Patent application number | Description | Published |
20090249498 | Methods of diagnosing alzheimer's disease and markers identified by set association - The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD. | 10-01-2009 |
20090260092 | METHODS OF DIAGNOSING ALZHEIMER'S DISEASE AND MARKERS IDENTIFIED BY SET ASSOCIATION - The present disclosure relates to genetic markers and methods of diagnosing and screening for late-onset Alzheimer's disease (LOAD). As such, the disclosure encompasses a whole-genome association analysis of single nucleotide polymorphisms (SNPs) of which a number are located within the GRB2-associated binding protein 2 (GAB2) gene as well as other markers associated with other genes. The disclosure identifies two novel haplotypes within the GAB2 gene, i.e., a LOAD risk-enhancing and a LOAD risk-decreasing haplotype. These haplotypes modify LOAD risk differentially in combination with APOE alleles. Further encompassed are therapeutic methods and agents of decreasing the deterioration of cells associated with LOAD. | 10-15-2009 |
20110263439 | MARKERS ASSOCIATED WITH ALZHEIMER'S DISEASE - This application discloses SNPs capable of predicting increased or decreased risk of developing late onset Alzheimer's disease. | 10-27-2011 |
20150080703 | ACCELERATED EVALUATION OF TREATMENTS TO PREVENT CLINICAL ONSET OF ALZHEIMER'S DISEASE - Systems and methods for evaluating prospective treatments for progressive brain disorders like Alzheimer's disease and the progressive effects of aging involve the use of an imaging device communicatively coupled to a computing device. The imaging device may takes a plurality of brain imaging measurements from each of a plurality of human subjects who are divided into a treated group and an untreated group based on various subject data including whether the subjects carry certain alleles of genes known to increase the risk of developing the brain disorder at issue. The computing device receives the brain imaging measurements from the imaging device and applies an advanced processing method that permits enhanced computational efficiency when calculating rates of change for the two groups and determining whether any calculated difference between the rates is statistically significant. | 03-19-2015 |
Patent application number | Description | Published |
20090212595 | VEHICLE SIDE FAIRING SYSTEM - A vehicle side fairing having a first fairing panel fixedly secured to the underside of a trailer box, and a second fairing panel slidable mounted to plural cylindrical bars mounted on the underside of the trailer box in a fore and aft orientation. The second fairing panel is secured to the wheel set with a mechanical fastener that selectively joins and releases the second fairing panel and the wheel set. | 08-27-2009 |
20090212596 | VEHICLE SIDE FAIRING SYSTEM - A vehicle side fairing having a first fairing panel fixedly secured to the underside of a trailer box, and a second fairing panel slidably mounted to the first fairing panel. The second fairing panel is releasably secured to the wheel set so that the second fairing panel can be moved with an adjustment in the position of the wheel set. | 08-27-2009 |
20090230726 | VEHICLE FAIRING STRUCTURE - A fairing structure for a vehicle having a front vehicular component and a rear vehicular component in tandem and separated by a gap, comprising a top fairing surface adapted to be attached to the rear vehicular component, a first side surface adapted to be attached to a first side of the rear vehicular component, joining a first end of the top surface and generally perpendicular to the top surface, and a second side surface adapted to be attached to a second side of the rear vehicular component, joining a second end of the top surface opposite the first end and generally perpendicular to the top surface. Each of the top and first and second side surfaces has a proximal edge adapted to be positioned adjacent a vehicle, as well as a distal edge adapted to be positioned away from the vehicle with respect to the respective proximal edge. The proximal edges of the top and side surfaces attach to the leading top and side edges, respectively, of the front surface of the trailer box, so that an approximately uninterrupted surface is formed from the fairing structure to top and sides of the rear vehicular component. The area bounded by the distal edges of the surfaces is smaller than an area bounded by the proximal edges. The top side surface, the first side surface and the second side surface are made of a resilient material in the regions distal from the regions where the first side surface joins the top side surface, and where the second side surface joins the top side surface, the top side surface including a heat and fire resistant material in the regions proximate to the first and second side surface, and the first and second side surfaces including a heat and fire resistant material in the regions proximate to the top side surface. | 09-17-2009 |
20110025092 | VEHICLE FAIRING STRUCTURE - A fairing structure for a vehicle having a front vehicular component and a rear vehicular component in tandem and separated by a gap, comprising a top fairing surface adapted to be attached to the rear vehicular component, a first side surface adapted to be attached to a first side of the rear vehicular component, joining a first end of the top surface and generally perpendicular to the top surface, and a second side surface adapted to be attached to a second side of the rear vehicular component, joining a second end of the top surface opposite the first end and generally perpendicular to the top surface. Each of the top and first and second side surfaces has a proximal edge adapted to be positioned adjacent a vehicle, as well as a distal edge adapted to be positioned away from the vehicle with respect to the respective proximal edge. The proximal edges of the top and side surfaces attach to the leading top and side edges, respectively, of the front surface of the trailer box, so that an approximately uninterrupted surface is formed from the fairing structure to top and sides of the rear vehicular component. The area bounded by the distal edges of the surfaces is smaller than an area bounded by the proximal edges. The top side surface, the first side surface and the second side surface are made of a resilient material in the regions distal from the regions where the first side surface joins the top side surface, and where the second side surface joins the top side surface, the top side surface including a heat and fire resistant material in the regions proximate to the first and second side surface, and the first and second side surfaces including a heat and fire resistant material in the regions proximate to the top side surface. | 02-03-2011 |
20130169000 | CRASH BAR AERODYNAMIC DEVICE - An aerodynamic device for the crash bar of a tractor trailer and support structures is easily installed on the front and optionally on the rear of the crash bar forming a rounded fairing surface or “bull nose.” A device may optionally be attached to the crash bar support structures. Using a flexible material, such as EPDM extrusion, or forming a molded part in polyurethane elastomer, ensures that the fairing surface recovers its shape after being crushed so that the device may be used repeatedly with a retaining device at a docking bay during loading and unloading, for example. | 07-04-2013 |
20130181477 | VEHICLE SIDE FAIRING SYSTEM - A vehicle side fairing having a first fairing panel fixedly secured to the underside of a trailer box, and a second fairing panel coupled to the wheel set so that the second fairing panel moves with an adjustment in the position of the wheel set. | 07-18-2013 |
20130313856 | INTERMODAL CHASSIS SIDE FAIRING SYSTEM - A trailer or intermodal trailer chassis having a vehicle side fairing that accommodates, without being damaged, a container or other object lowered onto the trailer or intermodal chassis in a misaligned orientation. | 11-28-2013 |
20160001827 | VEHICLE SIDE FAIRING SYSTEM - A vehicle side fairing having a first fairing panel fixedly secured to the underside of a trailer box, and a second fairing panel coupled to the wheel set so that the second fairing panel moves with an adjustment in the position of the wheel set. | 01-07-2016 |
Patent application number | Description | Published |
20150030834 | STRENGTHENED GLASS ARTICLES HAVING IMPROVED SURVIVABILITY - Embodiments are directed to strengthened glass articles comprising a thickness t≦1 mm (1000 μm), an inner region under a central tension CT (in MPa), and at least one compressive stress layer adjacent the inner region and extending within the strengthened glass article from a surface of the strengthened glass article to a depth of layer DOL (in μm), wherein the strengthened glass article is under a compressive stress at the surface CS | 01-29-2015 |
20150079398 | Fracture-Resistant Layered-Substrates and Articles Including the Same - Embodiments of a layered-substrate comprising a substrate and a layer disposed thereon, wherein the layered-substrate is able to withstand fracture when assembled with a device that is dropped from a height of at least 100 cm onto a drop surface, are disclosed. The layered-substrate may exhibit a hardness of at least about 10 GPa or at least about 20 GPa. The substrate may include an amorphous substrate or a crystalline substrate. Examples of amorphous substrates include glass, which is optionally chemically strengthened. Examples of crystalline substrates include single crystal substrates (e.g. sapphire) and glass ceramics. Articles and/or devices including such layered-substrate and methods for making such devices are also disclosed. | 03-19-2015 |
20150239775 | STRENGTHENED GLASS WITH DEEP DEPTH OF COMPRESSION - Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of at least about 45 μm within the article are provided. In one embodiment, the compressive stress profile includes a single linear segment extending from the surface to the depth of compression DOC. Alternatively, the compressive stress profile includes two linear portions: the first portion extending from the surface to a relatively shallow depth and having a steep slope; and a second portion extending from the shallow depth to the depth of compression. The strengthened glass has a 60% survival rate when dropped from a height of 80 cm in an inverted ball drop test and an equibiaxial flexural strength of at least 10 kgf as determined by abraded ring-on-ring testing. Methods of achieving such stress profiles are also described. | 08-27-2015 |
20150239776 | STRENGTHENED GLASS WITH DEEP DEPTH OF COMPRESSION - Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of at least about 45 μm within the article are provided. In one embodiment, the compressive stress profile includes a single linear segment extending from the surface to the depth of compression DOC. Alternatively, the compressive stress profile includes two linear portions: the first portion extending from the surface to a relatively shallow depth and having a steep slope; and a second portion extending from the shallow depth to the depth of compression. The strengthened glass has a 60% survival rate when dropped from a height of 80 cm in an inverted ball drop test and an equibiaxial flexural strength of at least 10 kgf as determined by abraded ring-on-ring testing. Methods of achieving such stress profiles are also described. | 08-27-2015 |
20150259244 | STRENGTHENED GLASS WITH DEEP DEPTH OF COMPRESSION - Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of layer DOL of about 130 μm up to about 175 μm or, alternatively, to a depth of compression (DOC) in a range from about 90 μm to about 120 μm within the article. The compressive layer has a stress profile that includes a first substantially linear portion extending from a relatively shallow depth to the DOL or DOC and a second portion extending from the surface to the shallow depth. The second portion is substantially linear at a depth from 0 μm to 5 μm and has a steeper slope than that of the first portion of the profile. Methods of achieving such stress profiles are also described. | 09-17-2015 |
20150368153 | STRENGTHENED GLASS WITH DEEP DEPTH OF COMPRESSION - Chemically strengthened glass articles having at least one deep compressive layer extending from a surface of the article to a depth of at least about 45 μm within the article are provided. In one embodiment, the compressive stress profile includes a single linear segment extending from the surface to the depth of compression DOC. Alternatively, the compressive stress profile includes two linear portions: the first portion extending from the surface to a relatively shallow depth and having a steep slope; and a second portion extending from the shallow depth to the depth of compression. Methods of achieving such stress profiles are also described. | 12-24-2015 |