Butler, MA
Chris Butler, Acton, MA US
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20110298695 | OPTICAL COMPONENT CALIBRATION SYSTEM FOR LASER-BASED DISPLAY DEVICE - A laser-based display device includes a plurality of ultraviolet lasers configured to excite a phosphor-containing display screen in order to produce visible light. The laser-based display device also includes a reference laser used for calibration operations. A control system within the laser-based display device causes the reference laser beam to scan across one or more calibration features, and adjusts optical components of the laser-based display device, including activation timing of the ultraviolet lasers, based on feedback patterns generated by the calibration features, to compensate for drift effects. The calibration features may be disposed off-screen or on-screen. | 12-08-2011 |
20110298765 | Power Calibration of Multiple Light Sources in a Display Screen - A display device with multiple light sources includes a first detector for detecting a brightness of one or more different portions of the image formed on the display device, a second detector that measures output intensities of the light sources, and a controller that records correlation values that correlate input power settings of the light sources with the detected brightness and the measured output intensities. During operation of the display device, the controller applies the correlation values to determine the proper input power settings of the light sources so that brightness uniformity among the multiple light sources can be achieved. | 12-08-2011 |
20110298844 | Power Calibration of Multiple Light Sources in a Display Screen - A display device with multiple light sources includes a detector that dynamically measures output intensities of the light sources as the light sources are producing light to cause an image to be formed on a display screen. A controller for the display device compares the measured output intensities with desired output intensities determined from factory-calibrated correlation values and adjusts the inputs to the light sources to compensate for drift and other similar effects, so that brightness uniformity among the multiple light sources can be achieved. | 12-08-2011 |
Christopher Butler, Wayland, MA US
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20080256567 | SYSTEM AND METHOD FOR PROVIDING PACKAGED PROGRAMMING TO ELECTRONIC MEDIA PLAYERS - The present invention relates to providing packaged programming for use on electronic media players. In particular the present invention relates to providing entertainment programming packaged together with advertising, in downloadable form, for use on electronic media players. The service may be supported by subscription fees, by advertising fees, are a combination thereof. The service provider, in turn, uses a portion of the moneys generated for operating expenses and profit, as well as to pay pre-negotiated royalty fees to the copyright owners of the aforementioned programming. | 10-16-2008 |
Christopher J. Butler, Acton, MA US
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20100097678 | Servo Feedback Control Based on Designated Scanning Servo Beam in Scanning Beam Display Systems with Light-Emitting Screens - Scanning beam display systems that scan one servo beam and an excitation beam onto a screen that emits visible light under excitation of the light of the excitation beam and control optical alignment of the excitation beam based on positioning of the servo beam on the screen via a feedback control. | 04-22-2010 |
Christopher J. Butler, Arlington, MA US
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20100014138 | High Areal Density Holographic Data Storage System - An apparatus for recording or reading high areal density holographically stored information with high signal-to-noise ratio. The apparatus comprises a holographic imaging system for recording or reconstructing a holographic image, having a first numerical aperture and a first focal length and an additional optical system for filtering the signal beam, having a second numerical aperture and a second focal length, wherein the numerical aperture of the additional optical system is less than the numerical aperture of the holographic imaging system and/or the focal length of the additional optical system is greater than the optical length of the holographic imaging system. | 01-21-2010 |
20140241598 | Method and Apparatus for Processing Biometric Images - A method and apparatus for applying gradient edge detection to detect features in a biometric, such as a fingerprint, based on data representing an image of at least a portion of the biometric. The image is modeled as a function of the features. Data representing an image of the biometric is acquired, and features of the biometric are modeled for at least two resolutions. The method and apparatus improves analysis of both high-resolution images of biometrics of friction ridge containing skin that include resolved pores and lower resolution images of biometrics without resolved pores. | 08-28-2014 |
Christopher Ryan Butler, Canton, MA US
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20130053373 | Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, | 02-28-2013 |
20130296308 | Heterocyclic Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, | 11-07-2013 |
20140163015 | HEXAHYDROPYRANO[3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS - The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure | 06-12-2014 |
20140323474 | Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure | 10-30-2014 |
20140364426 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, | 12-11-2014 |
20150087637 | Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, | 03-26-2015 |
20150133438 | Heterocyclic Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, | 05-14-2015 |
20150224110 | Heteroaryl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, | 08-13-2015 |
20150231144 | Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure | 08-20-2015 |
20150239908 | Alkyl-Substituted Hexahydropyrano[3,4-d][1,3]Thiazin-2-Amine Compounds - Compounds, tautomers and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I, as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. | 08-27-2015 |
20150291621 | 2-Amino-6-Methyl-4,4a,5,6-Tetrahydropyrano[3,4-d][1,3]Thiazin-8a(8H)-yl-1,- 3-Thiazol-4-yl Amides - The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, | 10-15-2015 |
David Butler, Cambridge, MA US
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20110123520 | SITE-SPECIFIC DELIVERY OF NUCLEIC ACIDS BY COMBINING TARGETING LIGANDS WITH ENDOSOMOLYTIC COMPONENTS - The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components. | 05-26-2011 |
20120035115 | CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION - The invention features compounds of formula I or II: | 02-09-2012 |
20120095075 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure: | 04-19-2012 |
20140256785 | SITE SPECIFIC DELIVERY OF NUCLEIC ACIDS BY COMBINING TARGETING LIGANDS WITH ENDOSOMOLYTIC COMPONENTS - The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components. | 09-11-2014 |
20150203847 | CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION - The invention features compounds of formula I or II: | 07-23-2015 |
20150265708 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure | 09-24-2015 |
David Butler, Medford, MA US
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20080234498 | Pyrovalerone Analogues and Therapeutic Uses Thereof - New compounds that bind to monoamine transporters are described. The compounds of the present invention can be racemic or pure R— or S-enantiomers. Certain preferred compounds of the present invention have a high selectively dopamine transporter versus the serotonin transporter. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter. | 09-25-2008 |
20110311583 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ?-aminoalkyls, ?-(substituted)aminoalkyls, ?-phosphoalkyls, ?-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(0)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ?-aminoalkyl, ?-(substituted)aminoalky, ?-phosphoalkyl or ?-thiophosphoalkyl. | 12-22-2011 |
20120027796 | NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures: (Formula (I) or (XXXV)). | 02-02-2012 |
20120058144 | LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS - The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures XIV or XVII. | 03-08-2012 |
20120128760 | LIPID COMPOSITIONS - Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I). | 05-24-2012 |
20130338210 | COMPOSITIONS FOR NUCLEIC ACID DELIVERY - A method for delivering a nucleic acid to a cell can include exposing sample cells to a composition which includes charged lipids. | 12-19-2013 |
20140200257 | PEGYLATED LIPIDS AND THEIR USE FOR DRUG DELIVERY - The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery. | 07-17-2014 |
20150190515 | LIPID COMPOSITIONS - Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is | 07-09-2015 |
20150211006 | CHIRAL CONTROL - The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same. The invention specifically encompasses the identification of the source of certain problems with prior methodologies for preparing chiral oligonucleotides, including problems that prohibit preparation of fully chirally controlled compositions, particularly compositions comprising a plurality of oligonucleotide types. In some embodiments, the present invention provides chirally controlled oligonucleotide compositions. In some embodiments, the present invention provides methods of making chirally controlled oligonucleotides and chirally controlled oligonucleotide compositions. | 07-30-2015 |
David Charles Donnell Butler, Medford, MA US
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20140194610 | METHODS FOR THE SYNTHESIS OF FUNCTIONALIZED NUCLEIC ACIDS - Described herein are methods for the synthesis of derivatives of thiosulfonate reagents. Said reagents have utility for the synthesis of phosphorothiotriesters from H-phosphonates in a stereospecific fashion. | 07-10-2014 |
David J. Butler, Cotuit, MA US
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20100307307 | HEALTH AND SAFETY SYSTEM FOR A TABLE SAW - An improved health and safety system for a table saw includes one or more of: a blade guard that protects the operator from the saw blade, and contains and collects sawdust; a proximity detector and emergency saw motor braking means for use in connection with such blade guard; an anti-kickback device for use in connection with such blade guard, a rip fence adapter for use in connection with such a blade guard, and hoses and fittings to connect the dust containment and collection system of said blade guard to a shop dust collection blower or vacuum system. The system protects the saw operator from potential traumatic injury to a hand, and from ingesting potentially carcinogenic sawdust. | 12-09-2010 |
20100307308 | BLADE ENCLOSURE FOR A TABLE SAW - A below-table blade enclosure for a table saw protects the health and safety of the person operating the saw, by enclosing the saw blade, and thereby protecting the operator from exposure to hazardous and potentially carcinogenic saw dust. The blade enclosure contains and collects the saw dust, which is removed from the blade enclosure by an external dust collecting system, for example via a vacuum hose. | 12-09-2010 |
20120090439 | HEALTH AND SAFETY SYSTEM FOR A TABLE SAW - An improved health and safety system for a table saw includes one or more of: a blade guard that protects the operator from the saw blade, and contains and collects sawdust; a proximity detector and emergency saw motor braking means for use in connection with such blade guard; an anti-kickback device for use in connection with such blade guard, a rip fence adapter for use in connection with such a blade guard, and hoses and fittings to connect the dust containment and collection system of said blade guard to a shop dust collection blower or vacuum system. The system protects the saw operator from potential traumatic injury to a hand, and from ingesting potentially carcinogenic sawdust. | 04-19-2012 |
20150212512 | MACHINE CONTROL AND DATA LOGGING STATION - A machine control and data logging station, intended for use with a saw or other machine tool, features a processor which monitors a number of input lines, a real time clock and time stamp function. Any change of input signals from the machine tool will be recorded in flash memory. Both wired and wireless outputs may read the memory at any given time. Optionally, hardware or software data communication encryption may be employed to provide increased confidentiality and security. The station continually monitors sensor inputs and can react automatically to emergency-stop the machine tool upon sensing a dangerous condition. | 07-30-2015 |
Dawn Butler, Andover, MA US
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20130324873 | CAPNOGRAPHY SYSTEM FOR AUTOMATIC DIAGNOSIS OF PATIENT CONDITION - An improved medical capnographysystem ( | 12-05-2013 |
20150302555 | AUTOMATED CARDIOPULMONARY RESUSCITATION DEVICE WITH A DISPLAY - The invention relates to an automated CPR device for performing automated chest compressions of a patient. The CPR device is provided with display processing electronics for processing information data so that display content associated with the information data can be displayed in different rotated orientations so that the information can be oriented correctly relative to a user's viewing direction. The CPR device is configured with an orientation button for activating rotation of the displayed information. The orientation button is configured so that the location of the button relative to display content, at least along a single dimension, is the same. For example, the orientation button may be located adjacent to the middle of an edge of the display so that the button remains located adjacent to information located in the center of the display irrespective of the displayed orientation of the information, irrespective of the two orientations. | 10-22-2015 |
Evan James Butler, Boston, MA US
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20140350352 | SYSTEM AND METHOD OF ASSESSING STABILITY OF PATIENTS - In one embodiment, a technique for assessing a stability of a patient is provided. In particular, a plurality of estimated trends for each physiological variable of a patient are calculated by utilizing a plurality of physiological variables from a plurality of medical devices and a plurality of target ranges for each physiological variable. These trends are then used to calculate dynamically a single stability value over time of the patient based the target ranges input by a user for each physiological variable in relation to the estimated trends. In particular, this stability value a single value that accounts for and reflects the stability/acuity of a plurality of physiological variables to indicate quickly to physicians the stability of the patient. | 11-27-2014 |
Gabriel Butler, Somerville, MA US
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20090281963 | Fair Value Model Based System, Method, and Computer Program Product for Valuing Foreign-Based Securities in a Mutual Fund - A system and method for determining fair value prices of financial securities of international markets includes steps of selecting a universe of securities of a particular international market, computing overnight returns of each security in the selected universe over a predetermined past period of time, selecting at least one return factor of a domestic financial market from a plurality of return factors, computing, for each selected return factor, the return factor's daily return over said predetermined past period of time, calculating, for each selected return factor, a return factor coefficient for each security in the selected universe by performing a time series regression to obtain the contribution of each return factor's return to the security's overnight return, and storing each calculated return factor coefficient in a data file. | 11-12-2009 |
20110320385 | FAIR VALUE MODEL BASED SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR VALUING FOREIGN-BASED SECURITIES IN A MUTUAL FUND - A system and method for determining fair value prices of financial securities of international markets includes steps of selecting a universe of securities of a particular international market, computing overnight returns of each security in the selected universe over a predetermined past period of time, selecting at least one return factor of a domestic financial market from a plurality of return factors, computing, for each selected return factor, the return factor's daily return over said predetermined past period of time, calculating, for each selected return factor, a return factor coefficient for each security in the selected universe by performing a time series regression to obtain the contribution of each return factor's return to the security's overnight return, and storing each calculated return factor coefficient in a data file. | 12-29-2011 |
20120254070 | FAIR VALUE MODEL BASED SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR VALUING FOREIGN-BASED SECURITIES IN A MUTUAL FUND - A system for determining fair value prices of financial securities of international markets includes selecting a universe of securities of a particular international market, computing overnight returns of each security in the selected universe over a predetermined past period of time, selecting at least one return factor of a domestic financial market from a plurality of return factors, computing, for each selected return factor, the return factor's daily return over said predetermined past period of time, calculating, for each selected return factor, a return factor coefficient for each security in the selected universe by performing a time series regression to obtain the contribution of each return factor's return to the security's overnight return, and producing each calculated return factor coefficient in a data stream. | 10-04-2012 |
20130282615 | FAIR VALUE MODEL BASED SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR VALUING FOREIGN-BASED SECURITIES IN A MUTUAL FUND - A system for determining fair value prices of financial securities of international markets includes selecting a universe of securities of a particular international market, computing overnight returns of each security in the selected universe over a predetermined past period of time, selecting at least one return factor of a domestic financial market from a plurality of return factors, computing, for each selected return factor, the return factor's daily return over said predetermined past period of time, calculating, for each selected return factor, a return factor coefficient for each security in the selected universe by performing a time series regression to obtain the contribution of each return factor's return to the security's overnight return, and producing each calculated return factor coefficient in a data stream. | 10-24-2013 |
20140337197 | FAIR VALUE MODEL BASED SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR VALUING FOREIGN-BASED SECURITIES IN A MUTUAL FUND - A system for determining fair value prices of financial securities of international markets includes selecting a universe of securities of a particular international market, computing overnight returns of each security in the selected universe over a predetermined past period of time, selecting at least one return factor of a domestic financial market from a plurality of return factors, computing, for each selected return factor, the return factor's daily return over said predetermined past period of time, calculating, for each selected return factor, a return factor coefficient for each security in the selected universe by performing a time series regression to obtain the contribution of each return factor's return to the security's overnight return, and producing each calculated return factor coefficient in a data stream. | 11-13-2014 |
Gideon D.h. Butler, Chelmsford, MA US
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20140135666 | Chest Compression Monitor with Rotational Sensing of Compressions for Discrimination of CPR Movement from Non-CPR Movement - A chest compression monitor for measuring the depth of chest compressions achieved during CPR. A sensor of the chest compression monitor is disposed within its housing such that compression of the housing due to CPR compressions, and its resultant deformation, is detected by the sensor and used by the control system as the starting point for calculating chest compression depth based on an acceleration signal indicative of the downward displacement of the chest. | 05-15-2014 |
20150150755 | Chest Compression Monitor with Rotational Sensing of Compressions for Discrimination of CPR Movement from Non-CPR Movement - A chest compression monitor for measuring the depth of chest compressions achieved during CPR. A sensor of the chest compression monitor is disposed within its housing such that compression of the housing due to CPR compressions, and its resultant deformation, is detected by the sensor and used by the control system as the starting point for calculating chest compression depth based on an acceleration signal indicative of the downward displacement of the chest. | 06-04-2015 |
Glenn Butler, Holliston, MA US
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20090276320 | BEZEL FOR VENDING OR GAMING MACHINE - A bezel for use in a merchandising system is provided. The bezel includes an information display and a graphic display including one or more visual indicators. The bezel also includes a card reader configured to process payments from a cashless payment card. The bezel further includes a bill recycler access slot providing access to a bill recycler. In the bezel, illumination of the graphic display is controlled in response to information received from the bill recycler. | 11-05-2009 |
20100268792 | VENDING MACHINE WITH INTERACTIVE DISPLAY - A system and method are presented that include a remote server and a vending machine. The remote server transfers media control and content information via a communication link. The information includes an advertisement that relates to at least one product available for vending from the vending machine. The vending machine includes a product storage area, an interactive display, and a controller. The product storage area stores products available for sale from the vending machine. The interactive display receives a user selection of a product to vend. The controller receives the media information and displays graphical information relating to the advertisement using the interactive display, according to the media information. The controller receives a product selection signal from the interactive display, representing a product to vend, and dispenses a product from the product storage area according to the product selection signal. | 10-21-2010 |
Hanan Butler, Boston, MA US
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20130318049 | PARTIAL SOURCE VERIFICATION OF EDC DATA - Systems, methods, and other embodiments associated with partial source verification are described. In one embodiment, a method includes selecting, from a corpus of records, a set of records that includes fewer records than the corpus, where each record corresponds to an instance of an electronic form that records information about a given subject. The set of records is provided for source verification. | 11-28-2013 |
20130318106 | DATA VIEWER FOR CLINICAL DATA - Systems, methods, and other embodiments associated with a data view for clinical data are described. In one embodiment, a method includes receiving a request from a user to view summarized case report form (CRF) data, where the CRF data corresponds to a plurality case report forms (CRFs) stored in one or more normalized transactional tables. A view query is constructed based, at least in part, on the request and executed on one or more denormalized summary tables to construct a view. The denormalized summary tables store selected CRF data from the normalized transactional tables and are updated concurrently with each update to the transactional tables. The method includes rendering the view for display. | 11-28-2013 |
James M. Butler, Tyngsboro, MA US
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20090083320 | Display method and system for collecting media preference information - An end user media preferences “key” captures an end user's personal media interests and tastes in a unique display format that is saved locally to an end user's computer. The key is forged using a display interface on a given site. As the end user later navigates to different web sites having media discovery applications and services, he or she uses the key to facilitate a media discovery process on such sites. In this manner, the key captures, carries and controls access to the end user's personal interests and tastes across multiple sites. | 03-26-2009 |
20090083321 | Method for storing, transporting and using user media preferences information - An end user media preferences “key” captures an end user's personal media interests and tastes in a unique display format that is saved locally to an end user's computer. As the end user navigates to different web sites having media discovery applications and services, he or she uses the key to facilitate a media discovery process on such sites. In this manner, the key captures, carries and controls access to the end user's personal interests and tastes across multiple sites. On a given site, the key is used (by a local media discovery platform or process) to help match video, audio or other textual content with the end user based on the preference information that has been collected and embedded in the key. Upon receiving the key, the local media discovery platform or process immediately learns what the end user likes and can then locate the movies, video, news or other content that the end user would otherwise have to locate directly or via site-specific entry and processing of end user preference data. | 03-26-2009 |
James P. Butler, Brookline, MA US
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20130281830 | System and Method for Improved Lung Fourier Decomposition Magnetic Resonance Imaging - A system and method for producing a more accurate ventilation image, as compared to existing lung Fourier decomposition methods, and an image of ventilation dependent blood volume are provided. A time series of images depicting a subject's lungs during free-breathing are acquired and co-registered to a reference image. From the registration process, geometric information indicative proton density changes due to inhalation and exhalation of gas is obtained. This geometric information is used to correct the proton density values in the time series of image frames. These corrected proton density values are Fourier transformed to produce a Fourier spectrum, from which a signal peak occurring at the breathing frequency is extracted and Fourier transformed to produce a more accurate ventilation image. This more accurate ventilation image can be subtracted from a breathing frequency image produced by conventional lung Fourier decomposition methods to produce a ventilation dependent blood volume image. | 10-24-2013 |
20140155732 | SYSTEMS AND METHODS FOR PORTABLE MAGNETIC RESONANCE MEASUREMENTS OF LUNG PROPERTIES - A portable magnetic resonance (MR) system for quantitatively measuring properties of a subject's lungs, such as regional ventilation and lung density, is provided. The portable MR system includes a magnet, radio frequency (RF) coil assembly, and spectrometer system. The magnet can be positioned near the subject's chest. The magnetic field of the magnet substantially homogeneous in a region-of-interest located at a distance from the surface of the magnet that localizes the region-of-interest in the subject's lung. The RF coil assembly includes one or more RF coils that are sized to be positioned near the subject's chest, and receives MR signals from the region-of-interest. The spectrometer system controls the RF coil assembly and computes from the acquired MR signals, a quantitative metric indicative of a characteristic of the subject's lung in the region-of-interest. An active noise cancellation system is provided so RF shielding of the portable MR system is not required. | 06-05-2014 |
James S. Butler, Arlington, MA US
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20090197300 | MUTUALLY EXCLUSIVE DOMAIN FOLDING MOLECULAR SWITCH AND METHOD OF SYNTHESIS THEREOF - The invention is a fusion protein, embodying a mutually exclusive folding domain molecular switch, wherein the free energy released by folding of a first domain of the fusion protein drives an unfolding of a second domain of the fusion protein, and vice versa. The fusion protein is engineered so that folding the first domain unfolds the second domain, and vice versa, making the folded and unfolded states of the domains mutually exclusive. This is accomplished by insertion of an insert protein GCN4 into a surface loop of a target, protein barnase, subject to die topological design, criterion that the N—C terminal length of GCN4 be at least two-times greater than the Cα-Cα length of a surface loop of barnase. In the absence of the ligand AP-1, barnase is more stable and is folded and active. The presence of AP-1 induces folding of GCN4, forcibly unfolding and inactivating barnase. | 08-06-2009 |
John L. Butler, Cohasset, MA US
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20140369160 | ACTIVE CLOAKING WITH WIDEBAND TRANSDUCERS - Electro-mechanical transducers are used to actively cloak a targeted object in a way that absorbs incoming waves without reflection, sends them out the opposite side of the target and returns the wave without leaving a shadow behind the target. The present invention pertains to an improvement in the cloaking of an object without requiring the use of special materials for the object itself and allows the use of SONAR and other possible transducer systems that would be covered and rendered ineffective with passive cloaking materials. Other means are also provided for extending the bandwidth as well as increasing the efficiency for cloaking or other transducers. | 12-18-2014 |
John R. Butler, Somerville, MA US
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20140371201 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS - The present invention provides compounds of Formula I, | 12-18-2014 |
Nathan Butler, Sterling, MA US
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20150289050 | METHOD AND SYSTEM FOR LARGE SCALE AUDIO SYSTEM - Audio loudspeaker | 10-08-2015 |
Neal R. Butler, Acton, MA US
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20140204641 | SYSTEM FOR REGULATING THE OUTPUT OF A HIGH-VOLTAGE, HIGH-POWER, DC SUPPLY - A system for regulating the output of a high-voltage, high-power DC supply, the system includes a high-voltage DC power supply, a storage capacitor, and at least one non-dissipative regulator having an output voltage range less than an output voltage range of the high-voltage DC power supply. The regulator includes an internal storage capacitance and a control circuit configured to maintain a desired high-voltage output on a load. | 07-24-2014 |
20150300878 | PULSE GENERATOR AND SYSTEMS AND METHODS FOR USING SAME - A pulse generator generates high voltage discharge pulses in a manner that may be controlled and monitored. Pulse generator operation may be monitored to measure characteristics associated with pulse generator operation and to produce pulse generator data representative of those characteristics. Pulse generator operation may be monitored by monitoring the discharge pulses produced by the pulse generator and/or the charging of energy storage elements within the pulse generator in preparation for a subsequent discharge pulse. The pulse generator data may be used, for example, to identify pulse generator wear or degradation, to identify problems with pulse generator operation, and/or to control pulse generator operation for improved performance. The pulse generator may also be configured and controlled to generate a high-voltage initiation pulse to initiate a subsequent discharge pulse while being contained within a relatively small form factor. The pulse generator may be used in spectroscopy systems or other systems using high voltage discharge pulses. | 10-22-2015 |
Paul D. Butler, Methuen, MA US
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20150300878 | PULSE GENERATOR AND SYSTEMS AND METHODS FOR USING SAME - A pulse generator generates high voltage discharge pulses in a manner that may be controlled and monitored. Pulse generator operation may be monitored to measure characteristics associated with pulse generator operation and to produce pulse generator data representative of those characteristics. Pulse generator operation may be monitored by monitoring the discharge pulses produced by the pulse generator and/or the charging of energy storage elements within the pulse generator in preparation for a subsequent discharge pulse. The pulse generator data may be used, for example, to identify pulse generator wear or degradation, to identify problems with pulse generator operation, and/or to control pulse generator operation for improved performance. The pulse generator may also be configured and controlled to generate a high-voltage initiation pulse to initiate a subsequent discharge pulse while being contained within a relatively small form factor. The pulse generator may be used in spectroscopy systems or other systems using high voltage discharge pulses. | 10-22-2015 |
Scott J. Butler, North Oxford, MA US
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20120217871 | EHID Lamp Having Integrated Field Applicator and Optical Coupler - There is described an EHID lamp that comprises a field applicator, a means for coupling RF power to the field applicator, and a discharge vessel; the discharge vessel being disposed within the field applicator and containing a discharge medium; the field applicator being comprised of a solid, transparent or translucent dielectric material and having an optical control surface and a conductive coating that substantially covers its external surfaces. By combining functions served by otherwise individual components, the EHID lamp of this invention has the potential for reducing parts count, improving RF coupling to the plasma, reducing shadowing, and improving reliability. | 08-30-2012 |
Timothy J. Butler, Malden, MA US
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20120088721 | Cartilage Repair - This invention relates to compositions, methods of preparation thereof, and use thereof for cartilage repair. | 04-12-2012 |
Timothy P. Butler, Brookline, MA US
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20150061840 | METHODS AND SYSTEMS OF A RADIO FREQUENCY NETWORK NODE RFID TAG WITH HARDENED MEMORY SYSTEM - In embodiments of the present invention improved capabilities are described for a Radio Frequency identification (RFID) tag that includes an OTP-based hardened memory system for the RFID tag. | 03-05-2015 |
20150129666 | RADIO FREQUENCY IDENTIFICATION TAG WITH HARDENED MEMORY SYSTEM - In embodiments of the present invention improved capabilities are described for RFID tags with hardened memory, where the memory comprises a plurality of one time programmable (OTP) non-volatile memory locations for storing data, wherein the plurality of OTP non-volatile memory locations are configured to emulate a hardened memory system that retains data stored in the OTP non-volatile memory locations, wherein the data stored is retained after exposure of the RFID tag to an ionizing radiation exposure with an exposure level equal to or greater than 25 kGy. | 05-14-2015 |
20150130593 | EXTERNAL ACCESS TO MEMORY ON AN RFID TAG - In embodiments of the present invention improved capabilities are described for an RFID tag comprising a radio frequency (RF) network node and a communication facility, the RF network node comprising a data processing and controller block for digital information processing, a memory store, and a power management block for managing power requirements of the RFID tag, wherein an external computing device accesses the memory store through a communications bus. | 05-14-2015 |
20150302234 | EXTERNAL ACCESS TO MEMORY ON AN RFID TAG - In embodiments of the present invention improved capabilities are described for an RFID tag comprising a radio frequency (RF) network node and a communication facility, the RF network node comprising a data processing and controller block for digital information processing, a memory store, and a power management block for managing power requirements of the RFID tag, wherein an external computing device accesses the memory store through a communications bus. | 10-22-2015 |
Timothy P. Butler, Waltham, MA US
Patent application number | Description | Published |
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20080211630 | MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that provide enhanced memory capabilities, redundant functionality, and multiple frequency capabilities to the RFID tag using an inter-RF network node communication connection. The inter-RF network node communication may allow the coordination of RFID tag memory and functionality. | 09-04-2008 |
20080252459 | METHODS AND SYSTEMS OF A MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that may include memory storage for the RFID tag, the memory storage may include one time programmable (OTP) memory and many time programmable (MTP) memory and the storage of the information may be within the OTP and MTP memory. | 10-16-2008 |
20120169468 | MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that provide enhanced memory capabilities, redundant functionality, and multiple frequency capabilities to the RFID tag using an inter-RF network node communication connection. The inter-RF network node communication may allow the coordination of RFID tag memory and functionality. | 07-05-2012 |
20120169469 | MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that provide enhanced memory capabilities, redundant functionality, and multiple frequency capabilities to the RFID tag using an inter-RF network node communication connection. The inter-RF network node communication may allow the coordination of RFID tag memory and functionality. | 07-05-2012 |
20120169474 | MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that provide enhanced memory capabilities, redundant functionality, and multiple frequency capabilities to the RFID tag using an inter-RF network node communication connection. The inter-RF network node communication may allow the coordination of RFID tag memory and functionality. | 07-05-2012 |
20120182123 | MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that provide enhanced memory capabilities, redundant functionality, and multiple frequency capabilities to the RFID tag using an inter-RF network node communication connection. The inter-RF network node communication may allow the coordination of RFID tag memory and functionality. | 07-19-2012 |
20120206243 | METHODS AND SYSTEMS OF A MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that may include memory storage for the RFID tag, the memory storage may include one time programmable (OTP) memory and many time programmable (MTP) memory and the storage of the information may be within the OTP and MTP memory. | 08-16-2012 |
20120319823 | COORDINATED STORAGE SYSTEM IN A MULTIPLE RADIO FREQUENCY NETWORK NODE RFID TAG - In embodiments of the present invention improved capabilities are described for a Radio Frequency ID (RFID) tag that contains multiple Radio Frequency (RF) network nodes that provide enhanced memory capabilities, redundant functionality, and multiple frequency capabilities to the RFID tag using an inter-RF network node communication connection. The inter-RF network node communication may allow the coordination of RFID tag memory and functionality. | 12-20-2012 |
20130176115 | RFID DRIVE MANAGEMENT FACILITY - In embodiments of the present invention improved capabilities are described for managing RFID tags, where an RFID tag and associated RFID tag data are presented to a computing device through an RFID drive management facility as a seamless extension of a logical file system within the computing device such that the RFID tag and associated RFID tag data can be managed in a manner that is consistent with other items within the file system. | 07-11-2013 |
20140292490 | Methods and systems of a radio frequency network node RFID tag with hardened memory system - In embodiments of the present invention improved capabilities are described for a Radio Frequency identification (RFID) tag that includes an OTP-based hardened memory system for the RFID tag. | 10-02-2014 |
Timothy P. Butler, Needham, MA US
Patent application number | Description | Published |
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20100302038 | RFID Tag Incorporating At Least Two Integrated Circuits - Multiple RFID integrated circuit microradio chips are located at the feed point of an RFID tag antenna for greater, reliability, elimination of testing and to take advantage of coherent microradio operation for increased gain and power, better signal-to-noise ratios, improved range and low bit error rates. | 12-02-2010 |
William E. Butler, Boston, MA US
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20130290014 | Method of Equipoise Enrollment of Subjects in Clinical Trials - In a method of enrollment selection of subjects for a clinical trial, a plurality of physician investigators is polled regarding each subject of a plurality of subjects. Responses of the plurality of physician investigators are aggregated for each subject. A subject of the plurality of subjects is enrolled in response to the subject having an aggregate of responses for the clinical trial that exceeds a predetermined minimum value of responses for the clinical trial. | 10-31-2013 |
20130290026 | METHOD AND DEVICE FOR GENERATING A GRAPHICAL USER INTERFACE FOR PROCEDURE-BASED MEDICAL CHARGE CAPTURE - A method and device for reducing a complexity of procedure based medical charge capture and coding utilizing a computer system. The method and device including searching for previously generated coding scenarios associated with the provider, using existing coding scenarios or adding coding scenarios to a library, generating and filtering codes associated with at least one of the steps of searching, using, and adding, formatting a graphical user interface specification to use the codes from the generating and filtering step, and storing the graphical user interface for presentation. | 10-31-2013 |