Lieberman, US
Aaron Lieberman, Littleton, CO US
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20150111242 | CELL COLLECTING APPARATUS AND METHOD OF USE - The present invention provides an apparatus and method for microdissecting a biological sample. In particular, apparatuses of the invention include a cell collecting device | 04-23-2015 |
Aaron David Lieberman, Seattle, WA US
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20110281645 | METHOD AND APPARATUS FOR ONLINE RENDERING OF GAME FILES - A method and apparatus for automatically rendering a game file to an audio/video file format to allow the action recorded in the game file to be viewed without requiring the corresponding game and game system. | 11-17-2011 |
Aaron J. Lieberman, Cedar Hills, UT US
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20090154676 | SYSTEM AND METHOD TO DETERMINE AND DELIVER QUOTES FOR DISTANCE-SENSITIVE COMMUNICATION LINKS FROM MULTIPLE SERVICE PROVIDERS - To facilitate real-time pricing, an embodiment of the invention retrieves multiple quotes from multiple databases associated with multiple service providers. Information regarding a customer's location, and the locations of multiple service providers are used to determine the cost of services associated with each of the multiple service providers in real-time. The retrieved quotes are compared, and quotes below a pre-determined price threshold are provided to a user in real-time (e.g., via the Internet). The user can select a desired quote from the quotes provided, and purchase or request more information regarding the desired quote online. | 06-18-2009 |
Benjamin Lieberman, Littleton, CO US
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20150256550 | LOCATION AWARE SECURITY SYSTEM - Methods, computing devices, and systems that dynamically determine whether a request is authorized or fraudulent are described herein. A computing device may receive a request from a communication device, and a geographical location of the communication device may be determined. User information may be requested, and based on the information and the geographical location of the communication device, a risk value can be calculated. A determination of whether to honor the request may be based on the subscriber risk value. | 09-10-2015 |
Bruce Louis Lieberman, Bellevue, WA US
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20110035593 | ESTABLISHING SECURE MUTUAL TRUST USING AN INSECURE PASSWORD - A process for establishing secure mutual trust includes generating a one-time-password. The one-time-password is transferred between the devices in a communication occurring off of the network. Each device generates a set of authenticators by hashing a plurality of sub-strings of the password and the device's authentication certificate with a respective set of nonces. The devices exchange the respective sets of authenticators. Each device then alternates revealing its respective set of nonces and its authentication certificate in a multi-stage process. The devices re-calculate the authenticators based upon the respective set of nonces and authentication certificate revealed by the other device along with the one-time-password sub-strings that it posses. If each device determines that the authenticators re-calculated by the given device matches the authenticators previously received from the other device, secure mutual trust is established. | 02-10-2011 |
David Lieberman, Independence, MN US
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20130317678 | VEHICULAR DUAL MODE MASTER/SLAVE INTERFACE - A vehicular interface may include an electromechanical interface between a hand-held electronic device and subsystems on a vehicular bus or network. In selected embodiments the interface may operate in a “master mode” when a handheld device, such as a tablet computer or smart-phone, is not inserted therein. In this mode the interface may serve as a master controller and accesses and controls various subsystems on a vehicle (such as engine control subsystems, media controllers, navigation systems, sensors and transducers) as a master controller. In one embodiment, when a tablet device is inserted into the interface, the interface may automatically switch to “slave mode” in which it acts as an adapter or interface between the tablet device and the vehicular subsystems. In this mode of operation the user's exclusive interface is through the tablet computer and the tablet computer serves as the master controller for the system. | 11-28-2013 |
20150100658 | Dual Mode Master/Slave Interface - In an illustrative embodiment, a dual mode controller switches between a master mode in which the controller is the primary controller of external display devices and a slave mode wherein the controller functions mainly as a conduit for data, such as video data, sent from an external control and display device (ECD). | 04-09-2015 |
David Lieberman, St. Petersburg, FL US
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20140006127 | Systems and Methods for Earning Virtual Value Associated with Transaction Account Activities | 01-02-2014 |
Eric Lieberman, Scotch Plains, NJ US
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20110232636 | VALVED HOLDING CHAMBER AND MASK THEREFOR - Various embodiments of a valved holding chamber and a mask for a respiratory drug delivery apparatus each having an exhalation valve element having two portions which, based on the movement thereof, encourages proper use of the device. Also, a valved holding chamber having an MDI adapter having a rigid outer portion and a flexible inner portion structured to receive and hold an outlet of an MDI. In addition, a mouthpiece assembly for a valved holding chamber that includes a main body portion and a mouthpiece portion having a plurality of legs for supporting the valved holding chamber in a first orientation and preventing it from freely rolling. | 09-29-2011 |
20110247616 | SYSTEM AND METHOD FOR DISPENSING MEDICAMENT INTO A VENTILATOR CIRCUIT - A drug delivery adapter is configured to facilitate the delivery of one or more medicaments to a subject being ventilated by a circuit (not shown). The circuit may be a ventilator circuit, or the like, configured to convey a pressurized flow of breathable gas to the airway of the subject. The ventilator circuit may form a flow path between a pressure generator and the airway of the subject to deliver a pressurized flow of breathable gas from the pressure generator to the airway of the subject. The drug delivery adapter, in particular, is configured to enable the delivery of one or more medicaments into the pressurized flow of breathable gas being conveyed to the subject by the circuit without compromising the integrity of the circuit through the introduction of ambient air. To facilitate this delivery, the drug delivery adapter is configured to dock one or more types of medicament dispenser. | 10-13-2011 |
Eric Lieberman, Essex, CT US
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20080300856 | System and method for structuring information - A translational language system and method for structuring irregular, or unstructured, information are provided. The language system comprising at least one compulsory characteristic for defining a particular nuance of an irregular communication; and at least one term or phrase corresponding to the at least one compulsory characteristic for further defining the particular nuance of the irregular communication. | 12-04-2008 |
Eric A. Lieberman, Scotch Plains, NJ US
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20100294269 | NEBULIZING DRUG DELIVERY DEVICE WITH AN INCREASED FLOW RATE - The present invention provides a nebulizing drug delivery system for delivering an aerosolized drug to a user having various features to increase the capacity of the drug delivery device. The drug delivery system includes a heater to increase the viscosity of the drug, a double aerosolizing system to double the capacity of the device, and a valve system to continuously replenish drug to the aerosol generator thereby providing a high speed delivery. | 11-25-2010 |
20100313883 | ULTRASONIC BEBULILZER WITH METAL COATED ULTRASONIC GENRATOR - A nebulizer includes a piezoelectric transducer for aerosolizing a drug solution in a disposable cup module disposed above the transducer. Acoustic waves generated by the transducer propagate sequentially through transmitting medium, a first barrier, coupling medium, and a second barrier that forms part of the cup module, and into the interior of the cup module. The transducer at least partially comprises silver. The silver fluidly contacts the transmitting medium to discourage bacteria growth in the transmitting medium. The device includes electronics components that drive the transducer and measure an electrical characteristic associated with the transducer during operation. The electronics components measure changes in the electrical characteristic to determine when the drug solution level falls below a predetermined threshold, and deactivates the device accordingly. | 12-16-2010 |
Eric Andrew Lieberman, Scotch Plains, NJ US
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20130118499 | EXHAUST VALVE AND METHOD OF MANUFACTURE THEREFORE | 05-16-2013 |
Eric Wyld Lieberman, Bellevue, WA US
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20130120401 | Animation of Computer-Generated Display Components of User Interfaces and Content Items - Animation of computer-generated display components of user interfaces and content items is provided. An animation application or engine creates images of individual display components (e.g., bitmap images) and places those images on animation layers. Animation behaviors may be specified for the layers to indicate how the layers and associated display component images animate or behave when their properties change (e.g., a movement of an object contained on a layer), as well as, to change properties on layers in order to trigger animations (e.g., an animation that causes an object to rotate). In order to achieve high animation frame rates, the animation application may utilize three processing threads, including a user interface thread, a compositor thread and a rendering thread. Display behavior may be optimized and controlled by utilizing a declarative markup language, such as the Extensible Markup Language, for defining display behavior functionality and properties. | 05-16-2013 |
Harvey Lieberman, Hoboken, NJ US
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20120022099 | NOVEL POLYMORPHIC FORMS OF AN AZABICYCLO-TRIFLUOROMETHYL BENZAMIDE DERIVATIVE - The present disclosure is directed to solid forms of the compound of formula (I): | 01-26-2012 |
Howard B. Lieberman, Tenafly, NJ US
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20100168202 | RAD 9 AS A DIAGNOSTIC,PROGNOSTIC,AND THERAPEUTIC TOOL FOR PROSTATE CANCER - This disclosure provides a method of treating a human subject having a cancer which comprises administering to the subject a nucleic acid so as to inhibit expression of human RAD9 protein in a cell of the cancer so as to thereby treat the human subject. This disclosure also provides methods of assessing gains in prostate cancer therapy and detecting prostate cancer. | 07-01-2010 |
20120028260 | RAD9 AS A DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC TOOL FOR PROSTATE CANCER - This disclosure provides a method of treating a human subject having a cancer which comprises administering to the subject a nucleic acid so as to inhibit expression of human RAD9 protein in a cell of the cancer so as to thereby treat the human subject. This disclosure also provides methods of assessing gains in prostate cancer therapy and detecting prostate cancer. | 02-02-2012 |
Isador Lieberman, Plano, TX US
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20110319941 | Robot Guided Oblique Spinal Stabilization - A robotic system for performing minimally invasive spinal stabilization, using two screws inserted in oblique trajectories from an inferior vertebra pedicle into the adjacent superior vertebra body. The procedure is less traumatic than such procedures performed using open back surgery, by virtue of the robot used to guide the surgeon along a safe trajectory, avoiding damage to nerves surrounding the vertebrae. The robot arm is advantageous since no access is provided in a minimally invasive procedure for direct viewing of the operation site, and the accuracy required for oblique entry can readily be achieved only using robotic control. This robotic system also obviates the need for a large number of fluoroscope images to check drill insertion position relative to the surrounding nerves. Disc cleaning tools with flexible wire heads are also described. The drilling trajectory is determined by comparing fluoroscope images to preoperative images showing the planned path. | 12-29-2011 |
20120239149 | APPARATUS FOR REPLACING A DAMAGED SPINAL DISC - An apparatus for replacing a damaged spinal disc in a spinal column includes a first retaining device having an outer surface engageable with a first vertebra of the spinal column and an inner surface. A second retaining device has an outer surface engageable with a second vertebra of the spinal column and an inner surface. A resilient core has a first surface and a second surface. The first surface engages the inner surface of the first retaining device. The second surface engages the inner surface of the second retaining device. The resilient core has a tapered radially outer surface extending from adjacent the first surface to adjacent the second surface. The first retaining device may have a flange extending toward the second retaining device. A concave surface may extend between the first surface and the radially outer surface. The concave surface of the core may engage the flange when the apparatus is free of a load. | 09-20-2012 |
Isador H. Lieberman, Fort Lauderdale, FL US
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20090112269 | APPARATUS AND METHOD FOR AFFIXING BODY STRUCTURES - An apparatus for affixing a plurality of body structures together in a flexible manner includes a first articulated fastener having substantially rigid proximal and distal portions, longitudinally separated by a first flexible articulating portion. The first articulated fastener has a first thread direction. A second articulated fastener has substantially rigid proximal and distal portions, longitudinally separated by a second flexible articulating portion. The second articulated fastener has a second thread direction opposite the first thread direction. The first and second articulated fasteners are both adapted for insertion into each of the plurality of body structures. A method of affixing a plurality of body structures together in a flexible manner is also provided. | 04-30-2009 |
20100016874 | APPARATUS AND METHOD FOR CONNECTING TWO ELONGATE BODY TISSUES - An apparatus for connecting two elongate body tissues is described. A flexible outer surface has a first outer end longitudinally spaced from a second outer end. A flexible inner surface has a first inner end longitudinally spaced from a second inner end. A first end aperture is defined by a flexible connection between the first outer end and the first inner end. The first end aperture is configured to accept a first elongate body tissue. A second end aperture is defined by a flexible connection between the second outer end and the second inner end. The second end aperture is configured to accept a second elongate body tissue. The outer and inner surfaces are configured for relative eversion operative to longitudinally shift an instantaneous midpoint of the apparatus with respect to a reference location on the inner surface. A method of using the apparatus is also provided. | 01-21-2010 |
20100036418 | FACET AUGMENTATION - A method for augmenting or replacing a spinal facet ( | 02-11-2010 |
Isador H. Lieberman, Pepper Pike, OH US
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20110160776 | APPARATUS AND METHOD FOR BODY TISSUE FIXATION - A body tissue fixation apparatus includes a plate having oppositely disposed outer and tissue-contacting surfaces, and at least one fixation hole extending between the outer and tissue-contacting surfaces along a longitudinal axis. The fixation hole is defined in part by an inner hole surface having at least one serration. The plate is adapted for affixation to at least one body tissue member. At least one fixation device of the body tissue fixation apparatus has a shank and a head portion, the shank being insertable through the fixation hole in the plate to affix the plate to the body tissue member upon rotation of the head portion. At least one deformable member is connected to the head portion, the deformable member extending laterally in a direction substantially perpendicular to the longitudinal axis and being adapted to deflect to engage with at least one serration formed on the inner hole surface. Engagement between the deformable member and the serration helps to prevent displacement of the fixation device within the fixation hole. A method for using the body tissue fixation apparatus is also described. | 06-30-2011 |
Isador H. Lieberman, Ft. Lauderdale, FL US
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20100106196 | METHOD AND SYSTEM FOR ATTACHING A PLATE TO A BONE - A method for attaching a plate to a bone is described. A guide tool having a through bore and at least one distal locating feature is provided. The distal locating feature of the guide tool is placed into a predetermined relationship with the plate. A fastener is engaged with a distal end of a driver shaft of a fastener driver. The fastener driver has a driver orientation means associated with the driver shaft. The fastener is inserted into the through bore of the guide tool with the fastener driver. The driver orientation means is mated with a guide orientation means located in the through bore of the guide tool. At least a portion of the fastener is inserted through the fastener hole. The fastener is secured into the bone through actuation of the fastener driver. At least one of a fastener travel distance, a fastener insertion orientation, and a fastener insertion pitch is guided through the mating of the driver orientation means and the guide orientation means. The fastener driver is withdrawn from the guide tool. The guide tool is withdrawn from the plate. A system for attaching a plate to a bone is also provided. | 04-29-2010 |
Isidore Lieberman, Ft. Lauderdale, FL US
Patent application number | Description | Published |
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20150196326 | Robot Guided Oblique Spinal Stabilization - A robotic system for performing minimally invasive spinal stabilization, using two screws inserted in oblique trajectories from an inferior vertebra pedicle into the adjacent superior vertebra body. The procedure is less traumatic than such procedures performed using open back surgery, by virtue of the robot used to guide the surgeon along a safe trajectory, avoiding damage to nerves surrounding the vertebrae. The robot arm is advantageous since no access is provided in a minimally invasive procedure for direct viewing of the operation site, and the accuracy required for oblique entry can readily be achieved only using robotic control. This robotic system also obviates the need for a large number of fluoroscope images to check drill insertion position relative to the surrounding nerves. Disc cleaning tools with flexible wire heads are also described. The drilling trajectory is determined by comparing fluoroscope images to preoperative images showing the planned path. | 07-16-2015 |
Jay R. Lieberman, Avon, CT US
Patent application number | Description | Published |
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20140081408 | FEMORAL KNEE PROSTHESIS SYSTEM WITH AUGMENTS AND MULTIPLE LENGTHS OF SLEEVES SHARING A COMMON GEOMETRY - A modular knee prosthesis system includes a femoral component having a stem, a plurality of different sizes of sleeves mountable on the stem, and a plurality of different sizes of augments mountable on the femoral component. The system is modular, and provides the surgeon with the option of distally offsetting the joint line by selecting the size of sleeve that will provide the desired joint line. The different sizes of sleeves have different axial lengths but share a common geometry along a substantial part of their lengths so that the same bone cavity will accept multiple sizes of sleeves. | 03-20-2014 |
20140081410 | MODULAR KNEE PROSTHESIS SYSTEM WITH MULTIPLE LENGTHS OF SLEEVES SHARING A COMMON GEOMETRY - A modular knee prosthesis system includes a femoral component having a stem and a plurality of different sizes of sleeves mountable on the stem. The system is modular, and provides the surgeon with the option of distally offsetting the joint line by selecting the size of sleeve that will provide the desired joint line. The different sizes of sleeves have different axial lengths but share a common geometry along a substantial part of their lengths so that the same bone cavity will accept multiple sizes of sleeves. | 03-20-2014 |
20140081411 | SURGICAL INSTRUMENT SYSTEM WITH MULTIPLE LENGTHS OF BROACHES SHARING A COMMON GEOMETRY - An orthopaedic surgical instrument system includes a first broach including a first end configured to be separately secured to a handle and a tapered body having a plurality of cutting teeth defined therein, and a second broach including a first end configured to be separately secured to the handle in place of the first broach, a first tapered body extending distally from a second end positioned opposite the first end, and a second tapered body extending distally from the first tapered body. The tapered body of the first broach and the first tapered body of the second broach have a first outer geometry and the second tapered body has a second outer geometry different from the first outer geometry. | 03-20-2014 |
Jeff Lieberman, Cambridge, MA US
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20090023122 | Motor Learning And Rehabilitation Using Tactile Feedback - There is disclosed a process for motor learning, for teaching motion, or for rehabilitation of a student, the student having a motor sensory system. Plural transducers may be coupled around at least one joint of a student, the transducers for providing kinesthetic sensations to the student through its motor sensory system. Tactile control signals may be provided to control operation of the transducers to guide motions of the student. | 01-22-2009 |
20090309440 | System and Method For Device Suspension and Wireless Power Transmission - A system and method for device suspension and wireless power transmission are disclosed. According to one embodiment, an apparatus, comprises a suspended object having a wireless receiving circuit. A wireless transmission circuit is configured to transmit power to the wireless receiving circuit housed in the suspended object. A magnetic stabilization mechanism is beneath and not in contact with suspended object. A circuit is configured to magnetically control a position of the suspended object. | 12-17-2009 |
20110163611 | SYSTEM AND METHOD FOR DEVICE SUSPENSION AND WIRELESS POWER TRANSMISSION - A system and method for device suspension and wireless power transmission are disclosed. According to one embodiment, an apparatus, comprises a suspended object having a wireless receiving circuit. A wireless transmission circuit is configured to transmit power to the wireless receiving circuit housed in the suspended object. A magnetic stabilization mechanism is beneath and not in contact with suspended object. A circuit is configured to magnetically control a position of the suspended object. | 07-07-2011 |
Joshua S. Lieberman, Pompton Lakes, NJ US
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20100270322 | FLOW CONTROL ELEMENT FOR USE WITH LEAK-PROOF CUP ASSEMBLIES - There is provided a flow control element for use with a drinking cup cap having a first mating member in fluid communication with a spout aperture. The flow control element has a first stack and a first valve. The first stack has an upper portion that can be positioned to be removably sealed in or with the cap. The first valve is defined in a sidewall of the first stack and is configured to provide selective fluid communication with the spout aperture. | 10-28-2010 |
Judy Lieberman, Brookline, MA US
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20080227733 | Method for Treating and Preventing Ischemia-Reperfusion Injury Using Rna Interfering Agent - The present invention is based, at least in part, on the discovery of methods useful in the modulation, e.g., inhibition, of gene expression or protein activity, e.g., apoptosis-related gene expression, e.g., Fas gene expression or cytokine expression, e.g., proinflammatory cytokine expression. In particular, the present invention is based on novel RNA interfering agents, e.g., siRNA in reduction, e.g., prolonged reduction, of apoptosis-related gene expression or cytokine expression in cells. Inhibition of apoptosis-related gene expression or protein activity or cytokine gene expression or protein activity, e.g. by the siRNAs used in the methods of the invention, inhibits ischemia-reperfusion injury. | 09-18-2008 |
20090022783 | siRNA MICROBICIDES FOR PREVENTING AND TREATING DISEASES - The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally. | 01-22-2009 |
20100113560 | COMPOSITIONS AND METHODS FOR TREATING HEMATOPOIETIC MALIGNANCIES - Described herein are compositions and methods for the prevention and treatment of hematopoietic malignancies. The compositions are miRNAs and associated nucleic acids. | 05-06-2010 |
20100273859 | TREATMENT AND PREVENTION OF HIV INFECTION - Disclosed herein are methods for treating and/or preventing HIV infection in a cell. The methods involve downmodulating one or more of the HIV-dependency factors (HDFs) disclosed herein to thereby treat and/or prevent HIV infection in the cell. Downmodulating the HDFs can be by contacting the cell with an agent that downmodulates the HDF. Also disclosed herein are methods for treating and/or preventing HIV infection in a subject comprising downmodulating one or more of the HIV-dependency factors (HDFs), disclosed herein, to thereby treat and/or prevent HIV infection in the subject. The method may further comprise selecting a subject diagnosed with or at risk for HIV infection, prior to downmodulating. Downmodulating the HDFs may comprise administering an agent that downmodulates the HDF to the subject such that the agent contacts HIV host cells of the subject. The agent may inhibit HDF gene expression, protein synthesis, HDF function or HDF activity, or combinations thereof. | 10-28-2010 |
20100310583 | LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER - The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells. | 12-09-2010 |
20110142854 | COMPOSITIONS AND METHODS FOR INHIBITION OF RETROVIRUSES - Described herein are methods and compositions for the inhibition of retroviral integration and replication. The methods and compositions inhibit the activity of one or more components of the SET complex or base excision repair enzymes and induce autointegration of retroviral double-stranded nucleic acid. | 06-16-2011 |
20120040851 | miRNA TARGETS - The present invention provides systems for identifying, isolating, and/or characterizing targets of micro RNAs. | 02-16-2012 |
20120059043 | THERAPEUTIC AND DIAGNOSTIC STRATEGIES - The present invention encompasses the finding that microRNAs (miRNAs) regulate certain key proteins involved in DNA repair. In some embodiments, a miRNA suppresses levels and/or activity of one or more DNA repair proteins. In some such embodiments, such suppression renders cells hypersensitive to certain DNA damage agents (e.g., γ-irradiation and genotoxic drugs, among others). The present invention provides various reagents and methods associated with these findings including, among other things, strategies for treating cell proliferative disorders, certain diagnostic systems, etc. | 03-08-2012 |
20120087973 | siRNA MICROBICIDES FOR PREVENTING AND TREATING DISEASES - The invention provides a microbicidal composition comprising at least one siRNA. The siRNA is an RNA duplex made of one or two molecules. A portion of the siRNA is identical to a target sequence in an essential gene of a virus. The virus may be a herpesvirus, for example, HSV-1 or HSV-2. Preferably, the herpesvirus is HSV-2. The microbicidal composition further comprises a pharmaceutically acceptable carrier. Also included in the invention are methods to prevent and treat viral infections by administration of the microbicidal composition. Preferably, the microbicidal composition is administered transmucosally. | 04-12-2012 |
20120100160 | Methods for Inducing Mixed Chimerism - Fusion protein-siRNA complexes that specifically target activated T cells, and methods of use thereof, are described. | 04-26-2012 |
20120258534 | METHOD OF DELIVERING RNA INTERFERENCE AND USES THEREOF - The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell. | 10-11-2012 |
20130129752 | TARGETED DELIVERY TO LEUKOCYTES USING PROTEIN CARRIERS - Disclosed herein are is a leukocyte-selective delivery agent comprising, a targeting moiety that selectively binds LFA-I, a protein carrier moiety covalently linked to the targeting moiety, and a therapeutic agent associated with the carrier moiety. The delivery agent may be further selective for activated leukocytes, wherein the targeting moiety selectively binds LFA-I in its activated conformation. The targeting moiety comprises an antibody or functional fragment thereof, such as an scFV. Examples of antibodies or fragments thereof which selectively bind LFA-I activated conformation bind to the locked open I domain of LFA-I, or binds to the leg domain of the β2 subunit of LFA-I ((ILP2)—The antibody or functional fragment thereof may alternatively bind non-selectively to both low affinity and high affinity LFA-I. Examples of a non-protein carrier are a basic polypeptide such as protamine or a functional fragment thereof. One such fragment is RSQSRSRYYRQRQRSRRRRRRS. The therapeutic agent may comprise one or more of a nucleic acid, a small molecule, a polypeptide, and an antibody or functional fragment thereof. An example of a nucleic acid delivery agent comprises an RNA interference molecule. Examples of RNA interference molecules are siRNA, dsRNA, StRNA, shRNA, miRNA, and combinations thereof. Specific siRNAs are provided. Other examples of a nucleic acid delivery agent are a small RNA, an antagomir, an LNA, and an antisense oligonucleotide. Methods for leukocyte-selective delivery, or activated leukocyte-selective delivery in vivo, in vitro and ex vivo are also provided. | 05-23-2013 |
20130302331 | METHOD OF DELIVERING RNA INTERFERENCE AND USES THEREOF - The invention provides a method of RNA interference, which comprises contacting the cell with a fusion protein-double stranded RNA complex, the complex comprising the double stranded RNA segment containing a double stranded RNA of interest and a fusion protein, the fusion protein comprising (1) a targeting moiety, which will specifically binds to a site on a target cell, and (2) a binding moiety, which will bind to the double stranded RNA, wherein the double stranded RNA segment initiates RNA interference in the cell. | 11-14-2013 |
20130338215 | COMPOSITION AND METHOD FOR OLIGONUCLEOTIDE DELIVERY - The invention provides aptamer-gene modulator conjugates, where the aptamer and the gene modulator are linked together. The invention further provides a method for cell-specific delivery of gene modulators to hard to transfect cells such as CD4+ cell. | 12-19-2013 |
20140155332 | SELECTIVE INHIBITORS OF TUMOR-INITIATING CELLS - Described herein are novel malignancy associated gene signature biomarkers, and assays and methods thereof, to classify prognosis or malignant potential of a cancer and identify cancer-initiating cells. The malignancy associated gene signature biomarkers, assays and methods described herein provide, in part, new methodologies to screen for novel drugs for treating cancers and tumors, such as, for example, triple-negative breast tumors. Using the assays and methods described herein proteasome inhibitors, histone deacetylase inhibitors, and glycolysis inhibitors, were identified as being highly effective in altering gene expression signatures specifically in malignant or cancer-initiating cells. | 06-05-2014 |
20140377263 | LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER - The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have reduced expression or are lacking in the cancer stem cells. In some embodiments, the miRNAs that are reduced or lacking in cancer stem cells are let-7 miRNAs. In alternative embodiments, the present invention relates to a method of treating and/or preventing cancer comprising targeting cancer stem cells by administering miRNAs which have increased expression levels in the cancer stem cells. Another aspect of the present invention relates to methods to enrich for a cancer stem cell population. Another aspect of the present invention relates to methods to identify miRNAs which contribute to the self-renewal capacity of cancer stem cells. | 12-25-2014 |
20150337306 | METHODS AND COMPOSITIONS FOR THE PRODUCTION OF SIRNAS - The technology described herein relates to siRNAs, e.g., methods and compositions relating to the production of siRNAs in bacterial cells. | 11-26-2015 |
20150353991 | MIRNA TARGETS - The present invention provides systems and methods for identifying, isolating, and/or characterizing microRNAs, their targets, and microRNA response elements, and for predicting their biological function. | 12-10-2015 |
Kenneth W. Lieberman, Tenafly, NJ US
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20110190760 | INTEGRATED FIBER OPTIC RAMAN SPECTROSCOPY AND RADIO FREQUENCY ABLATION - Technologies are generally described for detecting diseased tissues through fiber optic based Raman spectroscopy, image acquisition, and/or RF induced hyperthermia treatment of the detected tissues in an integrated manner. A fiber optic bundle for carrying optical and RF signals for the spectroscopy, visual imaging, and RF ablation may also be used to detect a temperature of the treated tissue such that level and duration of the RF signal can be controlled for optimum results. A shielding configuration in the form of a coaxial waveguide of the fiber optic bundle may be used to guide and deliver the RF signal. Sources and detectors for the optical and RF signals may be integrated into an endoscopic probe containing the fiber optic bundle or be externally positioned. An integrated or remote controller may be employed to manage the optical imaging, spectroscopy, RF ablation, and thermal sensing operations. | 08-04-2011 |
Mark Tony Lieberman, Raleigh, NC US
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20080273925 | In situ pH adjustment for soil and groundwater remediation - A method for increasing the pH of subsurface material, contaminated with organic and inorganic compounds is disclosed. The pH is increased by introducing a solid alkaline material formulated into a suspension where particle size, surface charge and degree of flocculation are controlled to enhance transport and distribution throughout the treatment zone. | 11-06-2008 |
Marya Lieberman, South Bend, IN US
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20130034908 | ANALYTICAL DEVICES FOR DETECTION OF LOW-QUALITY PHARMACEUTICALS - An analytical device, in particular, a paper analytical device (PAD), for detection of at least two chemical components indicative of a low quality pharmaceutical product is provided. The analytical device can include a porous, hydrophilic medium, at least two assay regions associated with the porous, hydrophilic medium, at least one assay reagent or precursor thereof in the assay regions, and at least one electronically readable information zone. | 02-07-2013 |
20150160245 | PPM QUANTIFICATION OF IODATE USING PAPER DEVICE - A highly sensitive method that utilizes a Paper Analytical Device (PAD) which measures part per million (ppm) levels of iodate iodometric titration is provided. The PAD quantifies concentrations of 0.6-15 parts per million (ppm) of iodine. The PAD has at least 12 reaction zones that contain dried reagents thereon and at least one electronically readable information zone. Salt and water are mixed and drops are placed onto 12 reaction zones that contain the loaded dry reagents. The PAD is shaken and the reaction zones turn blue if a preset iodate concentration has been exceeded. Test results are analyzed by comparing the PAD or an image of the PAD with standards, either by eye or with image analysis software to measure the color intensities which are compared to a calibration curve to quantify the iodate levels. The image analysis quantifies iodine with an average absolute accuracy and precision of 0.9 ppm over a range of 0.6-15 ppm. | 06-11-2015 |
Michael D. Lieberman, Silver Spring, MD US
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20160125005 | Apparatus and Method for Profiling Activities and Transitions - A method and apparatus for generating a structured profile of activities and transitions is provided. The method includes receiving data related to a plurality of activities and a plurality of transitions, wherein each of the plurality of transitions is a path between a pair of activities among the plurality of activities, storing the data related to the plurality of activities and the plurality of transitions into the storage device, reducing a dimension of the data by indexing the data using state variables, generating a plurality of nodes, wherein each of the plurality of nodes corresponds to each of the plurality of activities, generating a plurality of links, wherein each of the plurality of links corresponds to each of the plurality of transitions, and storing the plurality of nodes and the plurality of links as the structured profile at the storage device. | 05-05-2016 |
Michael Ian Lieberman, Portland, OR US
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20090012816 | SYSTEMS AND METHODS FOR CLINICAL ANALYSIS INTEGRATION SERVICES - Certain embodiments of the present invention provide systems and methods for organizing and querying patient data by a clinical information system via a clinical analysis integration service. Certain embodiments provide an electronic patient data system for exchanging electronic patient data between a data repository and a clinical system. The electronic patient data system includes an electronic data repository configured to aggregate and store patient-related data. The electronic data repository is accessible to and searchable by a plurality of clinical systems via a clinical analysis integration service. The system also includes a clinical analysis integration service providing data from the electronic data repository to one or more clinical systems in response to a query from a clinical system. In certain embodiments, one or more clinical systems may provide feedback to the electronic data repository and engage in an iterative dialog. | 01-08-2009 |
Paul M. Lieberman, Wynnewood, PA US
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20140113897 | COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF EPSTEIN-BARR NUCLEAR ANTIGEN 1 - The present invention embraces compounds that modulate the activity of Epstein-Barr Nuclear Antigen 1 (BBNA1) protein and use thereof in methods for treating latent Epstein-Barr virus infection. R | 04-24-2014 |
Randy A. Lieberman, Bloomfield, MI US
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20080208133 | SYSTEMS AND METHODS FOR GAINING ACCESS AROUND AN IMPLANTED MEDICAL DEVICE - Systems for gaining access into a body of a patient around an implanted body of an elongate medical device include a sheath having a deformable wall that allows insertion of the device body into a lumen surrounded by the sheath wall. The sheath wall may include first and second edges that extend from a proximal end to a distal end of the lumen, or just extend along a distal portion of the lumen. A tool, which includes a groove sized to grasp about a circumference of the device body, may facilitate insertion of the device body into the lumen of those sheath embodiments that include the first and second edges, by spreading at least one of the first and second edges of the wall apart from the other of the first and second edges while the device body is grasped within the tool. | 08-28-2008 |
20110282289 | Systems and Methods for Gaining Access Around an Implanted Medical Device - Systems for gaining access into a body of a patient around an implanted body of an elongate medical device include a sheath having a deformable wall that allows insertion of the device body into a lumen surrounded by the sheath wall. The sheath wall may include first and second edges that extend from a proximal end to a distal end of the lumen, or just extend along a distal portion of the lumen. A tool, which includes a groove sized to grasp about a circumference of the device body, may facilitate insertion of the device body into the lumen of those sheath embodiments that include the first and second edges, by spreading at least one of the first and second edges of the wall apart from the other of the first and second edges while the device body is grasped within the tool. | 11-17-2011 |
Richard Lieberman, Baltimore, MD US
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20090198517 | Pharmacy Episodes of Care - A computer-implemented method for grouping, categorizing, and profiling pharmaceutical claims data to assist health care managers in determining (a) medication treatment experience, outcomes, and medication compliance behaviors of patients and (b) appropriate drug prescribing, medication coordination, and cost-efficiency of health care providers. An objective means is provided for categorizing and quantifying patterns of prescription drug utilization as a health care service within a clinically relevant time frame. A pharmacy episode group (PEG) is a pharmacologically homogenous grouping of drugs with the same therapeutic ingredients used by a patient once or over an extended period of time. The PEG is a patient-centered pharmacy classification unit, which uses script-level pharmacy claim data as input data and assigns each script to the appropriate episode. Pharmacy episodes are categorized based on algorithms linking the pattern of a physician's recommended use (drug supply) and the patient's pattern of compliance (intervals between fill dates). The system also identifies multi-drug and concurrent use drug episodes, flags patients' records where intervals between scripts suggest non-compliance with recommended therapy, selects the most recent claims, resets windows (episode start and end dates), and ultimately assigns all pharmacy claims to episodes. | 08-06-2009 |
20120143627 | Pharmacy Episodes of Care - Grouping, categorizing, and profiling pharmaceutical claims data to assist health care managers is described. In aspects, a method is described including receiving pharmacy claims data records, validating each of the claims data records for a valid drug code, establishing a number of validated pharmacy claims data records received for each drug identified, grouping the validated pharmacy claims data records to one or more pharmacy episodes, categorizing each pharmacy episode, and storing the validated pharmacy claims data records and associated pharmacy episodes for monitoring usage of prescription drugs. In various embodiments, a pharmacy episode group is a pharmacologically homogenous grouping of drugs with the same therapeutic ingredients used by a patient once or over an extended period of time, and pharmacy episodes are categorized based on algorithms linking the pattern of a physician's recommended use and the patient's pattern of compliance. | 06-07-2012 |
Richard N. Lieberman, Baltimore, MD US
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20120303378 | SYSTEM AND METHOD FOR MONITORING AND MEASURING QUALITY PERFORMANCE OF HEALTH CARE DELIVERY AND SERVICE - A software driven health care quality management system is disclosed. This system is user friendly, allowing easy navigation through various screens that enable the user to identify drivers of Star Rating System performance. The present invention offers easy drill-down functionality from a plan level, to a provider group, individual provider, and member level to provide actionable data that can improve the quality of care and ultimately a plan's star ratings. This system addresses each of the drivers that influence overall plan revenue, by providing an enterprise business intelligence system, designed to maximize process quality measures, promote value-based purchasing, and maximize risk-adjusted revenue for such health plans and health provider organizations. | 11-29-2012 |
Rick G. Lieberman, Streetsboro, OH US
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20090074535 | FASTENER ASSEMBLY - A fastener assembly configured to secure a component to an interior wall of a housing includes a wall mount configured to securely mount to the interior wall of the housing. The wall mount includes a first plate secured to a second plate through a neck. The first plate has a larger axial cross-sectional area than the second plate, which, in turn, has a larger axial cross-sectional area than the neck. The second plate is configured to pass through a portion of a securing passage formed through the housing. The first plate is larger than the portion of the securing passage, so that the first plate is unable to pass through the securing passage. The wall mount is configured to be rotated into a locked position with respect to the securing passage, wherein the wall mount is prevented from shifting in the locked position. | 03-19-2009 |
Sarah M. Lieberman, Bridgewater, NJ US
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20120216270 | Method and Apparatus for Graphical Presentation of Firewall Security Policy - A graphical representation of the firewall and a network coupled to the firewall is generated and displayed. A number of an inbound port of the network is displayed. An arrow adjacent to the port number pointing toward the network is displayed to indicate that a communication is permitted to the port. The port number and the arrow are located between an icon for the network and an icon for the firewall. A port number of a destination of a communication originating from the network is displayed. Also, another arrow adjacent to the destination port number pointing toward the firewall is displayed to indicate that a communication is permitted to the destination port number. The destination port number and the other arrow are located between an icon for the network and an icon for the firewall. | 08-23-2012 |
Stevan Lieberman, Washington, DC US
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20090119198 | Method for Domain Trading - A method for domain portfolio trading involving the assessment of risk level based on various tangible criteria and applying this determination to the assignment of a value. Once the aggregated level of risk and actual value number are determined, a real-time, online domain portfolio trading mechanism allows those involved to track, move, implement and otherwise conduct business in an instantaneous environment. | 05-07-2009 |
Stevan H. Lieberman, Silver Spring, MD US
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20110282752 | Website Creation Method - Creation of a website that gathers data on visitors as if it is run by an actual company related to the content of the website. The data gathered on visitors is then sold and/or the entire website is then sold. The website is not a shell or template, but rather is an actual operating website that generates its own traffic and advertisements. The website can even feature polls, contributions, and email lists. | 11-17-2011 |
20120105440 | Augmented Reality System - User created, maintained, and managed spatially coordinated and aware virtual data association system allowing any type of information to be associated to any item of location in the real world and associated viewing methods. | 05-03-2012 |
20120256917 | Augmented Reality System - User created, maintained, and managed spatially coordinated and aware virtual data association system allowing any type of information to be associated to any item of location in the real world and associated viewing methods. A method for allowing individuals to be able to see 2D or 3D objects that are placed in a virtual environment via a portable viewing device such as a cell phone or a heads up display. By displaying user-selected augmented reality (AR) feeds over a portable viewing device, individuals are capable of customizing the channels returned from an assortment of geo-spatial databases. | 10-11-2012 |
Steven H. Lieberman, Washington, DC US
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20100293054 | Method of Customizing Webpages for Content/Advertising by Using Cost perAction Fees and Rebates - A method for advertisers to promote their services or products on the Internet using a cost-per-action fee with a low to zero pay-per-click fee. A business method provides for an online search advertising company that dynamically customizes webpages for content and advertising based on searches performed by users and other important criteria. Advertisers can opt-in to an automated rebate system that automatically pays them and the user back for sales made through the system. | 11-18-2010 |
Steven H. Lieberman, Silver Spring, MD US
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20120011440 | Method for Online Grid Associations - A method of permitting account holders to communicate, interact and otherwise associate at least one primary grid account with additional grids by linking avatars via unique associations in a database between 3-dimensional online environments. A process is used where a user can register and make purchases relating to item listings and the association between the primary grid and the at least one additional grids. In addition, a process of delivery identification, linking avatars and listing and linking items also are combined. | 01-12-2012 |
Todd Lieberman, Philadelphia, PA US
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20140032303 | METHOD AND SYSTEM FOR PHONE NUMBER CLEANING - A system for tracking telephone calls made in response to advertising campaigns in electronic or other media is provided. The system permits an advertiser to associate specific and distinct telephone numbers with associated advertising campaigns. The system cleans at least one phone number to be assigned to a campaign by determining that unwanted phone traffic associated with the at least one phone number is below a defined threshold. | 01-30-2014 |
20140046755 | METHOD AND SYSTEM FOR COLLECTING DATA FROM ADVERTISING CAMPAIGNS INCLUDING PHONE NUMBER PLACEMENT TECHNIQUES - A system for tracking telephone calls made in response to advertising campaigns in electronic or other media is provided. The system permits an advertiser to associate specific and distinct telephone numbers with associated advertising campaigns. The system further modifies advertiser-provided information in response to the advertising campaign to which a potential customer responds, and includes the associated telephone number in the modified advertiser information. The system processes telephone calls made to the selected telephone numbers, and provides reports to advertisers of call data associated with the respective advertising campaigns. | 02-13-2014 |
20140052528 | MONITORING CAMPAIGN REFERRAL SOURCES - A method and system for tracking telephone calls made in response to advertising campaigns in electronic or other media. An advertiser is permitted to associate a specific and distinct telephone number with an associated advertising campaign. Telephone calls made to the selected telephone numbers are correlated to the referring campaign and reports are providers to advertisers of call data associated with the respective advertising campaign. | 02-20-2014 |
20140052529 | METHOD AND SYSTEM FOR TRACKING TELEPHONE CALLS - A system for tracking telephone calls made in response to advertising campaigns in electronic or other media is provided. The system permits an advertiser to associate specific and distinct telephone numbers with associated advertising campaigns. The system further modifies advertiser-provided information in response to the advertising campaign to which a potential customer responds, and includes the associated telephone number in the modified advertiser information. The system processes telephone calls made to the selected telephone numbers, and provides reports to advertisers of call data associated with the respective advertising campaigns. | 02-20-2014 |
Todd Lieberman, Haverford, PA US
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20110106631 | System and Method for Generating and Managing Interactive Advertisements - Embodiments of the present invention relate to a system and method for creating an interactive advertisement. The interactive advertisement is configured to convey a brand message to a user while at the same time provide website security by reducing unauthorized website access by Interenet bots. According to certain embodiments of the present invention, users are required to adequately respond to the interactive advertisement in order to access certain website content. The user responses to the interactive advertisements are collected and utilized to generate marketing reports which illustrate the effectiveness of an interactive advertisement in conveying an advertiser's message. | 05-05-2011 |
20120166294 | SYSTEM AND METHOD FOR SKIPPABLE PRE-ROLL VIDEO ADVERTISING - A system and method for presenting a skippable pre-roll interactive advertisement (e.g., a pre-roll video). The interactive advertisement is configured to be presented in advance of content requested by a user and convey a brand message to a user while at the same time providing the user with an associated type-in challenge (i.e., a challenge or question relating to the pre-roll advertisement) which, if answered appropriately, allows the user to skip or bypass the pre-roll advertisement and advance to the desired content. The user response to the interactive advertisement may be collected and utilized to generate marketing reports which illustrate the effectiveness of an interactive advertisement in conveying an advertiser's message. | 06-28-2012 |
20130204666 | System and Method for Generating and Managing Interactive Advertisements - Embodiments of the present invention relate to a system and method for creating an interactive advertisement. The interactive advertisement is configured to convey a brand message to a user while at the same time provide website security by reducing unauthorized website access by Internet bots. According to certain embodiments of the present invention, users are required to adequately respond to the interactive advertisement in order to access certain website content. The user responses to the interactive advertisements are collected and utilized to generate marketing reports which illustrate the effectiveness of an interactive advertisement in conveying an advertiser's message. | 08-08-2013 |
Todd Lieberman, Lasayette Hill, PA US
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20120059709 | METHOD AND SYSTEM FOR TRACKING TELEPHONE CALLS - A system for tracking telephone calls made in response to advertising campaigns in electronic or other media is provided. The system permits an advertiser to associate specific and distinct telephone numbers with associated advertising campaigns. The system further modifies advertiser-provided information in response to the advertising campaign to which a potential customer responds, and includes the associated telephone number in the modified advertiser information. The system processes telephone calls made to the selected telephone numbers, and provides reports to advertisers of call data associated with the respective advertising campaigns. | 03-08-2012 |
Wayne Lieberman, Austin, TX US
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20090309214 | Circuit Module Turbulence Enhancement - Turbulence inducers are provided on circuit modules. Rising above a substrate or heat spreader surface, turbulence generators may be added to existing modules or integrated into substrates or heat spreaders employed by circuit modules constructed according to traditional or new technologies. | 12-17-2009 |