140378440 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS - The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Alzheimer's disease, Alzheimer's disease related disorders, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury, based on baclofen and acamprosate combination. | 12-25-2014 |
20150157626 | THERAPEUTIC APPROACHES FOR TREATING CMT AND RELATED DISORDERS - Compositions and methods for the treatment of Charcot-Marie-Tooth disease and related disorders. Also provided are combination therapies for treating this disease by decreasing PMP22 expression in a subject. | 06-11-2015 |
20150224092 | NOOTROPIC COMPOSITIONS FOR IMPROVING MEMORY PERFORMANCE - The invention relates to compositions and methods for improving memory and related functions as alertness, attention, concentration, learning, and language processing. More particularly, the invention relates to compositions comprising at least two drugs selected from cinacalcet, baclofen, acamprosate, mexiletine, sulfisoxazole and torasemide useful to enhance memory and related functions in healthy subjects or subjects suffering from conditions or disorders having a negative impact on their memory. | 08-13-2015 |
20150231123 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL - The present invention relates to compositions and methods for controlling glycaemia in a mammalian in need thereof. The present invention relates to compositions and methods for the treatment of diabetes disease and related disorders. More specifically, the present invention relates to novel therapies or combinatorial therapies of diabetes and related disorders, based on compositions controlling the blood glucose level. | 08-20-2015 |
20150238452 | BACLOFEN AND ACAMPROSATE BASED THERAPY OF MACULAR DEGENERATION DISORDERS - The present invention relates to combinations and methods for the treatment of macular degeneration disorders. More specifically, the present invention relates to novel combinatorial therapies of Age related Macular Degeneration based on baclofen and acamprosate combination. | 08-27-2015 |
20150246044 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE - The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present invention relates to novel combinatorial therapies of Parkinson's disease and related disorders targeting the alpha-synuclein aggregation network. In particular, the invention relates to compounds which, alone or in combination(s), can effectively protect neuronal cells from alpha-synuclein aggregates. The invention also relates to methods of producing a drug or a drug combination for treating Parkinson's disease and to methods of treating Parkinson's disease or a related disorder. | 09-03-2015 |
20150301069 | DIAGNOSTIC TOOLS FOR CHARCOT-MARIE-TOOTH DISEASE - The present invention relates in particular to methods of detecting predisposition to or diagnosis and/or prognosis of Charcot-Marie-Tooth (CMT) and related disorders. More specifically, the invention relates to development, validation and application of new biomarkers, which can be used for detecting the presence or risk of CMT disease and related disorders. In particular, the present invention relates to metabolite, lipid, carbohydrate and proteinaceous biomarkers that can be measured in biological body fluids and easily available extracts of biopsies, which can be used to aid in the detection, prediction of drug treatment and follow up of this treatment of neurodegenerative disorders, including CMT disease. The present invention also relates to methods for identification of CMT disease sub-types, assessing the responsiveness to the treatments and the efficacy of treatments in subjects having CMT or a related disorder. | 10-22-2015 |
20150374647 | THERAPEUTIC APPROACHES FOR TREATING EPILEPSY AND RELATED DISORDERS THROUGH REDUCTION OF EPILEPTOGENESIS - The present invention relates to compositions and methods for the treatment of epilepsy and related disorders. More specifically, the present invention relates to novel combinatorial therapies of epilepsy and related disorders. | 12-31-2015 |