Fabrizio, US
David Fabrizio, Swampscott, MA US
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20100121033 | TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR - The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. | 05-13-2010 |
20110053842 | TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR - The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins. | 03-03-2011 |
20110305663 | SERUM ALBUMIN BINDING MOLECULES - The present invention relates to an antibody-like protein based on the tenth fibronectin type III domain ( | 12-15-2011 |
David Fabrizio, South Hamilton, MA US
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20130310317 | TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS FOR TYROSINE KINASES RECEPTORS, INCLUDING IGF-IR - The present invention provides innovative proteins that bind to insulin-like growth factor-I receptor (IGF-IR), as well as other important proteins. The invention also provides innovative proteins in pharmaceutical preparations and derivatives of such proteins and the uses of same in diagnostic, research and therapeutic applications. The invention further provides cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. | 11-21-2013 |
20140038893 | TARGETED THERAPEUTICS BASED ON ENGINEERED PROTEINS THAT BIND EGFR - The present invention relates to single domain proteins that bind to epidermal growth factor receptor (EGFR). The invention also relates to single domain proteins for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins. | 02-06-2014 |
David A. Fabrizio, South Hamilton, MA US
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20140256589 | METHODS FOR ACCELERATED SELECTION OF POLYPEPTIDES - In certain embodiments, the disclosure provides a method for generating an mRNA-protein fusion molecule. In other embodiments, the disclosure provides a method for selecting a desired polypeptide. | 09-11-2014 |
Dean Fabrizio, Trumbull, CT US
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20090314852 | Straw apparatus for mixing and drinking beverages - There is disclosed an expandable drinking and mixing straw apparatus that can be compactly stored and expanded when necessary to provide a deployed dual-functionality mixing and drinking apparatus. The several disclosed embodiments of the straw apparatus provide a unified apparatus as well as functionally equivalent embodiments with two straw sub-component members defined by an outer straw and an inner straw which sub-component members are bonded together at specified locations. When force is applied to the undeployed straw apparatus, a plurality of veins expands from the apparatus to provide mixing means without compromising suction functionality. Straw sub component bonding means, vein bending and stopping means, and method of deployment of the drinking and mixing straw apparatus are disclosed. | 12-24-2009 |
Dino A. Fabrizio, Davenport, FL US
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20150100353 | System and Method for Valuation, Acquisition and Management of Insurance Policies - A system and method for the valuation, acquisition, and management of insurance policies whereby specific business methods, algorithms, and systems are utilized to measure specific benchmarks set by risk bearers, affiliates and clients. The benchmarks set are based on the ratios set by the risk bearer based on their specific objectives for profitability. Profitability is measured by a number of factors and ratios to include but not be limited to ROI, ROE, Combined Ratio, Expense Ratio, Loss Ratio. | 04-09-2015 |
Edward Vincent Fabrizio, Vernon, CT US
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20090285569 | ELECTRIC TANKLESS WATER HEATER - In various embodiments, the invention provides a system for heating a liquid, such as, for example, water, comprising a plurality of liquid heaters, the inlets and outlets of which are respectively connected in a parallel flow relationship by respective manifolds, and configured to provide liquid having a temperature of greater than about 90 degrees Fahrenheit at a flow rate of greater than about 10 gallons per minute. In various embodiments, the present invention provides an electric tankless liquid heater system capable of delivering hot liquids, and in particular water, at even higher flow rates and or temperatures, including, but not limited to, flow rates greater than about: (1) 12 gpm; (2) 18 gpm; (3) 20 gpm; and (5) 20 gpm; and/or temperatures of greater than about: (1) 100° F.; (2) 120° F.; (3) 140° F.; and (4) 180° F. | 11-19-2009 |
20100278519 | ELECTRIC TANKLESS WATER HEATER - In various aspects, the present invention provides an electric tankless liquid heater system capable of delivering liquid, such as, for example, water, with an acceptable increase in output liquid temperature upon a sudden and substantial decrease in liquid demand. In various aspects, the electric tankless liquid heater comprises an inlet manifold and a plurality of liquid heaters the inlets of which are connected in a parallel flow relationship by the inlet manifold, and the outlets of which are each connected to a separate outlet conduit, and which is configured to provide water to a plurality of automatic water fixtures with a less than about 2° F. (about 1.1° C.) increase in output water temperature upon about a one-and-a-half-fold or greater decrease in water demand that occurs in less than about 500 milliseconds as measured by the increase time of the inlet liquid pressure. | 11-04-2010 |
20110013893 | ELECTRIC TANKLESS WATER HEATER - In various embodiments, the invention provides a system for heating a liquid, such as, for example, water, comprising a plurality of liquid heaters, the inlets and outlets of which are respectively connected in a parallel flow relationship by respective manifolds, and configured to provide liquid having a temperature of greater than about 90 degrees Fahrenheit at a flow rate of greater than about 10 gallons per minute. In various embodiments, the present invention provides an electric tankless liquid heater system capable of delivering hot liquids, and in particular water, at even higher flow rates and or temperatures, including, but not limited to, flow rates greater than about: (1) 12 gpm; (2) 18 gpm; (3) 20 gpm; and (5) 20 gpm; and/or temperatures of greater than about: (1) 100° F.; (2) 120° F.; (3) 140° F.; and (4) 180° F. | 01-20-2011 |
Emanuele Fabrizio, San Jose, CA US
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20100306040 | ON-LINE REFERRAL - Various methods and systems are provided to facilitate on-line transactions through the issuance of rewards for users who referral a product that is purchased by another. In one example, a user selects a product that the user purchased and an email recipient. The payment provider, who the user used to purchase the product, sends an email with a URL to the recipient, where the URL contains the merchant product page and the email address of the user or person making the referral. If the recipient purchases the referred product, such as clicking on the link or copying and pasting the URL, the payment provider is notified and issues a reward to the user based on the purchase by the recipient. | 12-02-2010 |
Eve F. Fabrizio, Republic, MO US
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20120182666 | CONDUCTIVE POLYMER COMPOSITES - The invention is directed, in an embodiment, to an inherently conductive polymer comprising a conductive polymer, carbon nanotubes, and dinonylnaphthalene sulfonic acid. The conductive polymer may comprise polyaniline. The invention is also directed to polymeric films and supercapacitors comprising the inherently conductive polymer. | 07-19-2012 |
Eve F. Fabrizio, Bay Village, OH US
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20100001211 | Method and apparatus for enhancing detection characteristics of a chemical sensor system - A method and apparatus for increasing detection characteristics of a chemical sensor array that has been previously exposed to an agent in order to detect and categorize the agent. Ultraviolet light at a predetermined wavelength is applied to the chemical sensor array, in order to desorb the agent from the chemical sensor array, so as to increase a resistance of the chemical sensor array. Alternatively or together with the ultraviolet light, a bias voltage is applied to at least one biasing electrode making up the chemical sensor array, in order to desorb the agent from the chemical sensor array, so as to increase the resistance of the chemical sensor array. The chemical sensor array may be a carbon nanotube sensor array. | 01-07-2010 |
Eve F. Fabrizio, Ann Arbor, MI US
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20100179288 | Highly porous and mechanically strong ceramic oxide aerogels - Structurally stable and mechanically strong ceramic oxide aerogels are provided. The aerogels are cross-linked via organic polymer chains that are attached to and extend from surface-bound functional groups provided or present over the internal surfaces of a mesoporous ceramic oxide particle network via appropriate chemical reactions. The functional groups can be hydroxyl groups, which are native to ceramic oxides, or they can be non-hydroxyl functional groups that can be decorated over the internal surfaces of the ceramic oxide network. Methods of preparing such mechanically strong ceramic oxide aerogels also are provided. | 07-15-2010 |
Mark A. Fabrizio, Lowell, MA US
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20130346170 | Customized Customer Loyalty Rewards Program Enhanced Rewards Distribution System and Method - A customer loyalty rewards program random enhanced reward distribution system and method may comprise a server ( | 12-26-2013 |
Matthew Fabrizio, Rochester, NY US
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20100285281 | MICROSTRUCTURED IMAGE OVERCOAT LAYER FOR IMPROVED IMAGE UNIFORMITY APPLIED WITH BLANKET OVERCOATER AND FUNCTIONAL EMBOSSING ROLLER - In accordance with various embodiments, there are printing apparatuses and methods of enhancing an image quality on a media. The method of enhancing an image quality on a media can include providing an ink-based halftone image on a media, wherein the halftone image can include an amount of noise. The method can also include depositing a transparent overcoat layer at least over the halftone image, wherein the transparent overcoat layer can include a major amount of cross-linkable resin and a minor amount of a photoinitiator. The method can further include embossing the transparent overcoat layer to form an embossed micro-structured overcoat layer and curing the embossed micro-structured overcoat layer to form the micro-structured overcoat layer, such that the micro-structured overcoat layer reduces the amount of noise. | 11-11-2010 |
20110193917 | SYSTEM AND METHOD FOR EXTRACTING SOLID-INK PELLETS FROM A CONTAINER - The present disclosure provides systems and methods for supplying solid-ink pellets from a container to a printing apparatus. The solid-ink pellets are held in a collapsible, hermetic bag, which is carried in the container. The bag is partially or fully transparent. A vacuum interface provides an access point to the bag. Further, a perforated nozzle, adapted to engage the vacuum interface, provides airflow within the bag and is configured to apply a suction force to extract solid-ink pellets from the bag. | 08-11-2011 |
Petrini Fabrizio, Millwood, NY US
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20140269320 | Scalable Flow and Cogestion Control with OpenFlow - A method of performing congestion management in a network is provided. The method includes monitoring a congestion status at a switch in the network. It is determined at the switch that the congestion status indicates that there is congestion at the switch. Based on the congestion being related to data received at the switch from a source at a first rate, a first message is transmitted from the switch to the source requesting the source to send the data at a second rate that is slower than the first rate. Based on the congestion being related to data requests received at the switch from a destination at third rate, a second message is transmitted from the switch to the destination requesting the destination to request the data at a fourth rate slower than the third rate. | 09-18-2014 |
20150055476 | Scalable Flow and Cogestion Control with OpenFlow - A method of performing congestion management in a network is provided. The method includes monitoring a congestion status at a switch in the network. It is determined at the switch that the congestion status indicates that there is congestion at the switch. Based on the congestion being related to data received at the switch from a source at a first rate, a first message is transmitted from the switch to the source requesting the source to send the data at a second rate that is slower than the first rate. Based on the congestion being related to data requests received at the switch from a destination at third rate, a second message is transmitted from the switch to the destination requesting the destination to request the data at a fourth rate slower than the third rate. | 02-26-2015 |
Robert A. Fabrizio, Stamford, CT US
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20130101088 | MOBILE PATIENT POSITIONING SHIELD FOR MULTIPLE EXPOSURE IMAGING EXAMS - A mobile patient positioning stand having vertical rails allowing a shield to be manually moved up and down to different heights based on the height of anatomy of the patient desired to be imaged. The shield may be positioned at a shield height for a certain height of anatomy of a patient so that markers on the shield identify multiple image areas within the total image area. After the shield is positioned, an image detector and a source of radiation may be vertically positioned to provide images at the multiple image areas. Vertical positioning of the detector may be determined by the markers or by equal height detector alignment markers on the shield. The multiple image areas may be connected by aligning stitching markers in the images, that may be on the shield. This aligning may be done by an automated computer software process that recognizes the stitching markers. | 04-25-2013 |
20130114790 | MOBILE PATIENT POSITIONING CART FOR MULTIPLE EXPOSURE IMAGING EXAMS - A mobile patient positioning stand has a vertical rail allowing a shield structure to be moved up and down to different heights based on the height of anatomy of the patient desired to be imaged. The structure may be moved to position a shield of the structure at a height so that anatomy of a patient to be imaged is located within multiple image areas identified by markers on the shield. Then, an image detector holder and detector may be moved up and down to different heights behind the shield, based on the height of the markers. A source of radiation provides images at the multiple image areas. The multiple image areas may be connected by aligning stitching markers that may be on the shield, and are in the images. The aligning may be done by an automated computer software process that recognized patient anatomy and/or the stitching markers. | 05-09-2013 |