Patent application number | Description | Published |
20090281144 | Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors - Bis-quaternary pyridinium-aldoxime salts are disclosed, and their associated polymorphic character, along with their methods of preparation. Such polymorphic salts may then be used for treatment of exposure to cholinesterase inhibitors, such as a phosphorous containing cholinesterase inhibitor type compound. | 11-12-2009 |
20100040692 | TWO PHASE BIOACTIVE FORMULATIONS - The present invention relates to two-phase systems of a bioactive ingredient in particle form that has limited or no solubility in a liquid medium, which provides stability to the active ingredient that is similar to the active ingredient when in the solid state. The active ingredient may be capable of therapeutically treating for the presence of a cholinesterase inhibitor. | 02-18-2010 |
20100086601 | Modified Calcium Phosphate Nanoparticle Formation - The present disclosure relates to non-aggregating nanoparticles and their associated methods of preparation. The nanoparticles may have a surface and a size range of 1 nm to 999 nm, along with a zeta potential of −50 to 50 millivolts. A polycation and/or polyanion may be disposed on the nanoparticle surface. In addition, an active ingredient may be encapsulated within the nanoparticles or associated with the polycation or polyanion on the nanoparticle surface. | 04-08-2010 |
20100098754 | PROCESSING OF HEAT-SENSITIVE ACTIVE AGENTS - The present disclosure relates to a method of melt processing an active agent. The method may include encapsulating an active agent in a first polymer material exhibiting a first processing temperature T | 04-22-2010 |
20110015568 | Dry To Wet Injector - The present disclosure relates to an apparatus and method for combining a solid particulate with a solvent prior to an injection protocol within an injector device. The solid particulate may be a pharmaceutical compound and the microcapsules contain a solvent for such particulate. Upon application of pressure, the microcapsules may be configured to burst and release the solvent, thereby dispersing and/or partially dissolving the particulate. The injector therefore allows for the use of relatively unstable pharmaceutically active compounds in a device that requires relatively long storage times and the use of pharmaceutical compounds that are relatively stable in the dry state. | 01-20-2011 |
20110195125 | Nanoparticles For Drug Delivery To The Central Nervous System - The present disclosure relates to compositions and methods for producing nanoparticles to provide relatively more rapid delivery of such particles across the blood-brain barrier. The nanoparticles may be formed from bis-quaternary pyridinium-aldoxime salts that may also be of a specific polymorphic structure and which may be formed in either hydrophobic or hydrophilic type liquid media. In addition, the nanoparticle for transport across the blood-brain barrier may comprise a polymeric resin encapsulating a bis-quaternary pyridinium-2-aldoxime salt of the formula: | 08-11-2011 |
20120070503 | Nanoparticle-Based Targeted Drug Delivery For In Vivo Bone Loss Mitigation - The present invention is directed to nanoparticle-based targeted drug delivery system for treatment of bone-loss. An enantiomeric phenothiazine is formulated into an in-vivo nanoparticle delivery system which may contain bone-targeting functionality. The nanoparticle formulations and their associated influence on whole bone porosity may now also be evaluated utilizing nuclear magnetic resonance (NMR) and relaxation time profiles, and in particular, median T | 03-22-2012 |
20130164381 | Nanoparticle-Based Targeted Drug Delivery For In Vivo Bone Loss Mitigation - The present invention is directed to nanoparticle-based targeted drug delivery system for treatment of bone-loss. An enantiomeric phenothiazine is formulated into an in-vivo nanoparticle delivery system which may contain bone-targeting functionality. The nanoparticle formulations and their associated influence on whole bone porosity may now also be evaluated utilizing nuclear magnetic resonance (NMR) and relaxation time profiles, and in particular, median T | 06-27-2013 |
Patent application number | Description | Published |
20080201115 | MULTIPLE INSERTS OF DIFFERENT GEOMETRY IN A SINGLE ROW OF A BIT - A method for designing a roller cone drill bit having a plurality of cutting elements in a row. The method includes defining a pitch pattern for the plurality of cutting elements such that a first group of adjacent cutting elements are arranged in a first pitch and a second group of adjacent cutting elements are arranged in a second pitch in the row, wherein the first group of adjacent cutting elements have a different extension length than the second group of adjacent cutting elements, evaluating the pitch pattern of the plurality of cutting elements in the row, and modifying at least one of the plurality of cutting elements based on the evaluating of the pitch pattern of the plurality of cutting elements. | 08-21-2008 |
20110297454 | ROLLING CUTTER ASSEMBLED DIRECTLY TO THE BIT POCKETS - A drill bit having a bit body, a plurality of blades extending radially from the bit body, a plurality of cutter pockets disposed on the plurality of blades, at least one rolling cutter disposed in one of the cutter pockets, wherein each rolling cutter has a substrate, a cutting face, a cutting edge, and a side surface, and at least one blocker positioned adjacent to each of the at least one rolling cutters on a leading face of the blade, wherein each blocker has a retention end and an attachment end is disclosed. The retention end of each blocker is positioned adjacent to a portion of the cutting face of each rolling cutter to retain the rolling cutter in the cutter pocket and the attachment end is attached to a portion of the blade. | 12-08-2011 |
20140353046 | HYBRID BIT WITH ROLLER CONES NEAR THE BIT AXIS - A drill bit includes a bit body having a longitudinal axis extending there through, a plurality of journals extending downward and radially outward from the bit body, each journal having a journal axis extending from a base of the journal through the length of the journal, wherein the journal axis at the base is at a first radial distance from the longitudinal axis, a roller cone rotatably mounted to each of the journals, and at least one blade protruding from the bit body and extending axially and radially along the bit body from a first end to a second end, wherein the first end is at a second radial distance from the longitudinal axis greater than the first radial distance, and wherein the second end is at a gage region of the drill bit. | 12-04-2014 |