Morley, AU
Alexander Alan Morley, Adelaide AU
Patent application number | Description | Published |
---|---|---|
20100304444 | METHOD OF AMPLIFICATION - The present invention relates generally to a method of amplifying a nucleic acid region of interest and, more particularly, to a method of amplifying a nucleic acid region of interest via a nested single tube PCR. The method of the invention is designed to provide a means to selectively inactivate the functionality of the outer primer or primers and to maintain amplification efficiency throughout the reaction. The development of a means to achieve efficient amplification by the outer primer followed by efficient amplification with the inner primers, in the context of a single tube nested PCR, is useful in a range of applications including, but not limited to, the diagnosis and/or monitoring of disease conditions which are characterized by specific gene sequences and the characterization or analysis of specific gene regions of interest. Still further, the method of the present invention enables quantification to be performed and not just simple detection. | 12-02-2010 |
Alexander Alan Morley, Glenelg AU
Patent application number | Description | Published |
---|---|---|
20090202999 | METHOD FOR DNA BREAKPOINT ANALYSIS - The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not only the identification of the breakpoint position but, further, enables the isolation of the DNA segment across which the breakpoint occurs. This provides a valuable opportunity to conduct further analysis of the breakpoint region, such as to sequence across this region. The method of the present invention is useful in a range of applications including, but not limited to, providing a routine means to characterise the gene breakpoint associated with disease onset in a patient and thereby enable the design of patient specific probes and primers for ongoing monitoring of the subject disease condition. In addition to monitoring the progression of a condition characterised by the existence of the breakpoint, there is also enabled assessment of the effectiveness of existing therapeutic drugs and/or new therapeutic drugs and, to the extent that the condition is a neoplasm, prediction of the likelihood of a subject's relapse from a remissive state. | 08-13-2009 |
20100248310 | METHOD OF DNA AMPLIFICATION - The present invention relates generally to a method of amplifying a nucleic acid region of interest and, more particularly, to a method of amplifying a nucleic acid region of interest using a PCR method designed to minimise the generation of amplicons from primers which have bound to nucleic acid regions other than the specific region of interest. The method of the present invention is based on the determination that by rendering inefficient the functionality of either the forward primer or the reverse primer, the rate of amplification of irrelevant nucleic acid regions can be reduced relative to amplification of the region of interest. The provision of a selective means of amplifying a nucleic acid region of interest is useful in a range of applications including, but not limited to, the diagnosis and/or monitoring of disease conditions which are characterised by specific gene sequences, the characterisation or analysis of gene regions of interest, the identification or characterisation of DNA breakpoint regions and the isolation of gene sequences of interest where only the nucleotide sequence at one end of the gene sequence of interest is known. | 09-30-2010 |
Alexander Alan Morley, Glenegl AU
Patent application number | Description | Published |
---|---|---|
20100216138 | METHOD FOR DNA BREAKPOINT ANALYSIS - The present invention relates to a method for identifying a DNA breakpoint and agents for use therein. More particularly, the present invention provides a method for identifying a gene translocation breakpoint based on the application of a novel multiplex DNA amplification technique. The method of the present invention facilitates not only the identification of the break-point position but, further, enables the isolation of the DNA segment across which the breakpoint occurs. This provides a valuable opportunity to conduct further analysis of the breakpoint region, such as to sequence across this region. The method of the present invention is useful in a range of applications including, but not limited to, providing a routine means to characterise the gene break-point associated with disease onset in a patient and thereby enable the design of patient specific probes and primers for ongoing monitoring of the subject disease condition. In addition to monitoring the progression of a condition characterised by the existence of the breakpoint, there is also enabled assessment of the effectiveness of existing therapeutic drugs and/or new therapeutic drugs and, to the extent that the condition is a neoplasm, prediction of the likelihood of a subject's relapse from a remissive state. | 08-26-2010 |
Alexander Alan Morley, South Australia AU
Patent application number | Description | Published |
---|---|---|
20080268433 | Use of Mitochondrial Point Mutations as Sensitive Clonal Markers - The present invention relates to a method of detecting an aberrant population of cells in a subject and, more particularly, to a method of qualitatively and/or quantitatively detecting a clonal population of aberrant cells in a subject by ‘screening for mitochondrial DNA mutations. The method of the present invention is useful in a range of applications including, but not limited to, diagnosing a condition characterised by the presence of a clonal population of aberrant cells (such as a neoplastic condition), monitoring the progression of such a condition, predicting the likelihood of a subject's relapse from a remissive state to a disease state or for assessing the effectiveness of existing therapeutic drugs and/or new therapeutic agents. In a related aspect, the present invention also provides a method of characterising clonal populations of aberrant cells by determining the nature and range of mitochondrial DNA mutations expressed by a specific population of aberrant cells. | 10-30-2008 |
20090209432 | Detecting targets using nucleic acids having both a variable region and a conserved region - The invention relates to nucleic acid molecules for use in detecting a target nucleic acid molecule which is a member of a class of nucleic acid molecules and which is characterised by a specific variant region, said nucleic acid molecule comprising (i) a nucleic acid stem region which comprises a nucleic acid interaction site directed to a conserved region of the class of which said target nucleic acid molecule is member, or part thereof and which conserved region is located proximally to a variant region; operate y linked to (ii) a nucleic acid recognition region comprising at least two nucleotides. The nucleic acids are used in arrays and are an efficient means of screening molecules exhibiting a unique nucleotide sequence within a randomly varying population. The invention is useful in monitoring the effectiveness of therapeutic drug therapies and the progression of medical conditions, characterised by the presence of clonal populations of cells, particularly clonal lymphocyte populations. | 08-20-2009 |
Alexander Alan Morley, Malvern AU
Patent application number | Description | Published |
---|---|---|
20120058515 | METHOD OF REGULATING OLIGONUCLEOTIDE FUNCTIONALITY - The present invention relates generally to a method of regulating oligonucleotide functionality and, more particularly, to a method of regulating the functionality of a primer or probe. The method of the invention is designed to provide a means to selectively inactivate or activate the functionality of an oligonucleotide, such as a primer, thereby providing means to regulate the progress of any method using that oligonucleotide. The development of a means to regulate the functionality of an oligonucleotide, such as a primer, is useful in a range of applications including, but not limited to, amplification reactions such as PCR, isothermal amplification and nucleic acid strand extension. With respect to amplification reactions, these have wide utility including the diagnosis and/or monitoring of disease conditions which are characterised by specific gene sequences and the characterisation or analysis of specific gene regions of interest. | 03-08-2012 |
20130078676 | METHOD OF REGULATING OLIGONUCLEOTIDE FUNCTIONALITY - The present invention relates generally to a method of regulating oligonucleotide functionality and, more particularly, to a method of regulating the functionality of a primer or probe. The method of the invention is designed to provide a means to selectively inactivate or activate the functionality of an oligonucleotide, such as a primer, thereby providing means to regulate the progress of any method using that oligonucleotide. The development of a means to regulate the functionality of an oligonucleotide, such as a primer, is useful in a range of applications including, but not limited to, amplification reactions such as PCR, isothermal amplification and nucleic acid strand extension. With respect to amplification reactions, these have wide utility including the diagnosis and/or monitoring of disease conditions which are characterised by specific gene sequences and the characterisation or analysis of specific gene regions of interest. | 03-28-2013 |
20130309680 | METHOD OF DETERMINING RNA INTEGRITY - A method of determining a quantitative measure of the integrity of RNA in a sample, the method comprising: (i) assaying a sample containing instances of an RNA molecule transcribed from a reference gene, at least some of the instances being damaged, to determine quantitative measures of the relative or absolute numbers of intact instances of each of a plurality of segments of the RNA molecule in the sample, the segments having respective different lengths; (ii) based on a relationship between the determined quantitative measures and the respective different lengths of the segments, determining a quantitative measure of integrity of the instances of the RNA molecule in the sample; and (iii) determining the total number of instances of an RNA molecule of interest in a sample by using the quantitative measure of integrity and the length of a corresponding degradation-relevant segment of the RNA molecule of interest. | 11-21-2013 |
Bruce Thomas Morley, Victoria AU
Patent application number | Description | Published |
---|---|---|
20110309004 | Fruit Handling Equipment - Fruit handling equipment comprising a conveyor having a plurality of linked carriages, each supporting at least one fruit carrying cup pivotally secured to the carriage, each cup having a latching mechanism operable to hold the cup in a fruit carrying mode and releasable to cause the cup to pivot to a delatched position to eject the fruit, and remotely controllable means in each carriage to release the latching mechanism. | 12-22-2011 |
20130043104 | SINGULATOR - A singulator for use with fruit handling equipment including spaced fruit supports driven at a particular speed, the singulator causing the fruit to assume single file for transfer to the fruit supports, the singulator including a first pair of belts arranged in a V formation travelling at different speeds, wherein the first pair of belts merges into a second pair of belts arranged in a V formation and both travelling at about the speed of the fruit supports, and wherein the second pair of belts is adapted to be operated so as to transfer the fruits substantially at the same speed as the fruit supports, whereby fruit are transferred to the fruit supports in single file whilst moving at the same speed as the fruit supports. | 02-21-2013 |
Carl Morley, Victoria AU
Patent application number | Description | Published |
---|---|---|
20150203181 | MARINE PROPELLERS - Some embodiments relate to a propeller having a hub and a plurality of radially extending blades, wherein a radial extreme of each of the blades is integral with an end plate defining a ring segment coaxial with the propeller hub, each ring segment having a concave inner surface and conforming generally to a frustoconical ring, the radial cross section of which is angled at between 0° and 15° to an axis of rotation of the propeller. | 07-23-2015 |
David Morley, Camberwell AU
Patent application number | Description | Published |
---|---|---|
20090307162 | METHOD AND APPARATUS FOR AUTOMATED ASSISTANCE WITH TASK MANAGEMENT - The present invention relates to a method and apparatus for assisting with automated task management. In one embodiment, an apparatus for assisting a user in the execution of a task, where the task includes one or more workflows required to accomplish a goal defined by the user, includes a task learner for creating new workflows from user demonstrations, a workflow tracker for identifying and tracking the progress of a current workflow executing on a machine used by the user, a task assistance processor coupled to the workflow tracker, for generating a suggestion based on the progress of the current workflow, and a task executor coupled to the task assistance processor, for manipulating an application on the machine used by the user to carry out the suggestion. | 12-10-2009 |
Grant Morley, Ascot Vale Vic AU
Patent application number | Description | Published |
---|---|---|
20100291233 | TREATMENT OF NEUROLOGICAL DISORDERS - This invention relates to the use of selenate or a pharmaceutically acceptable salt thereof in methods and compositions of treating or preventing non-tauopathy neurological disorders. In some embodiments, the invention relates to the use of selenate or a pharmaceutically acceptable salt thereof in combination with other therapies for use in methods of treating or preventing non-tauopathy neurological disorders. | 11-18-2010 |
20150140130 | TREATMENT OF NEUROLOGICAL DISORDERS - A treatment of a neurological disorder, including hypoxia, oxygen-glucose deprivation and acute brain trauma in a subject involves administering an effective amount of selenate or a pharmaceutically acceptable salt thereof to the subject. The treatment prevents incurring a symptom, holds in check a symptom or treats an existing symptom of the neurological disorder. | 05-21-2015 |
John William Morley, Blaxland AU
Patent application number | Description | Published |
---|---|---|
20130310899 | STIMULATION METHOD FOR MAINTAINING THE RESPONSIVENESS OF ELECTRICALLY EXCITABLE CELLS TO REPEATED ELECTRICAL STIMULATION - A method of neural stimulation is described for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. A stimulating signal ( | 11-21-2013 |
Peter Robert Morley, Victoria AU
Patent application number | Description | Published |
---|---|---|
20090066078 | Close-Coupled Fitting - The close-coupled fitting allows practical vessel/s to be connected in a manifold configuration with minimal space between them. As an example, a Tee-piece close-coupled fitting is in the shape of a “T” and comprises a fitting at an approximate 90° angle extending from the 180° plane. One end of the section on the 180° plane is a female socket that begins approximately flush with one side of the 90° fitting and has an internal limit that intrudes some-way into the opening of the 90° fitting. The male socket of the 180° plane extends outwards from the other side of the 90° fitting. Multiple Tee-piece close-coupled fittings connect along the 180° plane by inserting the male socket into the female socket. This invention allows an alternative manner of manufacture for storage units that affords flexibility and maximises the available space for such units. | 03-12-2009 |