Patent application number | Description | Published |
20090054360 | Method and Composition for Treating Allergic Diseases - A method and composition for treating allergic diseases and/or airway inflammation including pollinosis, bronchial asthma, allergic rhinitis, atopic dermatitis and anaphylactic shock with the administration to a subject an amount of an anti-infectious agent such as ribavirin and optionally combined with an anti-inflammatory agent selected from inhaled steroids, leukotriene receptor antagonists and beta- | 02-26-2009 |
20090264503 | SHORT INTERFERENCE RIBONUCLEIC ACIDS FOR TREATING ALLERGIC DISEASES - Provided herein are compounds, methods and compositions for treating allergic diseases. In particular, an isolated double stranded short interfering ribonucleic acid (siRNA) with a ribonucleotide sequence complementary to at least a portion of a target gene RNA such as an airway inflammation related-gene RNA, thereby resulting in the cleavage of the expressed target gene RNA via RNA interference mechanism, and is useful as a medicament for treating allergy by alleviating or minimizing airway inflammation of a subject. | 10-22-2009 |
20110287456 | SYNTHETIC PEPTIDES, METHODS AND KITS FOR DIAGNOSING AUTOIMMUNE DISEASES - Provided herein are synthetic peptides, methods and kits for easy detecting or diagnosing an autoimmune disease, particularly, Henoch-Schönlein purpura (HSP), based on the detection of autoimmune antibodies with peptides derived from β-2-glycoprotein-1 (β2-GPI). | 11-24-2011 |
Patent application number | Description | Published |
20100234239 | METHODS AND COMPOSITIONS FOR IDENTIFYING, CLASSIFYING AND MONITORING SUBJECT HAVING BCL-2 FAMILY INHIBITOR-RESISTANT TUMORS AND CANCERS - The invention is directed to methods and kits that allow for identifying, classifying, and monitoring cancer patients for Bcl-2 family inhibitor therapies. The methods and compositions of the invention are directed to determining amplification of Bcl-x | 09-16-2010 |
20110110861 | Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells - The present invention relates to methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, which can be used to treat and/or prevent diseases such as cancer, autoimmunity and infections. The present invention also relates to methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. The present invention further relates to methods of detecting cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. | 05-12-2011 |
20140335104 | Methods of Detecting Cells with a Disrupted Cell Membrane, Cells Infected with A Pathogen, Dying Cells or Dead Cells - The present invention relates to methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, which can be used to treat and/or prevent diseases such as cancer, autoimmunity and infections. The present invention also relates to methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. The present invention further relates to methods of detecting cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. | 11-13-2014 |
20150211075 | METHODS AND COMPOSITIONS FOR IDENTIFYING, CLASSIFYING AND MONITORING SUBJECT HAVING BCL-2 FAMILY INHIBITOR-RESISTANT TUMORS AND CANCERS - The invention is directed to methods and kits that allow for identifying, classifying, and monitoring cancer patients for Bcl-2 family inhibitor therapies. The methods and compositions of the invention are directed to determining amplification of Bcl-x | 07-30-2015 |
20150265721 | Compounds and Methods for Modulating an Immune Response - The present invention relates to the identification of proteins which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. | 09-24-2015 |
Patent application number | Description | Published |
20100087436 | METHOD OF PREVENTING OR TREATING ORGAN, HEMATOPOIETIC STEM CELL OR BONE MARROW TRANSPLANT REJECTION - Methods of preventing or treating organ, hematopoietic stem cell or bone marrow transplant rejection are disclosed. | 04-08-2010 |
20100197711 | BENZOTHIAZOLE COMPOUNDS - The present invention relates to benzothiazole compounds that mimic the activity of BH3 only proteins and are capable of binding to and neutralizing pro survival Bcl 2 proteins. The invention also relates to the use of such compounds in the regulation of cell death or cell survival and the treatment and/or prophylaxis of diseases or conditions associated with the deregulation of cell death or cell survival. | 08-05-2010 |
20120039806 | Compounds and Methods for Modulating an Immune Response - The present invention relates to the identification of proteins which bind the dendritic cell marker known as Clec9A. The present invention provides new compounds for targeting therapeutic agents such as antigens to dendritic cells. Also provided are methods of modulating a humoral and/or T cell mediated immune response to the antigen, methods of delivery of a cytotoxic agent to dendritic cells thereof involved in diseased states, methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, and methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof. | 02-16-2012 |
Patent application number | Description | Published |
20090048164 | THERAPEUTIC PRO-APOPTOTIC BH3-LIKE MOLECULES AND METHODS FOR GENERATING AND/OR SELECTING THE SAME - The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides therapeutic agents which inhibit pro-survival molecules and which are capable of inducing or facilitating apoptosis of a target cell or cell population such as cancer cells. The present invention further provides methods for generating or selecting the therapeutic molecules and pharmaceutical compositions comprising the therapeutic molecules. | 02-19-2009 |
20100199368 | BCL-2-MODIFYING FACTOR (BMF) SEQUENCES AND THEIR USE IN MODULATING APOPTOSIS - The present invention relates generally to novel molecules capable of, inter alia, modulating apoptosis in mammalian cells and to genetic sequences encoding same. More particularly, the present invention relates to a novel member of the Bcl-2 family of proteins, referred to herein as “Bmf”, and to genetic sequences encoding same and to regulatory sequences such as a promoter sequence directing expression of Bmf. Bmf comprises a BH3 domain which facilitates interaction to pro-survival Bcl-2 family members thereby triggering apoptosis. Bmf is regarded, therefore, as a BH3-only molecule. The molecules of the present invention are useful, for example, in therapy, diagnosis, antibody generation and as a screening tool for therapeutic agents capable of modulating physiological cell death or survival and/or modulating cell cycle entry. The present invention further contemplates genetically modified animals in which one or both alleles of Bmf are mutated or partially or wholly deleted alone or in combination with a mutation in one or both alleles of another Bcl-2-type molecule such as but not limited to Bim. The genetically modified animals are useful inter alia in screening for agents which ameliorate the symptoms of diseases caused by defects in apoptosis or which specifically promote apoptosis of target cells. | 08-05-2010 |
Patent application number | Description | Published |
20120216116 | Method for customizing avatars and heightening online safety - In accord with the present invention, a method is defined for an ordinary computer user to customize an avatar, so as to determine how the avatar is animated afterwards. The animation method used is preferably intuitive and simple so that ordinary computer users can learn and manipulate avatars easily and efficiently. Interaction with the virtual character can preferably involve animation of its face. Preferably the invention comprises the steps of offering an avatar a default setting of a mechanism of muscle movement, and a user interacts with the mechanism of muscle movement so as to customize the avatar. The method is preferably used in stand-alone application and multimedia communication, such as Internet, email and wireless applications. Users are able to be creative in the process of animation, thus may reveal personal flavors and personality traits through an avatar. In accord with the present invention, a method is defined for an intelligent system to analyze potentially damaging information, and send special signals to users in real time, so as to alert potential victims and discourage predators. The present invention defines a method to intelligently process messages that are being sent through online chat sessions, so as to alert potential victims and discourage predators or pedophiles. The method uses intelligent systems that are loaded with a set of rules. By analyzing the messages against these rules, potentially damaging messages can be captured. Then, instructions can be triggered by the intelligent systems. As a result, graphic outputs will be displayed to alert potential victims and discourage predators. The services can be offered in real time. | 08-23-2012 |
20140019374 | METHOD FOR CUSTOMIZING AVATARS AND HEIGHTENING ONLINE SAFETY - In accord with the present invention, a method is defined for an intelligent system to analyze potentially damaging information, and send special signals to users in real time, so as to alert potential victims and discourage predators. The present invention defines a method to intelligently process messages that are being sent through online chat sessions, so as to alert potential victims and discourage predators or pedophiles. The method uses intelligent systems that are loaded with a set of rules. By analyzing the messages against these rules, potentially damaging messages can be captured. Then, instructions can be triggered by the intelligent systems. As a result, graphic outputs will be displayed to alert potential victims and discourage predators. The services can be offered in real time. | 01-16-2014 |
Patent application number | Description | Published |
20080240299 | Demodulation of 16-QAM, DCM data symbols using two hybrid-QPSK constellations - In one embodiment, a demapper uses two hybrid-QPSK constellations to demap pairs of equalized data symbols recovered from 16-QAM, DCM OFDM symbols, wherein the equalized data symbols in a pair correspond to the same four-bit group. A first hybrid-QPSK constellation is generated by combining the real components of both 16-QAM mapping constellations onto one coordinate plane. The demapper generates a first set of two decision variables by combining the real components of each equalized data symbol in a pair to correspond to the first hybrid-QPSK coordinate plane. A log-likelihood ratio is then calculated for both decision variables in the set to determine likelihood estimates for the first and second bits of the four-bit group. This process is repeated for the imaginary components of each corresponding pair of equalized data symbols to generate likelihood estimates for the third and fourth bits of the four-bit group. | 10-02-2008 |
20090207926 | ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING USING SUBSYMBOL PROCESSING - In one embodiment, a transmitter converts digital input data into combined-OFDM signals and a receiver recovers data from the transmitted combined-OFDM signals. For transmission, digital data is mapped into data symbols using a commonly known modulation technique, such as QAM or DQPSK. The data symbols are subsequently divided into two or more groups according to a specified grouping pattern. Each group of data symbols is then converted into a separate OFDM subsymbol using IFFT processing. The OFDM subsymbols are then combined according to a specified combining pattern to create a combined-OFDM symbol. Combined-OFDM symbols are then prepared for transmission by affixing cyclic prefixes, converting the symbols to analog format, and performing spectral shaping of the analog signal. Upsampling may be employed to increase the signal bandwidth. In alternative embodiments, OFDM subsymbols may be combined using interleaving to create an interleaved-OFDM symbol. | 08-20-2009 |
20110261898 | MULTIPLE-INPUT MULTIPLE-OUTPUT OFDM SYSTEMS - Disclosed is a method of processing a series of data bits for transmission on a transmit link, the method comprising mapping the series of data bits to a series of data symbols; demultiplexing the series of data symbols to a plurality of substreams of symbols; modulating each substream of symbols to a corresponding series of OFDM symbols; and space precoding the plurality of series of OFDM symbols to form one or more series of space precoded OFDM symbols, wherein the demultiplexing is dependent on channel state information for the transmit link. | 10-27-2011 |
20120033761 | Hybrid Adaptive Antenna Array - Disclosed is a hybrid antenna array ( | 02-09-2012 |
20120182948 | Wireless Data Communications - A wireless data communications method and transmitter are disclosed. A transmitter ( | 07-19-2012 |
20120269286 | OUT-OF-BAND EMISSION CANCELLATION - A transmission signal pre-processing method and apparatus for out-of-band emission cancellation are disclosed. For each of N subchannels in a band weighting each of N subchannel symbols by a calculated value in the range from 0 to 1 is performed. Precoding said N weighted symbols, organised as an N×1 matrix, by multiplication by a unitary matrix is then performed. | 10-25-2012 |
20120307925 | Peak-To-Average Power Ratio Reduction For Wireless Communication Systems - Disclosed is a wireless communication signal peak-to-average power ratio reduction, method. The method comprises calculating a peak envelope from an envelope of an input signal using a clipping threshold; smoothing the peak envelope using a window function; mapping the smoothed peak envelope to an attenuation function using the clipping threshold; and applying the attenuation function to the input signal. | 12-06-2012 |
20130005282 | Reducing Out-Of-Band Emission - Disclosed is a transmitter for a communication system. The transmitter comprises a sidelobe suppression module configured to apply a suppression matrix to an input vector comprising symbols to be transmitted by the transmitter; a modulation module configured to modulate the precoded vector to a time-domain symbol using a plurality of subcarriers, each symbol in the precoded vector having a corresponding subcarrier; and a digital-to-analog conversion module configured to convert the time-domain symbol to an analog waveform for transmission. The suppression matrix is constructed such that emissions at one or more predetermined suppression distances lying outside a frequency band defined by the subcarriers are set to zero according to a predetermined emission model. | 01-03-2013 |
20140105325 | Arbitrary Sample Rate Conversion For Communication Systems - Disclosed is a communication modulator with sample rate conversion. The modulator comprises a symbol mapping module configured to map an input bitstream to a symbol sequence; a pre-distortion module configured to multiply the symbol sequence by a discrete frequency response to produce a pre-distorted symbol sequence; a modulation module configured to modulate the pre-distorted symbol sequence to a time-domain baseband sample sequence; a sample rate conversion module configured to convert the sample rate of the baseband sample sequence to a different sample rate to produce a sample-rate-converted baseband sample sequence; and an up-conversion module configured to up-convert the sample-rate-converted baseband sample sequence to an intermediate frequency signal. The discrete frequency response by which the pre-distortion module multiplies the symbol sequence is configured to compensate for passband droop introduced to the sample-rate-converted baseband sample sequence by the sample rate conversion module. | 04-17-2014 |
20140194142 | WIRELESS LOCALISATION SYSTEM - Disclosed is an apparatus for estimating the location of a remote node. The apparatus comprises an antenna array comprising a plurality of elements in a fixed spatial arrangement, at least one element being a transmitting element configured to transmit a first wireless signal to the remote node, and at least two elements being receiving elements configured to receive a second wireless signal transmitted by the remote node in response to the first wireless signal. The apparatus further comprises a signal processing unit connected to the antenna array, the signal processing unit being configured to: estimate a plurality of round trip distances using the wireless signals, each round trip distance being from a transmitting element to the remote node and back to a receiving element; and estimate the location of the remote node using the round trip distance estimates. | 07-10-2014 |
20140321523 | REDUCING OUT-OF-BAND EMISSION - Disclosed is a transmitter for a communication system. The transmitter comprises a sidelobe suppression module configured to apply a suppression matrix to an input vector comprising symbols to be transmitted by the transmitter; a modulation module configured to modulate the precoded vector to a time-domain symbol using a plurality of subcarriers, each symbol in the precoded vector having a corresponding subcarrier; and a digital-to-analog conversion module configured to convert the time-domain symbol to an analog waveform for transmission. The suppression matrix is constructed such that emissions at one or more predetermined suppression distances lying outside a frequency band defined by the subcarriers are set to zero according to a predetermined emission model. | 10-30-2014 |