Osvaldo
Osvaldo Barbarisi, Avellino IT
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20090183933 | All wheel drive electrically-variable transmission - A transaxle ( | 07-23-2009 |
Osvaldo Barbosa-Torres, Santa Catarina MX
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20120193078 | LOW MAINTENANCE CONDENSER - A low maintenance condenser for using in commercial refrigeration systems comprising a single metallic flat section having two or more integrally formed pipes for the flowing of a refrigerant fluid and a flat longitudinal heat dissipation section at each side of a pipe, wherein the first end of the first pipe comprising the refrigerant fluid inlet and the second end of the last pipe comprising the fluid outlet, and wherein the first end of the next pipe is connected to the second end of the previous pipe, successively until the last pipe, in order to form a single circuit having a single refrigerant fluid inlet and a single refrigerant fluid outlet. | 08-02-2012 |
Osvaldo Bergaglio, Sasso Marconi IT
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20100088921 | APPARATUS FOR DRYING A PAINTING PRODUCT AND OPERATING METHOD THEREOF - An apparatus for drying a paint applied onto a bodywork of a motor vehicle, which apparatus is provided with a radiating assembly equipped with at least one catalytic panel fed with hydrocarbon gas for generating a first infrared radiation emission spectrum in the short-wavelength infrared band, in virtue of a catalytic reaction between the hydrocarbon gas and the oxygen present in the air, and arranged so as to emit the infrared radiations towards the bodywork to dry the paint, and is further provided with at least one air supplying device for blowing compressed air onto the catalytic panel so as to affect the catalytic reaction and generate a second infrared radiation emission spectrum distributed on the entire short-wavelength infrared band and broader than the first emission spectrum. | 04-15-2010 |
Osvaldo Bosetti, Varese (va) IT
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20120298658 | BIODEGRADABLE ONE-WAY VENTING VALVE FOR AN AIRTIGHT CONTAINER - The present invention concerns a venting valve for a container ( | 11-29-2012 |
Osvaldo Brioni, Brescia IT
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20090049955 | Method and Apparatus for the Recovery of the Secondary Metallurgy (LF) Slag and Its Recycling in the Steel Production Process by Means of Electric Furnace - A method for the recovery of the secondary metallurgy (LF) slag from a plant for the production of steel comprises a cooling step of the slag, by means of the passage of air and/or other gas, a breakdown step, i.e. transformation of several phases present in the mass into powder and a step of drawing the powder. | 02-26-2009 |
20090107295 | Method and apparatus for the recovery of refractory debris materials and ladle slags as process slags in iron metallurgy producton in eafs, and the related metering to the furnace for the formation of the process slag - A method for the recovery of refractory debris materials and ladle slags as process slags in the iron metallurgy production in EAFs and the related metering to the furnace for the formation of the process slag comprises the following steps: grinding and screening of the refractory debris materials until powders of controlled granulometry are obtained, storage of the powders in storage sites, injection of the powders into an EAF furnace by means of automatic metering of the various components. | 04-30-2009 |
Osvaldo Buccafusca, Ft. Collins, CO US
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20100109481 | MULTI-APERTURE ACOUSTIC HORN - A device, for transmitting or receiving ultrasonic signals, includes a transducer and an acoustic horn. The transducer is configured to convert between electrical energy and the ultrasonic signals, and may be a micro electromechanical system (MEMS) transducer. The acoustic horn is coupled to the transducer, and includes multiple apertures through which the ultrasonic signals are transmitted or received in order to manipulate at least one of a radiation pattern, frequency response or magnitude of the ultrasonic signals. The multiple apertures have different sizes. | 05-06-2010 |
Osvaldo Cerise, Aosta IT
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20100004736 | ANGIOPLASTY STENTS - An angioplasty stent comprises a body comprising a plurality of successive segments connected in pairs by bridge means so that the successive segments can be oriented relative to one another for the purposes of bending of the body in any direction defined by a linear combination of respective orientation axes defined by the bridge connection means. During the radial expansion of the stent, the axial contraction of the segments resulting from the opening-out of the respective loops is compensated by axial projection of the bridge elements from the respective concave portions. The wall of the body comprises arms for supporting a lumen as well as regions which are selectively deformable during the expansion of the stent, the arms and the selectively deformable regions having different cross-sections and/or cross-sectional areas. At least one portion of the body may have a substantially reticular structure, the branches of which define geometrical figures identifiable as fractals. | 01-07-2010 |
20110213457 | ANGIOPLASTY STENTS - An angioplasty stent comprises a body comprising a plurality of successive segments connected in pairs by bridge means so that the successive segments can be oriented relative to one another for the purposes of bending of the body in any direction defined by a linear combination of respective orientation axes defined by the bridge connection means. During the radial expansion of the stent, the axial contraction of the segments resulting from the opening-out of the respective loops is compensated by axial projection of the bridge elements from the respective concave portions. The wall of the body comprises arms for supporting a lumen as well as regions which are selectively deformable during the expansion of the stent, the arms and the selectively deformable regions having different cross-sections and/or cross-sectional areas. At least one portion of the body may have a substantially reticular structure, the branches of which define geometrical figures identifiable as fractals. | 09-01-2011 |
Osvaldo Chu, Sarasota, FL US
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20090011092 | REDUCED SUGAR CITRUS JUICE BEVERAGE - Citrus juice beverage products and their method of production are formulated to reduce the sugar content of the beverage while the beverage products have sensory, taste, mouth feel and texture characteristics that mimic those of whole citrus juice. Orange juice beverage products are especially preferred. The beverage products have a relatively low Brix, on the order of between about 7 and about 8 Brix. Also included in the beverage products is a sweetener which does not add a significant caloric load to the beverage product. A sinking pulp added to the beverage product in an amount to achieve texture and other sensory characteristics of a whole juice. | 01-08-2009 |
20100055269 | METHOD FOR PRODUCTION OF COCONUT WATER BEVERAGE AND BLENDED JUICE BEVERAGES WITH COCONUT WATER - A method for producing a coconut water beverage having a pH below 4.5 by adding a food grade acid to coconut water. The method coverts coconut water from a low-acid food to a high-acid food which allows the coconut water to be subjected to less severe commercial sterilization processing and preserves the natural taste and aroma of the coconut water. The present invention is also directed to a blended beverage comprising coconut water and fruit juice and having natural isotonic properties. | 03-04-2010 |
20130251873 | Reduced Sugar Citrus Juice Beverage - Citrus juice beverage products and their method of production are formulated to reduce the sugar content of the beverage while the beverage products have sensory, taste, mouth feel and texture characteristics that mimic those of whole citrus juice. Orange juice beverage products are especially preferred. The beverage products have a relatively low Brix, on the order of between about 7 and about 8 Brix. Also included in the beverage products is a sweetener which does not add a significant caloric load to the beverage product. A sinking pulp added to the beverage product in an amount to achieve texture and other sensory characteristics of a whole juice. | 09-26-2013 |
Osvaldo De Lazaro Casagrande Junior, Santana BR
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20120178939 | Chromium and nickel catalysts for oligomerization recations and process for obtaining alpha-olefins using said catalysts - The present invention refers to the synthesis of precatalysts and the use of such precatalysts in ethylene oligomerization reactions for the selective production of alpha-olefins. More specifically, it refers to the preparation and use of coordination compounds containing polydentate ligands comprising Group 6 and 10 transition metal compounds, in particular chromium (III) and nickel (II). Such catalytic precursors present high catalytic activity and selectivity for the production of alpha-olefins. | 07-12-2012 |
Osvaldo Di Loreto, Boussu BE
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20100193600 | Method and Device for Spraying a Pulverulent Material Into a Carrier Gas - Method of spraying a pulverulent material into a carrier gas, comprising the acceleration of the carrier gas under pressure up to a sonic velocity before an expansion enabling the pulverulent material to be entrained, with formation of a constant stream of carrier gas entraining an adjustable predetermined amount of pulverulent materials, and safety device for spraying pulverulent material into a carrier gas. | 08-05-2010 |
20100196597 | Method of Treating a Chamber Having Refractory Walls - Method of treating a chamber having refractory walls, in which: a treatment composition, comprising at least one organosilicon compound and at least one hydrocarbide, is sprayed into said chamber, in the presence of oxygen; and said sprayed treatment composition is heated, the spraying in the presence of oxygen taking place in the closed chamber in which the treatment composition, in a predominantly liquid state, is atomized in the form of suspended particles, the method further including said at least one organosilicon compound decomposing to form a colloidal silica aerosol in the closed chamber, an overpressure being established therein, and a colloidal silica layer being spread over the refractory walls with, as a result of said overpressure, the colloidal silica penetrating into the microcracks. | 08-05-2010 |
20100196609 | Dry Mix for Treating Refractory Substrates and Process Using Same - Dry mix for treating refractory substrates, comprising combustible particles of at least one oxidisable substance which, in the presence of oxygen, gives rise to an exothermic reaction, and particles of at least one other substance, wherein these particles form together, during said exothermic reaction, a coherent mass capable of adhering to and/or interacting with the treated substrate, characterised in that it comprises, as particles of at least one other substance, particles of at least one expanding substance, in that the dry mix without the particles of this at least one expanding substance has a first bulk density and in that the mix comprising said at least one expanding substance has a second bulk density lower than said first bulk density. | 08-05-2010 |
Osvaldo Falesiedi, San Benigno Canavese IT
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20120304819 | INERTIAL TRACTION DEVICE - Impulse traction device for moving a body (M) resting on a bearing surface (S), characterized in that it comprises impulse means generating opposed alternate impulses (Ivo+, Ivo−) according to an impulse direction (I), wherein said impulse di-reaction (I) is oblique with respect to said bearing surface (S), | 12-06-2012 |
20120312616 | VEHICLE TRACTION MODULE AND RESPECTIVE TERRESTRIAL VEHICLE - Vehicle traction module ( | 12-13-2012 |
20150159637 | INERTIAL TRACTION SYSTEM - Inertial traction system based on counter-rotating masses (W) with a variable arm between a maximum value and a minimum value and rotating with an angular direction equal and opposed between each other in planes at least parallel between each other, comprising at least a rotor in order to keep the rotation of said pair of masses (W), means for varying said arm, controllable decoupling means between said rotor and said pair of masses (W), first control means in order to control at least said means for varying the arm in order to compose the respective centrifugal and/or Coriolis forces of the respective masses in order to generate impulses according to a movement line (V) so that a number or an intensity of said impulses is prevalent with respect to a single direction (I) of said line (V). | 06-11-2015 |
Osvaldo Funes, Godoy Cruz AR
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20110226466 | Electric Submersible Pump Service Truck - A self propelled or trailer frame is provided with a cradle on which the tool for subterranean use can be assembled preferably in a shop protected from the weather. The tool is transported to a well site and the truck is positioned for deployment. The cradle is on a sub-frame that can translate off the end of the truck bed to get an end of the tool closer to the wellhead. The truck has a hydraulic linkage to upend the nearest end to the wellhead to a point close to where a hook in a derrick that is over the wellhead can be attached to the tool for hoisting the tool up so as to lift it off the cradle with minimal side loading on the derrick as the tool lower end leaves the cradle. The tool can be an electric submersible pump and can be used for delivery as well as removal of the tool through a wellhead. | 09-22-2011 |
Osvaldo Geromini, Orbe CH
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20130216682 | DEHYDRATED FOOD PRODUCT - A dehydrated food product of homogeneous composition in the form of flakes, where the flakes have a porosity of 30 to 70% which assists them dissolve and/or disperse rapidly in water. The flakes are typically used for the preparation of sauces, soups, fonds, gravies, stocks, and consommés. | 08-22-2013 |
Osvaldo Giangrandi, Bagnacavallo (ra) IT
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20150352762 | MANUFACTURING PROCESS OF SHOE WITH INTERNALLY WATERPROOFED FABRIC UPPER - A manufacturing process is provided for a shoe with a fabric upper that is internally provided with a waterproof coating layer made of plastic material. The process includes the step of piercing of the upper in order to inject plastic material in an intermediate space between a core of a mold and the upper. | 12-10-2015 |
Osvaldo Gonsa, Frankfurt DE
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20120120831 | QOS MULTIPLEXING VIA BASE STATION-RELAY NODE INTERFACE - The invention relates to methods for providing IP packets from a core network node to a relay node, wherein the IP packets are conveyed via a base station to the relay node on a wireless interface. To suggest an interface termination for data transport between core network and a relay node that is allowing for a flexible QoS control, preferably on a per user equipment basis this invention proposes two different multiplexing modes for use on the interface between base station and relay node: a first mode in which there is only a single dedicated radio bearer between the base station and the relay node to which all IP packets are multiplexed/mapped, and a second multiplexing mode where multiple dedicated radio bearers between the base station and the relay node are configured and the base station is multiplexing IP packets to the individual dedicated radio bearers according to their QoS class. | 05-17-2012 |
20120147830 | ENHANCED RANDOM ACCESS PROCEDURE FOR MOBILE COMMUNICATIONS - The invention relates to a random access procedure for use in a mobile communication system. Furthermore, the invention also provides a mobile terminal and a base station that as suitably adapted to perform the random access procedure as well as the definition of a special format of a random access response message signalled during the random access procedure. To suggest a random access procedure that allows more information to be conveyed in the first scheduled transmission of the random access procedure, the invention proposes a random access procedure for use in a mobile communication system, wherein a base station transmits a random access response in response to receiving a random access preamble from a mobile terminal, wherein the random access response message comprises a grant for a scheduled transmission by the mobile terminal and an indication on the uplink transmission mode for the scheduled transmission. | 06-14-2012 |
Osvaldo Gonsa, Friedrichsdorf DE
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20110305213 | HARQ OPERATION FOR MACRO-DIVERSITY TRANSMISSIONS IN THE DOWNLINK - The invention relates to a downlink transmission scheme that supports downlink HARQ operation and macro-diversity that is capable of overcoming the problem of HARQ protocol de-synchronization when using HARQ in the downlink with multiple data transmitting network nodes. In this scheme, a distributed HARQ protocol operation for downlink data transmissions involving multiple network nodes is provided, where only one network node is terminating downlink HARQ protocol operation towards to mobile terminal, i.e. retransmissions of a data packet are sent from a single network node, a single HARQ transmitter, to the mobile terminal. The multiple network nodes send a first transmission of the data packet to the mobile terminal in a single transmission time interval using HARQ. One of the multiple network nodes is designated as the HARQ terminating node that controls/handles all retransmissions of the data packet. | 12-15-2011 |
20130343261 | Dynamic PUSCH deactivation/activation for component carriers of a relay node - The invention relates to a method for dynamically controlling the PUSCH of a SCell in a backhaul link of a communication system utilizing a relay node with carrier aggregation, where the SCell is inband with respect to the access link between the relay node and the UEs. In order to avoid subframe blocking due to inband operation, the PUSCH of an SCell may be deactivated. The new downlink-only configuration of the SCell allows the relay node to use all resources of the SCell for scheduling resources for uplink and downlink transmissions in the access link. The PUSCH may deactivated and activated e.g. depending on the need for higher data rates in the uplink and downlink of the access link between the relay node and the UEs. The decision to deactivate/activate the PUSCH of an SCell may be taken by the DeNB or the relay node. | 12-26-2013 |
Osvaldo Marinotti, Aliso Viejo, CA US
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20110189120 | AEGYPTIN AND USES THEREOF - The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed. | 08-04-2011 |
20130123349 | AEGYPTIN AND USES THEREOF - The present invention relates to the discovery of the Aegyptin gene and Aegyptin protein, a molecule that interacts with collagen and inhibits platelet adhesion, activation and aggregation. Novel biological tools, prophylactics, therapeutics, diagnostics, and methods of use of the foregoing are also disclosed. | 05-16-2013 |
Osvaldo Mascarello, Milano IT
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20090107164 | REFRIGERANT ACCUMULATION AND OIL RECOVERY DEVICE FOR REFRIGERANT FLUID RECOVERY/REGENERATION/RECHARGING SYSTEMS - A refrigerant accumulation and oil recovery device for recovery/regeneration/recharging units for a refrigerant fluid withdrawn from refrigeration or air conditioning plants or heat pumps, characterised by comprising a refrigerant fluid accumulation/evaporation vessel and an oil recovery vessel, said vessels being closed at their top by at least one plate which supports them both, the plate presenting a plurality of passages defining, with said vessels, a part of the charging/recycling circuit of said recovery/regeneration unit, in which said accumulation/evaporation vessel and said oil recovery vessel present at least one wall in common, such that any refrigerant fluid leakage from one of said vessels at the connection interface between said common wall and said plate is recovered into the other. | 04-30-2009 |
Osvaldo Mascarello, Milan IT
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20090242814 | VALVE - A valve comprises a cup-shaped element presenting an outer surface on which a driver element is mountable and, inserted in said cup-shaped element, a core comprising at least one seal element arranged to block a first fluid passage provided in a bush, said core being movable within said cup-shaped element against the action of an elastic element between a first position in which said seal element rests on said bush such as to close its first passage and a second position in which said seal element is detached from said bush such as to open its first passage, said bush being associated with a closure element for the cup shaped element, the closure element presenting, for its fixing to the cup-shaped element, means cooperating with an inner surface of said cup-shaped element. | 10-01-2009 |
Osvaldo Milnes Pizarro, Nunao CL
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20130133642 | UNIT FOR HARNESSING SOLAR POWER - A unit for harnessing solar power for heating water at high pressure, in which the circuit is exposed to freezing, comprising: a heat exchanger made as a single piece for a hydraulic circuit, made up of parallel polymer pipes ( | 05-30-2013 |
Osvaldo Nogueira Sanches, Sao Paulo BR
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20090048554 | EXTRACORPOREAL CIRCULATION SYSTEM - The present model of utility is related to an extracorporeal circulation system used as an extracorporeal blood circulation system or as a temporary respiratory mechanical support known as ECMO that is quickly changed from one into the other, providing the physician with more time to evaluate the real need to install a long term ECMO. | 02-19-2009 |
Osvaldo Pensado, San Antonio, TX US
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20160069789 | System, Apparatus Or Method For Characterizing Pitting Corrosion - The present invention relates to a system, apparatus or and method to quantify features of relatively small defects or anomalies on a selected surface. Such defects may be associated with localized corrosion, such as pitting, that takes place on the surface of a metal exposed to a metallic environment. | 03-10-2016 |
Osvaldo Pensado-Rodriguez, San Antonio, TX US
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20120038376 | Local Electrochemical Impedance Spectroscopy (LEIS) for Detecting Coating Defects in Buried Pipelines - A system and associated methods for acquiring and analyzing LEIS data from a buried structure, such as a pipeline. A special probe having adjustable electrodes is placed in the soil above the structure. A voltage is applied to the structure, causing more current to emanate from a coating defect than from intact coating. The probe electrodes acquire a response signal, which is analyzed to detect the defect. | 02-16-2012 |
Osvaldo Pinali Doederlein, Curitiba (parana) BR
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20100076893 | METHOD FOR PROCESSING AND ROUTING FINANCIAL TRANSACTIONS FROM CAPTURE POINTS AND AUTHORIZED BY FINANCIAL INSTITUTIONS, IMPLEMENTED THROUGH SOFTWARE - A method for the routing of messages coming from capture points directly, or indirectly, connected to the Tecban network, and authorized by the Financing Institutions, which are also connected to the Tecban network, remarkably conceived to consolidate the ATM network of Tecban, as well as the proprietary networks of the Financing institutions administered by Tecban, through a number of encoded instructions, contained in a software used in computer networks to exchange messages among the several elements involved. | 03-25-2010 |
Osvaldo Podhajcer, Buenos Aires AR
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20100297024 | PROMOTER INDUCIBLE BY REACTIVE OXYGEN SPECIES AND VECTOR COMPRISING THE SAME - The invention provides promoters inducible by reactive oxygen species (ROS), capable of driving the expression of a gene of interest, particularly in a tumor cell. More particularly, it refers to promoters inducible by reactive oxygen species, that may be used to drive the expression of a gene of interest, such as a therapeutic gene, or a reporter gene for use in image diagnosis. The promoters comprise at least a fragment of a promoter sequence responsive to said reactive oxygen species, and corresponding to a gene highly expressed in cancer cells, wherein the fragment of the promoter sequence responsive to reactive oxygen species (ROS) is selected from the group of: the VE element of the VEGF promoter, the E6 element of the promoter of the EGR-1 gene, the MMP-1 element and a chimeric promoter containing an E6 element and a VE element. It also provides vectors carrying a human therapeutic or non therapeutic gene of interest, operably linked to said promoter sequence and compositions comprising the same. | 11-25-2010 |
20100310686 | EXTRACTS OF DESCHAMPSIA ANTARCTICA DESV, WITH ANTINEOPLASTIC ACTIVITY - The present disclosure provides a novel antineoplastic extract obtained from | 12-09-2010 |
20110177178 | Extracts of Deschampsia antarctica Desv. with antineoplastic activity - This invention describes antineoplastic compound derived from | 07-21-2011 |
20130084263 | Pharmaceutical kit and method for treating cancer - This invention is related to the field of cancer treatment, more specifically to gene therapy in combination with a suitable chemotherapeutic agent. The present invention is related to a new oncolytic virus, which is able to inhibit the growth of malignant tumors or is a treatment of hyperproliferative mammalian cells, or is a treatment of cancer. The oncolytic virus works in combination with a suitable chemotherapeutic agent. More specifically, the present invention provides a pharmaceutical kit comprising an oncolytic adenovirus and a chemotherapeutic agent, and a method for the treatment of cancer. | 04-04-2013 |
Osvaldo Prestini, Nembro (8g) IT
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20150303013 | MULTIPHASE MEDIUM VOLTAGE VACUUM CONTRACTOR - A multiphase medium voltage vacuum contactor is disclosed which can include a mounting frame on which there are positioned: for each phase, a current interrupter having a vacuum bulb which contains a fixed contact and a corresponding movable contact; and an actuator for moving the movable contacts between a closed position where they are coupled each to a corresponding fixed contact and an open position where they are each electrically separated from the corresponding fixed contact, and an electronic unit driving the actuator. An exemplary voltage transformer for feeding the electronic unit can be mounted on the frame. One or more sacrificial fault-protection devices and/or current sensors can be operatively associated to the voltage transformer and embedded into an electrically insulating coating encasing the transformer. | 10-22-2015 |
Osvaldo Quiroz Venegas, Santiago CL
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20120099984 | Mechanical Seal - A mechanical seal is disclosed having a rotatable sealing face and a stationary sealing face that are in opposed relation and arranged to be urged, into contact to form a seal. One of the sealing faces is mounted on a support assembly that includes a biasing device operative to move that sealing face into contact with the other sealing face. In one form of the invention, the biasing device comprises one or more resilient members that in use are deformed to provide the biasing force. In a second form of the invention, the support assembly forms part of a fluid barrier of the seal and the biasing device is fluid impervious and forms part of the barrier. In a third form of the invention, the biasing device is exposed to fluid pressure in the chamber and the biasing force increases on increasing the fluid pressure in the chamber. | 04-26-2012 |
20120107115 | Mechanical Seal With Improved Seal Assembly - Mechanical seals, seal assemblies and pumps are disclosed. A mechanical seal includes a sealing member and a mount that forms part of a mounting assembly to mount the sealing member to a support structure of the seal. In an embodiment, the mount forms part of a seal assembly and is an elastomeric ring bonded to the sealing member. | 05-03-2012 |
20120134799 | Adjustable mechanical seal - A mechanical seal is disclosed that has first and second sealing faces that are urged into contact to form a seal therebetween. One sealing face is mounted on a rotatable portion of the seal and the second sealing face is mounted on a support assembly. The joint further comprises a joint permitting rotary movement between the support assembly and a stationary portion of the seal to allow adjustment of the potion of the rotatable portion relative to the stationary portion without affecting the alignment of the first and second sealing faces. | 05-31-2012 |
20140356160 | MECHANICAL SEAL - A mechanical seal is disclosed having a rotatable sealing face and a stationary sealing face that are in opposed relation and arranged to be urged, into contact to form a seal. One of the sealing faces is mounted on a support assembly that includes a biasing device operative to move that sealing face into contact with the other sealing face. In one form of the invention, the biasing device comprises one or more resilient members that in use are deformed to provide the biasing force. In a second form of the invention, the support assembly forms part of a fluid barrier of the seal and the biasing device is fluid impervious and forms part of the barrier. In a third form of the invention, the biasing device is exposed to fluid pressure in the chamber and the biasing force increases on increasing the fluid pressure in the chamber. | 12-04-2014 |
Osvaldo Reyes Acosta, Ciudad De La Habana CU
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20090005294 | Peptides for the Treatment of Cancer Associated with the Human Papilloma Virus (HPV) and Other Epithelial Tumors - This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules. | 01-01-2009 |
20090136511 | Interleukin-15 Antagonist Peptide - Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor α subunit (IL15Rα) and TNFα-mediated apoptosis. | 05-28-2009 |
20090221508 | IMMUNOMODULATORY AND ANTI-TUMOUR PEPTIDES - The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKKYKGKFW, showing aminoacids substitutions, these peptides unable to bind to the lipopolysaccharide and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies. | 09-03-2009 |
20100055118 | Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof - Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use. | 03-04-2010 |
20100273702 | CHIMERICAL PEPTIDIC MOLECULES WITH ANTIVIRAL PROPERTIES AGAINST THE VIRUSES OF THE FLAVIVIRIDAE FAMILY - The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family. | 10-28-2010 |
20110212105 | METHOD TO BLOCK THE INFECTION BY FLAVIVIRUSES, MOLECULES AND USES - The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin. | 09-01-2011 |
20110250196 | PHARMACEUTICAL COMPOSITION USING GONADOTROPIN - RELEASING HORMONE (GNRH) COMBINED VARIANTS AS IMMUNOGEN - A pharmaceutical composition using natural gonadotropin-releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors. | 10-13-2011 |
20110251140 | PEPTIDE ANTAGONIST OF INTERLEUKIN-15 ACTIVITY - The present invention is related to the field of molecular immunology, particularly to a peptide derived from the sequence of interleukine-15 (IL-15), wherein said peptide was optimized to inhibit the biological activity of this molecule. In the present invention, it is shown that this peptide inhibits IL-15-induced T cell proliferation, Tumor Necrosis Factor α (TNFα) induction and the expression of IL-8 and IL-6 by the IL-15 receptor a subunit (IL-15Rα), all these effects mediated by the binding of the peptide to the IL-15Rα. The invention is also related to the use of the peptide to treat pathologies where the abnormal expression of IL-15 or IL-15Rα is related to the course of the disease, such as rheumatoid arthritis (RA) and prostate cancer. | 10-13-2011 |
20120135021 | CELL PENETRATING PEPTIDES AND ITS USE FUSED TO BIOMOLECULES WITH THERAPEUTIC ACTION - The present invention relates to use of a new cell penetrating peptides (CPP) and in particular to the region 32-51 of protein | 05-31-2012 |
20150190491 | Pharmaceutical Composition Using Gonadotropin-Releasing Hormone (GNRH) Combined Variants as Immunogen - A pharmaceutical composition using natural gonadotropin—releasing hormone (GnRH), and/or some of its mimetic peptides, indistinctly bound by its amino or carboxyl extremes to a carrier molecule; in one case by its carboxyl extreme and in the other case by the amino terminal extreme, thus eliciting a faster and more potent immunological response against the endogenous GnRH hormone. This finally leads to the ablation of the GnRH and consequently of the rest of the involved hormones in the stream GnRH/LH-FSH/Testosterone-(estrogens). An advantage of this formulation consists on facilitating the exposition to the immune system of a greater number of epitopes of the GnRH or its mimetics, minimizing thus the steric hindrance produced by the carriers. This invention has a direct application in the castration of pets and animals of economic interest, in the control of human fertility as well as in the treatment of hormone-sensitive tumors, such as that of the prostate, the breast, ovary, the endometry, testicles, hypophysis, salivary glands and other kinds of human tumors. | 07-09-2015 |
Osvaldo Reyes Acosta, Playa CU
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20130130971 | Method for Inhibiting HIV Replication in Mammal and Human Cells - The present invention describes a method to inhibit replication of the human immunodeficiency virus (HIV) by negatively modulating or altering the cytoskeleton, more precisely the proteins forming the intermediate cytoskeletal filaments, wherein the said proteins are vimentin and/or keratin-10. The replication of the virus is inhibited in human cells by intervening in the structure of these proteins. The present invention is also related to the use of agents, which comprise peptides and/or interfering RNA and/or lipidic compounds, said agents producing a negative modulation or alteration of the cytoskeleton to prevent or to treat the HIV infection. The invention provides means and methods for altering the cytoskeleton/filament structure of cells, as a result of which the infection of human cells by HIV is disturbed and can even be completely inhibited. The cytoskeleton is altered by reducing the amount of vimentin and/or keratin (e.g. by transcriptional control using interfering RNA) or by using peptides that disrupt the cytoskeleton. | 05-23-2013 |
Osvaldo Reyes Acosta, La Habana CU
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20130224313 | CANCER THERAPY METHOD - This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide. | 08-29-2013 |
20140112976 | Cyclic Peptides with an Anti-Neoplasic and Anti-Angiogenic Activity - The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems. | 04-24-2014 |
20140206621 | Cancer Therapy Method - This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide. | 07-24-2014 |
Osvaldo Tufi, Roma IT
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20130319902 | BLISTER HOLDER PROVIDED WITH MEANS DESIGNED TO DETECT THE NUMBER OF EXTRACTED PRODUCTS FROM THE BLISTER AND WITH GSM/GPRS COMMUNICATION MEANS TO REMOTELY DIALOGUE WITH A CONTROL CENTER - A pocket-sized blister-pack case, designed to receive a blister pack of a known type with a plurality of cells each containing a product, for example a pharmaceutical product in the form of a pill or tablet, has a plurality of capacitive and/or optical sensors for counting and displaying the number of pills that are taken out of the respective cell, as likewise the date and time of when they were taken, and is able to communicate via a packet mobile-radio interface the data to an authorized remote control centre that can check the degree of compliance of the patient to the therapy prescribed and can dialogue with the patient himself via packet and/or circuit mobile-radio interface. | 12-05-2013 |
Osvaldo Uresti, Paris FR
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20150110540 | Applicator for a Cosmetic Product and Associated Applicator Assembly - The invention relates to an applicator for a cosmetic product, comprising a core having a first end, referred to as a proximal end, and a second, free end, referred to as a distal end, a plurality of protrusions projecting from the core, and a plurality of plates also projecting from the core, wherein the protrusions and the plates are moulded with the core, the core is curved in its direction of extension so as to define a concave part and a convex part, and wherein the protrusions extend substantially over the concave part of the core and the plates extend substantially over the convex part of the core. The invention also relates to an associated applicator assembly. | 04-23-2015 |
20150110541 | Applicator for a Cosmetic Product and Associated Applicator Assembly - The invention relates to an applicator for a cosmetic product, comprising a core having a first end, referred to as a proximal end, and a second, free end, referred to as a distal end, and a plurality of plates, wherein the plates are moulded with the core, the plates being capable of forming, over the same angular portion of the core, converging channels designed so as to have at least two successive regions of convergence in the same direction of rotation about the core. The invention also relates to an associated applicator assembly. | 04-23-2015 |
20150136162 | DEVICE FOR DISPENSING ARTIFICIAL EYELASHES - The invention relates to a device ( | 05-21-2015 |
20150181968 | Device For Dispensing Artificial Eyelashes - The invention relates to a device for dispensing artificial eyelashes, comprising a housing equipped with a dispensing region, a carrier to which a plurality of artificial eyelashes is fixed, a movement mechanism capable of being actuated to cause movement of the carrier in order to convey the artificial eyelashes towards the dispensing region and to allow the artificial eyelashes to exit through said dispensing region, said eyelashes being oriented transversely to an axis of extension of the carrier, at least when they are passing through said dispensing region. | 07-02-2015 |
Osvaldo Zambetti, Miiano IT
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20140035547 | METHOD FOR CONTROLLING A MULTIPHASE INTERLEAVING CONVERTER AND CORRESPONDING CONTROLLER - A method is provided for controlling a converter of the multiphase interleaving type. According to the method, there is detected when a change of the load applied to an output terminal of the converter occurs. All the phases of the converter are simultaneously turned off, and a driving interleaving phase shift is recovered so as to restart a normal operation of the converter. A controller for carrying out such a method is also provided. | 02-06-2014 |
Osvaldo Zambetti, Milano IT
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20110205767 | METHOD FOR CONTROLLING A MULTIPHASE INTERLEAVING CONVERTER AND CORRESPONDING CONTROLLER - A method is provided for controlling a converter of the multiphase interleaving type. According to the method, there is detected when a change of the load applied to an output terminal of the converter occurs. All the phases of the converter are simultaneously turned off, and a driving interleaving phase shift is recovered so as to restart a normal operation of the converter. A controller for carrying out such a method is also provided. | 08-25-2011 |