Patent application number | Description | Published |
20110123586 | INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA - Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production. | 05-26-2011 |
20140100242 | INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA - Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production. | 04-10-2014 |
20150238475 | INHIBITION OF QUORUM SENSING-MEDIATED PROCESSES IN BACTERIA - Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production. | 08-27-2015 |
Patent application number | Description | Published |
20090018368 | EXPEDITIOUS SYNTHESIS OF DPD - This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria | 01-15-2009 |
20090286873 | AI-2 compounds and analogs based on Salmonella typhimurium LsrB structure - This invention relates to crystals comprising apo-LsrB and holo-LsrB. The structure of holo-LsrB identifies a tetrahydroxytetrahydrofuran derived from 4,5-dihydroxy-2,3-pentanedione (DPD) as the active autoinducer-2 (AI-2) molecule in | 11-19-2009 |
20100160423 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS - A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote | 06-24-2010 |
20100273890 | IDENTIFICATION OF BACTERIAL AUTOINDUCER AND USE IN TREATING BACTERIAL PATHOGENICITY - A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena. | 10-28-2010 |
20140024707 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS - A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote | 01-23-2014 |
20140275232 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS - A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote | 09-18-2014 |
20150126474 | BROAD SPECTRUM PRO-QUORUM-SENSING MOLECULES AS INHIBITORS OF VIRULENCE IN VIBRIOS - Using a whole-cell high-throughput screen, eleven molecules were identified that activate | 05-07-2015 |
20150191765 | SYSTEMS AND METHODS TO DETECT BIOFILM STREAMER GROWTH AND THEIR USES - The present invention relates to a method of measuring biofilms and/or biofilm streamers, wherein the method comprises a system that has at least one channel and a biofilm streamer promotion element, a fluid capable of moving along the channel, wherein the fluid has a flow driven by a controlled pressure; and a measuring element capable of measuring a flow rate of the fluid through the channel. Additionally, method of screening for compound(s) that promote and/or inhibit biofilm and/or biofilm streamers using this system are also contemplated. Uses of the system, methods and identified compounds are contemplated for medical and/or industrial environments. | 07-09-2015 |
20150306067 | SMALL MOLECULE ANTAGONISTS OF BACTERIAL QUORUM-SENSING RECEPTORS - A novel small molecule antagonizes two types of acyl homoserine lactone receptors: membrane-bound and cytoplasmic. A focused library of analogs and derivatives of the original antagonist was synthesized. Analog and derivative molecules harbor a range of activities. The novel small molecule and most potent antagonist protects the eukaryote | 10-29-2015 |
Patent application number | Description | Published |
20100286461 | PROCESS FOR CONTINUOUS HETEROGENEOUSLY CATALYZED PARTIAL DEHYDROGENATION OF AT LEAST ONE HYDROCARBON TO BE DEHYDROGENATED - A process for continuous heterogeneously catalyzed partial dehydrogenation of at least one hydrocarbon to be dehydrogenated in a reactor which is manufactured from a steel with specific elemental composition on its side in contact with the reaction gas, and also partial oxidations of the dehydrogenated hydrocarbon and the reactor itself. | 11-11-2010 |
20110038763 | PROCESS FOR CONTINUOUS HETEROGENEOUSLY CATALYZED PARTIAL DEHYDROGENATION OF AT LEAST ONE HYDROCARBON TO BE DEHYDROGENATED - A process for continuous heterogeneously catalyzed partial dehydrogenation of at least one hydrocarbon to be dehydrogenated in a reactor which is manufactured from a composite material which consists, on its side in contact with the reaction chamber, of a steel B with specific elemental composition which, on its side facing away from the reaction chamber, either directly or via an intermediate layer of copper, or of nickel, or of copper and nickel, is plated onto a steel A with specific elemental composition, and also partial oxidations of the dehydrogenated hydrocarbon and the reactor itself. | 02-17-2011 |
20110110830 | SHELL-AND-TUDE REACTOR FOR PREPARING MALEIC ANHYDRIDE - An apparatus for preparing maleic anhydride by heterogeneously catalyzed gas-phase oxidation of a feed stream comprising hydrocarbons having at least 4 carbon atoms per molecule, which comprises a reactor having a bundle of reaction tubes into which a solid-state catalyst over which the exothermic reaction of the feed stream with an oxygen-comprising gas stream takes place has been introduced and also one or more. pumps and one or more heat exchangers which are located outside the reactor and through which a heat transfer medium formed by a salt melt flows through the intermediate space in the reactor between the reaction tubes and takes up the heat of reaction, with the temperature of the salt melt being in the range from 350 to 480° C., wherein the reaction tubes are made of a heat-resistant alloy steel which comprises either at least 0.5% by weight of chromium or at least 0.25% by weight of molybdenum or at least 0.5% by weight of chromium and at least 0.25% by weight of molybdenum, is proposed. | 05-12-2011 |
Patent application number | Description | Published |
20100286461 | PROCESS FOR CONTINUOUS HETEROGENEOUSLY CATALYZED PARTIAL DEHYDROGENATION OF AT LEAST ONE HYDROCARBON TO BE DEHYDROGENATED - A process for continuous heterogeneously catalyzed partial dehydrogenation of at least one hydrocarbon to be dehydrogenated in a reactor which is manufactured from a steel with specific elemental composition on its side in contact with the reaction gas, and also partial oxidations of the dehydrogenated hydrocarbon and the reactor itself. | 11-11-2010 |
20110038763 | PROCESS FOR CONTINUOUS HETEROGENEOUSLY CATALYZED PARTIAL DEHYDROGENATION OF AT LEAST ONE HYDROCARBON TO BE DEHYDROGENATED - A process for continuous heterogeneously catalyzed partial dehydrogenation of at least one hydrocarbon to be dehydrogenated in a reactor which is manufactured from a composite material which consists, on its side in contact with the reaction chamber, of a steel B with specific elemental composition which, on its side facing away from the reaction chamber, either directly or via an intermediate layer of copper, or of nickel, or of copper and nickel, is plated onto a steel A with specific elemental composition, and also partial oxidations of the dehydrogenated hydrocarbon and the reactor itself. | 02-17-2011 |
20110110830 | SHELL-AND-TUDE REACTOR FOR PREPARING MALEIC ANHYDRIDE - An apparatus for preparing maleic anhydride by heterogeneously catalyzed gas-phase oxidation of a feed stream comprising hydrocarbons having at least 4 carbon atoms per molecule, which comprises a reactor having a bundle of reaction tubes into which a solid-state catalyst over which the exothermic reaction of the feed stream with an oxygen-comprising gas stream takes place has been introduced and also one or more. pumps and one or more heat exchangers which are located outside the reactor and through which a heat transfer medium formed by a salt melt flows through the intermediate space in the reactor between the reaction tubes and takes up the heat of reaction, with the temperature of the salt melt being in the range from 350 to 480° C., wherein the reaction tubes are made of a heat-resistant alloy steel which comprises either at least 0.5% by weight of chromium or at least 0.25% by weight of molybdenum or at least 0.5% by weight of chromium and at least 0.25% by weight of molybdenum, is proposed. | 05-12-2011 |