Patent application number | Description | Published |
20090162315 | Enterotoxin gene cluster (egc) superantigens to treat malignant disease - The use of classical superantigens for treatment of cancer has resulted in a low response rates and serious toxicity in humans which is attributable, in part, to the presence of preformed superantigen specific antibodies in the plasma of treated patients. The present invention addresses this problem by providing a method for treating tumors comprising the administration of one or a plurality of egc (enterotoxin gene cluster) staphylococcal enterotoxins comprising staphylococcal enterotoxins G, I, M, N, O. These superantigens in native unmodified form can be administered intrathecally, intratumorally, intravenously to humans with advanced lung cancer while resolving pleural effusions and prolonging survival to 300% above control patients treated with talc pleurodesis. Intratumoral egc superantigens induces a significant and sustained reduction of the tumor size. In contrast to classic Sags, the egc superantigens induced minimal toxicity, are rarely associated with the presence of preformed antibodies and are used as a plurality with a broad T cell Vβ profile. Useful egc superantigen compositions for parenteral administration native egc enterotoxins, homologues, fragments and fusion proteins of native egc enterotoxins capable of activating a broad spectrum of T cells expressing T cell receptor/α motifs. T cell survival-enhancing cytokines IL-7, Il-15, Il-23 are used. together with parenteral egc SE therapy. Also disclosed is combined therapy that includes parenteral, intratumoral or intrathecal superantigen compositions in combination with (i) intratumoral low, non-toxic doses of one or more chemotherapeutic drugs or (ii) systemic chemotherapy at reduced and non-toxic doses of chemotherapeutic drugs or (iii) radiation therapy or (iv) anti-angiogenic and tyrosine kinase inhibitors. | 06-25-2009 |
Patent application number | Description | Published |
20090024701 | Port Type Agnostic Proxy Support For Web Services Intermediaries - Methods, systems, and products are disclosed in which port type agnostic proxy support for web services intermediaries is typically provided by receiving in a web services intermediary a request for execution of a web services operation, wherein the request includes parametric information from which an endpoint for a target service that supports the operation can be identified; identifying, in dependence upon the parametric data, the endpoint for a target service that supports the operation; creating a target service request for execution of the operation on the target service; and issuing the target service request to the target service. Exemplary embodiments typically also include the return path of request-response processing: receiving in the intermediary a response from the target service; creating in the intermediary, in dependence upon the response from the target service, a response from the intermediary; and returning the response from the intermediary to the requesting client. | 01-22-2009 |
20110161930 | MELDING OF MEDIATION FLOW SERVICE COMPONENT ARCHITECTURE (SCA) COMPONENTS - Embodiments of the present invention provide a method, system and computer program product for melding mediation and adaptation modules of a service component architecture (SCA) system. A method for melding mediation and adaptation modules of an SCA system can include selecting each of a mediation module and an adaptation module in an integrated development tool executing in memory by a processor of a computer and loading respectively different descriptor files for each of the mediation module and the adaptation module. The method further can include combining descriptors from the different descriptor files into a single descriptor file for a melded module. Finally, the method can include modifying names and wiring descriptors in the single descriptor file for the melded module to account for a combination of the mediation component and the adaptation component in the melded component. | 06-30-2011 |
20120254834 | MELDING OF MEDIATION FLOW SERVICE COMPONENT ARCHITECTURE (SCA) COMPONENTS - Embodiments of the present invention provide a method, system and computer program product for melding mediation and adaptation modules of a service component architecture (SCA) system. A method for melding mediation and adaptation modules of an SCA system can include selecting each of a mediation module and an adaptation module in an integrated development tool executing in memory by a processor of a computer and loading respectively different descriptor files for each of the mediation module and the adaptation module. The method further can include combining descriptors from the different descriptor files into a single descriptor file for a melded module. Finally, the method can include modifying names and wiring descriptors in the single descriptor file for the melded module to account for a combination of the mediation component and the adaptation component in the melded component. | 10-04-2012 |
20140123105 | MELDING OF MEDIATION FLOW SERVICE COMPONENT ARCHITECTURE (SCA) COMPONENTS - Embodiments of the present invention provide a method, system and computer program product for melding mediation and adaptation modules of a service component architecture (SCA) system. A method for melding mediation and adaptation modules of an SCA system can include selecting each of a mediation module and an adaptation module in an integrated development tool executing in memory by a processor of a computer and loading respectively different descriptor files for each of the mediation module and the adaptation module. The method further can include combining descriptors from the different descriptor files into a single descriptor file for a melded module. Finally, the method can include modifying names and wiring descriptors in the single descriptor file for the melded module to account for a combination of the mediation component and the adaptation component in the melded component. | 05-01-2014 |
Patent application number | Description | Published |
20090125113 | HYBRID GLENOID FOR SHOULDER ARTHROPLASTY - Glenoid prosthesis with a hybrid design (combining both peg and keel designs), and surgical methods for reconstitution of a shoulder joint. The hybrid design combines both peg and keel components into one device. The hybrid glenoid component of a shoulder prosthesis includes an oval body having a concave lateral articulating surface and an opposing convex medial surface. The medial surface is provided with a plurality of pegs and a single inferior protrusion. The pegs are used to attain both a superior location as well as a central location. The inferior protrusion provides stability in the superior-to-inferior translation of the humeral head, as well as rotational articulation of the same. | 05-14-2009 |
20090156903 | ARTICULATING HOOK ELEVATOR AND ARTHROSCOPIC METHOD FOR USING SAME - An articulating hook elevator for manipulating tissue during arthroscopic procedures. The articulating hook elevator comprises a shaft, a proximal end, and a distal end provided with an articulating paddle. The hook may be actuated by a switch and can articulate into a standard tip for traditional manipulation of tissue, or into a rotated or articulated position. In this manner, effective manipulation and retraction of tissue from the surgical site without tissue collapse may be achieved, allowing a surgeon to better visualize the internal condition of the arthroscopic site and speed up the overall procedure. | 06-18-2009 |
20100125297 | AC JOINT REPAIR USING SUTURE BUTTON GRAFT CONSTRUCT AND METHOD OF SURGERY - Apparatus and methods for fixation of bone to bone, or soft tissue to bone. The apparatus comprises two fixation devices (for example, two buttons) joined by a biologic material (for example, a graft or tendon). Each fixation device is provided with at least one opening that allows the passage of the flexible material attached to the biologic material. The button may be formed, for example, of metal, PEEK or PLLA. | 05-20-2010 |
20100262153 | PARALLEL DRILL GUIDE - A parallel drill guide and system which maintains contact on the bone at various angles. The parallel drill guide comprises a fixed sleeve and a parallel, axially slidable, sleeve for guiding the insertion of two parallel wires or pins into bone at any angle while maintaining contact between the bone and the guide. The drill guide is also provided with a locking mechanism that locks the slidable sleeve into position at any lateral distance relative to the fixed sleeve, using a novel off-axis locking device. | 10-14-2010 |
20120179262 | HUMERAL COMPONENT OF A SHOULDER PROSTHESIS AND METHODS OF SHOULDER ARTHROPLASTY - A humeral component of a shoulder prosthesis encloses a stem module which has a shank and an upper shank portion with a stem support surface. A joint adapter is adapted to hold either a liner or a spherical cap. The joint adapter has an adapter support surface which interfaces with the stem support surface. Further, the stem support surface and the adapter support surface have corresponding radial arc shaped sections which allow positioning of the joint adapter against the stem module at different inclination angles. For fastening the joint adapter to the stem module, a bolt or screw is provided. | 07-12-2012 |
20130046312 | PARALLEL DRILL GUIDE - A parallel drill guide and system which maintains contact on the bone at various angles. The parallel drill guide comprises a fixed sleeve and a parallel, axially slidable, sleeve for guiding the insertion of two parallel wires or pins into bone at any angle while maintaining contact between the bone and the guide. The drill guide is also provided with a locking mechanism that locks the slidable sleeve into position at any lateral distance relative to the fixed sleeve, using a novel off-axis locking device. | 02-21-2013 |
20130053971 | SHOULDER PROSTHESIS - A humeral prosthesis includes a stem component and a head component joined by an inclination component. The inclination component is provided with an opening that is designed to accommodate a pair of expandable tabs extending from a side of a plate. The plate is also provided with a taper extending opposite to the pair of expandable tabs. Inclination angle, radial offset, and version are adjustable and are separately and independently set and fixed. | 02-28-2013 |
20140188232 | HUMERAL COMPONENT OF A SHOULDER PROSTHESIS - A humeral component of a shoulder prosthesis encloses a stem module which has a shank and an upper shank portion with a stem support surface. A joint adapter is adapted to hold either a liner or a spherical cap. The joint adapter has an adapter support surface which interfaces with the stem support surface. Further, the stem support surface and the adapter support surface have corresponding radial arc shaped sections which allow positioning of the joint adapter against the stem module at different inclination angles. For fastening the joint adapter to the stem module, a bolt or screw is provided. | 07-03-2014 |
20140288657 | FENESTRATED HUMERAL PROSTHESIS AND METHODS OF SHOULDER ARTHROPLASTY - A humeral prosthesis includes a stem component and a head component joined by an inclination component or block. The stem component and the inclination component are provided with openings/holes/fenestrations/eyelets that allow attachment of soft tissue (and optional fracture repair). A first plurality of suture holes are provided to the lateral stem body and a second plurality of suture holes are provided on the medial aspect of the inclination block. These suture holes are intended for subscapularis or lesser tuberosity reattachments. Inclination angle, radial offset, and version are adjustable and are separately and independently set and fixed. | 09-25-2014 |
Patent application number | Description | Published |
20090065713 | Variable-ratio neutron-gamma ray source - A variable-ratio neutron-gamma ray source comprises a neutron generator, a shield, a collimator, and an external gamma target. The neutron generator generates neutrons and the shield reduces external radiation exposure. The collimator collimates the neutrons into a neutron beam that traverses the shield. The external gamma target generates a dual neutron-gamma ray beam from the neutron beam, wherein the dual neutron-gamma ray beam has a variable neutron-gamma ratio as a function of a thickness of the external gamma target. | 03-12-2009 |
20090067574 | Neutron-gamma ray tomography - A neutron-gamma ray tomography system comprises a source, a detector array, and an image processor. The source illuminates an object with a dual neutron-gamma ray beam. The detector array characterizes neutron and gamma ray attenuation in the object. The image processor generates tomography as a function of the neutron and gamma ray attenuation. | 03-12-2009 |
20100123107 | METHOD AND COMPOSITION FOR MODERATED NUCLEAR FUEL - A nuclear fuel composition includes a transuranic fuel and a neutron moderator mixed with transuranic fuel. The neutron moderator includes at least one of hafnium or zirconium. | 05-20-2010 |
20100252245 | Nano-particle wave heat pipe - A heat transfer tube includes a container, a cavity within the container, a substantially homogeneous nanoparticle powder located within the cavity, and a gas. The cavity is in a partial vacuum state. The nanoparticle powder includes a material in a solid state capable of substantially freely emitted and reabsorbing a gas as a function of temperature, such as a hydrate, hydride, or other material. | 10-07-2010 |
20110138811 | SOLAR RECEIVER AND SOLAR POWER SYSTEM HAVING COATED CONDUIT - A solar receiver device includes a metal conduit and a glass container disposed around the metal conduit such that there is a space between the glass container and the conduit. A coating is disposed on the metal conduit and has a composition that includes at least one element from silicon, titanium, aluminum, barium, and samarium. | 06-16-2011 |
20110317800 | NUCLEAR FUEL - A nuclear fuel composition includes a nuclear fissile material and a neutron-absorption material that adjoins the nuclear fissile material. The nuclear fuel composition may be used in a nuclear reactor, such as a thermal reactor. | 12-29-2011 |
20120288059 | CHARACTERISTIC X-RAY COMPUTED LAMINOGRAPHY SYSTEM FOR HOME MADE EXPLOSIVES (HME) DETECTION - A homemade explosives (HME) detection system provides a coded-source, x-ray computed laminography imaging system which detects material composition by the ratio of the transmitted characteristic X-rays within a coded x-ray beam. Motion-free 3-Dimensional geometrical details are obtained through computed laminography imaging techniques. | 11-15-2012 |
Patent application number | Description | Published |
20100016464 | DENTAL COMPOSITIONS WITH NATURAL TOOTH FLUORESCENCE - The invention features a dental composition containing a polycyclic aromatic compound, such as 2-ethyl 9,10-dimethoxy anthracene (EDMOA), in an amount that provides the composition with fluorescence mimicking that of natural teeth. | 01-21-2010 |
20100089286 | DENTAL FILLER AND METHODS - A dental filler is disclosed. The filler is produced by admixing a metal oxide sol and a water-soluble organic binder; drying said mixed sol into a dried product; and calcining said dried product; wherein said filler is a substantially amorphous cluster. The filler can be mixed into a hardenable resin to provide radiopaque dental materials having desirable strength and aesthetic character. | 04-15-2010 |
20100297588 | DENTAL COMPOSITIONS WITH NATURAL TOOTH FLUORESCENCE AND METHODS - Hardenable dental compositions which include a fluorescent diether terephthalate and a resin system, such that when hardened, the compositions have a natural tooth fluorescence, methods of making the compositions, and dental articles made from the compositions are disclosed. | 11-25-2010 |
20110200971 | Dental Compositions with Fluorescent Pigment - The invention features a dental composition containing a fluorescent organic pigment, e.g. a hydroxyl substituted aryl guanamine an or a fluorescent compound encapsulated in a thermo plastic or thermo set polymer, in an amount that provides the composition with fluorescence resembling that of natural teeth. | 08-18-2011 |
Patent application number | Description | Published |
20100197557 | SHEAR-THINNING, DISPENSABLE LIQUID ABRASIVE CLEANSER WITH IMPROVED SOIL REMOVAL, RINSEABILITY AND PHASE STABILITY - An improved liquid abrasive cleanser is described that shows greatly improved soil removal performance along with improved rinsing characteristics. The improved cleanser is comprised of abrasives, at least one surfactant, an associative polymer thickener, a pH adjusting agent and water. The compositions of the present invention show pseudo-plastic rheology in that they shear thin upon dispensing through a bottle closure, but re-thicken on hard surfaces to provide vertical cling. | 08-05-2010 |
20110071069 | SHEAR-THINNING, DISPENSABLE LIQUID ABRASIVE CLEANSER WITH IMPROVED SOIL REMOVAL, RINSEABILITY AND PHASE STABILITY - An improved liquid abrasive cleanser is described that shows greatly improved soil removal performance along with improved rinsing characteristics. The improved cleanser is comprised of abrasives, silica, at least one surfactant, an associative polymer thickener, a pH adjusting agent and water. The compositions of the present invention show pseudo-plastic rheology in that they shear thin upon dispensing through a bottle closure, but re-thicken on hard surfaces to provide vertical cling. | 03-24-2011 |
20110180101 | MULTI-SURFACE ACIDIC BATHROOM CLEANING SYSTEM - A multi-surface bathroom cleaning system is described that allows for easier cleaning of all bathroom surfaces from all angles, especially under the rim of a toilet bowl, and which comprises an acid/nonionic composition contained in and dispensable from a package comprising an angled-neck sprayer bottle fitted with an invertible trigger sprayer assembly, wherein the cleaning system may be used in an entirely upside-down orientation to spray upwards at an acute angle. | 07-28-2011 |
20110180619 | FOAMING HYPOCHLORITE CLEANING SYSTEM - A foaming hypochlorite cleaning system is described that allows for easier cleaning of all hard-to-reach surfaces from all angles, especially underneath a range hood and up underneath the rim of a toilet bowl, and which comprises an alkaline hypochlorite and anionic surfactant composition contained in and dispensable from a package comprising an angled-neck sprayer bottle fitted with an invertible trigger sprayer assembly, wherein the cleaning system may be used in an entirely upside-down orientation to spray upwards at an acute angle. | 07-28-2011 |
20120234352 | MULTI-SURFACE ACIDIC BATHROOM CLEANING SYSTEM - A multi-surface bathroom cleaning system is described that allows for easier cleaning of all bathroom surfaces from all angles, especially under the rim of a toilet bowl, and which comprises an acid/nonionic composition contained in and dispensable from a package comprising an angled-neck sprayer bottle fitted with an invertible trigger sprayer assembly, wherein the cleaning system may be used in an entirely upside-down orientation to spray upwards at an acute angle. | 09-20-2012 |
20150060322 | CLEANING PRODUCT EXHIBITING INCREASED STABILITY WITH CRYSTALLINE PARTICLES - Methods and apparatus are provided that exhibit increased stability with crystalline particles. A cleaning product includes a cleaning agent disposed within the cleaning product. The cleaning agent includes an oxidizing agent. Further, an alumina structuring agent disposed within the cleaning product includes crystalline particles having a crystallite size less than six nanometers. | 03-05-2015 |
20150087575 | RELEASING A CLEANING AGENT WITH AN ENCAPSULATION MATERIAL - Compositions and apparatus are provided for releasing a cleaning agent with an encapsulation material. An abrasive material and an encapsulation material are disposed within a cleaning product. The encapsulation material is configured to release contents in a cleaning event. A cleaning agent is sorbed by the encapsulation material and configured to be released from the encapsulation material during the event. | 03-26-2015 |
Patent application number | Description | Published |
20090204204 | Drug/Drug Deliver Systems For The Prevention And Treatment Of Vascular Disease - A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity. | 08-13-2009 |
20100268329 | Drug/Drug Delivery Systems For The Prevention And Treatment Of Vascular Disease - A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity. | 10-21-2010 |
20110177152 | Drug/Drug Delivery Systems For The Prevention And Treatment Of Vascular Disease - A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity. | 07-21-2011 |
20120226347 | Drug/Drug Delivery Systems For The Prevention And Treatment Of Vascular Disease - A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity. | 09-06-2012 |
20140134225 | Drug/Drug Delivery Systems For The Prevention And Treatment Of Vascular Disease - A drug and drug delivery system may be utilized in the treatment of vascular disease. A local delivery system is coated with rapamycin or other suitable drug, agent or compound and delivered intraluminally for the treatment and prevention of neointimal hyperplasia following percutaneous transluminal coronary angiography. The local delivery of the drugs or agents provides for increased effectiveness and lower systemic toxicity. | 05-15-2014 |
Patent application number | Description | Published |
20100054680 | Optical fiber assemblies for fiber to the subscriber applications - Disclosed are spools, fiber optic assemblies, and methods for use with a lashing machine or other suitable deployment for routing the fiber optic cable toward the subscriber allowing the craft to quickly and easily deploy the fiber optic cable in the field. The fiber optic assemblies may include a spool, at least one fiber optic cable disposed on the spool, and a fiber optic connector. In one embodiment, the spool includes a first spool flange and a second spool flange that include notches that overlap at angular positions for allowing the spooling of fiber optic cable off the same. In another embodiment, the fiber optic connector is attached to the spool for plug and play connectivity of the spool. In other embodiments, a splitter may be attached to the spool for splitting the optical signal. | 03-04-2010 |
20110222826 | STRAIN-RELEIF MEMBER AND FIBER OPTIC DROP CABLE ASSEMBLY USING SAME - A strain-relief member having a body formed from a block copolymer and designed for use in a fiber optic drop cable assembly. The body has a central channel and a cylindrical connector-end portion sized to surround an end-portion of a connector. The body also has a tapered cable-end portion sized to surround an end portion of a fiber optic cable that connects to the connector and that has a preferential bend axis. The strain-relief member is configured to limit an amount of strain in the strength components to less than 0.041 when subjected to flex and proof testing. A fiber optic drop cable assembly that has a fiber optic cable with a preferential bend axis and that employs the strain-relief member is also disclosed. | 09-15-2011 |
20130259434 | OVERMOLD BONDING SYSTEM FOR FIBER OPTIC CABLE - A fiber optic cable assembly includes a fiber optic cable, a tether, and an overmold. The fiber optic cable includes an optical fiber, a strength member, and a jacket, where the jacket includes an interior portion contacting the strength member and an exterior portion adjoining the interior portion. The interior and exterior portions of the jacket both include polyethylene, and the exterior portion further includes an additive that is not in the interior portion. The tether is coupled to the fiber optic cable at an attachment point. The optical fiber or another optical fiber spliced to the optical fiber, diverges from the fiber optic cable via the tether. The overmold encloses the attachment point and is attached directly to a discrete section of the exterior portion of the jacket proximate to the attachment point. The additive facilitates bonding of the overmold to the discrete section. | 10-03-2013 |
Patent application number | Description | Published |
20110174328 | Ergonomic Mascara Applicator - An ergonomic applicator is provided for applying a cosmetic composition to the eyelashes. The applicator comprises a handle portion and a head portion wherein the longitudinal axis of the head portion is positioned or can be rotatably positioned at an obtuse angle with respect to the longitudinal axis of the handle. The handle being suitable dimensioned for holding between the thumb and fingers without rotation of the handle. The head portion having at its distal end means for holding a charge of cosmetic composition and transferring it to the eyelashes on contact therewith, such as but not limited to, bristles, projections, indentations fins, tines, Velcro, teeth, grooves, sponges and flocked surfaces. | 07-21-2011 |
20110297174 | Cosmetic Applicator - An applicator for applying a cosmetic composition comprising an applicator element. The applicator element may be elongated along a longitudinal axis. The applicator has a first portion and a second portion separateable from the first portion and capable of moving independently from the first portion along the longitudinal axis. The first and/or second portions of the applicator element include means for holding a charge of cosmetic composition and transferring it to an integument on contact therewith. | 12-08-2011 |
20110299913 | Partially Extendable Hair Brush - A grooming device comprising a grooming element. The grooming element may be elongated along a longitudinal axis. The grooming device has a first portion and a second portion separateable from the first portion and capable of moving independently from the first portion along the longitudinal axis. The first and/or second portions of the grooming element include means engaging keratin fibers or for improving the aesthetic appearance of keratin fibers. | 12-08-2011 |
20130101333 | Cosmetic Cap Sealing System - Packages are provided including an applicator that engages with a wiper of a container in a manner such that the applicator and wiper are capable of rotating together in relation to the container. The package also includes a cap configured to fit over the applicator when the applicator is engaged with the wiper element. The cap is engaged with the wiper such that the wiper is caused to rotate when the cap is rotated, screwed onto, and/or unscrewed from, the container, thereby moving the applicator element in a rotational motion in the interior of the container. | 04-25-2013 |
20130101334 | Functional Dynamic Cosmetic Package - Packages for cosmetics are provided including an applicator that engages with a wiper component of a container in a manner such that the applicator and wiper are capable of moving together in one or more directions within the container, including without limitation, vertically, horizontally, diagonally, rotationally, and any combination of such movements. This increased range of mobility permits the applicator element to access more of the cosmetic material within the container than heretofore possible. | 04-25-2013 |
20130114989 | Press-On Cosmetic Applicator System - Packaging for cosmetic products, such as mascara, are provided, including a container for holding a cosmetic composition and an applicator which is disposed within a cut-out portion of the container. The container includes a number of passages through at least one side such that a portion of the applicator is brought into contact with the passages when seated on the container. The applicator is adapted to seal the container when seated on the container. The applicator is further adapted to be removed from the container and pressed or squeezed onto keratinous fibers (e.g., eyelashes) of a user to apply the cosmetic product. | 05-09-2013 |
Patent application number | Description | Published |
20100152125 | Compositions And Methods For The Diagnosis, Treatment, And Prevention Of Amyotrophic Lateral Sclerosis And Related Neurological Diseases - One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective amount of an inhibitor of the formation of advanced glycation end products. Another aspect of the invention relates to a proteasome activity-based screening assay to select compounds which may be useful for treating or preventing a neurodegenerative disease, and the materials used therein. Yet another aspect of the invention relates to molecules, and methods of use thereof, which bind at or adjacent to SOD-I Trp32, including molecules that bind in a site adjacent to SOD-I Trp32 whether or not it is oxidized, for treating or preventing neurodegenerative disease. | 06-17-2010 |
20130289022 | TETRAMERIC ALPHA-SYNUCLEIN AND USE THEREOF - Disclosed herein are methods and related compositions for identifying compounds that stabilize natively folded tetrameric α-synuclein. These methods and compositions are useful for the treatment and diagnosis of α-synuclein-associated diseases and disorders. | 10-31-2013 |
20130309690 | TETRAMERIC ALPHA-SYNUCLEIN AS BIOMARKERS - The present invention provides the surprising finding that alpha-synuclein exists in vivo as a folded tetramer. Provided are various methods and technologies that arise from this finding, including methods and kits for identifying individuals susceptible to or suffering from certain diseases, disorders or conditions associated with stability of alpha-synuclein tetramers, and/or individuals likely (or not) to respond to therapy with agents that alter level and/or stability of alpha-synuclein tetramers. | 11-21-2013 |
20130316384 | ICE-CLEAVED ALPHA-SYNUCLEIN AS A BIOMARKER - The present disclosure provides ICE-cleaved alpha-synuclein fragments as biomarkers for alpha-synuclein-associated disease or disorder and/or for ICE-regulator therapy. | 11-28-2013 |
20140309172 | ICE INHIBITING COMPOUNDS AND USES THEREOF - The present disclosure identifies caspase-1/ICE as a therapeutic target for α-synuclein associated diseases and disorders. Related methods and compositions are also provided. | 10-16-2014 |
Patent application number | Description | Published |
20090307504 | Method, Apparatus, and System for Managing, Reviewing, Comparing and Detecting Data on a Wide Area Network - Embodiments of the present invention are directed to a data management system, apparatus and process for uniquely identifying and protecting data. In preferred embodiments, the data management system comprises a data management server, a key generator, a source print generator and a source print detector. In some preferred embodiments, the data management system further comprises a data embedding system. Keys are created by the data management system for application to source files to create a fingerprint for the source file. The fingerprint is compared to unknown files to identify uses of the source file. | 12-10-2009 |
20110304731 | Ornament apparatus, system and method - Embodiments of the present invention are directed to an ornamental system, apparatus and method that is dynamically modifiable. Embodiments of the ornament system comprise a processor, at least one ornamental member and a data controller. The processor is a computer which stores user input data for transmission and transmits a request for the transmission of data files. The ornamental member is configured to receive and display image data stored in a database, wherein the stored data can be changed at any time. Embodiments of the present invention can be coupled to other ornamental systems across a wide area network, wherein users can share data files for display. | 12-15-2011 |
20120214465 | LOCATION-BASED CONTROL OF FUNCTIONS OF ELECTRONIC DEVICES - A mobile personal communication device, such as a mobile telephone (cellular, satellite, or the like), that is capable of determining its geographic location, through an on-board GPS unit or other geographic locating mechanism, has a function that is disabled, enabled, modified or otherwise controlled when the personal communication device is determined to be within a defined area. The function controlled based on geographic region may include: the transmission of a data stream, such as a video or audio data stream, from or to the personal communication device; the disamblement or modification of ringers or other mechanism for audible notification of an event, for example, an incoming call or message from an external caller; the disablement or modification of an on-board camera or other on-board recording mechanism; and/or the disablement or modification of screen savers, disabling or modification of display lighting or backlighting or other functions of the personal communication device. | 08-23-2012 |
Patent application number | Description | Published |
20100284656 | Short profile optical connector - A connector that enables fiber optic cables to terminate at equipment in cabinets having little space available for cable routing, without over bending. The construction includes a connector housing, and a yoke including a collar joined to a rear end of the housing. A tubular cable bend limiter is fixed at one end to the collar and the limiter directs a cable containing one or more bend insensitive fibers through a bend of, e.g., 90 degrees, between the collar and the opposite end of the limiter with a fiber bend radius of less than one inch (25.4 mm). If the limiter creates a fiber bend radius of 0.300 inch (7.62 mm), the distance between the front of the connector and the cable after bending may be as little as 1.26 inches (32 mm), allowing the cable and connector to be routed and terminated in limited space without impairing performance. | 11-11-2010 |
20110229085 | SIMPLEX CONNECTORS FOR MULTICORE OPTICAL FIBER CABLES - An optical fiber cable connector includes a ferrule subassembly, in which a ferrule is mounted into a receptacle including a barrel section having a flange at its base. The ferrule subassembly is loaded into an enclosure having a plug housing at its lead end. The plug housing is configured to provide a connection between an endface of a multicore fiber mounted into the ferrule and a corresponding surface in a mating socket. A collar is rotatably mounted onto the barrel section of the ferrule subassembly such that it butts up against the flange. The collar has an opening that fits around the barrel section, and an outer perimeter that fits into a receiving cavity with the plug housing. The ferrule, receptacle, receptacle barrel section, mounted multicore fiber, enclosure, and plug housing have a common longitudinal axis. As a result, the ferrule, receptacle, receptacle barrel section, and mounted multicore fiber are continuously rotatable with respect to the enclosure and plug housing, thereby enabling a precise rotational alignment of the multicore fiber within the enclosure. | 09-22-2011 |
20110229086 | MULTIFIBER CONNECTORS FOR MULTICORE OPTICAL FIBER CABLES - Structures and techniques are described relating to the alignment of multicore fibers within a multifiber connector. These structures and techniques include: multicore fibers having a number of different shapes, including, for example, circular, elliptical, D-shaped, double D-shaped, and polygonal; multifiber ferrules, having a plurality of fiber guide holes therein of various shapes; alignment fixtures for aligning multicore fibers within multifiber ferrules; and various multicore fiber alignment techniques. | 09-22-2011 |
20120219254 | SINGLE-FIBER CONNECTORS FOR OPTICAL FIBER CABLES - An optical fiber cable connector includes a ferrule with a guide hole that is shaped to closely receive a multicore fiber having a flat side indicative of the rotational orientation of the cores of the multicore fiber. The ferrule includes a flat surface at one side of the guide hole, corresponding in position to the flat side of the multicore fiber. Installing the multicore fiber into the guide hole with its flat side abutting the flat surface along the side of the guide hole provides alignment of the cores with respect to an optical component to which the multicore fiber endface is to be connected. | 08-30-2012 |
20120219255 | CONNECTORS FOR USE WITH POLARIZATION-MAINTAINING AND MULTICORE OPTICAL FIBER CABLES - An optical fiber ferrule has a plurality of guide holes therein for guiding a respective plurality of flat-sided fibers at an end of a multifiber optical fiber cable. The fibers' flat sides identify a particular rotational orientation of the fiber. Rotational alignment is achieved by urging the fibers' flat sides against a corresponding reference surface within the ferrule or within an alignment fixture. Also described is a fiber array block having a plurality of V-shaped grooves extending across an outer surface and terminating at an endface. The V-shaped grooves are shaped to guide a respective plurality of flat-sided fibers. A lid is installable across the plurality of V-shaped grooves, over fibers that have been loaded therein. | 08-30-2012 |
20130259429 | MULTI-FERRULE CONNECTOR FOR MULTICORE FIBER TERMINATIONS - A ganged connector housing Is configured to receive a plurality of single-fiber connectors. Each connector is removably retainable at a respective location in the connector housing. Each single-fiber connector comprises a ferrule configured to receive and retain a single multicore fiber. The single-fiber connectors have a high-density packing footprint within the connector housing. Each single-fiber connector and its respective ferrule is configured to enable individual repositioning, tuning, alignment, repair or replacement of a respective multicore fiber terminated therein, independent of other optical fibers within the plurality of single fiber ferrules, and without requiring replacement of the entire set of multicore fibers. | 10-03-2013 |
20130315540 | OPTICAL CONNECTOR FOR CABLES HAVING A BEND INSENSITIVE FIBER - An optical connector has a housing, and a retention member for retaining a cable with a fiber that has a specified minimum bend radius. A rear portion of a connector ferrule and spring are seated in the retention member, a front end of the member engages the connector housing, and the spring urges the ferrule toward the front of the connector housing. An elongated cable support has an axial passage that opens at a front end and at a back end of the support for receiving the cable, and the front end of the support is joined at the rear of the retention member. The passage in the support has a radially outward flare at the back end which acts to limit the cable from bending in the vicinity of the connector, so that the cable fiber is not strained below the specified minimum bend radius. | 11-28-2013 |
Patent application number | Description | Published |
20090172023 | DATA MANAGEMENT SYSTEM FOR MANUFACTURING ENTERPRISE AND RELATED METHODS - A method, system, and interface for managing data in a manufacturing enterprise that provides a visual indication of projected results of currant activities. Method includes collecting multi-dimensional data comprising planned values and dynamically updated actual values, processing the values, projecting future events based on records of present and past events and comparison between the planned values and the processed actual values, and displaying an extrapolated status report indicating discrepancies between the planned values and the actual values. The system includes the interface comprising dynamically updated two-dimensional graphic display, a first dimension attribute corresponding to a preset interval of first dimension value from a present first dimension value onward, an array of second dimension attributes, sets of feature attributes that are associated with the second dimension attributes and presented as data in graphic or alphanumeric forms. The sets are located substantially within boundaries of the second dimension attributes. | 07-02-2009 |
20100269252 | BATHTUB COVER - A cover for a bathtub includes a base and wall that extends from the base. The wall defines an interior space and includes a plurality of wall segments. A panel is connected to the wall and closes an end of the interior space. The panel is adapted to engage the bathtub and has a plurality of pockets for protecting the bathtub. | 10-28-2010 |
20150050380 | VACUUM TOOLING APPARATUS AND METHOD - A new and improved method and apparatus for producing a temporary wheel protective cover or shield which can be temporarily installed on the wheel of the vehicle to protect it during the time interval between its manufacture date and its delivery to a customer. A tooling apparatus is used to form a cylindrical hub portion in the protective cover which includes a hub forming member, a reciprocally movable operating member slidably supported by a hub and a camming element operatively attached to the operating member. A plurality of radially extendable fingers are held in associated pockets and each of the fingers defines a cam contact surface abutably engageable with the camming element such that movement of the camming element towards the cam contact surfaces defined by the fingers, urges the fingers radially outwardly. When the camming element moves away from the finger cam contact surfaces, the fingers are allowed to retract in order to release the molded hub portion of the protective cover. | 02-19-2015 |
Patent application number | Description | Published |
20110168951 | THERMALLY STABLE CONDUCTING POLYMERS, METHODS OF MAKING, AND METHODS OF USE THEREOF - Disclosed herein are thermally stable conducting polymers prepared by template polymerization of a conducting monomer in the presence of a sulfonated poly(amic acid). The resulting conducting polymer-sulfonated poly(amic acid) complex can be thermally converted to a conducting polymer-sulfonated poly(imide) complex having high thermal stability and high conductivity. Also disclosed are articles prepared from the thermally stable conducting polymer. | 07-14-2011 |
20120224247 | STRETCHABLE DEVICES AND METHODS OF MANUFACTURE AND USE THEREOF - Stretchable electrochromic devices are disclosed including a stretchable electrochromic substrate; and a stretchable and transparent polymeric electrolyte coating or impregnating the stretchable electrochromic substrate. The stretchable electrochromic devices can find utility in the preparation of wearable electronic garments. Other devices using a stretchable and transparent polymeric electrolyte are disclosed. | 09-06-2012 |
20120226015 | SELENIUM-BASED MONOMERS AND CONJUGATED POLYMERS, METHODS OF MAKING, AND USE THEREOF - Substituted selenophene monomers, and polymers and copolymers having units derived from a substituted selenophene are disclosed. Also provided are methods of making and using the same. | 09-06-2012 |
20130289286 | SELENIUM-BASED MONOMERS AND CONJUGATED POLYMERS, METHODS OF MAKING, AND USE THEREOF - Substituted selenophene monomers, and polymers and copolymers having units derived from a substituted selenophene are disclosed. Also provided are methods of making and using the same. | 10-31-2013 |
20150017421 | ELECTRICALLY CONDUCTIVE SYNTHETIC FIBER AND FIBROUS SUBSTRATE, METHOD OF MAKING, AND USE THEREOF - Electrically conductive synthetic fiber and fibrous substrate (e.g. synthetic leather) are disclosed. The electrically conductive polymeric fiber and polymeric fibrous substrate are made electrically conductive by the use of an electrically conductive polymer disposed on the fibers and in contact with inorganic desiccant particles located at the surface of the fibers. The new material finds utility as an electrode for devices and as a resistive heating element, and as a pathway to efficient thermoelectrics. | 01-15-2015 |
Patent application number | Description | Published |
20080269693 | MULTIFUNCTIONAL MEDICAL ACCESS DEVICE - A medical access device is provided including a syringe needle having a proximal end and a distal end configured for percutaneous use; and a deployable safety shield supportable relative to the syringe needle. The safety shield includes a body portion configured to selectively receive the syringe needle. The body portion has a distal end defining a nose member, wherein the body portion is movable between an uncovered position where the distal end of the syringe needle is exposed and a covered position wherein the syringe needle is shielded and the nose member extends beyond the distal end of the syringe needle to establish a blunt penetration tip for the medical access device. When the body portion is in the covered position the nose member defines a passage into the syringe needle. | 10-30-2008 |
20100298739 | Multifunctional Medical Access Device - A medical access device is provided including a syringe needle and a safety shield supportable on the syringe needle. The safety shield includes a pair of spaced legs each having a distal segment and a proximal segment, each of the proximal segments having a proximal end fixed with respect to the syringe needle and a distal end hingedly attached to the distal segment at a hinge member, each proximal segment including a camming surface. The safety shield also includes a nose member connected to a distal end of each distal segment of the pair of spaced legs. The safety shield also includes a trigger being movable to move the camming member into engagement with the camming surfaces of the proximal segments to effect movement of the legs between a first position and a second position. | 11-25-2010 |
20100331726 | Medical Device with Incorporated Disinfecting Wipe and Method of Using Same - A medical device including a barrel having an open first end and capable of supporting a needle at a second end of the barrel is provided and includes a lid releasably adhered to and overlying the open first end of the barrel in a fluid tight manner; and a pad secured to a surface of the lid such that the pad is disposed within a cavity of the barrel when the lid is adhered to the barrel, wherein the pad comprises a disinfecting solution. | 12-30-2010 |
20120277679 | Safety IV Catheter Assemblies - A safety IV catheter assembly is disclosed which includes a catheter assembly, a needle assembly and a needle guard assembly. The needle guard assembly includes a needle guard, a biasing member and a bushing. The bushing is slidably positioned about the needle and includes an inner diameter which is smaller than an enlarged diameter portion of the needle such that the needle cannot be withdrawn through the bore of the bushing. | 11-01-2012 |
20130030370 | Vascular Access Assembly and Safety Device - A plurality of different vascular access assemblies are described which protect a clinician from accidental needle stick injury upon withdrawal of a needle from a catheter assembly. Each of the vascular access assemblies include a safety device for guarding the needle tip of the needle upon withdrawal of a needle from the catheter assembly. | 01-31-2013 |
20130085473 | Pre-Pierced IV Access Port - An access port for the introduction of a needle cannula tip into an IV tube set includes a rigid tubular housing and a resilient member disposed adjacent an inlet of the housing. The resilient member includes an axial perforation extending through the resilient member, and is normally closed by the resilient character of the resilient member. A depression is defined in a proximal face of the resilient member, and includes sidewalls extending between the proximal face and the axial perforation to guide the tip of the cannulated needle toward the perforation as the cannulated needle is introduced into the access port. | 04-04-2013 |
20130340891 | Blunt Tip Vial Access Cannula - This present disclosure provides a non-coring vial access cannula which has sufficient structural strength that it may be made from a thermoplastic resin instead of metal, thus reducing the likelihood and severity of operator injury by an accidental needle stick. The vial access cannula of the present disclosure has (i) a needle hub suitable for receiving a hypodermic syringe or an IV set (e.g., a Luer lock), (ii) a cannula portion having a centrally disposed lumen, wherein the centrally disposed lumen terminates in one or more distal openings and is in fluid communication with the needle hub, and (iii) a solid tip member distal to the one or more distal openings, wherein the solid tip member has a blade with a cutting edge. | 12-26-2013 |
20140018738 | Safety IV Catheter Assemblies - A safety IV catheter assembly is disclosed which includes a catheter assembly, a needle assembly and a needle guard assembly. The needle guard assembly includes a needle guard, a biasing member and a bushing. The bushing is slidably positioned about the needle and includes an inner diameter which is smaller than an enlarged diameter portion of the needle such that the needle cannot be withdrawn through the bore of the bushing. | 01-16-2014 |
20140058329 | Vascular Access Assembly with Safety Device - A plurality of different vascular access assemblies are described which protect a clinician from accidental needle stick injury upon withdrawal of a needle from a catheter assembly. Each of the vascular access assemblies include a safety device for guarding the needle tip of the needle upon withdrawal of a needle from the catheter assembly. | 02-27-2014 |
Patent application number | Description | Published |
20110165675 | CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION - A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization. | 07-07-2011 |
20110238167 | METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE - Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. The finally thinned membrane may then be treated by capping of calcification nucleation sites and borohydride reduction. The leaflets may be formed to have more than one region of uniform thickness, such as a thicker peripheral sewing region. | 09-29-2011 |
20120158128 | PROSTHETIC HEART VALVE DELIVERY SYSTEMS AND PACKAGING - Packaging for dry prosthetic tissue heart valves and their delivery systems includes a primary sterile barrier that permits gas sterilization of the tissue implant, and a secondary sterile barrier that also prevents oxidation of the implant during long-term storage. Dry tissue heart valves and their delivery systems are placed within a primary container such as a rigid tray that limits movement of the components therein. The primary container is placed within a secondary container, and the assembly is then sterilized. The outer sterile barrier may include a double seal so that a first gas-permeable seal can be closed for sterilization, after which a second gas-impermeable seal can be closed to seal out any further oxygen contact with the tissue implant. A collapsible delivery handle for a surgical heart valve may be provided which reduces the size of the packaging. | 06-21-2012 |
20130110097 | METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE | 05-02-2013 |
20130116676 | METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE - Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. | 05-09-2013 |
20130134064 | CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION - A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization. | 05-30-2013 |
20130310929 | METHODS OF CONDITIONING SHEET BIOPROSTHETIC TISSUE - Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface. The wavelength, power and pulse rate of the laser are selected which will smooth the fibrous surface as well as ablate the surface to the appropriate thickness. Alternatively, a dermatome is used to remove a layer of material from the fibrous surface of the membrane. Thinning may also employ compression. Stepwise compression with cross-linking to stabilize the membrane is used to avoid damaging the membrane through inelastic compression. Rather, the membrane is bound in the elastic compressed state through addition cross-linking. The foregoing several thinning techniques may be employed together to achieve strong thin membranes. | 11-21-2013 |
20130325111 | PRE-ASSEMBLED BIOPROSTHETIC VALVE AND SEALED CONDUIT - A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve. The bioprosthetic heart valve may have separate bovine pericardial leaflets or a whole porcine valve. The sealed conduit includes a tubular matrix impregnated with a bioresorbable medium such as gelatin or collagen. The valved conduit is stored dry in packaging in which a desiccant pouch is supplied having a capacity for absorbing moisture within the packaging limited to avoid drying the bioprosthetic tissue out beyond a point where its ability to function in the bioprosthetic heart valve is compromised. The heart valve may be sewn within the sealed conduit or coupled thereto with a snap-fit connection. | 12-05-2013 |
20140088692 | SYSTEMS AND METHODS FOR REPLACING A NATIVE HEART VALVE AND AORTA WITH A PROSTHETIC HEART VALVE AND CONDUIT - A medical device includes an expandable conduit, a prosthetic heart valve and a delivery device, including a balloon catheter. The expandable conduit may include one or more inner or outer sleeves supported by a frame or stent. The sleeve(s) may be a bioprosthetic tissue wrapped, molded or sewn about the frame or stent. Coupled to an end of the expandable conduit is the prosthetic heart valve. The conduit and heart valve may be crimped on the balloon catheter for percutaneous deployment. The frame may be constructed of a balloon-expandable material for the conduit portion and a self-expandable material for the prosthetic heart valve portion. The prosthetic heart valve is anchored at the native heart valve and then the conduit to be expanded into place to protect the aorta. The self-expanding prosthetic heart valve avoids the need for balloon mounting. This provides for a smaller diameter and easier delivery. | 03-27-2014 |
20140200659 | CAPPING BIOPROSTHETIC TISSUE TO REDUCE CALCIFICATION - A treatment for bioprosthetic tissue used in implants or for assembled bioprosthetic heart valves to reduce in vivo calcification. The method includes applying a calcification mitigant such as a capping agent or an antioxidant to the tissue to specifically inhibit oxidation in tissue. Also, the method can be used to inhibit oxidation in dehydrated tissue. The capping agent suppresses the formation of binding sites in the tissue that are exposed or generated by the oxidation and otherwise would, upon implant, attract calcium, phosphate, immunogenic factors, or other precursors to calcification. In one method, tissue leaflets in assembled bioprosthetic heart valves are pretreated with an aldehyde capping agent prior to dehydration and sterilization. | 07-17-2014 |
Patent application number | Description | Published |
20110130984 | ESTIMATING REMAINING BATTERY SERVICE LIFE IN AN IMPLANTABLE MEDICAL DEVICE - Methods for estimating a remaining service life of an implantable medical device (IMD) battery are presented. In one embodiment, a characteristic discharge model of the battery is employed. Systems employing the methods may include an external device coupled to the IMD, for example, via a telemetry communications link, wherein a first portion of a computer readable medium included in the IMD is programmed to provide instructions for the measurement, or tracking, of time and the measurement of battery voltage, and a second portion of the computer readable medium included in the external device is programmed to provide instructions for carrying out the calculations when the voltage and time data is transferred via telemetry from the IMD to the external device. | 06-02-2011 |
20140277248 | GRAPHICAL DISPLAY OF REMAINING LONGEVITY OF ENERGY SOURCE OF IMPLANTABLE MEDICAL DEVICE AND METHOD - Displaying remaining longevity of energy source of implantable medical device having a longevity characterized by a depth of discharge representative of a first stage of discharge, e.g., beginning of service, a second stage of discharge, e.g., recommended replacement time, and a third stage of discharge, e.g., end of service. A display is configured to display in graphical form using a scale length representative of a time between the first stage of discharge and the third stage of discharge. A first portion of the display between the second stage of discharge and the third stage of discharge is indicated in a first color, e.g., red. A second portion of the display between the remaining longevity and the second stage of discharge is indicated in a second color, e.g., green. A third portion of the display between the first stage of discharge and the remaining longevity is indicated in a third color, e.g., white. | 09-18-2014 |