Patent application number | Description | Published |
20130045211 | METHODS AND COMPOSITIONS FOR ENHANCED IMMUNOLOGICAL THERAPY AND TARGETING OF GRAM-POSITIVE BACTERIA - The present invention relates to methods and compositions for use in modulating, including inhibiting the growth and/or reducing the virulence of gram-positive bacteria. The present invention provides methods and compositions for disrupting the cell wall and/or cell membrane in gram-positive bacteria such that cell wall or cell membrane target(s) are rendered exposed or accessible and sensitive to a modulation thereof. Methods for modulation of one or more gram-positive bacterial cell wall or cell membrane targets in a gram-positive bacteria are provided comprising disrupting the cell wall such that the cell wall or cell membrane target, which is particularly a sortase, is rendered exposed or accessible and sensitive to a modifying, modulating or binding agent, which is particularly an antibody or fragment thereof, wherein the cell wall or cell membrane target is inaccessible or relatively insensitive to the modifying, modulating or binding agent in the absence of cell wall disruption. | 02-21-2013 |
20130302306 | BACTERIOPHAGE LYSIN AND ANTIBIOTIC COMBINATIONS AGAINST GRAM POSITIVE BACTERIA - The present invention provides compositions and methods for prevention, amelioration and treatment of gram positive bacteria, particularly Staphylococcal bacteria, with combinations of lysin, particularly Streptococcal lysin, particularly the lysin PlySs2, and one or more antibiotic, including daptomycin, vancomycin, oxacillin, linezolid, or related antibiotic(s). | 11-14-2013 |
Patent application number | Description | Published |
20090034812 | SUPERIMPOSING BRAIN ATLAS IMAGES AND BRAIN IMAGES WITH DELINEATION OF INFARCT AND PENUMBRA FOR STROKE DIAGNOSIS - Brain images are processed and analyzed with the aid of a computer for stroke diagnosis or therapeutic decision making, where multiple stroke-related images are superimposed. The superimposed images include brain images that have infarct and penumbra regions, and patient-specific brain atlas images. The infarct and penumbra regions are determined and delineated on the superimposed images. Each patient-specific brain atlas image may be formed by mapping a pre-existing brain atlas to a co-ordinate system in which the brain images are co-registered. A brain atlas may depict brain structures such as anatomy structures, blood supply territories (BST), or cerebral vasculature. The superimposed images may be used to determine any overlap between a particular brain structure and the infarct and penumbra regions. | 02-05-2009 |
20090129671 | METHOD AND APPARATUS FOR IMAGE SEGMENTATION - A 3D image may be segmented based on one or more intensity thresholds determined from a subset of the voxels in the 3D image. The subset may contain voxels in a 2D reference slice. A low threshold and a high threshold may be used for segmenting an image, and they may be determined using different thresholding methods, depending on the image type. In one method, two sets of bordering pixels are selected from an image. A statistical measure of intensity of each set of pixels is determined. An intensity threshold value is calculated from the statistical measures for segmenting the image. In another method, the pixels of an image are clustered into clusters of different intensity ranges. An intensity threshold for segmenting the image is calculated as a function of a mean intensity and a standard deviation for pixels in one of the clusters. A further method is a supervised range-constrained thresholding method. | 05-21-2009 |
20090324052 | DETECTION AND LOCALIZATION OF VASCULAR OCCLUSION FROM ANGIOGRAPHY DATA - A technique for detecting and localising vascular occlusions in the brain of a patient is presented. The technique uses volumetric angiographic data of the brain. A mid-sagittal plane and/or lines is/are identified within the set of angiographic data. Optionally, the asymmetry of the hemispheres is measured, thereby obtaining an initial indication of whether an occlusion might be present. The angiographic data is mapped to pre-existing atlas of blood supply territories, thereby obtaining the portion of the angiographic data corresponding to each of the blood supply territories. For each territory (including any sub-territories), the asymmetry of the corresponding portion of the angiographic data about the mid-sagittal plane/lines is measured, thereby detecting any of the blood supply territory including an occlusion. The angiographic data for any such territory is displayed by a three-dimensional imaging technique. | 12-31-2009 |
20100021035 | METHOD FOR IDENTIFYING A PATHOLOGICAL REGION OF A SCAN, SUCH AS AN ISCHEMIC STROKE REGION OF AN MRI SCAN - A method for identifying a pathological region of a scan (such as a stroke region within a MRI DWI volume scan) is proposed. A region of the scan which is likely to contain pathological tissue (e.g. infracted tissue) is identified by obtaining a parameter which, for a given slice, or portion of a slice, characterises the distribution of the intensity of pixels, e.g. the relative proportion of high intensity pixels. In a first case, such a parameter is used to identify those slices of a volume scan which are likely to include infarction. In a second case, such a parameter (hemisphere parameter) is obtained for each of the left- and right-hemispheres of a brain, to estimate which hemisphere contains the stroke. In either case, the parameter may be calculated based on ranges, percentiles and functions of the percentiles of the intensity distribution. These ranges, percentiles and functions of the percentiles are not pre-defined but are selected to maximise sensitivity. | 01-28-2010 |
20120099779 | METHOD AND SYSTEM FOR SEGMENTING A BRAIN IMAGE - A method is proposed for segmenting a brain image into a CSF region, a WM region and a GM region. An upper limit for the intensity values of a CSF region in the image is estimated such that the points of the image having an intensity less than this upper limit include a subset of the points which form a spatially connected group and which have a peaked intensity distribution. In other words, the invention exploits both the expected spatial distribution and expected intensity distribution of the CSF region. This makes it possible for the method to provide reliable discrimination of the CSF region even in CT images with poor image quality. Various methods are proposed for using the upper limit, and for improving the segmentation accuracy. | 04-26-2012 |