Iwan
Iwan Beuvink, Basel CH
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20100280094 | COMPOSITIONS AND METHODS TO TREAT MUSCULAR & CARDIOVASCULAR DISORDERS - The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2. | 11-04-2010 |
20110097716 | Methods for Detecting Oligonucleotides - The invention provides methods and compositions for detecting and/or quantifying nucleic acid oligonucleotides. These methods and compositions are useful for detecting and quantifying diagnostic and/or therapeutic synthetic target oligonucleotides, such as aptamers, RNAi, siRNA, antisense oligonucleotides or ribozymes in a biological sample. | 04-28-2011 |
20120041052 | Compositions and Methods to Treat Muscular & Cardiovascular Disorders - The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2. | 02-16-2012 |
20120114744 | COMPOSITIONS AND METHODS TO TREAT MUSCULAR & CARDIOVASCULAR DISORDERS - The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2. | 05-10-2012 |
Iwan Kartawira, Cary, NC US
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20120106948 | OPTICAL NETWORK IN-BAND CONTROL PLANE SIGNALING, VIRTUALIZED CHANNELS, AND TANDEM CONNECTION MONITORING SYSTEMS AND METHODS - The present disclosure provides improvements with respect to in-band control plane signaling, virtualized channels, and tandem connection monitoring in optical networks utilizing Synchronous Optical Network (SONET), Synchronous Digital Hierarchy (SDH), Optical Transport Network (OTN), and the like. In an exemplary embodiment, the present disclosure includes an optical network operating a control plane with in-band signaling utilizing SONET/SDH path level overhead. In another exemplary embodiment, the present disclosure includes an optical network operating virtualized SONET/SDH or OTN channels with manually cross-connections at intermediate line terminating elements. In yet another exemplary embodiment, the present disclosure includes a tandem connection monitoring selection method across multiple operator domains. | 05-03-2012 |
Iwan Kawrakow, Ljulin BG
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20130079579 | DEVICE AND METHOD FOR RADIATION DOSIMETRY - A method and a device for regulating a therapeutic beam directed at an object are provided. The method includes displaying at least one multidimensional image data record encompassing at least one target area of the object. The method also includes determining the treatment beam dosage directed at the at lest one target area, and recording and optionally visualizing an isoline or isosurface dependent on the treatment beam dosage in the at least one multidimensional image data record. The method includes adjusting the isoline or isosurface such that the isoline or isosurface approximates a contour of the target area as closely as possible or corresponds to the contour, and regulating the treatment beam dosage by evaluation of the adjusted isoline or isosurface. | 03-28-2013 |
20130177135 | Method for Determining a 4D Plan for Carrying out Intensity-Modulated Radiation Therapy - A method for determining a 4D plan for carrying out intensity-modulated radiation therapy of a target volume subject to irregular periodic motion, with a radiation therapy apparatus is provided. The method includes selecting positions of a radiation source. The number of positions is selected to be identical in all 3D radiation therapy plans. The method also includes selecting a number of respective aperture settings assigned to a respective position of the radiation source to be identical in all 3D radiation therapy plans. A geometrical, temporal, and/or dynamic restriction that restricts a change of the aperture from one aperture setting to another aperture setting is predetermined, and the 3D radiation therapy plans are determined such that the 3D radiation therapy plans fulfill predetermined restrictions for aperture settings in each case. | 07-11-2013 |
20150196781 | Determining an Irradiation Plan for a Particle Irradiation Unit - A target volume within a test object is irradiated according to an irradiation plan with a particle beam using a particle irradiation unit. The irradiation plan is determined in order to apply the energy of the particle beam in the target volume according to a predetermined dose distribution. In addition, a boundary condition is specified for at least one of the isoenergy layers and the irradiation plan is additionally specified such that the boundary condition is met for the at least one isoenergy layer. The boundary condition includes one or more of a minimum boundary energy, a maximum boundary energy, a minimum grid point number, a minimum total particle number, a minimum total dose, a minimum dose contribution to a total dose to be administered, a minimum contribution to a target function which is calculated for determining the irradiation plan, and a minimum dose compensation error. | 07-16-2015 |
Iwan Kawrakow, Cleveland, OH US
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20150154756 | Single- And Multi-Modality Alignment Of Medical Images In The Presence Of Non-Rigid Deformations Using Phase Correlation - A phase correlation method (PCM) can be used for translational and/or rotational alignment of 3D medical images even in the presence of non-rigid deformations between first and second images of a registered volume of a patient. | 06-04-2015 |
Iwan Kawrykow, Sofia BG
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20140263990 | SYSTEMS AND METHODS FOR IMPROVED RADIOISOTOPIC DOSE CALCULATION AND DELIVERY - Disclosed herein are methods including calibrating a radiotherapy machine to identify an effective radiation source size of a radiation source contained within the radiotherapy machine, the radiation source having a nominal radiation source size, to improve accuracy of a predicted dose profile for one or more radiation beams from the radiation source to further improve accuracy of radiation dose calculation and treatment delivery. | 09-18-2014 |
20140275696 | Systems And Methods For Isotopic Source External Beam Radiotherapy - The subject matter described herein provides methods for developing an IMRT treatment plan for a radiotherapy system. In one aspect, the method can include providing initial treatment parameters. These parameters can include a number of isotopic beams, a transmission angle for each beam, a prescribed dose for a target, and dose volume histogram constraints. The method can further include determining an initial fluence map including one or more beamlets. The initial fluence map can specify a fluence value for each beamlet. The method can further include determining a delivery sequence for the fluence values in the initial fluence map. The delivery sequence can include one or more apertures formed by the leaves of a collimator. These apertures can have a specified size constrained to substantially less than a maximum size associated with the collimator, when the isotopic beam is near a critical structure. Related apparatus and systems are also described. | 09-18-2014 |
Iwan Maerki, Yverdon-Les-Bains CH
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20110169978 | FUNCTIONAL OPTICAL COHERENT IMAGING - The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOD. Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions. | 07-14-2011 |
Iwan Märki, Yverdon CH
Iwan Pangalila, Hamburg DE
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20110309194 | Mounting System for Attaching a Structural Monument in a Desired Position in an Aircraft Cabin - The invention relates to a mounting system ( | 12-22-2011 |
20120006941 | Mounting system for attaching a box in a compartment of an aircraft galley - A mounting system ( | 01-12-2012 |
20120085862 | AIRCRAFT GALLEY HAVING A PARTITION PANEL SYSTEM - An aircraft galley partition panel system has first and second partition panels. An assembly slot extends from an edge of the first panel and receives an assembly section of the second panel such that main surfaces of the first and second panels are substantially perpendicular. A first guide device carried by the assembly slot interacts with a complementary second guide device arranged in a region of the assembly section of the second panel. An assembly section of the first partition panel carries a third guide device which interacts with a complementary fourth guide device arranged in a region of a lateral surface of the second panel facing the assembly section of the first panel. Projections of the first and second connecting devices are received in complementary recesses in a base body of the aircraft galley to connect the first and second panels respectively to the base body. | 04-12-2012 |
20120217342 | FASTENING ARRANGEMENT FOR FASTENING A STORAGE CONTAINER IN A COMPARTMENT OF AN AIRCRAFT GALLEY, STORAGE CONTAINER AND AIRCRAFT GALLEY - A fastening arrangement for fastening a storage container in a compartment of an aircraft galley comprises a latching mechanism including a latch and a first biasing mechanism, the first biasing mechanism being adapted to bias the latch into a latched position in a first operational state of the latching mechanism, such that the latch is adapted to interact with the storage container upon insertion of the storage container into the compartment of the aircraft galley so as to be moved from its latched position into an unlatched position against the biasing force applied to the latch by the first biasing mechanism, and such that the latch is adapted to be moved back into its latched position by the biasing force applied to the latch by the first biasing mechanism when the storage container has reached a predefined position in the compartment of the aircraft galley. | 08-30-2012 |
Iwan Van Hende, Tao-Yuan Hsien TW
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20120143497 | Method of creating customized exercise routes for a user - A method of creating an exercise route for a user is disclosed. The method includes providing a database having geographic data, and receiving a plurality of input route parameters from the user, the input route parameters including a type of exercise to be performed on the exercise route. The method further includes processing the geographic data from the database and the plurality of input route parameters to define the exercise route from a starting point to an ending point, and presenting the exercise route to the user. | 06-07-2012 |
20130297201 | Method of creating exercise routes for a user and related personal navigation device - A method of creating an exercise route for a user of a personal navigation device includes receiving a selection of a length of an exercise route to be generated, and generating a first plurality of suggested exercise routes according to a current position of the personal navigation device and the selected length of the exercise route, where each of the first plurality of suggested exercise routes has a starting point and ending point substantially equal to one another and equal to the current position of the personal navigation device. The method further includes displaying the first plurality of suggested exercise routes to the user on a display of the personal navigation device, receiving, from the user, selection of a selected suggested exercise route from the first plurality of suggested exercise routes, and displaying routing instructions on the display of the personal navigation device for the selected suggested exercise route. | 11-07-2013 |
20130304377 | Method of creating varied exercise routes for a user - A method of creating an exercise route for a user of a personal navigation device includes receiving a selection of a length of an exercise route to be generated, and generating a first plurality of suggested exercise routes, each suggested exercise route of the first plurality of suggested exercise routes being generated according to a current position of the personal navigation device, one or more waypoints to be visited along the suggested exercise route, and the selected length of the exercise route, wherein each of the first plurality of suggested exercise routes has a starting point and ending point substantially equal to one another and equal to the current position of the personal navigation device. The method further includes receiving, from the user, selection of a selected suggested exercise route from the first plurality of suggested exercise routes, and displaying routing instructions for the selected suggested exercise route. | 11-14-2013 |
Iwan Vulic, Almelo NL
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20130267633 | Stabilized Polyolefins Having Increased Agrochemical and UV Resistance and Methods of Use - Polyolefin thin films having a stabilizing amount of a stabilizer composition including: | 10-10-2013 |
Iwan Zarembo, Walldorf DE
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20150286746 | Parser Wrapper Class - A system, a method, a device, and a computer program product for parsing a document are provided. A processing instance for parsing by at least one parsing module in a plurality of parsing modules is generated. The generated processing instance is intercepted. Based on the intercepted generated processing instance, a parsing module is selected. Using the selected parsing module, the processing instance is parsed to generate a parsed processing instance. | 10-08-2015 |
Iwan Zarembo, Reilingen DE
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20130160132 | CROSS-SITE REQUEST FORGERY PROTECTION - Various embodiments of systems and methods for Cross-Site Request Forgery (XSRF) protection are described herein. An XSRF protection framework provides rich configuration possibilities for protection using an XSRF token. In one aspect—XSRF encoding is performed for a set of URLs according to a configuration and then a token validation is performed for incoming requests to protected resources. In another aspect—XSRF token leakage via the referrer header to external URLs is prevented. | 06-20-2013 |