Sham, US
Hing Sham, South San Francisco, CA US
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20150315198 | PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS - In one aspect this invention relates generally to compounds of Formula: | 11-05-2015 |
Hing L. Sham, South San Francisco, CA US
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20090048298 | Novel acetyl-CoA Carboxylase (ACC) Inhibitors and their use in Diabetes, Obesity and Metabolic Syndrome - The present invention relates to compounds of formula (I) | 02-19-2009 |
Hing L. Sham, Palo Alto, CA US
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20100331335 | Inhibitors of Jun N-Terminal Kinase - The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: | 12-30-2010 |
20130072494 | INHIBITORS OF JUN N-TERMINAL KINASE - The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: | 03-21-2013 |
20150087825 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF - Compounds are provided having a structure according to Formula (I): wherein A | 03-26-2015 |
20150087826 | SPIROCYCLIC DIGYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF - Compounds are provided having a structure according to Formula (I): wherein A | 03-26-2015 |
20150259330 | INHIBITORS OF JUN N-TERMINAL KINASE - The present disclosure provides inhibitors of c-Jun N-terminal kinases (JNK) having a structure according to the following formula: | 09-17-2015 |
20150307518 | SPIROCYCLIC DIHYDRO-THIAZINE AND DIHYDRO-OXAZINE BACE INHIBITORS, AND COMPOSITIONS AND USES THEREOF - Compounds are provided having a structure according to Formula (I): wherein A | 10-29-2015 |
Hing L. Sham, Vernon Hills, IL US
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20100190822 | Pharmaceutical Compositions As Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV) - The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. | 07-29-2010 |
20130059873 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) - The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. | 03-07-2013 |
Ivan King Yu Sham, Seattle, WA US
Patent application number | Description | Published |
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20110060711 | PROCESSING RELATIONAL DATABASE PROBLEMS USING ANALOG PROCESSORS - Systems, methods and articles solve queries or database problems through the use of graphs. An association graph may be formed based on a query graph and a database graph. The association graph may be solved for a clique, providing the results to a query or problem and/or an indication of a level of responsiveness of the results. Thus, unlimited relaxation of constraint may be achieved. Analog processors such as quantum processors may be used to solve for the clique. | 03-10-2011 |
20140136942 | DELIVERY AND DISPLAY OF PAGE PREVIEWS DURING PAGE RETRIEVAL EVENTS - A system and process are disclosed for providing users with page previews during page loading events, such that the delay experienced before the display of page content is reduced. The previews may include screenshots of the pages or of portions thereof, and may be generated periodically and cached by the system for delivery to user devices. The process of generating and delivering the previews via the Internet or some other network may be implemented partly or wholly within an intermediary system that sits logically between the user devices and content servers. The process may be used with existing browsers without the need for any browser modifications, or may be used with a “preview-aware” browser that includes special program code for providing page previews. | 05-15-2014 |
20140136951 | SELECTIVE UPDATING OF PREVIEW CONTENT - A system and process are disclosed for providing users with page previews during page loading events, such that the delay experienced before the display of page content is reduced. The previews may include screenshots of the pages or of portions thereof, and may be generated periodically and cached by the system for delivery to user devices. The process of generating and delivering the previews via the Internet or some other network may be implemented partly or wholly within an intermediary system that sits logically between the user devices and content servers. The process may be used with existing browsers without the need for any browser modifications, or may be used with a “preview-aware” browser that includes special program code for providing page previews. | 05-15-2014 |
20140136971 | DELIVERY AND DISPLAY OF PAGE PREVIEWS DURING PAGE RETRIEVAL EVENTS - A system and process are disclosed for providing users with page previews during page loading events, such that the delay experienced before the display of page content is reduced. The previews may include screenshots of the pages or of portions thereof, and may be generated periodically and cached by the system for delivery to user devices. The process of generating and delivering the previews via the Internet or some other network may be implemented partly or wholly within an intermediary system that sits logically between the user devices and content servers. The process may be used with existing browsers without the need for any browser modifications, or may be used with a “preview-aware” browser that includes special program code for providing page previews. | 05-15-2014 |
20140136973 | SEGMENTED DELIVERY OF PREVIEW CONTENT - A system and process are disclosed for providing users with page previews during page loading events, such that the delay experienced before the display of page content is reduced. The previews may include screenshots of the pages or of portions thereof, and may be generated periodically and cached by the system for delivery to user devices. The process of generating and delivering the previews via the Internet or some other network may be implemented partly or wholly within an intermediary system that sits logically between the user devices and content servers. The process may be used with existing browsers without the need for any browser modifications, or may be used with a “preview-aware” browser that includes special program code for providing page previews. | 05-15-2014 |
Ka Yiu Sham, Great Falls, VA US
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20100246199 | Cycling Computer with Detachable Lighting Apparatus for Bicycle or Other Vehicle - A lighting apparatus useable with a bicycle or other manually operated vehicle includes first and second housings, as well as a connection mechanism by which the first and second housings are attachable to and detachable from each other. A central processing unit and at least one power source are receivable within the first housing, while the second housing includes a light emitting element that is adjustable to multiple angular positions relative to the first housing to provide illumination at different emission angles. The second housing constitutes one of a plurality of second housings that are interchangeable to provide for varied lighting conditions. The connection mechanism allows relative pivotal movement between the first and second housings and permits electrical communication between the light emitting element and the power source when the first and second housings are attached to each other. | 09-30-2010 |
Kelvin Sham, Thousand Oaks, CA US
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20100125062 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS - Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like. | 05-20-2010 |
20100160280 | AMINOPYRIDINE AND CARBOXYPYRIDINE COMPOUNDS AS PHOSPHODIESTERASE 10 INHIBITORS - Pyridine and pyrimidine compounds: | 06-24-2010 |
20130079325 | PYRIDINE AND PYRIMIDINE DERIVATIVES AS PHOSPHODIESTERASE 10 INHIBITORS - Pyridine and pyrimidine compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, and the like. | 03-28-2013 |
20140045855 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS - Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 02-13-2014 |
20140275058 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-18-2014 |
20140296226 | Amino-Oxazine and Amino-Dihydrothiazine Compounds as Beta-Secretase Modulators and Methods of Use - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A | 10-02-2014 |
20150031668 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS - Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: | 01-29-2015 |
20150252011 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE - The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: | 09-10-2015 |
20150307521 | AMINO-OXAZINE AND AMINO-DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A | 10-29-2015 |
Kelvin K.c. Sham, Thousand Oaks, CA US
Patent application number | Description | Published |
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20090149468 | Substituted heterocyclic compounds and methods of use - The present invention relates to therapeutic diazobicyclo pyridines and their use in the treatment of arthritis, rheumatoid arthritis, psoriatic arthritis or osteoarthritis, organ transplant, acute transplant or heterograft and homograft rejection, ischemic and reperfusion injury, transplantation tolerance induction, multiple sclerosis, inflammatory bowel disease, ulcerative colitis, Crohn's disease, lupus, graft vs. host diseases, T-cell mediated hypersensitivity diseases, contact hypersensitivity, delayed-type hypersensitivity, gluten-sensitive enteropathy, Type 1 diabetes, psoriasis, contact dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Graves' Disease, Addison's disease, autoimmune polyglandular disease, autoimmune alopecia, pernicious anemia, vitiligo, autoimmune hypopituatarism, Guillain-Barre syndrome, autoimmune diseases, glomerulonephritis, serum sickness, uticaria, respiratory allergies, asthma, hayfever, allergic rhinitis, skin allergies, scleracielma, mycosis fungoides, acute inflammatory responses, acute respiratory distress syndrome, dermatomyositis, alopecia areata, chronic actinic dermatitis, eczema, Behcet's disease, Pustulosis palmoplanteris, Pyoderma gangrenum, Sezary's syndrome, atopic dermatitis, systemic schlerosis, morphea, Type II diabetes and cancers where PKC theta or other PKC-family kinases are activated, overexpressed or facilitate tumor growth or survival of tumor cells, T cell leukemia, thymoma, T and B cell lymphoma, colon carcinoma, breast carcinoma and lung carcinoma or provides resistance to chemotherapeutic drugs. | 06-11-2009 |
20100029611 | S1P1 receptor agonists and use thereof - The present invention relates to compounds of Formula (I): | 02-04-2010 |
20100292234 | TRIAZOLE FUSED HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF - The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula I | 11-18-2010 |
Kelvin K. C. Sham, Thousand Oaks, CA US
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20110306591 | HETEROARYLOXYCARBOCYCLYL COMPOUNDS AS PDE10 INHIBITORS - Heteroaryloxycarbocyclyl compounds, and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of PDE10, such as obesity, non-insulin dependent diabetes, schizophrenia, Huntington's Disease, bipolar disorder, obsessive-compulsive disorder, and the like. | 12-15-2011 |
Kin-Joe Sham, Shoreview, MN US
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20080288035 | Stimulation Device for Treating Osteoarthritis - A device for providing therapeutic treatment to a body part such as a joint to promote healing of the body part comprises a signal generator for generating a pulsed electromagnetic field based upon a selected treatment mode, a controller for storing the treatment mode and communicating the treatment mode to the signal generator, a heat source configured to provide thermal therapy to the body part, and monitoring means for monitoring the electromagnetic field generated by the electromagnetic stimulating means. The device may also include telemetry means in communication with the monitoring means for remotely accessing the controller to modify the treatment mode. The device can also be disposable. | 11-20-2008 |
20110004261 | ELECTROMAGNETIC THERMAL THERAPY - A portable, non-invasive device for providing therapeutic treatment to a joint to promote healing of the joint includes a cuff positionable around the joint. The cuff includes an electromagnetic stimulator configured to provide an electromagnetic field within the joint and a single-use thermal exchange component configured to provide temperature-based therapy to the joint. | 01-06-2011 |
20110065977 | DISPOSABLE, SINGLE-USE THERMAL EXCHANGE COMPONENT - A disposable housing including a single-use thermal exchange component can be configured to be mechanically, removably coupled to a receptacle on a cuff positionable around a joint to provide temperature-based therapy to the joint. | 03-17-2011 |
20120330090 | ELECTROMAGNETIC THERMAL THERAPY - A portable, non-invasive device for providing therapeutic treatment to a joint to promote healing of the joint includes a cuff positionable around the joint. The cuff includes an electromagnetic stimulator configured to provide an electromagnetic field within the joint and at least one thermal therapy component including an activation circuit configured to activate the electromagnetic stimulator circuit, the thermal therapy component coupleable to the cuff, the thermal therapy component comprising at least two substances in separate compartments separated by a breakable barrier, wherein the at least two substances are configured to react upon mixing to produce thermal energy exchangeable with the joint. | 12-27-2012 |
20140046232 | BRACE TO PROVIDE HOT AND COLD THERAPY - A portable, non-invasive device for providing therapeutic treatment to a joint to promote healing of the joint includes a cuff positionable around the joint, a pouch coupled to the cuff and sized to receive a first thermal therapy component including at least two substances in separate compartments separated by a breakable barrier, wherein the at least two substances are configured to react upon mixing to produce thermal energy exchangeable with the joint, and a holder coupled to the cuff and configured to mechanically, removably receive a disposable housing including a second thermal therapy component. | 02-13-2014 |
Kin-Joe Sham, Blaine, MN US
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20150289815 | APPARATUS AND METHOD FOR INTRAVASCULAR MEASUREMENTS - Intravascular diagnosis apparatus and methods are disclosed. In one aspect of the disclosed technology, a monitoring guidewire includes a core wire having or made of one or more of MP35N, L605, Elgiloy, and an alloy of nickel, cobalt, molybdenum and chromium, a sensor disposed in a distal region of the core wire, and a housing substantially coextensive with the core wire and surrounding the core wire, the housing being more flexible than the core wire for at least the distal portion of the housing. | 10-15-2015 |
Patrick Sham, Milpitas, CA US
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20120057473 | FAULT DIAGNOSTICS FOR IMPROVED QUALITY OF SERVICE - Providing a near-carrier class service to a non-carrier class backhaul network, including: monitoring a connection of the non-carrier class backhaul network of at least one picocell by periodically sending at least one message to a monitoring agent located within an interne service provider network; tracing the connection to the monitoring agent through a network operations center when an acknowledgement in response to the at least one message is not received from the monitoring agent; generating an alert message that provides detailed information about a point of failure in the connection when a loss of connection is detected in tracing the connection; and generating a solution to fix the loss of connection so that the near-carrier class service can be provided to the non-carrier class backhaul network of the at least one picocell. | 03-08-2012 |