Shen, NJ
Diandian Shen, Somerset, NJ US
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20120135094 | OREGANO AND MINT ANTI-INFLAMMATORY COMPOSITIONS AND METHODS - The present invention relates to bioactivity-guided isolation and identification of bioactive compounds from oregano and mint plants, in particular, rosmarinic acid, oleanolic acid and ursolic acid, and use of these compounds or combinations thereof as anti-inflammatory agents for the treatment of conditions related to pain and inflammation and/or as ingredients of dietary supplements. The invention also relates to optimization of the methods for qualitative and quantitative analysis of the bioactive compounds in oregano and mint plants. In particular, this invention introduces an LC/MS (SIM mode) method to achieve co-quantitation of the three organic acids using a unique tandem column system. In addition, the invention also relates to the methods for recovering various water-soluble polyphenols and triterpenes from aromatic plants. | 05-31-2012 |
Dong-Ming Shen, Rahway, NJ US
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20130143859 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS - Compounds of structural formulas I-1 and I-2 are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the enzymatic activity of PrCP such as abnormal metabolism, including obesity; diabetes; metabolic syndrome; obesity related disorders; and diabetes related disorders. | 06-06-2013 |
Fei Shen, Budd Lake, NJ US
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20160101445 | CALIBRATION OF SEMICONDUCTOR METROLOGY SYSTEMS - A method of cleaning calibration and other substrates that improves the correlation of measurements from calibration and product substrates and increases the useful life of the calibration substrates is herein disclosed. By exposing a calibration substrate to ultraviolet light, a reaction is triggered that results in the cleaning of the contaminants from the calibration substrate. For instance, monatomic oxygen is introduced to contaminants on the surface of a calibration substrate to remove the contaminants without inducing modifications in the substrate itself. Through the cleaning process, the temperature of the calibration substrate may be controlled to limit adverse effects caused by the overheating of the calibration substrate. | 04-14-2016 |
Henry Shen, Princeton, NJ US
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20090215995 | B-7 related nucleic acids and polypeptides useful for immunomodulation - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 08-27-2009 |
20100125127 | B7-related nucleic acids and polypeptides useful for immunomodulation - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 05-20-2010 |
20100136575 | B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 06-03-2010 |
20110294162 | B-7 RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 12-01-2011 |
20120329990 | B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 12-27-2012 |
20130144042 | B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 06-06-2013 |
20140154260 | B-7 RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 06-05-2014 |
20140194598 | B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION - The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject. | 07-10-2014 |
Jianhua Shen, Princeton, NJ US
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20130216110 | Method and System for Coronary Artery Centerline Extraction - A method and system for extracting coronary artery centerlines from 3D medical image volumes is disclosed. Heart chambers are segmented in a 3D volume. Coronary artery centerlines are initialized in the 3D volume coronary artery based on the segmented heart chambers. The coronary artery centerlines are locally refined based on a vesselness measure. A length of each coronary artery centerline is shrunk to verify that the coronary artery centerline is within a coronary artery. The coronary artery centerline is the extended using data-driven vessel tracing. | 08-22-2013 |
Jing Shen, Tenafly, NJ US
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20100221723 | EARLY DETECTION OF CANCER BY METHYLATED DNA IN BLOOD - This invention relates to early detection of cancer by detecting methylated DNA in blood. In one embodiment, there is provided a method of predicting the occurrence of hepatocellular carcinoma in a subject, comprising the steps of preparing DNA samples from blood samples of the subject; and determining methylation status of a group of genes comprising RASSF1A, p16 and p15, wherein hypermethylation of these genes as compared to normal control samples indicates the subject is likely to develop hepatocellular carcinoma in the future. | 09-02-2010 |
Jinghua Shen, Hamilton, NJ US
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20130038466 | APPARATUS FOR VISULLY AND REMOTLLY DETERMINING THE ANGULLAR POSITION OF THE RELATIVE ROTATION OF PARTS - A visually and remotely readable apparatus is provided which comprises a plurality of sensing units, a control unit and a flexible printed cable (FPC) to connect two units for exchanging information therebetween. A preferable structure of the sensing unit includes a fixed part secured to the body of the apparatus and two oppositely positioned rotatable parts, where two rotatable parts mounted on a common shaft with the fixed part arranged therebetween forming two angular position sensors. Each sensor is based on the capacitive coupling between two working surfaces of the rotatable part and the respective working surfaces of the fixed part with the electrodes are secured thereto. Two working surfaces of one part are confronted with two respective working surfaces of another part forming two working surface pair. Each sensor has two working surface pairs, one working surface pair is sensing pair for sensing angular position; another is coupling pair for coupling sensing signals. A plurality of transmitting electrodes are secured to the working surface of the sensing pair of the fixed part; a receiving electrode is secured to the working surface of the sensing pair of the rotatable part; an output electrodes is secured to the working surface of the coupling pair of the fixed part; a coupling electrode connected to the receiving electrode is secured to the working surface of the coupling pair of the rotatable part. To each of the plurality of the transmitting electrodes is applied a respective one of polyphase squarewave voltages. The capacitive coupling between the electrodes of the sensing pair is dependent on the relative positions of two rotatable part, and the output signal voltages on the output electrode which coupled from the coupling electrode represents the angular position of the rotatable part. In the first embodiment provided for the sensors, the shape of working surfaces is in a conical frustum; the second embodiment, the shape of working surfaces is a cylinder; the third embodiment, the shape of working surfaces is a disc; the fourth embodiment, with a cylinder-shaped working surface and a disk-shaped working surface, is a combination of the second and the third embodiments provided as an example of the application of the embodiments. A circuit of the control unit is provided for processing data, generating control signals for the sensors. By using radio frequency identification (RFID) technique to exchange information with the reader station outside of the apparatus and power the system are also disclosed in the invention. | 02-14-2013 |
Jingrong Shen, Hamilton, NJ US
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20130038466 | APPARATUS FOR VISULLY AND REMOTLLY DETERMINING THE ANGULLAR POSITION OF THE RELATIVE ROTATION OF PARTS - A visually and remotely readable apparatus is provided which comprises a plurality of sensing units, a control unit and a flexible printed cable (FPC) to connect two units for exchanging information therebetween. A preferable structure of the sensing unit includes a fixed part secured to the body of the apparatus and two oppositely positioned rotatable parts, where two rotatable parts mounted on a common shaft with the fixed part arranged therebetween forming two angular position sensors. Each sensor is based on the capacitive coupling between two working surfaces of the rotatable part and the respective working surfaces of the fixed part with the electrodes are secured thereto. Two working surfaces of one part are confronted with two respective working surfaces of another part forming two working surface pair. Each sensor has two working surface pairs, one working surface pair is sensing pair for sensing angular position; another is coupling pair for coupling sensing signals. A plurality of transmitting electrodes are secured to the working surface of the sensing pair of the fixed part; a receiving electrode is secured to the working surface of the sensing pair of the rotatable part; an output electrodes is secured to the working surface of the coupling pair of the fixed part; a coupling electrode connected to the receiving electrode is secured to the working surface of the coupling pair of the rotatable part. To each of the plurality of the transmitting electrodes is applied a respective one of polyphase squarewave voltages. The capacitive coupling between the electrodes of the sensing pair is dependent on the relative positions of two rotatable part, and the output signal voltages on the output electrode which coupled from the coupling electrode represents the angular position of the rotatable part. In the first embodiment provided for the sensors, the shape of working surfaces is in a conical frustum; the second embodiment, the shape of working surfaces is a cylinder; the third embodiment, the shape of working surfaces is a disc; the fourth embodiment, with a cylinder-shaped working surface and a disk-shaped working surface, is a combination of the second and the third embodiments provided as an example of the application of the embodiments. A circuit of the control unit is provided for processing data, generating control signals for the sensors. By using radio frequency identification (RFID) technique to exchange information with the reader station outside of the apparatus and power the system are also disclosed in the invention. | 02-14-2013 |
Jinshan Shen, Skillman, NJ US
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20140065164 | IP-10 ANTIBODY DOSAGE ESCALATION REGIMENS - In certain embodiments, the present invention provides a method of treating an IP10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IPIO antibody; (b) detecting the level of the anti-IPIO antibody in a sample of the subject; and (c) if the level of the anti-IPIO antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IPIO antibody in the subject such that the IP-10 related disease in the subject is treated. | 03-06-2014 |
20140127229 | IP-10 ANTIBODY DOSAGE ESCALATION REGIMENS - In certain embodiments, the present invention provides a method of treating an IP-10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IP-10 antibody; (b) detecting the level of the anti-IP-10 antibody in a sample of the subject; and (c) if the level of the anti-IP-10 antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IP-10 antibody in the subject such that the IP-10 related disease in the subject is treated. In certain embodiments, the present invention provides an isolated monoclonal anti-idiotypic antibody, or an antigen binding portion thereof, which binds to the anti-IP-10 antibody MDX-1100. | 05-08-2014 |
Juan Shen, New Brunswick, NJ US
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20130289128 | ARYLPROPIONYL-TRIKETONE ANTIBACTERIAL AGENTS - The invention provides a compound of formula (I): or a salt thereof, wherein R | 10-31-2013 |
20150197512 | ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES - The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents. | 07-16-2015 |
Lan Shen, Annandale, NJ US
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20090131489 | 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACIDS AND ANALOGS - The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia. | 05-21-2009 |
Lan Shen, Clinton, NJ US
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20090176806 | SUBSTITUTED PYRROLINE KINASE INHIBITORS - The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. | 07-09-2009 |
20090181982 | SUBSTITUTED PYRROLINE KINASE INHIBITORS - The present invention is directed to novel substituted pyrroline compounds useful as kinase inhibitors and methods for treating or ameliorating a kinase mediated disorder. | 07-16-2009 |
Lichun Shen, Ledgewood, NJ US
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20130079328 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY - The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R | 03-28-2013 |
Liduo Shen, Bridgewater, NJ US
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20120193528 | QUANTITATIVE DETERMINATION OF RISEDRONATE IN URINE BY SPE-LC-MS-MS - The present invention is directed to a SPE-LC-MS-MS method for quantitatively determining risedronate in a urine sample. | 08-02-2012 |
Ling Shen, Cherry Hill, NJ US
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20140074306 | METHOD AND SYSTEM FOR ENERGY CONTROL MANAGEMENT - In order to reduce computation time and cost involved with determining one or more optimal parameters for a pre-cooling strategy, for a modeled system, a two-step genetic algorithms is used to optimize energy consumption of the modeled system with respect to cost of the energy consumption. A first step of the two-step genetic algorithms determines a population of potential solutions that are used to initialize a second step of the two-step genetic algorithm. The second step of the two-step genetic algorithm determines the one or more optimal parameters for the pre-cooling strategy from the population output by the first genetic algorithm. | 03-13-2014 |
20150253027 | ON-LINE OPTIMIZATION SCHEME FOR HVAC DEMAND RESPONSE - A computer-implemented method of optimizing demand-response (DR) of a heating, ventilation, and air-conditioning (HVAC) system of a building, includes determining ( | 09-10-2015 |
20150302640 | Functional Visualization in System-level Multi-Domain Simulators - A functional visualization of high-level system variables is based on information from a simulation environment. A functional model is imported from the simulation environment, including function nodes and connections. Each function node includes a function name, an associated component from the simulated system, and an associated physical variable. Each connection includes source and destination functions and a connection type. Values for the physical variables are obtained via a subscription with the simulation environment. The functional visualization is created and displayed based on the functional model and the values. | 10-22-2015 |
Michael Y. Shen, Collingswood, NJ US
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20110225001 | Management of Information Flow and Workflow in Medical Imaging Services - Managing information flow and workflow in medical imaging services includes mapping activities in medical imaging services to a set of discrete steps in a model medical imaging process. Data concerning the medical imaging services is collected and tracked using an electronic data store and a communications network. Collected data is correlated to at least one of the discrete steps in the model medical imaging process and process metrics for performance are calculated based upon the correlated data. | 09-15-2011 |
Qiong Shen, Kearny, NJ US
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20090253216 | Delivery and Sensing of Metered Amounts of Liquid Materials - A liquid delivery apparatus is provided for depositing liquid materials onto prescribed areas. The apparatus includes a sensing and delivery pin and a photo sensor. The apparatus is sized to deliver a droplet of liquid material to the surface of a target area without coming into contact with the target surface. The apparatus is also capable of drawing geometric features, such as lines and grids of liquid material. The photo sensor measures the intensity of light during a processing cycle. Measured reflected-light intensity can be compared in real-time to a reference curve which is based on test process cycles representing the light intensity expected when the process proceeds in the preferred fashion to produce a normal spot having an expected droplet size. The light intensity measurements can also be fitted with a mathematical function such as an asymmetric double sigmoidal curve. | 10-08-2009 |
Tian Shen, Princeton, NJ US
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20100228362 | TREMOR STABILIZING SYSTEM FOR HANDHELD DEVICES - A handheld device for canceling unintentional muscle movement. The device includes a base comprising a handgrip for a user to hold, a gripping element linked to the base for releasably connecting the handheld device to an object, a sensor that detects movement of the base, a controller linked to the sensor, and at least one actuator that operates under control of the controller to cause movement of the gripping element in a direction that at least partially counteracts the detected movement of the base. | 09-09-2010 |
Xiaohong Shen, Livingston, NJ US
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20140309250 | Pharmaceutical Formulations - This invention relates to solid oral pharmaceutical formulations of (S)-methyl (1-((4-(3-(5-chloro-2-fluoro-3-(methylsulfonamido)phenyl)-1-isopropyl-1H-pyrazol-4-yl)pyrimidin-2-yl)amino)propan-2-yl)carbamate (COMPOUND A) and the use of the formulations for treating proliferative diseases, such as solid tumor diseases. | 10-16-2014 |
20160038427 | Tamper Resistant Pharmaceutical Formulations - Disclosed in certain embodiments is a solid oral dosage form comprising a plurality of particles, each particle comprising (i) a core comprising an active agent susceptible to abuse and an internal adhesion promoter, wherein the cores are (i) dispersed in a matrix comprising a controlled release material or (ii) coated with a controlled release material. The dosage form can also include an alcohol resistant material. | 02-11-2016 |
Xiaole Shen, Livingston, NJ US
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20140018404 | CONTROLLED RELEASE ORAL DOSAGE FORMS OF POORLY SOLUBLE DRUGS AND USES THEREOF - Provided herein are controlled release oral dosage forms of poorly soluble drugs, methods of making the dosage forms, and methods of their use for the treatment of various diseases and/or disorders. | 01-16-2014 |
Xun Shen, Piscataway, NJ US
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20110306060 | PCSK9 IMMUNOASSAY - Methods of using PCSK | 12-15-2011 |
20120219558 | ANTAGONISTS OF PCSK9 - Antagonists of human proprotein convertase subtilisin-kexin type 9 (PCSK9) are disclosed. Said antagonists are effective in the inhibition of PCSK9 function and thereby provide compositions of matter useful for the treatment of conditions associated with PCSK9 activity. The present invention further discloses nucleic acids encoding PCSK9 antagonists as well as methods of making and using PCSK9 antagonists. | 08-30-2012 |
Yongquan Shen, Voorhees, NJ US
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20090232814 | Cancer biomarker genes and gene products and methods for using the same - Using gene expression analysis, specific biomarker genes and gene products have been identified which are activated in transformed cells, but suppressed in nontransformed cells; or suppressed in transformed cells, but activated in transformed cells affected by Contact Normalization. Thus, the present invention features compositions and methods for detecting, diagnosing, treating and prognosing cancer. | 09-17-2009 |
20120010152 | Targeting of Podoplanin with Lectin for Use in the Prevention and Treatment of Cancer - Lectin compositions and methods for reducing tumor cell growth and preventing or treating cancer are provided. | 01-12-2012 |
Youxun Shen, Short Hills, NJ US
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20110047060 | APPARATUSES, METHODS AND SYSTEMS FOR A MARGINAL CONTRIBUTION TO PERFORMANCE PLATFORM - The APPARATUSES, METHODS AND SYSTEMS FOR A MARGINAL CONTRIBUTION TO PERFORMANCE PLATFORM (“MCP PLATFORM”) brings about significant advances in the utility and efficacy of algorithmic trading. In one embodiment, the MCP Platform facilitates optimized trading of financial instruments by employing an optimization framework that extends down to the order-placement level. The MCP Platform may minimize a total, generalized cost associated with a trade by separating the overall optimization problem into current order placement decisions and future order placement decisions. Future order placement decisions may then be evaluated analytically and the current order placement decisions evaluated numerically to effectively reduce the dimensionality of the optimization problem and allow optimization to be performed in a relatively short period of time. | 02-24-2011 |
Yuan-Rong Shen, Randolph, NJ US
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20100284371 | USING THE REPETITION OF AN ERASURE INDICATOR BIT TO ENHANCE A POWER CONTROL COMMAND DURING HANDOFF - A wireless communication network ( | 11-11-2010 |
Zhongqi Shen, Plainsboro, NJ US
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20080262228 | Metabolites of 5-fluoro-8- quinoline and methods of preparation and uses thereof - The present invention relates to novel metabolites of 5-Fluoro-8-{4-[4-(6-methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}quinoline, which can be useful in treating CNS disorders. The present invention further relates to processes for their preparation, to pharmaceutical compositions comprising them, and to methods of using them. | 10-23-2008 |