Johansen, MA
Elizabeth Johansen, Somerville, MA US
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20080250632 | SYSTEM AND METHOD OF A CONFORMABLE CABLE - A method and system for providing a conformable cable are described. The method and system may include disposing a conformable material along at least a portion of a cable and configuring the cable into a desired position and shape in which the shape of the cord remains unchanged. | 10-16-2008 |
20080282902 | Automatic cooking appliance shutoff apparatus - The invention relates to an apparatus used for automatically shutting off cooking appliances, such as ovens, stoves, hot pots, toasters, grills, and others. More specifically, the apparatus is secured to a cooking appliance, e.g. to its control panel, and may prevent a cooking appliance from being turned on before a timer is set. The apparatus can also increase the ease with which a cooking appliance knob or other actuator may be used. To automatically shutoff the cooking appliance, the apparatus uses a timing mechanism with a spring. Pressure is exerted on a spring when the timer is set, storing enough force in the spring to enable it to turn the cooking appliance to the OFF position when time has expired. A mechanical stop is in place to keep the spring energy from releasing until the timer reaches the OFF position. | 11-20-2008 |
Elizabeth Whitney Johansen, Somerville, MA US
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20080269688 | Dose Indicating Assembly of a Pharmaceutical Injection Device - A dose indicating assembly in a pharmaceutical injection device ( | 10-30-2008 |
Jack Johansen, Concord, MA US
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20080272002 | System and Method for Proteomics - Significantly higher yield and better resolution in pI gels are obtained by creating traps having two or more layers of gel containing closely stepped immobilized pH buffers. Proteins move from a pH at which they are negatively charged towards an anode at which they are positively charged. Discrete regions containing immobilized pH buffers trap the proteins when the immobilized buffer pH and the protein pI are approximately the same. The protein is trapped within the second layer and not on the surface of or interface of the second layer. Significantly higher yields with better resolution can be obtained through the use of layered sample application gels prior to isoelectric focusing. Layered plugs are prepared with a range of immobilized pH buffers ranging, for example, over 2 pH units, with steps of 0.05 or 0.1 pH units. An array of multilayered plugs wherein each plug has different pH increments is also provided. The array can be used to isolate and trap a variety of proteins having different isoelectric pHs during a single run. Another embodiment provides plugs having at least three layers; a gate layer, a trap layer, and an exit layer. Another embodiment includes adding a carrier ampholytes to running buffers and or adding thiol containing reducing agents to reduce current and improve resolution and collection efficiency. | 11-06-2008 |
20100216146 | Methods and Kits for Hybridizing Multiple PNA Probe Panels to Nucleic Acid Samples - Described herein are methods and kits that employ multiple probe sets in combination with sequential steps of hybridization analysis for multiplex analysis and/or detection of nucleic acids having one or more distinguishable target sequences. | 08-26-2010 |
Jack T. Johansen, Concord, MA US
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20110003712 | Methods, Kits and Compositions for the Identification of Nucleic Acids Electrostatically Bound to Matrices - This invention pertains to methods, kits and compositions suitable for the detection, identification and/or quantitation of nucleic acids which are electrostatically immobilized to matrices using non-nucleotide probes which sequence specifically hybridize to one or more target sequences of the nucleic acid but do not otherwise substantially interact with the matrix. Once the nucleic acid is immobilized, the detectable non-nucleotide probe/target sequence complex, formed before or after the immobilization of the nucleic acid, can be detected, identified or quantitated under a wide range of assay conditions as a means to detect, identify or quantitate the target sequence in the sample. Because it is reversibly bound, the non-nucleotide probe/target sequence can optionally be removed from the matrix for detecting, identifying or quantitating the target sequence in the sample. Because the non-nucleotide probe/target sequence is protected against degradation, it is another advantage of this invention that the sample can be treated with enzymes which degrade sample components, either before or after the nucleic acid is bound to the matrix, in order to “clean up” the sample (e.g. a complex biological sample such as a cell lysate) and thereby improve the detection, identification or quantitation of the target sequence in the sample. The methods, kits and compositions of this invention are therefore particularly well suited for the analysis, and particularly single point mutation analysis, in a particle assay, in an array assay, in a nuclease digestion/protection assay and/or in a line assay format. When utilized in combination with non-nucleotide “Beacon” probes, the invention is particularly well suited for use in a self-indicating assay format. | 01-06-2011 |
Lisa M. Johansen, Belmont, MA US
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20100009970 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES - The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E) and the agent or combination of agents includes sertraline, a sertraline analog, UK-416244, or a UK-416244 analog. Also featured are screening methods for identification of novel compounds that may be used to treat a viral disease. | 01-14-2010 |
20100092479 | Compositions and methods for treatment of viral diseases - The present invention features compositions, methods, and kits useful in the treatment of viral diseases. In certain embodiments, the viral disease is caused by a single stranded RNA virus, a flaviviridae virus, or a hepatic virus. In particular embodiments, the viral disease is viral hepatitis (e.g., hepatitis A, hepatitis B, hepatitis C, hepatitis D, hepatitis E). | 04-15-2010 |
20110028564 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES - The invention features compositions, methods, and kits useful for the treatment of filovirus-mediated diseases, e.g., hemorrhagic fever caused by Ebola virus, in an animal. | 02-03-2011 |
20130289024 | COMPOSITIONS AND METHODS FOR TREATMENT OF FILOVIRUS-MEDIATED DISEASES - The invention features compositions, methods, and kits useful for the treatment of filovirus-mediated diseases, e.g., hemorrhagic fever caused by Ebola virus, in an animal. | 10-31-2013 |