Patent application number | Description | Published |
20080280879 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS - Compounds of the general Formula I, wherein X | 11-13-2008 |
20110092480 | Substituted Heterocyclic Derivatives and Their Pharmaceutical Use and Compositions - Compounds of the general Formula I, wherein X | 04-21-2011 |
20110098272 | Novel Compounds As Casein Kinase Inhibitors - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 04-28-2011 |
20120065188 | SUBSTITUTED HETEROCYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS - Compounds of the general Formula I, wherein X | 03-15-2012 |
20120157440 | NOVEL FUSED PYRIDINE COMPOUNDS AS CASEIN KINASE INHIBITORS - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: | 06-21-2012 |
20120202787 | Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; | 08-09-2012 |
20120252758 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 10-04-2012 |
20140045790 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 02-13-2014 |
20140088111 | Novel Bicyclic Pyridinones - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 03-27-2014 |
20140128374 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 05-08-2014 |
20140134193 | SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION - The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer. | 05-15-2014 |
20140336176 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 11-13-2014 |
20150072990 | Novel Pyrido[1,2-a]Pryazines And Their Use In The Treatment of Neurodegenerative and Neurological Disorders - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 03-12-2015 |
20150209445 | BIFUNCTIONAL CYTOTOXIC AGENTS - Cytotoxic dimers comprising CBI-based and/or CPI-based sub-units, antibody drug conjugates comprising such dimers, and to methods for using the same to treat cancer and other conditions. | 07-30-2015 |
20150291625 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands - The present invention provides, in part, compounds of Formula I: and pharmaceutically acceptable salts thereof and N-oxides thereof; processes and intermediates for preparation of; and compositions and uses thereof. The present invention further provides D1 agonists with reduced D1R desensitization, D1 agonists with a reduced β-arrestin recruitment activity relative to Dopamine, D1 agonists interacting significantly with the Ser188 but not significantly with the Ser202 of a D1R when binding to the D1R, D1 agonists interacting less strongly with the Asp103 and interacting less strongly with the Ser198 of a D1R when binding to the D1R, and their uses. | 10-15-2015 |
20150307494 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 10-29-2015 |
20150307522 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 10-29-2015 |
20150307551 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF - The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer. | 10-29-2015 |
20150344474 | HETEROAROMATIC COMPOUNDS AND THEIR USE AS DOPAMINE D1 LIGANDS - The present invention provides, in part, compounds of Formula I: | 12-03-2015 |
20150344490 | Heteroaromatic Compounds and their Use as Dopamine D1 Ligands - The present invention provides, in part, compounds of Formula I: | 12-03-2015 |
20160022626 | SPLICEOSTATIN ANALOGS AND METHODS FOR THEIR PREPARATION - The present invention is directed to novel cytotoxic spliceostatin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer. | 01-28-2016 |
20160024088 | Novel Pyrido[1,2-a]Pryazines And Their Use in the Treatment of Neurodegenerative and Neurological Disorders - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I | 01-28-2016 |
Patent application number | Description | Published |
20100008825 | RESONANT SENSOR CAPABLE OF WIRELESS INTERROGATION - A resonant sensor for detecting a specific environmental analyte is presented. The resonant sensor comprises a top conductive layer of two ground conductors and a center signal line, a bottom conductive layer of two ground lines shunted together by a shunt line and a sensing layer positioned between the top conductive layer and the bottom conductive layer. A capacitor is created by the overlap of the center signal line of the top conductive layer and the shunt line of the bottom conductive layer. Electrical properties of the sensing layer change in response to binding the specific environmental analyte with the sensing layer. The sensing layer can be an electro-optic polymer. Nanoparticles or carbon nanotubes can be dispersed within the sensing layer to bind with the specific environmental analyte. An integrated antenna can be incorporated into to sensor to receive radio frequencies for wireless, passive sensing. | 01-14-2010 |
20100066389 | CHARACTERIZATION TECHNIQUE FOR DIELECTRIC PROPERTIES OF POLYMERS - A test structure for polymer characterization over a wide frequency range, temperature range and under an applied DC electric field is disclosed. A high resistivity silicon substrate is topped by an adhesion layer. A polymer thin-film is deposited on a patterned metal | 03-18-2010 |
20100096678 | NANOSTRUCTURED BARIUM STRONTIUM TITANATE (BST) THIN-FILM VARACTORS ON SAPPHIRE - Varactor shunt switches based on a nonlinear dielectric tunability of Ba | 04-22-2010 |
20130342289 | VARACTOR SHUNT SWITCHES WITH PARALLEL CAPACITOR ARCHITECTURE - A parallel capacitor varactor shunt switch device may include a shunt layer, a coplanar waveguide (CPW) layer, and a tunable thin film dielectric layer that is interposed between the shunt layer and the CPW layer. The tunable thin film dielectric layer electrically isolates the shunt layer from the CPW layer. The shunt layer includes a plurality of parallel shunt lines. The CPW layer includes a CPW signal transmission line with two CPW ground lines parallel to the CPW signal transmission line. A plurality of varactor areas equal in number to the plurality of parallel shunt lines are defined in the CPW signal transmission line, each varactor area corresponding to an overlap of the CPW signal transmission line with a respective shunt line and each respective parallel shunt line and its corresponding varactor area defines a capacitor. | 12-26-2013 |
20130342953 | HIGH VOLTAGE NON-COPLANAR INTERDIGITATED VARACTOR - A high voltage varactor that provides a large tuning ratio and a high DC biasing capability includes a non-coplanar interdigitated structure having a stacked structure with a plurality of substantially parallel coplanar first electrode fingers and a plurality of substantially parallel coplanar second electrode fingers. The plurality of substantially parallel coplanar second electrode fingers are interdigitated with the plurality of substantially parallel coplanar first electrode fingers and are not coplanar with the plurality of substantially parallel coplanar first electrode fingers. A voltage tunable dielectric layer may be interposed between the plurality of substantially parallel coplanar first electrode fingers and the plurality of substantially parallel coplanar second electrode fingers. The voltage tunable dielectric layer may be a BST layer, or any other voltage tunable dielectric layer. | 12-26-2013 |
Patent application number | Description | Published |
20090249125 | DATABASE QUERYING - Data stored in relational databases can be retrieved using a relational database query language, while data stored in a multidimensional database is typically retrieved using a multidimensional database query language. However, most users do not have a functional working knowledge of multidimensional database query languages, which leaves large amounts of data inaccessible. Further, while some relational database query languages may be translated into a multidimensional database language, the information generated by such translations is often unusable, or returns large numbers of errors. In order to obtain effective translation of a relational database query language to a multidimensional database query language effective translation and filtering needs to occur. Using effective mapping and retrieval of database metadata along with effective, customizable business logic filtering of query components, more effective and reliable results may be achieved. | 10-01-2009 |
20110016477 | PRE-CALCULATION AND CACHING OF DEPENDENCIES - Dependencies among components may be pre-calculated, validated and cached. The cached dependencies may then be used in an execution environment to inject dependencies into the component. In one example, components for a web application are submitted to the operator of the application. Dependencies among the components may be pre-calculated, and the pre-calculated dependencies may be stored in a catalog. When a client accesses the web application, the components may be downloaded to the client along with the catalog. The client may provide a virtual machine or other execution environment under which the components execute. The execution environment may provide a dependency injection feature that connects components together at runtime based on the pre-calculated dependencies in the catalog. | 01-20-2011 |
Patent application number | Description | Published |
20090176256 | Methods and Products for Evaluating an Immune Response to a Therapeutic Protein - The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. A first aspect of the invention relates to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titre of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titre of untreated patients increased by the double of the standard deviation of this control antibody titre. | 07-09-2009 |
20120195884 | METHODS AND PRODUCTS FOR EVALUATING AN IMMUNE RESPONSE TO A THERAPEUTIC PROTEIN - The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. Aspects of the invention relate to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of a VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titre of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titre of untreated patients increased by the double of the standard deviation of this control antibody titre. | 08-02-2012 |
20130022961 | ASSAY FOR JC VIRUS ANTIBODIES - The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject. | 01-24-2013 |
20140322164 | METHOD OF ASSESSING RISK OF PML - The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML). | 10-30-2014 |
20150071917 | METHODS AND PRODUCTS FOR EVALUATING AN IMMUNE RESPONSE TO A THERAPEUTIC PROTEIN - The invention relates to methods and products for the identification of a clinically significant immune response in subjects treated with a therapeutic protein. A first aspect of the invention relates to methods and compositions for identifying a clinically significant immune response in patients treated with therapeutic amounts of VLA4 binding antibody (e.g., natalizumab). A second aspect of the invention concerns the chronological details of sample collection for determining the titre of antibodies against the therapeutic protein, e.g. the collection of at least two samples at two different time points. A third aspect of the invention relates to the selection of the critical threshold level, which corresponds to the antibody titre of untreated patients increased by the double of the standard deviation of this control antibody titre. | 03-12-2015 |
Patent application number | Description | Published |
20140178611 | APPARATUS AND METHODS EMPLOYING LIQUID-IMPREGNATED SURFACES - In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds: (i) 0<φ≦0.25, where φ is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium; and (ii) S | 06-26-2014 |
20140290699 | ARTICLES AND METHODS PROVIDING LIQUID-IMPREGNATED SCALE-PHOBIC SURFACES - This invention relates generally to articles, devices, and methods for inhibiting or preventing the formation of scale during various industrial processes. In certain embodiments, a vessel is provided for use in an industrial process, the vessel having a textured, liquid-impregnated surface in contact with a mineral solution, wherein the liquid-impregnated surface comprises a matrix of features spaced sufficiently close to stably contain an impregnating liquid lubricant therebetween or therewithin, wherein the impregnating lubricant has a low surface energy density, and wherein the spreading coefficient S | 10-02-2014 |
20150306642 | APPARATUS AND METHODS EMPLOYING LIQUID-IMPREGNATED SURFACES - In certain embodiments, the invention is directed to apparatus comprising a liquid-impregnated surface, said surface comprising an impregnating liquid and a matrix of solid features spaced sufficiently close to stably contain the impregnating liquid therebetween or therewithin, and methods thereof. In some embodiments, one or both of the following holds: (i) 0<φ≦0.25, where φ is a representative fraction of the projected surface area of the liquid-impregnated surface corresponding to non-submerged solid at equilibrium; and (ii) S | 10-29-2015 |
Patent application number | Description | Published |
20080220672 | RELEASABLE SPRING-LOCKING MECHANISM FOR RAPID WATERCRAFT FIN ATTACHMENT - The present invention provides fin attachment devices and methods based upon the concept of vertical, instead of horizontal, locking forces for fin attachment to watercraft. In some embodiments the spring force is employed as the actual locking mechanism, and insertion and desertion forces are designed into the spring. The spring may be designed so that the insertion force is less than the desertion force. | 09-11-2008 |
20090185853 | RELEASABLE LOCKING MECHANISM - The present invention provides attachment devices and methods based upon the concept of vertical, instead of horizontal, locking forces for attachment of a device to an object. In some embodiments, spring force is employed as the actual locking mechanism, and insertion and desertion forces are designed into the spring. The spring may be designed so that the insertion force is less than the desertion force. | 07-23-2009 |
20090199375 | LATCHING SYSTEM - Devices and methods based upon the concept of a split ring having certain multiple interior angles to engage a stem or post having annular ring(s) with angular geometries that are complimentary to those of the split ring. The disclosure provides designs for a wide range of insertion and desertion forces between latch engagement stems and latch engagement bodies. Changes to insertion contact angles and contact area on engagement stems and corresponding changes to insertion contact angles and engagement areas on engagement bodies can significantly modify insertion forces required to engage various devices. Similarly, changes in degrees of angle between desertion angles and contact areas on engagement stems with corresponding changes in desertion angles and contact areas on engagement bodies will significantly modify the total desertion forces required to disengage various devices. Accordingly, the instant latching mechanism provides insertion and desertion forces that can be controlled independently of each other. | 08-13-2009 |
20090275116 | Metallic PCR frames - The present invention is represented by a two part PCR well plate. Part one, the outer shell, is constructed from a thin metal.. Part two, the tubes, are thermoformed in an array of 96/384 or formed individually and inserted or welded into each tube cell location. The use of a rigid metal frame for the PCR array virtually eliminates all warping problems associated with temperature cycling. | 11-05-2009 |
20120078568 | INTERACTIVE ON-DEMAND ORTHOTIC VENDING MACHINE AND METHOD OF PRODUCING ORTHOTIC INCLUDING DISC VERSION - An orthotic vending machine may comprise a measuring apparatus and an orthotic fabricating apparatus. The measuring apparatus may comprises a plurality of probes capable of sensing pressure at various pixels on the underside surfaces of the person's feet at various configurations and determining the heights at the various pixels for the various configurations. The fabricating apparatus fabricates custom orthotics based on the sensed information from the measuring apparatus. | 03-29-2012 |
20120210545 | LATCHING SYSTEM - Devices and methods based upon the concept of a split ring ( | 08-23-2012 |
20130313954 | DRAWER SLIDE - In some example implementations, there is provided a drawer slide assembly. The drawer slide assembly may including an elongate member including a first slot extending through an upper region and a second slot. The drawer slide assembly may further include a first end cap coupled to the first end region of the elongate member, wherein the first end cap has a first projection that extends at least in part through the first opening; and a second end cap coupled to the second end region of the elongate member, wherein the second end cap has a second projection that extends at least in part through the second opening. | 11-28-2013 |
20150091428 | Drawer Slide - In some example implementations, there is provided a drawer slide assembly. The drawer slide assembly may including an elongate member including a first slot extending through an upper region and a second slot. The drawer slide assembly may further include a first end cap coupled to the first end region of the elongate member, wherein the first end cap has a first projection that extends at least in part through the first opening; and a second end cap coupled to the second end region of the elongate member, wherein the second end cap has a second projection that extends at least in part through the second opening. | 04-02-2015 |
20150192920 | INTERACTIVE ON-DEMAND ORTHOTIC VENDING MACHINE AND METHOD OF PRODUCING ORTHOTICS - An orthotic vending machine may comprise a measuring apparatus and an orthotic fabricating apparatus. The measuring apparatus may comprises a plurality of probes capable of sensing pressure at various pixels on the underside surfaces of the person's feet at various configurations (e.g., flat plane, shoe contour, or prescriptive optimal) and determining the heights at the various pixels for the various configurations. The fabricating apparatus may lay down a plurality of discs on a base layer having different hardnesses based on the measured pressure and heights by the measuring apparatus to fabricate customized orthotics. Alternatively, the fabricating apparatus may form the customized orthotic via solidifying a polymerizeable material in a honeycomb structure based on the measured pressure and heights by the measuring apparatus. As a further alternative, the fabricating apparatus may form the customized orthotic via milling orthotic blanks based on the measured pressure and heights by the measuring apparatus. The orthotic vending machine may be placed in shoe retail shops such that shoe purchasers may purchase a shoe and a customized orthotic during one visit to the shoe store. | 07-09-2015 |
20150285284 | Latching System - Devices and methods based upon the concept of a split ring ( | 10-08-2015 |
20150342349 | Drawer Slide - In some example implementations, there is provided a drawer slide assembly. The drawer slide assembly may including an elongate member including a first slot extending through an upper region and a second slot. The drawer slide assembly may further include a first end cap coupled to the first end region of the elongate member, wherein the first end cap has a first projection that extends at least in part through the first opening; and a second end cap coupled to the second end region of the elongate member, wherein the second end cap has a second projection that extends at least in part through the second opening. | 12-03-2015 |