Pugh, GB
Christopher Pugh, Northampton GB
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20150290310 | CROSS-PROTECTING SALMONELLA VACCINES - The present invention discloses that | 10-15-2015 |
Christopher William Pugh, Oxford GB
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20090286858 | ASSAYS FOR MODULATORS OF ASPARAGINYL HYDROXYLASE - The present invention is directed to methods of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprising contacting a HIF asparagine hydroxylase and a test substance in the presence of a substrate of the hydroxylase under conditions in which asparagine in the substrate is hydroxylated in the absence of the test substance; and determining hydroxylation of the substrate. | 11-19-2009 |
20100272726 | Assays, methods and means - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID NO: 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 10-28-2010 |
20100330668 | Interaction Between the VHL Tumour Suppressor and Hypoxia Inducible Factor, and Assay Methods Relating Thereto - The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate this interaction. | 12-30-2010 |
20140294842 | Assays, Methods and Means - A novel class of hydroxylases is described having the amino acid sequence of SEQ ID No. 2, 4, 6 and 8, and variants and fragments thereof having HIF hydroxylation activity. The polypeptides of the invention have in particular prolyl hydroxylase activity. An assay method monitors the interaction of the HIF hydroxylase with a substrate. Modulators of HIF hydroxylase are provided for use in the treatment of a condition associated with increased or decreased HIF levels or activity or for the treatment of a condition where it is desirable to modulate HIF levels or activity. | 10-02-2014 |
Daniel Pugh, Essex GB
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20100242290 | Tile Rebate Cutting Apparatus - A tile rebate cutting apparatus has a guide member, which may be formed by a spirit level, forming a linear guide for a rebate cutting tool, the rebate cutting tool incorporating at least one cutting device, the rebate cutting tool being adapted to engage with said guide member to move along a predetermined line determined by the position of the guide member to enable a cut for a rebate to be made in a ceiling tile. | 09-30-2010 |
Darren Pugh, Essex GB
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20100242290 | Tile Rebate Cutting Apparatus - A tile rebate cutting apparatus has a guide member, which may be formed by a spirit level, forming a linear guide for a rebate cutting tool, the rebate cutting tool incorporating at least one cutting device, the rebate cutting tool being adapted to engage with said guide member to move along a predetermined line determined by the position of the guide member to enable a cut for a rebate to be made in a ceiling tile. | 09-30-2010 |
David Pugh, Abertillery GB
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20110123867 | POWDERS - A titanium suboxide powder comprising Ti | 05-26-2011 |
David Pugh, Cambridge GB
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20150081223 | MICROSEISMIC SURVEY - Methods, computing systems, and computer-readable media for processing seismic data. The method may include obtaining a model of a subterranean domain, and determining one or more synthetic waveforms for one or more events located in the subterranean domain, based at least partially on the model. The method may also include identifying, using a processor, one or more arrival waves in the one or more synthetic waveforms, wherein at least one of the one or more arrivals represents a mode-converted wave, and generating a processing chain for determining at least a location of an event in the subterranean domain based at least partially on the at least one mode-converted wave. | 03-19-2015 |
Peter Robert William Pugh, Surrey GB
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20110100879 | IMPROVEMENTS IN OR RELATING TO FILTERS - A magnetic filter device and method for using same, for removing ferromagnetic particles from a liquid, which device comprises a vessel having an inlet for liquid to flow into the vessel and an outlet for the liquid to flow out of the vessel, and the vessel having one or more magnets suspended therein for removing ferromagnetic particles from liquid flowing between the inlet and outlet, characterised in that: the vessel is a horizontal pipe with the inlet at one end and the outlet at the other end, the magnets are suspended transverse to the longitudinal axis of the pipe in one or more sets, and the vessel has one or more helical flow generators which in use, generate helical flow of the liquid as it flows between the inlet and outlet, and/or one or more turbulent flow generators which in use, generate turbulent flow of the liquid as it flows between the inlet and outlet. The helical and/or turbulent flow of the liquid may mitigate the potential problems of liquid and/or particles by-passing the magnet or magnets, for example arising from laminar flow of the liquid and/or uneven distribution of particles in the liquid. | 05-05-2011 |
Rachel Marie Pugh, Cheshire GB
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20120022110 | PHARMACEUTICAL DEPOT FOR 5-FLUORO-2-[[(1S)-1-(5-FLUORO-2-PYRIDYL)ETHYL]AMINO]-6-[(5-ISOPROPOXY-1H-- PYRAZOL-3-YL)AMINO]PYRIDINE-3-CARBONITRILE - A pharmaceutical depot comprising (i) 5-fluoro-2-[[(1S)-1-(5-fluoro-2-pyridyl)ethyl]amino]-6-[(5-isopropoxy-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation. | 01-26-2012 |
20140045895 | PHARMACEUTICAL DEPOT FOR 5-FLUORO-2-[[(1S)-1-(5-FLUORO-2-PYRIDYL)ETHYL]AMINO]-6-[(5-ISOPROPOXY-1H-- PYRAZOL-3-YL)AMINO]PYRIDINE-3-CARBONITRILE - A pharmaceutical depot comprising (i) 5-fluoro-2-[[(1S)-1-(5-fluoro-2-pyridyl)ethyl]amino]-6-[(5-isopropoxy-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile, or a pharmaceutically-acceptable salt thereof, as a pharmaceutical agent (PA) and (ii) a polymer which degrades to create an acidic microclimate, wherein the PA is released from the polymer upon polymer degradation. | 02-13-2014 |
Rhoderick Pugh, Woking Surrey GB
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20080201401 | SECURE SERVER AUTHENTICATION AND BROWSING - Methods of authenticating a content-provider server by a server are provided. One method comprises determining a domain name of the content-provider server; obtaining a fragment of a database of IP addresses, the fragment corresponding to the domain name of the content-provider server and storing one or more IP addresses associated with the domain name; comparing the IP address of the content-provider server against the IP addresses of the fragment; and providing an indication that the IP address of the content-provider server is included or excluded from the fragment of IP addresses. | 08-21-2008 |
Rhoderick John Kennedy Pugh, Woking GB
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20090043765 | SERVER AUTHENTICATION - A method of authenticating a content-provider server, the method comprising: determining a domain name of the content-provider server; obtaining a fragment of a database of IP addresses, the fragment corresponding to the domain name of the content-provider server and storing one or more IP addresses associated with the domain name; comparing the IP address of the content-provider server against the IP addresses of the fragment; and providing an indication that the IP address of the content-provider server is included or excluded from the fragment of IP addresses. Additionally, a client computer and server operable to implement the method are described. | 02-12-2009 |
Richard H Pugh, Selby GB
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20150233640 | Blast Furnace Spool Liner - A hearth refractory assembly is provided to improve gas sealing of a blast furnace hearth. The blast furnace hearth has a metal outer shell and a spool extending outwardly therefrom. The spool has a spool metal outer wall and forms an opening in said hearth metal outer shell. The refractory liner assembly includes a plurality of hearth refractory bricks arranged in a stacked configuration and lining the interior of the hearth metal outer shell and the spool. A liner is positioned between the hearth refractory brick and said hearth metal outer shell or within the spool and covers substantially all of the spool opening. The liner is a sheet made substantially from graphite. | 08-20-2015 |
Robert Ian Pugh, Nottingham GB
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20090012333 | Process of Preparing Glycolaldehyde - The invention provides a process of preparing glycolaldehyde by reacting formaldehyde with hydrogen and carbon monoxide in the presence of a catalyst composition which is based on, a) a source of rhodium, and b) a ligand of general formula R | 01-08-2009 |
Roderick John Kennedy Pugh, Woking GB
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20110247053 | SERVER AUTHENTICATION - A method of authenticating a content-provider server, the method comprising: determining a domain name of the content-provider server; obtaining a fragment of a database of IP addresses, the fragment corresponding to the domain name of the content-provider server and storing one or more IP addresses associated with the domain name; comparing the IP address of the content-provider server against the IP addresses of the fragment; and providing an indication that the IP address of the content-provider server is included or excluded from the fragment of IP addresses. Additionally, a client computer and server operable to implement the method are described. | 10-06-2011 |
Simon Pugh, Hull GB
Tom Pugh, Chiswick GB
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20150254688 | SYSTEMS AND METHODS TO PREDICT BIDDING BEHAVIOUR - Systems and methods to predict bidding behaviour are described. The system identifies a listing that includes listing information that describes an item that is being auctioned on a network-based marketplace. The system further identifies bid classification information based on the number of bids received for the item. Finally, the system predicts whether no more bids are expected to be received for the item based on the classification information. | 09-10-2015 |