Patent application number | Description | Published |
20130040278 | Enhanced integrated journal - An apparatus and method to provide a more interactive book learning experience. The invention provides an interactive quiz component to book figures. Figures within an electronic document can be enlarged by a user input such as a touch gesture. Selected information from the enlarged figure can be hidden and used as an interactive quiz. Feedback and options for further review or interactions are provided based on user input. | 02-14-2013 |
20130042173 | Integrated electronic compilation of study material - An apparatus and method to electronically compile an integrated summary document across several different educational sources is provided. The integrated summary document can contain links back to the original sources. Within the integrated summary document, searches, social learning elements and other content can also be integrated and linked to external content. | 02-14-2013 |
20140025745 | Intergrated Learning Application - The instant invention is an apparatus and method to improve the learning experience by integrating feedback from multiple people through existing social media. The invention enables users, from within an application external to a social networking site, to automatically or manually post comments in social media related to the learning metrics of their own or other users that they have access to. These posts or comments are identifiable as associated with the external app and associated with user who posted and to the owner of the learning metric. The message can either be completely authored by the user, automatically or semi-automatically generated by the external app. | 01-23-2014 |
20140129286 | Analyzing Operational Results Using Rule-Based Policy Models - Methods, systems, and products that execute modeled business controls on a modeled input work item to generate a corresponding modeled output work item. Input data values included in the modeled input work item either match or approximate corresponding values included in a corresponding actual input work item. Each modeled business control is defined by business rules that represent a business policy, and the business rules and the input data values of the modeled input work item are used to generate the modeled output work item. An actual output work item from a business process is compared to the modeled output work item. The actual output work item includes actual output data values. The business process changes the actual input work item into the actual output work item. The modeled output work item includes modeled output data values. Differences between the actual and modeled output work items are reported. | 05-08-2014 |
Patent application number | Description | Published |
20090315987 | RAPID DETECTION OF REPLICATING CELLS - The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance. | 12-24-2009 |
20100248281 | RAPID DETECTION OF REPLICATING CELLS - The invention enables efficient, rapid, and sensitive enumeration of living cells by detecting microscopic colonies derived from in situ cell division using large area imaging. Microbial enumeration tests based on the invention address an important problem in clinical and industrial microbiology—the long time needed for detection in traditional tests—while retaining key advantages of the traditional methods based on microbial culture. Embodiments of the invention include non-destructive aseptic methods for detecting cellular microcolonies without labeling reagents. These methods allow for the generation of pure cultures which can be used for microbial identification and determination of antimicrobial resistance. | 09-30-2010 |
20120045826 | KITS AND DEVICES FOR DETECTING ANALYTES - The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests. | 02-23-2012 |
20120046203 | IMAGING ANALYZER FOR TESTING ANALYTES - The invention provides analyzers that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient and specific selection and sensitive imaging detection of individual microscopic targets at low magnification. Automated embodiments allow efficient walk-away, on-demand, random-access high-throughput testing. The analyzers perform tests without requiring wash steps thus streamlining engineering and lowering costs. Thus, the invention provides analyzers that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests for analytes. | 02-23-2012 |
20120149007 | METHOD FOR DETECTING ANALYTES - The invention provides an improved method for sensitive and specific detection of target molecules, cells, or viruses. The inventive method uses large area imaging to detect individual labeled targets complexed with a target-specific selection moiety. The invention eliminates wash steps through the use of target-specific selection through one or more liquid layers that can contain optical dye and density agents. By eliminating washes the invention simplifies instrumentation engineering and minimizes user steps and costs. The invention uses sensitive image analysis to enumerate individual targets in a large area, is scalable, and can be deployed in systems ranging in complexity from manual to highly automated. | 06-14-2012 |
Patent application number | Description | Published |
20100028955 | Sequence Amplification with Target Primers - The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. This can be accomplished via the use of target primers and isothermal multiple strand displacement (MDA) processes. The use of these target primers and MDA, as described herein, allows for, for example, the reduction in the amplification of undesired hybridization events (such as primer dimerization and the “jackpot mutation” effect of PCR) while allowing for the amplification of the target nucleic acid sequences. | 02-04-2010 |
20100124765 | SEQUENCE AMPLIFICATION WITH TARGET PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. This can be accomplished via the use of target primers. The use of these target primers, as described herein, allows for the reduction in the amplification of undesired hybridization events (such as primer dimerization) while allowing for the amplification of the target nucleic acid sequences. | 05-20-2010 |
20110257385 | METHODS FOR FLIP-STRAND IMMOBILIZING AND SEQUENCING NUCLEIC ACIDS - Provided herein are compositions, materials, methods and kits for immobilizing a template polynucleotide in a first orientation, and immobilizing a complementary sequence of the template polynucleotide in an orientation that is flipped compared to the orientation of the template polynucleotide. Provided herein are adaptive oligonucleotides that can be used in various nucleic acid manipulations to generate immobilized complement polynucleotides that are flipped in orientation compared to the orientation of the immobilized template polynucleotides. | 10-20-2011 |
20120122104 | Triple-Stranded Nucleobase Structures and Uses Thereof - The present disclosure relates to compositions and methods of using triplex structures generated by a duplex of a polypurine tract and complementary polypyrimidine tract and a triplex-forming nucleobase polymer that hydrogen bonds to both the purine and pyrimidine bases of the polypurine-polypyrimidine duplex. | 05-17-2012 |
20120142059 | SEQUENCE AMPLIFICATION WITH TARGET PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. This can be accomplished via the use of target primers and isothermal multiple strand displacement (MDA) processes. The use of these target primers and MDA, as described herein, allows for the reduction in the amplification of undesired hybridization events (such as primer dimerization and the “jackpot mutation” effect of PCR) while allowing for the amplification of the target nucleic acid sequences. | 06-07-2012 |
20140065624 | Analyzing Messenger RNA and Micro RNA in the Same Reaction Mixture - The present teachings provide methods, compositions, and kits for performing primer extension reactions on at least two target polynucleotides in the same reaction mixture. In some embodiments, a reverse transcription reaction is performed on a first target polynucleotide with a hot start primer comprising a self-complementary stem and a loop, and extension products form at high temperatures but extension products form less so at low temperatures since the self-complementary stem of the hot start primer prevents hybridization of the target specific region to the target. However, non-hot start primers with free target specific regions can hybridize to their corresponding targets at the low temperature and extension can happen at the low temperature. | 03-06-2014 |
20140206000 | SEQUENCE AMPLIFICATION WITH LINEAR PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences for various sequencing and/or identification techniques. The use of these primers, as described herein, allows for the reduction in the amplification of nonspecific hybridization events (such as primer dimerization) while allowing for the amplification of the target nucleic acid sequences. | 07-24-2014 |
20140235845 | SEQUENCE AMPLIFICATION WITH LOOPABLE PRIMERS - The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers. The use of these primers, as described herein, results in nucleic acid structures that can reduce the amplification of nonspecific hybridization events (such as primer dimerization) while allowing the amplification of the target nucleic acid sequences. | 08-21-2014 |
20140303017 | Multiplexed Amplification of Short Nucleic Acids - The present teachings provide methods, compositions, and kits for reverse transcribing and amplifying small nucleic acids such as micro RNAs. High levels of multiplexing are provided by the use of a zip-coded stem-loop reverse transcription primer, along with a PCR-based pre-amplification reaction that comprises a zip-coded forward primer. Detector probes in downstream decoding PCRs can take advantage of the zip-code introduced by the stem-loop reverse transcription primer. In some embodiments, further amplification is achieved by cycling the reverse transcription reaction. The present teachings also provide compositions and kits useful for performing the reverse transcription and amplification reactions described herein. | 10-09-2014 |
20140349301 | Methods for Normalizing and for Identifying Small Nucleic Acids - The present teachings are generally directed to methods for normalizing at least one species of small nucleic acid that is present in a population of small nucleic acid species, wherein the relative concentration of at least one small nucleic acid species is substantially greater than the relative concentration of at least one other small nucleic acid species in the population. At least one small nucleic acid species is normalized using a multiplicity of primers comprising degenerate sequences. In some embodiments, a small nucleic acid species is identified by inserting at least part of an extension product from a normalized population into a vector and subsequently sequencing the insert. In some embodiments, a small nucleic acid species is identified by determining the sequence of at least part of an extension product. | 11-27-2014 |
20150252418 | HOT START REVERSE TRANSCRIPTION BY PRIMER DESIGN - The present teachings provide methods, compositions, and kits for performing primer extension reactions. In some embodiments, a reverse transcription reaction is performed on a target polynucleotide with a hot start primer comprising a blunt-ended self-complementary stem, and a loop, and extension products form at high temperatures but reduce extension product formation at low temperatures. | 09-10-2015 |