Patent application number | Description | Published |
20120322722 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use - The present invention pertains generally to the field of therapeutic compounds and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as “PVA compounds”), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy. | 12-20-2012 |
20130217617 | Pyruvamide Compounds as Inhibitors of Dust Mite Group 1 Peptidase Allergen and Their Use - The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the following formula (for convenience, collectively referred to herein as “PVA compounds”), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy. | 08-22-2013 |
Patent application number | Description | Published |
20120016849 | Sharing and Deconflicting Data Changes In A Multimaster Database System - A computer-based method and system for sharing and deconflicting data changes amongst a plurality of replication sites. In a particular embodiment, data changes at sites to data objects are tracked by each site on a per-data object basis using per-data object version vectors. In another particular embodiment, data changes at sites to links connecting two data objects are tracked by each site on a per-link set basis using per-link set version vectors. In another particular embodiment, per-object version vectors are used to detect a conflict resulting from concurrent changes at two or more sites in which one of the concurrent changes includes an object resolution change. | 01-19-2012 |
20130132348 | MANAGING DISCONNECTED INVESTIGATIONS - A system and a method enable an information analyst to use a stand-alone computer-based investigation application to conduct a disconnected investigation on shared database data in a remote location where network access to a shared data repository of the system might be only periodically available, unreliable, or non-existent. In addition, the system and method enable the disconnected investigation to incrementally incorporate ongoing updates made to the shared repository of data, and to periodically publish interim or final results of the disconnected investigation to the shared data repository. A disconnected investigation can be conducted entirely at the disconnected investigation location without having any network connectivity to the shared repository of data. | 05-23-2013 |
20130191336 | CROSS-ACL MULTI-MASTER REPLICATION - Techniques for cross-ACL multi-master replication are provided. The techniques allow a replication site in a multi-master replication system implementing an asynchronous replication protocol and an access control policy to appropriately apply received data change updates to data maintained at the site even where a data change update is missing information because of the implemented access control policy. | 07-25-2013 |
20130191338 | CROSS-ACL MULTI-MASTER REPLICATION - Techniques for cross-ACL multi-master replication are provided. The techniques allow a replication site in a multi-master replication system implementing an asynchronous replication protocol and an access control policy to appropriately apply received data change updates to data maintained at the site even where a data change update is missing information because of the implemented access control policy. | 07-25-2013 |
20140114972 | SHARING INFORMATION BETWEEN NEXUSES THAT USE DIFFERENT CLASSIFICATION SCHEMES FOR INFORMATION ACCESS CONTROL - Systems and methods for sharing information between distributed computer systems connected to one or more data networks. In particular, a replication system implementing methodologies for sharing database information between computer systems where the databases use different classification schemes for information access control is disclosed. | 04-24-2014 |
20140129518 | CROSS-ONTOLOGY MULTI-MASTER REPLICATION - A system and method providing cross-ontology multi-master replication is described. In a first embodiment a method for cross-ontology multi-master replication comprising the steps of: obtaining, at an importing site, an exporting site ontology and a set of one or more database changes; wherein the exporting site ontology defines a set of one or more data types; and after mapping the exporting site ontology to an importing site ontology, incorporating the set of one or more database changes into a database including mapping each of one or more data types of the set of data types to a data type defined by the importing site ontology using an ontology map. | 05-08-2014 |
20140258233 | CROSS-ACL MULTI-MASTER REPLICATION - Techniques for cross-ACL multi-master replication are provided. The techniques allow a replication site in a multi-master replication system implementing an asynchronous replication protocol and an access control policy to appropriately apply received data change updates to data maintained at the site even where a data change update is missing information because of the implemented access control policy. | 09-11-2014 |
Patent application number | Description | Published |
20090205431 | REINFORCED ELASTOMERIC DIAPHRAGM - A diaphragm is provided that includes a plurality of zonal portions that define reinforced and non-reinforced areas of the diaphragm. A first zonal portion extends from a marginal edge portion toward a central portion and is formed of a fabric material. A second zonal portion extends from the first zonal portion toward the central portion and is formed of an elastomer. A third zonal portion defines the central portion and is formed of a fabric material. The combination of reinforced and non-reinforced portions provides for a decrease in the radial tension (spring rate) of the diaphragm and helps prevent undesired changes to the flow control valve flow setpoint. | 08-20-2009 |
20100006165 | HYDRAULICALLY ACTUATED PNEUMATIC REGULATOR - A hydraulically actuated pneumatic regulator is configured to receive hydraulic fluid from a hydraulic source and pressurized air from a pressurized air source to control air pressure downstream of the pneumatic regulator. The hydraulically actuated pneumatic regulator includes a valve element, an actuator, and pneumatic-to-hydraulic servo. The actuator is adapted to receive one or more pneumatic control signals supplied by the pneumatic-to-hydraulic servo, and is operable, in response to the pneumatic control signals, to control the air pressure downstream of the pneumatic regulator. | 01-14-2010 |
20100006788 | VALVE ASSEMBLY HAVING MAGNETICALLY-ENERGIZED SEAL MECHANISM - A valve assembly is provided that includes a flowbody, a valve element movably disposed within the flowbody, and a magnetically-energized seal mechanism. The magnetically-energized seal mechanism includes a wiper seal carried by one of the flowbody and the valve element and movable between a retracted position and an extended position. A first magnetic element is fixedly coupled to the wiper seal, and a second magnetic element is fixedly coupled to one of the flowbody and the valve element. The second magnetic element magnetically repels the first magnetic element to bias the wiper seal toward the extended position. | 01-14-2010 |