Patent application number | Description | Published |
20140030721 | Exonuclease Enabled Proximity Extension Assays - The present invention relates to a proximity probe based detection assay (“proximity assay”) for an analyte in a sample, specifically a proximity probe extension assay (PEA), an in particular to an improvement in the method to reduce non-specific “background” signals, wherein the improvement comprises the use in such assays of a component comprising 3′ exonuclease activity, said method comprising: (a) contacting said sample with at least one set of at least first and second proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to the analyte; (b) allowing the nucleic acid domains of the proximity probes to interact with each other upon binding of said proximity probes to said analyte, wherein said interaction comprises the formation of a duplex; (c) contacting said sample with a component comprising 3′ exonuclease activity; (d) extending the 3′ end of at least one nucleic acid domain of said duplex to generate an extension product, wherein the step may occur contemporaneously with or after step (c); and (e) amplifying and detecting the extension product. | 01-30-2014 |
20150044674 | Hyperthermophilic Polymerase Enabled Proximity Extension Assay - The present invention relates to a proximity probe based detection assay (“proximity assay”) for an analyte in a sample, specifically a proximity probe extension assay (PEA), an in particular to an improvement in the method to reduce non-specific “background” signals, wherein the improvement comprises the use in such assays of a hyperthermophilic polymerase, said method comprising: (a) contacting said sample with at least one set of at least first and second proximity probes, which probes each comprise an analyte-binding domain and a nucleic acid domain and can simultaneously bind to the analyte; (b) allowing the nucleic acid domains of the proximity probes to interact with each other upon binding of said proximity probes to said analyte, wherein said interaction comprises the formation of a duplex; (c) extending the 3′ end of at least one nucleic acid domain of said duplex to generate an extension product, wherein the extension reaction comprises increasing the temperature of assay above room temperature and uses a polymerase enzyme which is characterised as having less than 20% of its maximal enzyme activity at 40° C. and having less than 10% of its maximal enzyme activity at 25° C., wherein the optimum temperature for maximal activity of the polymerase is more than 40° C. and wherein the polymerase is selected from | 02-12-2015 |
Patent application number | Description | Published |
20080308498 | CHROMATOGRAPHY COLUMN AND METHOD OF MAINTENANCE - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 12-18-2008 |
20090039008 | METHOD FOR CONDUCTING MAINTENANCE ON A CHROMATOGRAPHY COLUMN - The present invention relates to methods for conducting maintenance on chromatography columns used in industrial-scale chromatography. In particular, the invention is concerned with safer methods for performing maintenance on such columns, such as cleaning and replacing bed supports, distributors, nozzles, O-rings and other column components, by the use of a handling device to support, lift, carry and manipulate such column components. | 02-12-2009 |
20090044393 | CHROMATOGRAPHY COLUMN AND METHOD OF MAINTENANCE - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 02-19-2009 |
20100181241 | CHROMATOGRAPHY COLUMN AND METHOD OF MAINTENANCE - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 07-22-2010 |
20100276370 | METHOD FOR CONDUCTING MAINTENANCE ON A CHROMATOGRAPHY COLUMN - The present invention relates to methods for conducting maintenance on chromatography columns used in industrial-scale chromatography. In particular, the invention is concerned with safer methods for performing maintenance on such columns, such as cleaning and replacing bed supports, distributors, nozzles, O-rings and other column components, by the use of a handling device to support, lift, carry and manipulate such column components. | 11-04-2010 |
20100276371 | CHROMATOGRAPHY COLUMN AND METHOD OF MAINTENANCE - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 11-04-2010 |
20110042290 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 02-24-2011 |
20130248431 | METHOD AND ARRANGEMENT FOR SECURING A DISTRIBUTOR PLATE TO A BACKING PLATE OF A CHROMATOGRAPHY COLUMN - The present invention relates to methods for securing a distributor plate to a backing plate of a chromatography column without the need for releasable fixing means such as screws or bolts. The invention also relates to chromatographic columns utilizing such methods. The method employs a negative pressure or vacuum to affix the distributor to the backing plate. | 09-26-2013 |
Patent application number | Description | Published |
20110147311 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components. | 06-23-2011 |
20120279034 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A method of maintenance of a chromatography column is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. The provision of guide elements which can be reversibly attached to the column facilitates removal or insertion of column components. | 11-08-2012 |
20130161248 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 06-27-2013 |
20130186833 | CHROMATOGRAPHY COLUMN AND MAINTENANCE METHOD - A chromatography column and method of maintenance is described which does not require the use of a hoist or crane for disassembly. The method provides improved operator safety by reducing the need for the operator to work below a suspended or supported load within the column. Furthermore, the removal or replacement of column components is facilitated by providing access to the interior of the column and by the provision of a handling device. | 07-25-2013 |
20150321121 | AN ADAPTOR FOR A CHROMATOGRAPHY COLUMN - An adaptor for a chromatography column, the adaptor comprising a substantially circular bottom plate provided with an end surface; a ring shaped wall element arranged at the periphery of the bottom plate. The bottom plate and the wall element having a common axis and the adaptor is provided with a filter connection arrangement for removably connecting a filter on the end surface of the bottom plate of the adaptor. | 11-12-2015 |
20150336027 | CHROMATOGRAPHY COLUMN AND METHOD OF CONDUCTING MAINTENANCE ON A CHROMATOGRAPHY COLUMN - A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction. | 11-26-2015 |
Patent application number | Description | Published |
20100282978 | ISOTOPE PRODUCTION SYSTEM AND CYCLOTRON - A cyclotron that includes a magnet yoke having a yoke body that surrounds an acceleration chamber. The cyclotron also includes a magnet assembly to produce magnetic fields to direct charged particles along a desired path. The magnet assembly is located in the acceleration chamber. The magnetic fields propagate through the acceleration chamber and within the magnet yoke, wherein a portion of the magnetic fields escapes outside of the magnet yoke as stray fields. The cyclotron also includes a vacuum pump that is coupled to the yoke body. The vacuum pump is configured to introduce a vacuum into the acceleration chamber. The magnet yoke is dimensioned such that the vacuum pump does not experience magnetic fields in excess of 75 Gauss. | 11-11-2010 |
20100282979 | ISOTOPE PRODUCTION SYSTEM AND CYCLOTRON HAVING A MAGNET YOKE WITH A PUMP ACCEPTANCE CAVITY - A cyclotron that includes a magnet assembly to produce a magnetic field to direct charged particles along a desired path. The cyclotron also includes a magnet yoke that has a yoke body that surrounds an acceleration chamber. The magnet assembly is located in the yoke body. The yoke body forms a pump acceptance (PA) cavity that is fluidicly coupled to the acceleration chamber. The cyclotron also includes a vacuum pump that is configured to introduce a vacuum into the acceleration chamber. The vacuum pump is positioned in the PA cavity. | 11-11-2010 |
20100283371 | ISOTOPE PRODUCTION SYSTEM AND CYCLOTRON HAVING REDUCED MAGNETIC STRAY FIELDS - A cyclotron that includes a magnet yoke that has a yoke body that surrounds an acceleration chamber and a magnet assembly. The magnet assembly is configured to produce magnetic fields to direct charged particles along a desired path. The magnet assembly is located in the acceleration chamber. The magnetic fields propagate through the acceleration chamber and within the magnet yoke. A portion of the magnetic fields escape outside of the magnet yoke as stray fields. The magnet yoke is dimensioned such that the stray fields do not exceed 5 Gauss at a distance of 1 meter from an exterior boundary. | 11-11-2010 |
20110255646 | SELF-SHIELDING TARGET FOR ISOTOPE PRODUCTION SYSTEMS - A self-shielding target for isotope production systems is provided. The target includes a body configured to encase a target material and having a passageway for a charged particle beam, and a component within the body, wherein the charged particle beam induces radioactivity in the component. Additionally, at least one portion of the body is formed from a material having a density value greater than a density value of aluminum to shield the component. | 10-20-2011 |
20120161671 | PARTICLE ACCELERATORS HAVING ELECTROMECHANICAL MOTORS AND METHODS OF OPERATING AND MANUFACTURING THE SAME - A particle accelerator including an electrical field system and a magnetic field system that are configured to direct charged particles along a desired path within an acceleration chamber. The particle accelerator also includes a mechanical device that is located within the acceleration chamber. The mechanical device is configured to be selectively moved to different positions within the acceleration chamber. The particle accelerator also includes an electromechanical (EM) motor having a connector component and piezoelectric elements that are operatively coupled to the connector component. The connector component is operatively attached to the mechanical device. The EM motor drives the connector component when the piezoelectric elements are activated thereby moving the mechanical device. | 06-28-2012 |
20120321026 | TARGET APPARATUS AND ISOTOPE PRODUCTION SYSTEMS AND METHODS USING THE SAME - A target apparatus for a radioisotope production system. The target apparatus includes a production chamber that is configured to contain a starting liquid. The production chamber is configured to receive a particle beam that is incident upon the starting liquid thereby generating radioisotopes and transforming a portion of the starting liquid into vapor. The target apparatus also includes a condensing chamber and a fluid channel that fluidly couples the production and condensing chambers and is configured to allow the vapor to flow from the production chamber to the condensing chamber. The condensing chamber is configured to transform the vapor into a condensed liquid. | 12-20-2012 |
20140362964 | TARGET APPARATUS AND ISOTOPE PRODUCTION SYSTEMS AND METHODS USING THE SAME - Isotope production system including a particle accelerator configured to produce a particle beam. The isotope production system also includes a target apparatus having a window configured to receive a particle beam and also separate production and condensing chambers. The production chamber is configured to contain a starting liquid and located so that the particle beam is incident upon the starting liquid thereby generating radioisotopes and transforming a portion of the starting liquid into vapor. The target apparatus also includes a fluid channel that extends between and fluidly couples the production and condensing chambers. The fluid channel is configured to allow the vapor to flow from the production chamber into the condensing chamber. The condensing chamber is configured to transform the vapor in the condensing chamber into a condensed liquid. | 12-11-2014 |
20150077022 | PARTICLE ACCELERATORS HAVING EXTRACTION FOILS - A particle accelerator including an electrical field system and a magnetic field system that are configured to direct a particle beam of charged particles along a designated path within an acceleration chamber. The particle accelerator also includes a foil holder having a beam window and a positioning slot that at least partially surrounds the beam window. The positioning slot is dimensioned to hold an extraction foil such that the extraction foil extends across the beam window and into the path of the charged particles. The positioning slot is defined by interior reference surfaces that face the extraction foil and retain the extraction foil within the positioning slot. The reference surfaces permit the extraction foil to move relative to the reference surfaces when the particle beam is incident on the extraction foil. | 03-19-2015 |
20150086476 | SYSTEMS, METHODS AND APPARATUS FOR MANUFACTURING RADIOISOTOPES - A standalone radiopharmaceutical preparation hotcell for preparing a radiopharmaceutical includes a housing and a plurality of compartments defined within the housing. The plurality of compartments including at least a pharmaceutical synthesizing and dispensing compartment and a different second compartment, the synthesizing and dispensing compartment being maintained at a first pressure and the second compartment being maintained at a different second pressure using a compartment pressurization system. | 03-26-2015 |
20160050742 | EXTRACTION SYSTEM AND PARTICLE ACCELERATOR HAVING A FOIL HOLDER - A particle accelerator including an electrical field system and a magnetic field system that are configured to direct a particle beam of charged particles along a designated path within an acceleration chamber. The particle accelerator also includes a foil holder having a beam window and a positioning slot that at least partially surrounds the beam window. The positioning slot is dimensioned to hold an extraction foil such that the extraction foil extends across the beam window and into the path of the charged particles. The positioning slot is defined by interior reference surfaces that face the extraction foil and retain the extraction foil within the positioning slot. The reference surfaces permit the extraction foil to move relative to the reference surfaces when the particle beam is incident on the extraction foil. | 02-18-2016 |