Patent application number | Description | Published |
20080287469 | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation - The invention relates generally to phosphoinositide 3-kinases (PI3Ks), and more particularly to methods of inhibiting leukocyte accumulation comprising selectively inhibiting phosphoinositide 3-kinase delta (PI3Kδ) and phosphoinositide 3-kinase gamma (PI3Kγ) activities in endothelial cells. The disclosed methods may be used to treat individuals having an inflammatory condition where leukocytes are found to be accumulating at the site of insult or inflamed tissue. The inflammatory condition may be attributed to or associated with an underlying disorder not typically associated with inflammation, e.g. cancer, coronary vascular disease, etc. | 11-20-2008 |
20100029693 | NOVEL PI3K DELTA INHIBITORS AND METHODS OF USE THEREOF - The present invention relates generally to phosphoinositide 3-kinases (PI3Ks), and more particularly to specific, selective, improved PI3Kδ inhibitors and methods of inhibiting undesirable levels of PI3Kδ activity using these PI3Kδ inhibitors to treat disorders mediated by PI3Kδ. | 02-04-2010 |
20110044942 | METHODS OF TREATMENT FOR SOLID TUMORS - The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises administration of a compound of formula I, | 02-24-2011 |
20130344138 | METHODS OF TREATMENT FOR SOLID TUMORS - The invention provides methods that relate to a novel therapeutic strategy for the treatment of hematological malignancies and inflammatory diseases. In particular, the method comprises administration of a compound of formula I, | 12-26-2013 |
20140235643 | NOVEL QUINOXALINE INHIBITORS OF PI3K - The invention provides methods that relate to a novel therapeutic strategy for the treatment of cancer and inflammatory diseases. In particular, the method comprises administration of a compound of Formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such compound admixed with at least one pharmaceutically acceptable excipient. | 08-21-2014 |
Patent application number | Description | Published |
20130116266 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA - Compounds that inhibit P13Kδ activity, including compounds that selectively inhibit P13Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (P13Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which P13Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 05-09-2013 |
20130231356 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 09-05-2013 |
20140121223 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 05-01-2014 |
20140121224 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 05-01-2014 |
20140378479 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA - Compounds that inhibit PI3Kδ activity, including compounds that selectively inhibit PI3Kδ activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3Kδ) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3Kδ plays a role in leukocyte function, using the compounds also are disclosed. | 12-25-2014 |
Patent application number | Description | Published |
20080250401 | Tiling across loop nests with possible recomputation - Described is a technology by which a series of loop nests corresponding to source code are detected by a compiler, with the series of loop nests tiled together, (thereby increasing the ratio of cache hits to misses in a multi-processor environment). The compiler transforms the series of loop nests into a plurality of tile loops within a controller loop, including using dependency analysis to determine which results from a tile loop need to be pre-computed before another tile loop. For dependency analysis, the compiler may use a directed acyclic graph as a high-level intermediate representation, and split the graph into sub-graphs each representing an array. The compiler uses descriptors processed from the graph to determine the controller loop and the tile loops within that controller loop. | 10-09-2008 |
20100088520 | PROTOCOL FOR DETERMINING AVAILABILITY OF PEERS IN A PEER-TO-PEER STORAGE SYSTEM - A method and system is provided for monitoring the availability of a peer in a P2P system that is used to provide remote storage or remote processing power. In one illustrative example, a recipient peer requests access to a service provisioned by another peer in a peer-to-peer network. The request may be a request to access a file or a file fragment that is being stored on the other peer. In order to make use of the accessed service, after receiving access to the service provisioned by the peer, the recipient peer needs to report to a central server that the service has been rendered. For instance, in some cases the file fragment accessed by the recipient peer may be encrypted, in which case the central server will send the recipient peer a decryption key after receiving the report that the service has been rendered. | 04-08-2010 |
20100174968 | HEIRARCHICAL ERASURE CODING - Arrangements are provided for efficient erasure coding of files to be distributed and later retrieved from a peer-to-peer network, where such files are broken up into many fragments and stored at peer systems. The arrangements further provide a routine to determine the probability that the file can be reconstructed. The arrangements further provide a method of performing the erasure coding in an optimized fashion, allowing fewer occurrences of disk seeks. | 07-08-2010 |
20110029840 | Erasure Coded Storage Aggregation in Data Centers - Embodiments of erasure coded storage aggregation are disclosed. The erasure coded storage aggregation includes storing a data file as erasure coded fragments in a plurality of nodes of one or more data centers. The erasure coded storage aggregation further includes monitoring an access frequency of the data file. Based on the comparison between the access frequency and a predetermined threshold, the data file is either reconstructed from the erasure coded fragments and stored in a storage node or retained as erasure coded fragments in the plurality of nodes of the one or more data centers. | 02-03-2011 |
20120089439 | MARKET DESIGN FOR A RESOURCE EXCHANGE SYSTEM - Providing a market design for a peer-to-peer resource exchange system. Prices for a plurality of resources such as storage space, upload bandwidth, and download bandwidth are calculated and balanced based on previous resource prices, a supply of the resources, and a demand for the resources. Further, prices for operations such as storage and retrieval are determined such that a total of the payments to resource suppliers equals a total of the payments received from the resource consumers. In some embodiments, incoming data operation requests are allocated to the peers such that equilibrium among the peers is achieved. | 04-12-2012 |
20130275390 | ERASURE CODED STORAGE AGGREGATION IN DATA CENTERS - Embodiments of erasure coded storage aggregation are disclosed. The erasure coded storage aggregation includes storing a data file as erasure coded fragments in a plurality of nodes of one or more data centers. The erasure coded storage aggregation further includes monitoring an access frequency of the data file. Based on the comparison between the access frequency and a predetermined threshold, the data file is either reconstructed from the erasure coded fragments and stored in a storage node or retained as erasure coded fragments in the plurality of nodes of the one or more data centers. | 10-17-2013 |