Patent application number | Description | Published |
20080221192 | Compounds and Compositions as Protein Kinase Inhibitors - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC kinases. | 09-11-2008 |
20090203666 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS - The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I. | 08-13-2009 |
20090306039 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb). | 12-10-2009 |
20090312308 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS - The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I. | 12-17-2009 |
20100056494 | PURINE COMPOUNDS AND COMPOSITIONS AS KINASE INHIBITORS FOR THE TREATMENT OF PLASMODIUM RELATED DISEASES - The invention provides a class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with kinase activity, particularly malaria. | 03-04-2010 |
20100184748 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS - The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb). | 07-22-2010 |
20110092491 | Compounds and Compositions as Inhibitors of Receptor Tyrosine Kinase Activity - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with cSRC, Lck, FGFR3, Flt3, TrkB, Bmx, and/or PFGFRα kinase activity. | 04-21-2011 |
20110152282 | HEDGEHOG PATHWAY MODULATORS - The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I). | 06-23-2011 |
20110237573 | N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS - The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A | 09-29-2011 |
20120196849 | COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS - The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I. | 08-02-2012 |
20120202782 | COMPOUNDS AND COMPOSITIONS AS ITPKB INHIBITORS - The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb). | 08-09-2012 |
20130079328 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY - The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R | 03-28-2013 |
20130296333 | HEDGEHOG PATHWAY MODULATORS - The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I). | 11-07-2013 |
20130310375 | N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS - The present invention relates to compositions and methods for modulating the Wnt signaling pathway. | 11-21-2013 |
20160082014 | N-(HETERO)ARYL, 2-(HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS - The present invention relates to methods for modulating the Wnt signaling pathway using compounds of Formula (1), | 03-24-2016 |
Patent application number | Description | Published |
20100309228 | Displaying Multi-Dimensional Data Using a Rotatable Object - Effective display of data organized along multiple dimensions on a device having a display area that is small compared to the amount of data being shown in the chart is provided. A three-dimensional object that can be rotated along various axes of rotation is displayed in a particular orientation, displaying information related to a data point. Rotation of the object causes the object to be displayed in a different orientation thereby displaying information related to a different data point. The coordinates of the new data point displayed are determined based on the original coordinates and the direction and amount of rotation of the object. In one embodiment, a data arranged along two-dimensions is associated with a cube that can be rotated vertically or horizontally. | 12-09-2010 |
20120311477 | PREDICTIVE SCROLLING - A system and a method are disclosed for effectively displaying database records on a device having a display area that is small compared to the underlying data being represented. A simulated catalogue is displayed with cards associated with database records. Detailed information is presented for a record on a card obscuring information related to other records. A user is allowed to swipe on the catalogue causing simulated movement of the cards thereby displaying information associated with a database record previously obscured. The catalogue is moved with an initial velocity determined by the speed of swiping and decelerated based on a drag factor until it comes to a stop and displays information for the record reached. The ability to determine the final record displayed when the catalogue stops allows pre-fetching of the data associated with the record. | 12-06-2012 |
20140157187 | PREDICTIVE SCROLLING - A system and a method are disclosed for effectively displaying database records on a device having a display area that is small compared to the underlying data being represented. A simulated catalogue is displayed with cards associated with database records. Detailed information is presented for a record on a card obscuring information related to other records. A user is allowed to swipe on the catalogue causing simulated movement of the cards thereby displaying information associated with a database record previously obscured. The catalogue is moved with an initial velocity determined by the speed of swiping and decelerated based on a drag factor until it comes to a stop and displays information for the record reached. The ability to determine the final record displayed when the catalogue stops allows pre-fetching of the data associated with the record. | 06-05-2014 |
20140337313 | EXECUTING DATABASE QUERIES USING MULTIPLE PROCESSORS - A system and a method are disclosed for efficiently executing database queries using a computing device that includes a central processing unit (CPU) and a processing unit based on single instruction multiple thread (SIMT) architecture, for example, a GPU. A query engine determines a target processing unit to execute a database query based on factors including the type and amount of data processed by the query, the complexity of the query, and the current load on the processing units. An intermediate executable representation generator generates an intermediate executable representation for executing a query on a database virtual machine. If the query engine determines that the database query should be executed on an SIMT based processing unit, a native code generator generates native code from the intermediate executable representation. The native code is optimized for execution using a particular processing unit. | 11-13-2014 |
20150242069 | Predictive Scrolling - A system and a method are disclosed for effectively displaying database records on a device having a display area that is small compared to the underlying data being represented. A simulated catalogue is displayed with cards associated with database records. Detailed information is presented for a record on a card obscuring information related to other records. A user is allowed to swipe on the catalogue causing simulated movement of the cards thereby displaying information associated with a database record previously obscured. The catalogue is moved with an initial velocity determined by the speed of swiping and decelerated based on a drag factor until it comes to a stop and displays information for the record reached. The ability to determine the final record displayed when the catalogue stops allows pre-fetching of the data associated with the record. | 08-27-2015 |
20160055206 | Executing Database Queries Using Multiple Processors - A system and a method are disclosed for efficiently executing database queries using a computing device that includes a central processing unit (CPU) and a processing unit based on single instruction multiple thread (SIMT) architecture, for example, a GPU. A query engine determines a target processing unit to execute a database query based on factors including the type and amount of data processed by the query, the complexity of the query, and the current load on the processing units. An intermediate executable representation generator generates an intermediate executable representation for executing a query on a database virtual machine. If the query engine determines that the database query should be executed on an SIMT based processing unit, a native code generator generates native code from the intermediate executable representation. The native code is optimized for execution using a particular processing unit. | 02-25-2016 |
Patent application number | Description | Published |
20100324032 | COMPOUNDS AND USES THEREOF IN MODULATING AMYLOID BETA - Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. | 12-23-2010 |
20100331551 | ALPHA-HALOKETONE DERIVATIVES OF IMIDAZOLYL-SUBSTITUTED AROMATIC COMPOUNDS AND COMPOUNDS PREPARED THEREFROM - Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided. | 12-30-2010 |
20120289587 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM - Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity. | 11-15-2012 |
20130165416 | COMPOUNDS AND USES THEREOF IN MODULATING LEVELS OF VARIOUS AMYLOID BETA PEPTIDE ALLOFORMS - The invention provides a novel compound having a structure corresponding to Formula (I): | 06-27-2013 |
20160024073 | GAMMA-SECRETASE MODULATORS - There are provided, imer alia, compounds and methods for lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. Since all of the major AB peptide variants, including the pathogenic AB42 as known in the art, are ultimately generated by gamma-secretase-mediated proteolysis of APP-C99 (i.e., the beta-secretase-mediated cleavage product of the amyloid protein precursor IAPPI), one approach to therapeutic intervention (e.g., intervention in Alzheimer's Disease, AD) relates to lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. | 01-28-2016 |
Patent application number | Description | Published |
20140040301 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 02-06-2014 |
20160085803 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085804 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085805 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085806 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085818 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085819 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085820 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085821 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085822 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085823 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085824 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085825 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085826 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
20160085827 | REAL-TIME AND ADAPTIVE DATA MINING - A method of analyzing data is presented. The method includes generating a query based on a topic of interest, expanding search terms of the query, executing the query on one or more data sources, monitoring a specific data source selected from the one or more data sources. The monitoring is performed to monitor for matches to the query. | 03-24-2016 |
Patent application number | Description | Published |
20150200588 | LOW-POWER, SELF-BIASING-CAPABLE CHARGE PUMP WITH CURRENT MATCHING CAPABILITIES - A charge pump is disclosed herein that includes an output node configured to be coupled to a charge storage device configured to store a charge to produce a control voltage based on the charge stored in the charge storage device; a charging circuit configured to provide charge to the charge storage device; a discharging circuit configured to remove charge from the charge storage device; and an amplifier. The amplifier includes an inverting input configured to receive the control voltage from the output node as a first input signal; and, a non-inverting input configured to receive a second input signal including a bias voltage, wherein the amplifier is configured to attempt to match respective levels of the bias voltage and the control voltage when the charge in the charge storage device is changing. | 07-16-2015 |
20150311875 | SENSE AMPLIFIER WITH IMPROVED RESOLVING TIME - Sense amplifiers that can provide improved resolving times can be used, for example, in clock and data recovery circuits. The sense amplifiers sense the value of a differential input signal using a latch circuit and then, after an initial sensing time, force the latch circuit to resolve a digital value that corresponds to the value of the input signal. An implementation of the sense amplifies uses a first latch with cross-coupled inverters that produce set and reset signals. A transistor pair couples the differential input signal to the cross-coupled inverters via a switch to ground. A discharge path circuit arranged to accelerate the resolving of the latch circuit is also coupled to the cross-coupled inverters. The discharge path can be enabled after an initial sensing time. | 10-29-2015 |
20150357017 | PROGRAMMABLE POWER FOR A MEMORY INTERFACE - Systems and methods for delay control are described herein. In one embodiment, a delay system comprises a first delay circuit configured to provide a voltage bias to a second delay circuit, wherein the voltage bias controls a delay of the second delay circuit, and to update the voltage bias at an update rate. The delay system also comprises an update controller configured to adjust the update rate of the first delay circuit. For example, the update controller may adjust the update rate based on timing requirements of a memory interface incorporating the delay system. The update rate may be reduced when the timing requirements are more relaxed to reduce power, and may be increased when the timing requirements are tighter. | 12-10-2015 |
20150358007 | DELAY STRUCTURE FOR A MEMORY INTERFACE - Systems and methods for delaying a signal are described herein. In one embodiment, a method for delaying a signal comprises receiving a first signal edge, and, in response to receiving the first signal edge, counting a number of oscillations of an oscillator. The method also comprises outputting a second signal edge if the number of oscillations reaches a predetermined number. The second signal edge represents a delayed version of the first signal edge. | 12-10-2015 |
20160079971 | DELAY CIRCUIT - Systems and methods for delay control are described herein. In one embodiment, a delay circuit comprises a first delay path and a second delay path. The delay circuit also comprises a plurality of switches, wherein each switch is coupled between different points on the first and second delay paths, and each switch is configured to turn on or off in response to a respective one of a plurality of select signals. The delay circuit further comprises a multiplexer having a first input coupled to an output of the first delay path, a second input coupled to an output of the second delay path, and an output coupled to an output of the delay circuit, wherein the multiplexer is configured to selectively couple one of the outputs of the first and second delay paths to the output of the delay circuit in response to a second select signal. | 03-17-2016 |