Nash, GB
Alastair Nash, Congleton GB
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20100217771 | RESOURCE ACCESS FILTERING SYSTEM AND DATABASE STRUCTURE FOR USE THEREWITH - A database structure ( | 08-26-2010 |
Alistair H. Nash, Altrincham GB
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20100005165 | SYSTEM, METHOD AND APPARATUS FOR USE IN MONITORING OR CONTROLLING INTERNET ACCESS - An apparatus method and system are described for categorizing Uniform Resource Locators (URLs) when accessing the Internet | 01-07-2010 |
Anthony Nash, Beckenham GB
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20100293055 | System for dynamically generating affiliate advertising within electronic communications - A system and method with a distributor physically acting upon a computer to send an electronic communication to a recipient. The system delivers dynamic content to the recipient's electronic communication based on the distributor's preferences using identifiers in static code placed within the body of the electronic communication. Cookies sent by the system to the recipient define the content and enable dynamic redirects to websites from hyperlinks from this content. | 11-18-2010 |
20110270710 | System for dynamically generating affiliate advertising within electronic communications - A system and method with a distributor physically acting upon a computer to send an electronic mail message to a recipient. The system uses an Internet browser add-on to identify the presence of an electronic mail message and insert a predetermined advertising code into the electronic mail message. The advertising code can be generally selected by the system or selected by the distributor. Once selected, the advertisements are associated within the server with the distributor as part of an affiliate marketing program. | 11-03-2011 |
Anthony Nash, Edinburgh GB
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20130205416 | ANTI-VIRAL AGENT - The present invention provides an agent, in particular a peptide, of formula A, comprising an amino acid sequence X1-X2-X3-X4-X5-X6 (SEQ ID NO 1) wherein X1 can be phenylalanine, isoleucine or tryptophan; X2 can be leucine or phenylalanine or alanine; X3 can be tyrosine or valine; X4 can be leucine, phenylalanine or isoleucine; 10 X5 can be phenyalanine or alanine; and X6 can be valine, arginine or tyrosine, or a fragment or variant of the peptide, wherein said peptide fragment or variant is capable of specifically binding to haemagglutinin, to inhibit the binding of a virus having haemagglutinin on its surface, for use in the treatment of a virus, for example influenza. | 08-08-2013 |
Brian Nash, Swindon GB
Patent application number | Description | Published |
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20090100413 | Stack Walking Enhancements Using Sensorpoints - A system and method for receiving an image of compiled user code, scanning the image to determine each of a plurality of functions included in the user code and creating a separately compiled executable module corresponding to selected ones of the plurality of functions, wherein the module includes instructions to create a stack trace for the selected ones of the functions. | 04-16-2009 |
20100275185 | System and Method for High Performance Coverage Analysis - A system and method for inserting at least one instrumentation point into a program at a first location, executing the program and removing the instrumentation point from the program when the executing program reaches the instrumentation point. The system and method further recording the at least one instrumentation point in a record when the instrumentation point is removed from the program. | 10-28-2010 |
Charlotte L. Nash, Portsmouth GB
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20150091922 | Diagnosing Graphics Display Problems - A mechanism is provided for diagnosing graphics display problems during running of an application. A frame of the application drawn by a graphics processing unit is selected. A central processing unit draws the frame. The graphics processing unit drawn frame and the central processing unit drawn frame are compared to determine if there is a graphics problem. | 04-02-2015 |
Claire Nash, Newport GB
Patent application number | Description | Published |
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20080223563 | U Shaped Cooler - An exhaust gas re-circulation cooler device comprises at least one cooling plate, said cooling plate comprising an upper plate wall and a lower plate wall; said upper and lower plate walls defining a plurality of gas passages which have a gas inlet at a first end of cooling plate and a gas outlet at said first end of said cooling plate; each said passage directing a gas flow between said inlet and said outlet and along a length of said plate; and said plate being sealed so as to be gas tight along a length of said plate, and at a second end of said plate. | 09-18-2008 |
Curtis Nash, Bursledon GB
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20100317353 | TELECOMMUNICATIONS NETWORK AND TELECOMMUNICATIONS DEVICE - A telecommunications network comprises an electronic call centre, and a telecommunications device operative to transmit and receive data over the network to/from a desired location. The telecommunications device is provided with routing means operative to route data transmissions between the telecommunications device and the desired location to the electronic call centre. The electronic call centre is operative to store a copy of the data transmission. | 12-16-2010 |
David Nash, Wiltshire GB
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20130299646 | Safety Line Anchor - An anchor arrangement for a safety line system is for use with a bracket to secure to a structure for mounting the safety line. The anchor arrangement either includes an alignment collar arranged to seat in a seat provided on the bracket, the alignment collar being able to seat in a plurality of different orientations with respect to the bracket; a resilient biasing means acting between the bracket and a reaction member provided as part of the anchor arrangement or a tension indicator for the safety line, which has a part of the bracket aligned adjacent and indicia zone on the anchor arrangement. | 11-14-2013 |
David John Nash, Harlow GB
Patent application number | Description | Published |
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20080318944 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - Disclosed are N-aroyl cyclic amine derivatives having the formula: | 12-25-2008 |
20090012083 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - Disclosed are N-aroyl cyclic amine derivatives having the formula: | 01-08-2009 |
20090012122 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - Disclosed are N-aroyl cyclic amine derivatives having the formula: | 01-08-2009 |
20090036442 | N-AROYL CYCLIC AMINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS - Disclosed are N-aroyl cyclic amine derivatives having the formula: | 02-05-2009 |
Douglas Nash, Sheffield GB
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20090295040 | Workpiece forming - A method of forming a workpiece ( | 12-03-2009 |
Geoffrey Richard Nash, Malvern GB
Patent application number | Description | Published |
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20100171130 | Semiconductor device and fabrication method - A semiconductor device comprising a plurality of regions of semiconductor material forming a junction at an interface there-between, the junction including a depletion region having a width which varies spatially in at least one direction along the depletion region. Without limitation, the spatial variation in depletion region width is provided by ionised dopants having a concentration which varies spatially along said at least one direction. Alternatively, or in addition, the spatial variation in depletion region width is achieved by varying the thickness of the region(s) of semiconductor spatially along said at least one direction, for example by creating a plurality of cells within said region(s) devoid of said semiconductor material. A method of fabricating a semiconductor device comprising the step of varying the width of the depletion region spatially there-within in at least one direction along the depletion region. | 07-08-2010 |
Gerard Bernard Nash, Birmingham GB
Patent application number | Description | Published |
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20110281374 | BIOMARKER - A method of diagnosing or determining the degree of an arterial aneurysm, especially an abdominal aortic aneurysm, which comprises determining the presence or level of interleukin-1α (IL-1α) in a serum or plasma sample. | 11-17-2011 |
20130231257 | BIOMARKER - A method of diagnosing or determining the degree of an arterial aneurysm, especially an abdominal aortic aneurysm, which comprises determining the presence or level of interleukin-1α (IL-1aα) in a serum or plasma sample. | 09-05-2013 |
Guy Cameron Nash, Guildford GB
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20130189377 | COMPOSITIONS - The present invention concerns solid compressed oral pharmaceutical compositions comprising a mixture of at least two sulphate salts selected from the group consisting of sodium, potassium and magnesium for use, in particular, in cleansing the colon or treating faecal impaction, constipation, faecal retention, intestinal gas and cramping, or flatulence in a mammal. Methods of producing such compositions are also disclosed. | 07-25-2013 |
Henry Paul Nash, Manchester GB
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20110265084 | CROSS ARCHITECTURE VIRTUAL MACHINE MIGRATION - A system, method and computer program for transferring a running virtual machine from a first to a second physical machine, where each of the physical machines has a different instruction set architecture. The system may comprise a receiver for receiving a transfer request; responsive to receiving the transfer request, means for pausing the virtual machine; and means for collecting a state of the virtual machine. The system may include means for stopping a first interface component operable on the first physical machine; means for starting a second interface component operable on the second physical machine; and means for transferring the state to the second interface component. The system may further comprise means for starting the virtual machine on the second physical machine in response to the state transfer. | 10-27-2011 |
20150178128 | CROSS ARCHITECTURE VIRTUAL MACHINE MIGRATION - A system, method and computer program for transferring a running virtual machine from a first to a second physical machine, where each of the physical machines has a different instruction set architecture. The system may comprise a receiver for receiving a transfer request; responsive to receiving the transfer request, means for pausing the virtual machine; and means for collecting a state of the virtual machine. The system may include means for stopping a first interface component operable on the first physical machine; means for starting a second interface component operable on the second physical machine; and means for transferring the state to the second interface component. The system may further comprise means for starting the virtual machine on the second physical machine in response to the state transfer. | 06-25-2015 |
Ian Nash, Berkshire GB
Patent application number | Description | Published |
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20090003797 | Method, Apparatus and Computer Program Product for Providing Content Tagging - An apparatus for providing content tagging may include a storage element and a tagging element. The storage element may be configured to store a predefined text entry. The tagging element may be in communication with the storage element and may be configured to receive a content item and tag the content item with the predefined text entry. | 01-01-2009 |
20110010658 | USER INTERFACE SCROLLING - A method for displaying data items in a display window, including detecting a user input action, including receiving a first user input signal via user input device, the signal being indicative of a velocity of the user action; and depending on the velocity, entering one of a plurality of display states, in which states a respective number of data items are displayed in the display window is provided. A device and computer program product thereof is also provided. | 01-13-2011 |
Ian Nash, Reading GB
Patent application number | Description | Published |
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20140087774 | Data Delivery - A method of sending data from a first party participating in a telephone call to a second party participating in the telephone call, comprising, in the terminal of the first party, storing, as a consequence of the telephone call, identifier data that identifies the second party; using the stored identifier data to determine automatically a destination address for a data message; and sending, during the telephone call, the data message with the automatically determined destination address. A method for sending data from a first party participating in a telephone call to a second party participating in the telephone call, comprising, in the terminal of the first party: providing, while the telephone call is on-going, a user selectable option to transfer data to another party participating in the telephone call without user specification of a destination address. | 03-27-2014 |
Ian Alun Nash, Mcclesfield GB
Patent application number | Description | Published |
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20120004243 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS - The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy, halogeno and (1-6C)alkyl, or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines. | 01-05-2012 |
Ian Alun Nash, Cheshire GB
Patent application number | Description | Published |
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20090124604 | 4-OXOQUINAZOLIN-3-YL BENZAMIDE DERIVATIVES FOR THE TREATMENT OF CYTOKINE DISEASES - The invention concerns a compound of the Formula (I) wherein m is 1-2 and each R | 05-14-2009 |
20100152169 | 4-OXOQUINAZOLIN-3-YL BENZAMIDE DERIVATIVES FOR THE TREATMENT OF CYTOKINE DISEASES - The invention concerns a compound of the Formula (I) wherein m is 1-2 and each R | 06-17-2010 |
20120022110 | PHARMACEUTICAL DEPOT FOR 5-FLUORO-2-[[(1S)-1-(5-FLUORO-2-PYRIDYL)ETHYL]AMINO]-6-[(5-ISOPROPOXY-1H-- PYRAZOL-3-YL)AMINO]PYRIDINE-3-CARBONITRILE - A pharmaceutical depot comprising (i) 5-fluoro-2-[[(1S)-1-(5-fluoro-2-pyridyl)ethyl]amino]-6-[(5-isopropoxy-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation. | 01-26-2012 |
20120149739 | PHARMACEUTICAL DEPOT FOR N-{5-[(CYCLOPROPYLAMINO)CARBONYL]-2-METHYLPHENYL)-3-FLUORO-4-(PYRIDIN-2-Y- LMETHOXY)BENZAMIDE - A pharmaceutical depot comprising (i) N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation. | 06-14-2012 |
20120149740 | PHARMACEUTICAL DEPOT FOR N-{5-[(CYCLOPROPYLAMINO)CARBONYL]-2-METHYLPHENYL)-3-FLUORO-4-(PYRIDIN-2-Y- LMETHOXY)BENZAMIDE - A pharmaceutical depot comprising (i) N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3-fluoro-4-(pyridin-2-ylmethoxy)benzamide, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation. | 06-14-2012 |
20140045895 | PHARMACEUTICAL DEPOT FOR 5-FLUORO-2-[[(1S)-1-(5-FLUORO-2-PYRIDYL)ETHYL]AMINO]-6-[(5-ISOPROPOXY-1H-- PYRAZOL-3-YL)AMINO]PYRIDINE-3-CARBONITRILE - A pharmaceutical depot comprising (i) 5-fluoro-2-[[(1S)-1-(5-fluoro-2-pyridyl)ethyl]amino]-6-[(5-isopropoxy-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation. | 02-13-2014 |
Ian Alun Nash, Macclesfield GB
Patent application number | Description | Published |
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20090281150 | Compound 249 - A pharmaceutical depot comprising (i) N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-3-fluoro- | 11-12-2009 |
20130035346 | AMIDE DERIVATIVES BEARING A CYCLOPROPYLAMINOACARBONYL SUBSTITUENT USEFUL AS CYTOKINE INHIBITORS - The invention concerns a compound of the Formula (I), wherein Qa is heteroaryl and is substituted with halogeno; R1 and R2 are hydrogen; and Qb is phenyl or heteroaryl, and Qb may optionally bear 1 or 2 substituents selected from hydroxy, halogeno and (1-6C)alkyl, or a pharmaceutically-acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines. | 02-07-2013 |
James Nash, London GB
Patent application number | Description | Published |
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20100263329 | FILLING AND SEALING OF BEVERAGE CONTAINERS - The present invention provides, inter alia, a method of filling and sealing a beverage container, the method comprising the steps of: | 10-21-2010 |
20130042578 | Filling and Sealing of Beverage Containers - The present invention provides, inter alia, a method of filling and sealing a beverage container, the method comprising the steps of: a) dispensing a predetermined amount of beverage, preferably wine, into an open-topped container having a circular rim, preferably a plastics wine glass, to leave a headspace above the beverage in the container; b) temporarily tacking a generally flat flexible film lid sized to fit over the open top to the rim of the container at at least one position around the rim while leaving the remainder of the rim free; c) engaging the tacked lid to cause flexure thereof to create a gap between the lid and the rim on one side; d) dispensing an inert gas, preferably nitrogen, through the gap so created and into the headspace to displace air therefrom; and e) bringing a heat sealer into engagement with the lid to heat seal the lid to the rim about its entire circumference, thereby trapping the inert gas within the headspace. | 02-21-2013 |
John Edward Nash, Hythe GB
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20100089402 | MEDICO-SURGICAL DEVICES - A tracheal tube ( | 04-15-2010 |
Jonathan Nash, Lagrange GB
Patent application number | Description | Published |
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20110127897 | SHELF FOR AN APPLIANCE - A spill proof shelf and a refrigerator using the same are disclosed. The shelf has a glass plate formed through a glass-slumping process. The shelf also has a metal bracket coupled to the plate for supporting the plate. The bracket provides an interface of the shelf with the refrigerator. The plate has a lower planar portion and an upper planar portion surrounding the lower planar portion. The upper planar portion is smoothly transitioned to the lower planar portion through the glass-slumping process, to define a central recess. The plate also has a side portion extending perpendicularly from the upper planar portion. In case food or beverage spill occurs, it will be confined in the recess. | 06-02-2011 |
Kevin Nash, Herts GB
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20100022537 | I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE - This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development. | 01-28-2010 |
Mark Nash, West Sussex GB
Patent application number | Description | Published |
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20100144740 | SYNERGISTIC COMBINATIONS OF VR-1 ANTAGONISTS AND COX-2 INHIBITORS - A synergistic combination of a vanilloid receptor VR-1 antagonist and an NSAID or a pharmaceutically acceptable salt or solvate of either or both compounds thereof. | 06-10-2010 |
Michael Nash, Reading GB
Patent application number | Description | Published |
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20150343422 | COATED ARTICLES HAVING HIGH KNOx/KSOx RATIOS FOR SELECTIVE CATALYTIC REDUCTION - Articles comprising a catalyst film comprising VOx, MoO | 12-03-2015 |
Michael James Nash, Bicester GB
Patent application number | Description | Published |
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20130072715 | PROCESS FOR PREPARING V-Ti-P CATALYSTS FOR SYNTHESIS OF 2,3-UNSATURATED CARBOXYLIC ACIDS - The invention relates to a catalyst composition comprising a mixed oxide of vanadium, titanium, and phosphorus. The titanium component is derived from a water-soluble, redox-active organo-titanium compound. The catalyst composition is highly effective at facilitating the vapor-phase condensation of formaldehyde with acetic acid to generate acrylic acid, particularly using an industrially relevant aqueous liquid feed. | 03-21-2013 |
Philip Nash, Guildford GB
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20130162446 | OPTICAL SENSING SYSTEM WITH REDUNDANT INPUT AND OUTPUT TREES - An optical sensing system, comprising a plurality of optical sensors ( | 06-27-2013 |
Philip Nash, London GB
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20150185052 | OPTICAL MONITORING SYSTEM - An optical monitoring system comprising first and second sensor arrays interrogated via first and second optical connections from an interrogator location. The system is configured such that no wavelength is carried bi-directionally in the first and second optical connections. In typical systems the optical connections comprise trunk cables from the sensor arrays to the interrogator location. | 07-02-2015 |
Philip Nash, Surrey GB
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20100182872 | SEISMIC CABLE STRUCTURE - There is described an optical seismic cable ( | 07-22-2010 |
Philip J. Nash, London GB
Patent application number | Description | Published |
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20140063493 | SENSOR ARRAY - An arrangement for monitoring a submarine reservoir comprises a number of sensor units located in an array ( | 03-06-2014 |
Philip John Nash, Guilford GB
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20110096623 | Phase Based Sensing - A method of sensing using a phase based transducer in which a transducer response is provided at multiple different levels of sensitivity. The different levels of sensitivity are used to produce an output which does not overscale across a wide range of signal levels. This is particularly useful for use in conjunction with multiplexed arrays of fibre optic sensors for seismic surveying. Methods of sensor calibration and noise reduction are also described. | 04-28-2011 |
Philip John Nash, London GB
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20130194105 | SENSOR ARRAY - A sensor arrangement for monitoring a oil reservoir comprises a sensor array ( | 08-01-2013 |
Philip John Nash, Surrey GB
Patent application number | Description | Published |
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20080232748 | Fibre-Optic Package and Method of Making the Same - A fibre-optic package comprises at least two fibre optic devices or components ( | 09-25-2008 |
20090080828 | Fibre Optic Sensor Array - A fibre-optic sensor array ( | 03-26-2009 |
20090087136 | Fibre Optic Sensor Package - A fibre-optic sensor package ( | 04-02-2009 |
20090220244 | Demodulation of Phase Modulated Fibre-Optic Sensor System Signals - Demodulation apparatus for demodulating phase-modulated signals comprises a quadrature signal generator (QSG) for generating in-phase (I) and quadrature-phase (Q) signals in response to an unmodulated input signal. The QSG provides fast frequency tracking of the input signal and excludes any high-frequency content the input signal. | 09-03-2009 |
Richard J. Nash, Portsmouth GB
Patent application number | Description | Published |
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20110241899 | Targeted Enforcement For Road User Charging - A method is disclosed that includes, for a set of passages of a vehicle, where each passage is associated with at least one confidence level, applying at least one heuristic to confidence levels corresponding to the set to determine at least one score. The method also includes performing the applying at least one heuristic for a number of sets of passages of a number of vehicles and selecting a number of the sets based on their associated at least one scores. The method additionally includes outputting identifications corresponding to each of the selected sets. Apparatus and computer readable media are also disclosed. | 10-06-2011 |
20110246058 | Anomaly Detection For Road User Charging System - A computer readable medium embodies a program of machine-readable instructions executable by a processing apparatus to perform operations including determining information corresponding to a number of differences in distances between ending points of journeys taken by a vehicle and starting points of consecutive journeys taken by the vehicle, and transmitting one or more representations of the information. Another computer readable medium tangibly includes instructions for, for each of a number of vehicles, receiving one or more scores corresponding to a vehicle, and determining a ranked list containing at least a portion of the scores, and outputting the ranked list. Another computer readable medium includes instructions for, for each of a number of vehicles, receiving information corresponding to a vehicle, using one or more metrics, calculating one or more values from the received information, and communicating one or more representations of the one or more value to one or more entities. | 10-06-2011 |
Richard John Nash, Hampshire GB
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20080222448 | SYSTEM, METHOD AND PROGRAM PRODUCT FOR RECOVERING FROM A FAILURE - System, method and computer program product for recovering from a failure of a computing device. Start up of a first component of the device is monitored and a determination is made whether the first component has started successfully. If so, a second, higher level component of the device is started. Operational data received from the second component is monitored. If the operational data falls outside of an operational boundary, an action is performed on the second component to enable the second component to operate within a preferred operational boundary. If the first component does not start up successfully, a determination is made if start up of the first component is critical to operation of the second component. If so, a corrective action is performed relative to the first component and afterwards, an attempt is made to start up the second component. | 09-11-2008 |
Robert Nash, Ystrad Meurig GB
Patent application number | Description | Published |
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20110195929 | COMPOUNDS FOR THE TREATMENT OF FLAVIVIRAL INFECTIONS - Described are various compounds and methods for the treatment of flaviviral infections. In particular, alkaloids and imino sugars in arabinose and/or lyxose stereochemical configuration with antiflaviviral activity are described. | 08-11-2011 |
20110237538 | TREATMENT OF LYSOSOMAL STORAGE DISORDERS AND OTHER PROTEOSTATIC DISEASES - Described are various compounds, in particular iminosugars, and methods for the treatment of proteostatic diseases, in particular lysosomal storage disorders. The compound may be a pharmacoperone of an enzyme selected from: (a) Acid alpha-glucosidase; (b) Acid beta-glucosidase; (c) glucocerebrosidase; (d) alpha-Galactosidase A; (e) Acid beta-galactosidase; (f) beta-Hexosaminidase A; (g) beta-Hexosaminidase B; (h) Acid sphingomyelinase; (i) Galactocerebrosidase; (j) Acid ceramidase; (k) Arylsulfatase A; (l) alpha-L-Iduronidase; (m) Iduronate-2-sulfatase; (n) Heparan N-sulfatase; (o) alpha-N-Acetylglucosaminidase; (p) Acetyl-CoA: alpha-glucosaminide N-acetyltransferase; (q) N-Acetylglucosamine-6-sulfate sulfatase; (r) N-Acetylgalactosamine-6-sulfate sulfatase; (s) Acid beta-galactosidase; (t) Arylsulfatase B; (u) beta-Glucuronidase; (v) Acid alpha-mannosidase; (w) Acid beta-mannosidase; (x) Acid alpha-L-fucosidase; (y) Sialidase; and (z) alpha-N-acetylgalactosaminidase. | 09-29-2011 |
Robert Nash, Abingdon GB
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20100317690 | TREATMENT OF PROTEIN FOLDING DISORDERS - Described are various compounds and methods for the treatment of disorders arising from aberrant protein folding, including in particular lysosomal storage diseases. In particular, polyhydroxylated alkaloids and imino sugars which are pharmacoperones of an enzyme and which do not bind to a catalytic site of said enzyme are described. | 12-16-2010 |
Robert James Nash, Ceredigion GB
Patent application number | Description | Published |
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20090047306 | ADJUVANT COMPOSITIONS - An adjuvant composition comprises a Th1-activating alkaloid, optionally further comprising an auxiliary adjuvant selected from a type 2 adjuvant (e.g. alum and/or MF59), a type 1 adjuvant and/or a balanced adjuvant. Vaccines comprising the adjuvant composition include nucleic acid(s) which encode one or more antigenic protein(s); protein(s) or peptide(s); glycoprotein(s); polysaccharide(s) (e.g. carbohydrate(s)); fusion protein(s); lipid(s); glycolipid(s); peptide mimic(s) of polysaccharides carbohydrate(s) and a protein(s) in admixture; carbohydrate-protein conjugate(s); cells or extracts thereof; dead or attenuated cells or extracts thereof; tumour cells or extracts thereof; viral particles (e.g. attenuated viral particles or viral components); allergen(s) mixtures thereof. | 02-19-2009 |
20090117083 | IMMUNOMODULATORY ALKALOIDS - Immunotherapy comprises administration of an alkaloid at a dose sufficient to induce IL-2 production in dendritic cells in a patient. The alkaloid induces the production of IL-2 in dendritic cells. The alkaloids need not be naturally occurring, and may be synthetic analogues or derivatives of naturally occurring counterparts. Such analogues or derivatives are preferably pharmaceutically acceptable analogues, salts, isomers or derivatives as herein defined. However, preferred alkaloids are phytochemicals. Such phytochemicals may be isolated from natural sources or synthesised in vitro. Particularly preferred are alkaloids is selected from piperidine alkaloids; pyrrolin alkaloids; pyrrolidine alkaloids; pyrolizidine alkaloids: indolizidine alkaloids and nortropane alkaloids. | 05-07-2009 |
Robert James Nash, Ystrad-Meurig GB
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20130209516 | IMMUNOMODULATORY COMPOSITIONS - Isolated immunomodulatory (e.g. immunostimulatory) polyhydroxlated pyrrolizidine compounds having the formula (I), wherein R is selected from the group comprising hydrogen, straight or branched, unsubstituted or substituted, saturated or unsaturated acyl, alkyl (e.g. cycloalkyl), alkenyl, alkynyl and aryl groups, or a pharmaceutically acceptable salt or derivative thereof, are useful in therapy and prophylaxis, including increasing the Th1:Th2 response ratio, haemorestoration, alleviation of immuno-suppression, cytokine stimulation, treatment of proliferative disorders (e.g. cancer), vaccination, stimulation of the innate immune response and boosting of the activity of endogenous NK cells. | 08-15-2013 |
20140309258 | ANTI-INFLAMMATORY COMPOUNDS - Compositions comprising isolated ido-BR1 are described for use in therapy or prophylaxis, including the treatment of inflammatory diseases (for example as anti-inflammatory drugs) and to reduce inflammation. Also described are methods for monitoring the quality of a Cucurbitaceae extract, to processes for producing a Cucurbitaceae extract as well as to Cucurbitaceae extracts obtainable by such processes. | 10-16-2014 |
20150191501 | ADVANCED GLYCATION END PRODUCT ANALOGUES - Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families Solanaceae, Compositae, (Asteraceae), Guttiferae, Umbelliferae, Papaveraceae, Vitidaceae or Acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b). | 07-09-2015 |
Robert James Nash, Abingdon GB
Patent application number | Description | Published |
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20110015226 | Treatment of Energy Utilization Disease - Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon. | 01-20-2011 |
20140011841 | TREATMENT OF ENERGY UTILIZATION DISEASE - Described are compositions comprising imino sugar acids for the treatment of energy utilization disease (e.g. metabolic syndrome, including any disease or disorder associated therewith, for example central obesity, elevated levels of triglycerides and diabetes, including type 1 diabetes, type 2 diabetes and insulin resistance), processes for producing said compositions from various plant sources, together with various products, compounds, compositions, medical uses and methods based thereon. | 01-09-2014 |
Robin Nash, Huntworth GB
Patent application number | Description | Published |
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20150053603 | Filtration Apparatus - A filtration apparatus has a housing that has a main housing body and a base closure member. The base closure member is releasably attached to the main housing body, wherein the housing defines an enclosed space. A filter element is disposed in the enclosed space. The housing has a fluid inlet and a fluid outlet. The base closure member has a peripheral channel extending about an entire periphery of the base closure member, wherein the peripheral channel is in communication with the fluid inlet or the fluid outlet of the housing. The base closure member has a fluid inlet passage and/or a fluid outlet passage communicating with the peripheral channel and communicating with the filter element. | 02-26-2015 |