Fletcher, MA
Brian R. Fletcher, Fairhaven, MA US
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20090247325 | HIGH PERFORMANCE GOLF BALL HAVING A REDUCED DISTANCE - A golf ball comprising a core comprising from about 25 to 75 parts of butyl or halobutyl rubber and having a coefficient of restitution of 0.683 to 0.750 and a compression of less than about 60; an inner cover layer comprising an ionomer and having a Shore D hardness of at least about 60; and an outer cover layer comprising a polyurethane or polyurea having a Shore D hardness of less than about 55; wherein the golf ball has a dimple coverage of 55% to 75%, a coefficient of restitution of 0.696 to 0.775, and an Atti compression of at least about 80. | 10-01-2009 |
Gregory Fletcher, Boston, MA US
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20100138488 | Reliable, high-throughput, high-performance transport and routing mechanism for arbitrary data flows - The present invention leverages an existing content delivery network infrastructure to provide a system that enhances performance for any application that uses the Internet Protocol (IP) as its underlying transport mechanism. An overlay network comprises a set of edge nodes, intermediate nodes, and gateway nodes. This network provides optimized routing of IP packets. Internet application users can use the overlay to obtain improved performance during normal network conditions, to obtain or maintain good performance where normal default BGP routing would otherwise force the user over congested or poorly performing paths, or to enable the user to maintain communications to a target server application even during network outages. | 06-03-2010 |
20120215938 | Reliable, high-throughput, high-performance transport and routing mechanism for arbitrary data flows - The present invention leverages an existing content delivery network infrastructure to provide a system that enhances performance for any application that uses the Internet Protocol (IP) as its underlying transport mechanism. An overlay network comprises a set of edge nodes, intermediate nodes, and gateway nodes. This network provides optimized routing of IP packets. Internet application users can use the overlay to obtain improved performance during normal network conditions, to obtain or maintain good performance where normal default BGP routing would otherwise force the user over congested or poorly performing paths, or to enable the user to maintain communications to a target server application even during network outages. | 08-23-2012 |
20130304809 | Reducing TCP connection establishment time in an overlay network - Applications that run on an overlay network-based managed service achieve high performance gains using a set of TCP optimizations. In a first optimization, a typical single TCP connection between a client and an origin server is broken into preferably three (3) separate TCP connections. These connections are: an edge-to-client connection, an edge-to-edge connection, and edge-to-origin connection. A second optimization replicates TCP state along the connection to increase fault tolerance. In this approach, preferably a given TCP connection is maintained on two servers. When a packet is received by one server, called the primary, its state is updated and then passed to a second server, called the backup. Only when the backup sends an acknowledgement back to the primary can it then send a TCP acknowledgement back to the host that originally sent the packet. Another optimization reduces connection establishment latency. | 11-14-2013 |
20130304892 | Breaking a TCP connection into a set of relay connections in an overlay network - Applications that run on an overlay network-based managed service achieve high performance gains using a set of TCP optimizations. In a first optimization, a typical single TCP connection between a client and an origin server is broken into preferably three (3) separate TCP connections. These connections are: an edge-to-client connection, an edge-to-edge connection, and edge-to-origin connection. A second optimization replicates TCP state along the connection to increase fault tolerance. In this approach, preferably a given TCP connection is maintained on two servers. When a packet is received by one server, called the primary, its state is updated and then passed to a second server, called the backup. Only when the backup sends an acknowledgement back to the primary can it then send a TCP acknowledgement back to the host that originally sent the packet. Another optimization reduces connection establishment latency. | 11-14-2013 |
20150074187 | Reliable, high-throughput, high-performance transport and routing mechanism for arbitrary data flows - The present invention leverages an existing content delivery network infrastructure to provide a system that enhances performance for any application that uses the Internet Protocol (IP) as its underlying transport mechanism. An overlay network comprises a set of edge nodes, intermediate nodes, and gateway nodes. This network provides optimized routing of IP packets. Internet application users can use the overlay to obtain improved performance during normal network conditions, to obtain or maintain good performance where normal default BGP routing would otherwise force the user over congested or poorly performing paths, or to enable the user to maintain communications to a target server application even during network outages. | 03-12-2015 |
Jonathan A. Fletcher, Brookline, MA US
Patent application number | Description | Published |
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20090280495 | ACTIVATING MUTATIONS OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGETS - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 11-12-2009 |
20110081730 | ACTIVATING MUTATIONS OF PLATELET DERIVED GROWTH FACTOR RECEPTOR ALPHA (PDGFRA) AS DIAGNOSTIC MARKERS AND THERAPEUTIC TARGET - This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions. | 04-07-2011 |
20140357516 | METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING CANCER - The invention provides assays, methods, systems, compositions, and kits for diagnosing and treating cancer. | 12-04-2014 |
Martin Fletcher, Winchester, MA US
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20120034132 | Magnetic Particle Resuspension Probe Module - An acid injection module ( | 02-09-2012 |
P. Michael Fletcher, Chelmsford, MA US
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20110006225 | METHOD AND APPARATUS FOR EBEAM TREATMENT OF WEBS AND PRODUCTS MADE THEREFROM - A method and apparatus for sterilization of webs and products made therefrom using electron beams (ebeams) is provided. A controller is configured to modulate an ebeam to ensure that a non-continuously moving web is sterilized within a desired range of exposure. During sterilization in place operations, manifolds are configured to operate to ensure that sterilants do not enter an irradiation zone to prevent damage to ebeam emitters. | 01-13-2011 |
20110012030 | EBEAM STERILIZATION APPARATUS - Improved electron beam sterilization apparatus and shielding techniques for use in are provided. A controller modulates an ebeam when sterilizing an interior to an object to ensure that adequate dose is received. Sterilization carousels are configured with input/discharge feeds to reduce the possibility of humans being exposed to dangerous levels of radiation. The system reduces the amount of shielding required to thereby lower cost of installation. | 01-20-2011 |
20110012032 | ELECTRON BEAM STERILIZATION APPARATUS - Improved electron beam sterilization apparatus and shielding techniques for use in are provided. A controller modulates an electron beam when sterilizing an interior to an object to ensure that adequate dose is received. Sterilization carousels are configured with input/discharge feeds to reduce the possibility of humans being exposed to dangerous levels of radiation. The system reduces the amount of shielding required to thereby lower cost of installation. | 01-20-2011 |
20130015365 | ELECTRON BEAM STERILIZATION APPARATUS - Improved electron beam sterilization apparatus and shielding techniques for use in are provided. A controller modulates an electron beam when sterilizing an interior to an object to ensure that adequate dose is received. Sterilization carousels are configured with input/discharge feeds to reduce the possibility of humans being exposed to dangerous levels of radiation. The system reduces the amount of shielding required to thereby lower cost of installation. | 01-17-2013 |
Richard Fletcher, Medford, MA US
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20110004072 | Methods and apparatus for monitoring patients and delivering therapeutic stimuli - In an exemplary implementation of this invention, a user wears comfortable biosensors. These sensors gather physiological data from the user and transmit this data to another radio-enabled device. This other device may be a mobile phone. The data is further transmitted, via this other radio-enabled device, to one or more networks (such as wireless networks or the Internet). A processor analyzes this transmitted data, in real time, to recognize patterns in the data that indicate the need for therapeutic intervention. Upon recognition of such a pattern, the processor outputs instructions for a transducer to deliver therapeutic stimuli. These instructions are transmitted, over one or more wired or wireless networks, to a transducer which delivers the therapeutic stimuli to the user. | 01-06-2011 |
Richard Fletcher, Somerville, MA US
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20080198015 | RFID SYSTEM - An RFID system including a battery powered RFID reader configured to detect an RFID tag. The RFID reader include a mounting surface configured to be affixed relative to an external structure, and is capable of being wirelessly coupled to a receiver for transmitting data to the receiver. | 08-21-2008 |
20080198016 | RFID SYSTEM - An RFID system and network including an RFID reader capable of detecting an RFID tag. The RFID system further includes an intermediate device configured to be wirelessly coupled to the RFID reader. A third device is configured to be coupled to the intermediate device for communicating with the RFID reader via the intermediate device. | 08-21-2008 |
Richard Fletcher, Cambridge, MA US
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20100206949 | SYSTEM AND METHOD FOR RFID-BASED PRINTED MEDIA READING ACTIVITY DATA ACQUISITION AND ANALYSIS - The subject invention provides a means of automatically detecting and recording a person's use of magazines, i.e. printed media exposure, for the purpose of market research. The present invention comprises one or more electrically conductive marker regions applied to certain specific locations on one or more magazine pages. In one general embodiment, the presence and relative separation of the marker regions are detected by a capacitive sensors and electronic device that stores, processes and communicates the data wirelessly to an external device. In another embodiment, a passive chip less tag is used to indirectly measure the change in conductivity of the conductive regions caused by prolonged exposure to air or light. Exemplary methods are described for acquiring readership and exposure data using the present invention. | 08-19-2010 |
20120145573 | Blister Package with Integrated Electronic Tag and Method of Manufacture - A blister package with an integrated RFID tag is provided. The conductive lidding material is modified to serve not only to seal some contents within some formed blister film, but also to act as an RFID tag antenna. An electronic circuit is electrically connected to the lidding film antenna. Methods of manufacture which integrate with conventional blister package manufacturing processes are also provided. | 06-14-2012 |
Richard Ribon Fletcher, Medford, MA US
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20100268056 | Washable wearable biosensor - A washable, wearable biosensor that can gather sensor data, communicate the sensed data by wireless protocols, and permits the analysis of sensed data in real-time as a person goes about their normal lifestyle activities. The biosensor can be worn in multiple positions, can be put on or removed quickly without having to apply or remove gels and adhesives, and provides a snug, comfortable fit to gather data with minimal motion artifacts. The textile, wearable device can support integrated photoplethysmography, skin conductance, motion, and temperature sensors in a small wearable package. The supported sensors may be coupled to utilization devices by channel-sharing wireless protocols to enable the transmission of data from multiple users and multiple sensors (e.g. both sides of body, wrists or hands and feet, or multiple people). An on-board processor, or the receiving utilization device, can map patterns of the physiological and motion data to signals or alerts such as a likely seizure, drug craving, or other states that the wearer may exhibit or experience. The sensor data may be sent by wireless transmission and received by a mobile phone or other personal digital device, a computer, a favorite toy, or another wearable device. The sensors may include multiple photoplethysmographs and/or one or more EDAs which perform a time-domain measurement of skin conductance | 10-21-2010 |
William E. Fletcher, Acton, MA US
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20090198765 | Digital asset usage accountability via event journaling - A technique for establishing a perimeter of accountability for usage of digital assets such as data files. The accountability model not only tracks authorized users' access to files, but monitors passage of such files to uncontrollable removable storage media or through network connections and the like which may indicate possible abuse of access. In accordance with a preferred embodiment, an autonomous independent agent process running at a point of use, such as in the background of a client operating system kernel, interrupts requests for access to resources. The agent process senses low level system events, filters, aggregates them, and makes reports to a journaling server. The journaling server analyzes sequences of low level events to detect when aggregate events of interest occur, such as “FileEdit”, network file transfers and the like. Reports can be generated to provide an understanding of how digital assets have been accessed, used or communicated by individuals in an enterprise. | 08-06-2009 |