Patent application number | Description | Published |
20100250867 | COMPUTER ARCHITECTURES USING SHARED STORAGE - Shared storage architectures and methods are provided. A particular shared storage architecture is a system including shared storage including data and file system metadata separated from the data. The file system metadata includes location data specifying storage location information related to the data. Services are provided from service providers to service consumers through the shared storage. | 09-30-2010 |
20100251010 | COMPUTER ARCHITECTURES USING SHARED STORAGE - Shared storage systems and methods are provided. A particular shared storage system is a system including multiple instances of shared storage. Each of the instances of shared storage includes data and file system metadata separated from the data. The file system metadata includes location data specifying storage location information related to the data. A persistent common view is provided of local and remote files, file systems, and services in the shared storage. | 09-30-2010 |
20120185652 | COMPUTER ARCHITECTURES USING SHARED STORAGE - A method providing a persistent common view of data, services, and infrastructure functions accessible via a plurality of shared storage systems of a virtual shared storage system. The method includes applying different governance policies at two or more shared storage systems of the virtual shared storage system. The method includes transferring content from a particular shared storage system to a requesting device without using at least one of a server session, an application-to-server session, and an application session. The content corresponds to at least one of data, a service, and an infrastructure function provided via the particular shared storage system. | 07-19-2012 |
20120185653 | COMPUTER ARCHITECTURES USING SHARED STORAGE - A method includes providing a persistent common view of data, services, and infrastructure functions accessible via one or more shared storage systems of a plurality of shared storage systems of a virtual shared storage system. The method includes applying different governance policies to two or more shared storage systems of the plurality of shared storage systems. The method includes restricting access to first content accessible via a first shared storage system of the plurality of shared storage systems based on a security level associated with a data consumer. The first content corresponds to at least one of first data, a first service, and a first infrastructure function. | 07-19-2012 |
20120185725 | COMPUTER ARCHITECTURES USING SHARED STORAGE - A method includes providing a persistent common view of a virtual shared storage system. The virtual shared storage system includes a first shared storage system and a second shared storage system, and the persistent common view includes information associated with data and instructions stored at the first shared storage system and the second shared storage system. The method includes automatically updating the persistent common view to include third information associated with other data and other instructions stored at a third shared storage system in response to adding the third shared storage system to the virtual shared storage system. | 07-19-2012 |
20150143001 | COMPUTER ARCHITECTURES USING SHARED STORAGE - An Enterprise Service Bus (ESB) system includes a shared storage that stores data corresponding to files, a file system, and ESB infrastructure functions. The ESB system includes a metadata registry storing metadata associated with the ESB infrastructure functions, separate from the ESB infrastructure functions, and includes storage location information of the ESB infrastructure functions. The ESB system includes a processor configured to receive a request for access to the file system. The processor sends a portion of the metadata registry to a client device, the portion including a portion of the metadata and a directory structure identifying a set of the ESB infrastructure functions that the client device is authorized to access, the portion of the metadata allowing the client device to access a first infrastructure function of the set based on the storage location information. The processor further provides the first infrastructure function to the client device. | 05-21-2015 |
Patent application number | Description | Published |
20100011007 | SECURE HIGH PERFORMANCE MULTI-LEVEL SECURITY DATABASE SYSTEMS AND METHODS - In accordance with one or more embodiments of the present disclosure, systems and methods described herein provide for transferring data over one or more networks. A storage area network is adapted to communicate with the one or more networks. A first component is adapted to route data to and from the storage area network. A second component is adapted to route data to and from the storage area network. A gateway component is adapted to control the routing of data between the first and second components and the storage area network. The storage area network is adapted to separate metadata from the data and store the metadata in a secure server positioned behind the gateway component. | 01-14-2010 |
20100095122 | SYSTEM AND METHOD FOR COLLABORATION OVER SHARED STORAGE - In accordance with one or more embodiments of the present disclosure, systems and methods disclosed herein enable synergy among a group of users by providing a real-time, secure collaboration environment that allows for cooperative interaction and decision making and provide the ability for users to simultaneously view, revise, and review a document or multimedia file that resides in a shared data storage location. Real-time, low latency, rich collaboration between producers and consumers provides organization efficiency, and this collaboration provides real-time, low latency transmission of data. | 04-15-2010 |
20130227024 | SYSTEM AND METHOD FOR COLLABORATION OVER SHARED STORAGE - In accordance with one or more embodiments of the present disclosure, systems and methods disclosed herein enable synergy among a group of users by providing a real-time, secure collaboration environment that allows for cooperative interaction and decision making and provide the ability for users to simultaneously view, revise, and review a document or multimedia file that resides in a shared data storage location. Real-time, low latency, rich collaboration between producers and consumers provides organization efficiency, and this collaboration provides real-time, low latency transmission of data. | 08-29-2013 |
Patent application number | Description | Published |
20120297758 | Large Displacement Variator - A large displacement hydrostatic variator is disclosed which includes an input shaft coupled to at least first and second hydrostatic pumps. Two hydrostatic pumps are utilized instead of one larger hydrostatic pump because it has been found the two smaller hydrostatic pumps can operate at a faster speed than a larger hydrostatic pump with a displacement equivalent to that of the two smaller hydrostatic pumps. Each hydrostatic pump may include a carrier that includes a plurality of recesses. The recesses may serve as cylinders for slidably accommodating a piston in each piston of each pump may be pivotally coupled to an adjustable swash plate. A hydrostatic motor may be coupled to an output shaft. The motor includes a carrier that also includes a plurality of recesses that may also serve as cylinders for each slidably accommodating a piston. Each piston of the motor may be coupled to a swash plate. The adjustable swash plate of each pump may be coupled to an actuator, which may be controlled by a single controller. | 11-29-2012 |
20120324875 | OPTIMIZED SYSTEM RESPONSE WITH MULTIPLE COMMANDS - A method and system for operating a machine having first and second movable elements, first and second hydromechanical movers for moving the first and second movable elements, respectively, and first and second hydraulic pumps linked to the first and second hydromechanical movers, respectively. Movement requests for moving the first and second movable elements are processed such that the movement command to the second hydromechanical mover is reduced by a variable amount based on the magnitude of the first movement request. For commanded first hydromechanical mover movements below a certain level, flow to the second hydromechanical mover may optionally not be reduced. | 12-27-2012 |
20150059325 | Hybrid Apparatus and Method for Hydraulic Systems - A hydraulic system is disclosed. The hydraulic system includes a first actuator fluidly coupled to a first rotating group in a first closed-loop circuit, a flow control module fluidly coupled to the first closed-loop circuit via a first conduit, a second actuator fluidly coupled to the flow control module via a second conduit, a second rotating group in selective fluid communication with the first conduit and the second conduit via the flow control module, and a controller operatively coupled to the flow control module. The controller is configured to operate the flow control module in a first mode and a second mode. The first mode effects fluid communication between the second rotating group and the first closed-loop circuit via the first conduit, and blocks fluid communication between the second rotating group and the second actuator via the second conduit. | 03-05-2015 |
20150368879 | Combined Hydraulic Implement and Propulsion Circuit with Hybrid Energy Capture and Reuse - An integrated implement actuation and propulsion system for a machine is provided. The system may include: an implement circuit including a first pump and at least one hydraulic implement; a propulsion circuit including a second pump; a hydraulic motor; a brake valve; a back pressure valve; and a combiner valve connected to both the implement circuit and the propulsion circuit, the combiner valve being configured to effect selective fluid communication between the implement circuit and the propulsion circuit. | 12-24-2015 |
Patent application number | Description | Published |
20090031891 | Hydraulic circuit for rapid bucket shake out - A hydraulic circuit is disclosed. The hydraulic circuit may have a variable displacement pump. The variable displacement pump may have a fluidic displacement control configured to vary a flow of pressurized fluid based on a fluid signal and an electronic displacement control configured to vary the flow of pressurized fluid based on an electronic signal. The flow of pressurized fluid may be controlled by the one of the fluidic and electronic displacement controls that requests the smallest flow of pressurized fluid. The hydraulic circuit may also have a control valve connected between the pump and the fluidic displacement control, and the control valve may be configured to transmit the fluid signal to the fluidic displacement control. The hydraulic circuit may further have a controller configured to transmit a fluid signal to cause the fluidic control to request a maximum flow of pressurized fluid, and transmit an electronic signal requesting a flow smaller than the maximum flow, which causes the electronic displacement control to vary the flow of pressurized fluid. | 02-05-2009 |
20100043418 | HYDRAULIC SYSTEM AND METHOD FOR CONTROL - A hydraulic system is disclosed having at least two hydraulic circuits. The disclosed system compares pressures between the hydraulic circuits and alters valve commands of the circuit associated with higher pressures in order to reduce overall system pressure. | 02-25-2010 |
20120124988 | HYDRAULIC FAN CIRCUIT HAVING ENERGY RECOVERY - A hydraulic fan circuit is disclosed. The hydraulic fan circuit may have a primary pump, a motor, a fan connected to and driven by the motor, and a flywheel connected to and driven by one of the motor and the fan. The hydraulic fan circuit may also have a supply passage extending from the primary pump to the motor, a return passage extending from the motor to the primary pump, and a diverter valve configured to selectively connect the supply passage to a low-pressure sump. | 05-24-2012 |
20120134848 | HYDRAULIC FAN CIRCUIT HAVING ENERGY RECOVERY - A hydraulic fan circuit is disclosed. The hydraulic fan circuit may have a primary pump, a high-pressure passage fluidly connected to the primary pump, and a low-pressure passage fluidly connected to the primary pump. The hydraulic fan circuit may also have at least one accumulator in selective fluid communication with at least one of the high- and low-pressure passages, a motor, and a fan connected to the motor. The hydraulic fan circuit may further have a fan isolation valve fluidly connected to the high- and low-pressure passages. The fan isolation valve may be movable between a flow-passing position at which the motor is fluidly connected to the primary pump via the high- and low-pressure passages, and a flow-blocking position at which the motor is substantially isolated from the primary pump. | 05-31-2012 |
20120301325 | PUMP SYSTEM HAVING OPEN-LOOP TORQUE CONTROL - A pump system is disclosed. The pump system may have a pump with a displacement that is variable, and an actuator movable to adjust the displacement of the pump. The pump system may also have an electro-hydraulic valve fluidly connected to the actuator and configured to control movement of the actuator, and a variable resistor mechanically connected to at least one of the actuator and the pump. The variable resistor may be adjustable by movement of the at least one of the actuator and the pump to vary a current passing through the electro-hydraulic valve. | 11-29-2012 |
20130000290 | ENERGY RECOVERY SYSTEM HAVING ACCUMULATOR AND VARIABLE RELIEF - A swing energy recovery system for a machine is disclosed. The swing energy recovery system may have a pump configured to pressurize fluid, a motor driven by a flow of pressurized fluid from the pump, and an energy recovery arrangement configured to receive pressurized fluid discharged from the motor and selectively supply pressurized fluid to the motor. The swing energy recovery system may also have a pressure relief valve associated with the motor, and a controller in communication with the energy recovery arrangement and the pressure relief valve. The controller may be configured to selectively adjust a setting of the pressure relief valve based on an operating condition of the energy recovery arrangement. | 01-03-2013 |
20130000291 | HYDRAULIC CIRCUIT HAVING ENERGY STORAGE AND REUSE - A hydraulic circuit is disclosed. The hydraulic circuit may have a pump, a motor, a tank, and an accumulator. The hydraulic circuit may also have a valve movable between a first position at which an output of the pump is fluidly connected to the tank and the accumulator is fluidly connected to the motor, and a second position at which the output of the pump is fluidly connected to the motor. | 01-03-2013 |
20130098010 | Closed-Loop Hydraulic System Having Priority-Based Sharing - A hydraulic system is disclosed having first, second, and third pumps. The hydraulic system may also have a first actuator connected to the first pump in closed-loop manner, a second actuator connected to the second pump in closed-loop manner, and a third actuator. The hydraulic system may further have a selector valve associated with the third pump, and a first switching valve associated with the third pump and the third actuator. The first switching valve may be movable between a first position at which the third pump is connected to the third actuator in a closed-loop manner to move the third actuator in a first direction, a second position at which the third pump is connected to the third actuator in a closed-loop manner to move the third actuator in a second direction, and a third position at which the third pump is connected to the selector valve. | 04-25-2013 |
20130098013 | CLOSED-LOOP SYSTEM HAVING MULTI-CIRCUIT FLOW SHARING - A hydraulic system is disclosed. The hydraulic system may have a plurality of pumps with unidirectional functionality and being variable displacement, a common discharge passage connected to the plurality of pumps, and a common intake passage connected to the plurality of pumps. The hydraulic system may also have at least one actuator connected in closed-loop manner to the common discharge and common intake passages, and a switching valve associated with the at least one actuator and disposed between the at least one actuator and the common discharge and intake passages. The hydraulic system may additionally have at least one isolation valve configured to selectively isolate a portion of the common discharge passage and a portion of the common intake passage associated with one pump of the plurality of pumps from another pump of the plurality of pumps. | 04-25-2013 |
20130098014 | CLOSED-LOOP HYDRAULIC SYSTEM HAVING FORCE MODULATION - A hydraulic system is disclosed. The hydraulic system may have a unidirectional variable displacement first pump, a first actuator connected to the first pump via a closed-loop first circuit, and a first switching valve disposed between the first actuator and the first pump. The first switching valve may be configured to control a fluid flow direction through the first actuator. The hydraulic system may also have a second actuator connected to the first pump in parallel with the first actuator via the first circuit, and a second switching valve disposed between the second actuator and the first pump. The second switching valve may be configured to control a fluid flow direction through the second actuator. The hydraulic system may further have a modulation valve associated with the first circuit and configured to selectively modulate a pressure of the first circuit during actuation of the first or second switching valves. | 04-25-2013 |
20130098463 | METERLESS HYDRAULIC SYSTEM HAVING SHARING AND COMBINING FUNCTIONALITY - A hydraulic system is disclosed. The hydraulic system may have a unidirectional variable displacement first pump, a first hydraulic actuator connected to the first pump via a closed-loop first circuit, a unidirectional variable displacement second pump, and a second hydraulic actuator connected to the second pump via a closed-loop second circuit. The hydraulic system may also have a third pump selectively connectable in closed-loop manner to the first or second circuits, and a first valve disposed between the first hydraulic actuator and the first pump and configured to selectively direct fluid from the first circuit to the second and third pumps. | 04-25-2013 |
Patent application number | Description | Published |
20120310490 | OPERATOR INTERFACE WITH TACTILE FEEDBACK - An operator interface assembly for a machine includes a base, an operator input device, a first biasing member, and a second biasing member. The operator input device is operable to move in a direction in relation to the base. The first biasing member is operable to contact the operator input device at a first position and resist movement of the operator input device in the direction. The second biasing member is operable to contact the operator input device at a second position and resist movement of the operator input device in the direction. | 12-06-2012 |
20120324767 | HYDRAULIC SUSPENSION HITCH SYSTEM - The present disclosure provides a hitch suspension system that reduces a transfer of energy (e.g., provides a smoother ride) between two bodies hitched together, such as between a towing vehicle and a towed vehicle/trailer. In an embodiment, the suspension system includes a hydraulic cylinder with an extendable rod in fluid communication with a fluid pump. A control valve is fluidly coupled between the hydraulic cylinder and the fluid pump and is configured to adjust an extension length of the rod. Additionally, a variable orifice that adjusts resistance to extension and retraction of the rod is fluidly coupled between the hydraulic cylinder and the control valve. A first fixed restrictive element is fluidly coupled in series with the variable orifice to dissipate energy ad the rod extends and a second fixed restrictive element is fluidly coupled in series with the variable orifice to dissipate energy as the rod retracts. | 12-27-2012 |
20130008246 | HYDRAULIC ACCUMULATOR FLUID CHARGE ESTIMATION SYSTEM AND METHOD - A method for estimating a fluid charge of a hydraulic accumulator includes determining a first accumulator pressure at a first time with a pressure sensor, the first time during accumulator charging; determining a second accumulator pressure at a second time with the pressure sensor, the second time during accumulator charging; determining a first fan speed at the first time; determining a second fan speed at the second time; and estimating the fluid charge of the hydraulic accumulator as a function of the first accumulator pressure, the second accumulator pressure, the first fan speed, and the second fan speed. | 01-10-2013 |
20130152565 | HYDRAULIC SYSTEM HAVING ENERGY RECOVERY - A hydraulic system for a machine is disclosed. The hydraulic system may have a pump configured to pressurize fluid, a swing motor driven by pressurized fluid to swing a body of the machine relative to an undercarriage, and a first circuit fluidly connecting the pump to the swing motor. The hydraulic system may also have an energy recovery motor mechanically connected to the swing motor, at least one accumulator, and a second circuit fluidly connecting the at least one accumulator to the energy recovery motor. | 06-20-2013 |
20130317695 | OPERATOR INTERFACE WITH TACTILE FEEDBACK - An operator interface assembly for a machine is disclosed. The operator interface assembly comprises a base, an operator input device operable to move in a first direction in relation to the base to a second position and a third position, a first biasing member including a first spring end, and operatively associated with the base and wherein the first spring end is operable to contact the operator input device at a first position and resist movement of the operator input device in the first direction, a second biasing member including a second spring end, and operatively associated with the base and wherein the second spring end is operable to contact the operator input device at the second position, the second position different than the first position, and resist movement of the operator input device in the first direction, and a position sensor. | 11-28-2013 |
20140165549 | HYDRAULIC SYSTEM HAVING MULTIPLE CLOSED LOOP CIRCUITS - A hydraulic system is disclosed. The hydraulic system may have a first pump, a boom cylinder, and a first closed loop fluidly connecting the first pump to the boom cylinder. The hydraulic system may also have a second pump, a swing motor, and a second closed loop fluidly connecting the second pump to the swing motor. The hydraulic system may further have a third pump, an auxiliary actuator, and a third closed loop fluidly connecting the third pump to the auxiliary actuator. The hydraulic system may additionally have a combining valve configured to selectively connect the second closed loop to the first closed loop during a boom raising operation, and a control valve configured to selectively connect the third closed loop to the first closed loop during a boom lowering operation. | 06-19-2014 |
20140174069 | HYDRAULIC CONTROL SYSTEM HAVING SWING MOTOR ENERGY RECOVERY - A hydraulic control system for a machine is disclosed. The hydraulic control system may have a tank, a pump, a swing motor having a first chamber and a second chamber, and at least one control valve configured to control fluid flow between the pump, the swing motor, and the tank. The hydraulic system may also have an accumulator configured to selectively receive pressurized fluid discharged from the swing motor and selectively supply pressurized fluid to the swing motor and a controller. The hydraulic control system may further include a first valve and a second valve coupled between the accumulator and the first and the second chambers of the swing motor. One of the first or second valve moves between a first position, a second position, and a third position for selective charging and discharging of the accumulator. The second valve also moves between multiple positions to realize selective charging and discharging of the accumulator. | 06-26-2014 |
20140178164 | MACHINE HAVING HYDRAULICALLY ACTUATED IMPLEMENT SYSTEM WITH COMBINED RIDE CONTROL AND DOWNFORCE CONTROL SYSTEM - A machine is disclosed. The machine can include a frame and ground engaging propulsion elements coupled with the frame. A hydraulically actuated implement system can be coupled with the frame, and can include a linkage configured to couple with an implement, a hydraulic actuator coupled with the linkage and the frame, and a ride control and downforce control circuit configured to implement a ride control mode and a downforce control mode. The ride control mode can be configured to maintain a pressure of hydraulic fluid in the hydraulic actuator at a ride control pressure, and the downforce control mode can be configured to maintain the pressure of hydraulic fluid in the hydraulic actuator at a downforce control pressure to oppose the weight of the linkage and the implement such that the implement engages a substrate with a predetermined down force pressure which is proportionate to the downforce control pressure. | 06-26-2014 |
20140210184 | HYDRAULIC SUSPENSION HITCH SYSTEM - The present disclosure provides a hitch suspension system that reduces a transfer of energy (e.g., provides a smoother ride) between two bodies hitched together, such as between a towing vehicle and a towed vehicle/trailer. In an embodiment, the suspension system includes a hydraulic cylinder with an extendable rod in fluid communication with a fluid pump. A control valve is fluidly coupled between the hydraulic cylinder and the fluid pump and is configured to adjust an extension length of the rod. Additionally, a variable orifice that adjusts resistance to extension and retraction of the rod is fluidly coupled between the hydraulic cylinder and the control valve. A first fixed restrictive element is fluidly coupled in series with the variable orifice to dissipate energy ad the rod extends and a second fixed restrictive element is fluidly coupled in series with the variable orifice to dissipate energy as the rod retracts. | 07-31-2014 |
20150338329 | BULK MODULUS MEASUREMENT AND FLUID DEGRADATION ANALYSIS - An apparatus and method to analyze fluid degradation in a closed system is disclosed. The method includes collection of a sample fluid from the closed system. The sample fluid collected is maintained at a sample fluid pressure, which is substantially equivalent to a pressure of the closed system. Thereafter, a change of a volume of the sample fluid is caused, which generates a change in the sample fluid pressure. A series of sample fluid pressures and volumes of the sample fluid are taken. Next, a bulk modulus of the sample fluid is determined. The bulk modulus of the sample fluid is compared with a baseline bulk modulus. Lastly, the method involves generation of a communication when the bulk modulus of the sample fluid breaches a tolerance. | 11-26-2015 |
Patent application number | Description | Published |
20140136071 | SYSTEM WITH BLENDED ANTI-LOCK AND STABILITY CONTROL - A brake system for a mobile machine is disclosed. The brake system may have an anti-lock braking subsystem configured to calculate a maximum allowable brake command. The brake system may have a stability control subsystem configured to generate a desired differential brake command. The brake system may have a brake command adjustment subsystem. The brake command adjustment subsystem may be configured to calculate an ideal solution of a left brake command and a right brake command to satisfy a combination of the desired differential brake command and a desired total brake command. When the ideal solution is valid, the brake command adjustment subsystem may output the ideal solution as an actual brake command. When the ideal solution is invalid, the brake command adjustment subsystem may calculate a non-ideal solution of the left brake command and the right brake command. | 05-15-2014 |
20150247304 | IMPLEMENT SYSTEM HAVING HYDRAULIC START ASSIST - An implement system is disclosed for use with a machine having an engine. The implement system may have a pump driven by the engine, a first actuator configured to receive pressurized fluid from the pump during operation of the engine, and at least a second actuator configure to receive pressurized fluid from the pump during operation of the engine. The implement system may also have an accumulator configured to receive pressurized fluid from the first actuator during operation of the engine, and to discharge fluid to the first actuator and to the at least a second actuator when the engine is shut down. | 09-03-2015 |
20150247509 | MACHINE HAVING HYDRAULIC START ASSIST SYSTEM - A hydraulic system is disclosed for assisting starting of a machine having an engine. The hydraulic system may include a work tool, a pump driven by the engine to pressurize fluid, and an actuator configured to receive pressurized fluid from the pump and move the work tool. The hydraulic system may also include an accumulator configured to selectively receive pressurized fluid from the pump and from the actuator, an electric starter configured to start the engine, and a motor selectively supplied with fluid from the accumulator to assist the electric starter in starting the engine. | 09-03-2015 |
20150247513 | MACHINE HAVING HYDRAULIC START ASSIST SYSTEM - A hydraulic system is disclosed for assisting starting of a machine having an engine. The hydraulic system may include a work tool, a pump driven by the engine to pressurize fluid, and an actuator configured to receive pressurized fluid from the pump and move the work tool. The hydraulic system may also include an accumulator configured to selectively receive pressurized fluid from the pump and from the actuator, an electric starter configured to start the engine, and a motor selectively supplied with fluid from the accumulator to assist the electric starter in starting the engine. | 09-03-2015 |
Patent application number | Description | Published |
20130114197 | RACK MOUNTED UI DEVICE - A user interface (UI) demo is disclosed. The UT device has two displays ( | 05-09-2013 |
20160050795 | TOP LOADING CARTRIDGE - A top loading cartridge is provided herein. The top loading cartridge includes a support member, a rail member, and a lock mechanism. The support member to receive an electronic module. The rail member attached to the support member to engage with a tray that receives the top loading server cartridge. The lock mechanism to lock the top loading cartridge. | 02-18-2016 |
20160057885 | TOP LOADING CARTRIDGE - A top loading cartridge is provided herein. The top loading cartridge includes a support member, a rail member, and a lock mechanism. The support member to receive an electronic module. The rail member attached to the support member to engage with a tray that receives the top loading server cartridge. The lock mechanism to lock the top loading cartridge. | 02-25-2016 |
20160057887 | TOP LOADING CARTRIDGE - A top loading cartridge is provided herein. The top loading cartridge includes a support member, a rail member, and a lock mechanism. The support member to receive an electronic module. The rail member attached to the support member to engage with a tray that receives the top loading server cartridge. The lock mechanism to lock the top loading cartridge. | 02-25-2016 |
Patent application number | Description | Published |
20100261646 | SUSTAINED INTRAOCULAR DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES - Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents useful for managing elevated intraocular pressure (TOP) in the eye. In one embodiment, the microspheres are formed from polylactide-co-glycolide (“PLGA”); in another embodiment, the microspheres are formed from a blend PLGA and poly lactic acid (“PLA”). Relatively hydrophilic, and preferably carboxylated, polymeric materials such as PLGA are used for a drug such as timolol maleate, which is relatively water soluble, to increase drug loading. Higher molecular weight polymers, as well as the ratio of LA (which has a longer degradation time, up to one to two years) to GA (which has a short degradation time, as short as a few days to a week), are used to provide release over a longer period of time. The combination of drug loading and release rate, as well as the minimization of initial burst release, result in prolonged release of a higher amount of drug. | 10-14-2010 |
20110206773 | SUSTAINED DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES - Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (TOP) in the eye. | 08-25-2011 |
20160101054 | SUSTAINED DELIVERY OF DRUGS FROM BIODEGRADABLE POLYMERIC MICROPARTICLES - Biodegradable polymeric microparticle compositions containing one or more active agents, especially those useful for treating or preventing or one or more diseases or disorders of the eye, and methods of making and using thereof, are described. The microsphere compositions release an effective amount of the one or more active agents for a period greater than 14 days in vivo, preferably greater than 60 days in vivo, more preferably up to 73 days in vivo, more preferably greater than 90 days in vivo, even more preferably over 100 days in vivo, and most preferably greater than 107 days in vivo. In a preferred embodiment, the microparticle compositions contain one or more active agents such as AG1478 to induce nerve regeneration, specifically regeneration of the optic nerve useful for managing elevated intraocular pressure (IOP) in the eye. | 04-14-2016 |