Patent application number | Description | Published |
20080234287 | SULFUR-CONTAINING NAPHTHALIMIDE DERIVATIVES - The invention discloses novel sulfur-containing naphthalimide derivatives, and the preparation and uses thereof. The conjugated plane of naphthalimide derivatives of the invention is enlarged by incorporating 5- or 6-membered heteroaromatic ring and/or introducing S heteroatom, thus increasing the anti-tumor activity of naphthalimide. The compounds of the invention displays significant inhibiting activities to the proliferation of various tumor cells such as human lung cancer, gastric cancer, liver cancer, leucocythemia and the like. The inhibition of cell proliferation is dose-dependent. | 09-25-2008 |
20100165165 | METHOD AND DEVICE FOR A CMOS IMAGE SENSOR - A method for determining photocurrents corresponding to a plurality of wavelength ranges. The method includes receiving at least a light by a photodiode within a first wavelength range. The first wavelength range includes a second wavelength range and a third wavelength range. The method provides a first bias voltage to the photodiode and determines a first photocurrent within the first wavelength range, the first photocurrent being associated with the photodiode and the first bias voltage. The method also provides a second bias voltage to the photodiode, different from the first bias voltage, and determines a second photocurrent within the first wavelength range, the second photocurrent being associated with the photodiode and the second bias voltage. The method further includes processing information associated with the first and second photocurrents, and determining at least a third photocurrent corresponding to the second wavelength range and a fourth photocurrent corresponding to the third wavelength range. | 07-01-2010 |
20100197066 | METHOD OF INTERCONNECT FOR IMAGE SENSOR - A method for fabricating CMOS image sensor device, the method includes providing a semiconductor substrate having a P type impurity characteristic. The semiconductor substrate includes a surface region. The method forms a first dielectric layer having a first thickness overlying a first region of the semiconductor substrate. The method includes providing a N type impurity region in a portion of the semiconductor substrate underneath the first dielectric layer to cause formation of a photodiode device region characterized by at least the N type impurity region and the P type substrate. A second dielectric layer having a second thickness is formed in a second region of the surface region. The second dielectric layer is formed within a portion of the first region within the first thickness of the first dielectric layer. The method forms a polysilicon gate layer overlying at least the second region to form a contact member coupled to the second region. | 08-05-2010 |
20110069197 | SYSTEM AND METHOD FOR CMOS IMAGE SENSING - A system is provided for determining a color using a CMOS image sensor. The system includes an input port for receiving a user command. The system further includes an image sensor, an optical device that forms an image on the image sensor, and a processor. The image sensor includes an n-type substrate and a p-type epitaxy layer overlying the n-type substrate. The image sensor includes a control circuit that applies a first voltage on the n-type substrate to obtain a first output. The control circuit applies a second voltage on the n-type substrate to obtain a second output. The control circuit also applies a third voltage on the n-type substrate to obtain a third output. The p-type epitaxy layer includes a silicon germanium material. The image sensor additionally includes an epitaxy layer interposed between the n-type substrate and the p-type epitaxy layer. | 03-24-2011 |
20110070677 | SYSTEM AND METHOD FOR CMOS IMAGE SENSING - A method for forming a CMOS image sensing pixel, which is configured to determine a color, includes providing an n-type substrate that includes a first thickness and a first width. The method also includes forming a p-type layer, the p-type layer overlaying the n-type substrate. The p-type layer includes a second thickness and a second width. The second thickness and the second width are associated with a light characteristic. The method additionally includes forming an n-type layer, the n-type layer overlaying the p-type layer. The n-type layer includes a third thickness and a third width. In addition, the method includes forming a pn junction between the p-type layer and the n-type layer. The pn junction includes a fourth width. The method also includes providing a control circuit. The control circuit is electrically coupled to the n-type substrate. | 03-24-2011 |
20110149085 | SYSTEM AND METHOD FOR CMOS IMAGE SENSING - A method is provided for determining a color using a CMOS image sensor. The CMOS image sensor includes an n-type substrate and a p-type epitaxy layer overlying the n-type substrate. The method includes applying a first voltage on the n-type substrate and obtaining a first output, which is associated with the first voltage. The method further includes applying a second voltage on the n-type substrate and obtaining a second output, which is associated with the second voltage. The method additionally includes applying a third voltage on the n-type substrate and obtaining a third output, which is associated with the third voltage. The method also includes providing a plurality of weighting factors and determining the color based on the plurality of weighting factors, the first output, the second output, and the third output. | 06-23-2011 |
20110187909 | METHOD AND SYSTEM FOR CMOS IMAGE SENSING DEVICE - Method and system for manufacturing CMOS image sensing device with reduced blooming. The method includes a step for providing a substrate material. The substrate material can be characterized by a first dimension and a second dimension. In addition, the method includes a step for defining an active region on the substrate material. The active region is characterized by a third dimension and a fourth dimension. The method further includes a step for defining a non-active region on the substrate material. The non-active region is different from the active region. The non-active region is characterized by a fifth dimension and a sixth dimension, the non-active region including a silicon material. The method includes a step for defining a depletion region within the active region. In addition, the method includes a step for forming an n-type region positioned above the depletion region. | 08-04-2011 |
20120181589 | CMOS IMAGE SENSOR WITH NON-CONTACT STRUCTURE - A complementary metal oxide semiconductor (CMOS) image sensor device includes a capacitive coupled photodiode that is formed within a region of a semiconductor substrate. The photodiode receives an incident light and generates a corresponding electric charge. The CMOS image sensor device includes a reset transistor coupled to the photodiode for reverse biasing the photodiode with a predetermined voltage. The CMOS image sensor device further includes a buffer circuit and a capacitor, which is interposed between the photodiode and the buffer circuit. The capacitor is configured to transfer the electric charge to the buffer circuit. The buffer circuit may include an emitter follower or a source follower transistor. | 07-19-2012 |
20120228761 | SEMICONDUCTOR DEVICE AND METHOD FOR MANUFACTURING THE SAME - A semiconductor device includes a first substrate and a second substrate being bonded to each other, a posterior interconnect layer interposed between the first and second substrates, a weld pad disposed in the posterior interconnect layer, and a first annular opening disposed in the first substrate. The device further includes a dielectric layer formed in the first opening, a via surrounded by the first annular opening, and an interconnect layer disposed in the via. The device also includes a conductive bump disposed on the interconnect layer and electrically connected to the weld pad through the interconnect layer. | 09-13-2012 |
20130165544 | ISOCYANATE-TERMINATED PREPOLYMER, THE METHOD FOR PREPARING THE SAME AND THE USE THEREOF - The present invention pertains to the field of polyurethane, especially relates to an isocyanate-terminated prepolymer, the method for preparing the same and the use thereof. The present invention adjusts the reaction components and the ratios thereof to obtain an isocyanate-terminated prepolymer suitable for preparing flexible polyurethane foam under a relative low mold temperature. The method for preparing flexible polyurethane foam by using the isocyanate-terminated prepolymer provided in this present invention can reduce the mold temperature, production time and energy consumption, as well as to obtain a polyurethane flexible foam processing good physical and mechanical properties. | 06-27-2013 |
20160040989 | BUBBLE LEVEL AND APPARATUS CONTAINING A BUBBLE LEVEL - An apparatus and method for measuring the horizontal position uses a gas bubble in a bubble level. The gas bubble is in a cylindrical sealed housing that is partially filled with liquid. At least two light-emitting devices are used to illuminate the gas bubble and an inner bottom surface of the bubble level. A corresponding number of receiving devices are used to receive the light that is either reflected by the inner bottom surface or is reflected and refracted by the gas bubble. The amount of light received is translated into an electrical signal and is sent to a processing unit to calculate the position of the gas bubble. The light-emitting devices and the receiving devices are disposed in an alternating manner at the periphery of the cylindrical sealed housing. | 02-11-2016 |
Patent application number | Description | Published |
20100261783 | CRUCIFEROUS 3H-1,2-DITHIOLE-3-THIONE (D3T) AND METHODS OF PROTECTING AGAINST CELL INJURY - Astrocytes possess important roles in maintaining normal brain function and providing trophic support to the neurons. They also suffer a range of toxic insults, being a chief target of prooxidants such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+), 6-hydroxydopamine (6-OHDA), 4-hydroxy-2-nonenal (HNE), and acrolein. Recently, we have observed that the cellular antioxidants and phase 2 enzymes can be upregulated by 3H-1,2-dithiole-3-thione (D3T), a nutraceutical found in cruciferous vegetables, against many prooxidants in human neuroblastoma cell lines (SH-SY5Y). However, the regulation of the above cellular factors by D3T in astrocytes and their role in ameliorating the neurotoxic effects of the above neurotoxins have not been investigated. In this study, we show that incubation of human primary astrocytes with micromolar concentrations (5-100 IM) of D3T for 24 h resulted in significant increases in the levels of reduced glutathione (GSH), glutathione reductase (GR), and the phase 2 enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). D3T treatment also caused time-dependent increases in mRNA expression of the gamma-glutamylcysteine ligase catalytic subunit (GCLC), GR, and of NQO1 in these cells. Pretreatment of astrocytes with D3T was found to afford remarkable protection against the neurocytotoxicity elicited by MPTP, MPP+, 6-OHDA, HNE and acrolein. Taken together, this study demonstrates for the first time that in human astrocytes, the cruciferous nutraceutical D3T potently induces the cellular GSH system and the phase 2 enzyme NQO1, which is accompanied by dramatically increased resistance of these cells to the damage induced by various neurotoxicants. The results of this study may have important implications for the development of novel neuroprotective strategies. | 10-14-2010 |
Patent application number | Description | Published |
20100233741 | IMMUNO-BASED RETARGETED ENDOPEPTIDASE ACTIVITY ASSAYS - The present specification discloses SNAP-25 immune response inducing compositions, methods of making α-SNAP-25 antibodies that selectively binds to an epitope comprising a SNAP-25 having a carboxyl-terminus at the P | 09-16-2010 |
20100233802 | CELLS USEFUL FOR IMMUNO-BASED BOTULINUM TOXIN SEROTYPE A ACTIVITY ASSAYS - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 09-16-2010 |
20120149103 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-14-2012 |
20120149104 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-14-2012 |
20120149105 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-14-2012 |
20120149106 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-14-2012 |
20120156769 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-21-2012 |
20120156774 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-21-2012 |
20120156775 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-21-2012 |
20120156776 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-21-2012 |
20120164728 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 06-28-2012 |
20120208271 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 08-16-2012 |
20120208272 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 08-16-2012 |
20120214229 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 08-23-2012 |
20120214231 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 08-23-2012 |
20130236963 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 09-12-2013 |
20130267010 | Immuno-Based Retargeted Endopeptidase Activity Assays - The present specification discloses a retargeted endopeptidase pharmaceutical wherein the activity has been determined by the methods disclosed. | 10-10-2013 |
20140093957 | Cells Useful for Immuno-Based Botulinum Toxin Serotype A Activity Assays - The present specification discloses clonal cell lines susceptible to BoNT/A intoxication, methods of producing such clonal cell lines, and methods of detecting Botulinum toxin serotype A activity using such clonal cell lines. | 04-03-2014 |
20150301050 | IMMUNO-BASED RETARGETED ENDOPEPTIDASE ACTIVITY ASSAYS - The present specification discloses a retargeted endopeptidase pharmaceutical wherein the activity has been determined by the methods disclosed. | 10-22-2015 |
Patent application number | Description | Published |
20100027400 | MOTION LIMITING COVER FOR DATA STORAGE DEVICE - Disclosed herein are embodiments of motion limiting cover features that improve coil/VCM coupled resonance. The features are flexible in that their position and configuration can be customized to specifically target a certain type of undesirable motion, such as undesirable twisting (i.e., torsion) and/or bending. | 02-04-2010 |
20100142095 | HEAD SUSPENSION ASSEMBLY INTERCONNECT FOR A DATA STORAGE DEVICE - Interconnections for attaching a suspension assembly to an arm of an actuator or positioning device are disclosed. In illustrated embodiments, the interconnection includes one or more weld connections formed along opposed side seams of overlapping portions of the arm and head suspension assembly. In illustrated embodiments, the weld connections are formed along side surfaces generally transverse to upper and lower surfaces of the arm. In another embodiment, a groove pattern is formed, for example via a laser etching process, in an overlapping portion of the head suspension assembly or arm and an epoxy is inlayed in the groove to connect the head suspension assembly and arm. Illustrated embodiments also include multiple connections including, for example, a swage connection and a weld or other connection. | 06-10-2010 |
20100195243 | Variable Spindle Speed Control for Data Storage Devices - In a particular embodiment, a system is disclosed that includes a solid-state data storage medium, a disc data storage medium, and a controller adapted to selectively adjust a spindle speed associated with the disc data storage medium and a buffer size associated with the solid-state data storage medium responsive to a trigger. | 08-05-2010 |
Patent application number | Description | Published |
20120205836 | MOLD AND METHOD FOR INTEGRALLY MANUFACTURING FUNCTIONAL CORED SLAB AND SOLID SLAB WITH POLYGONAL GRID HONEYCOMB STRUCTURE - A mold and a method for integrally manufacturing a functional cored slab and a solid slab with a polygonal grid honeycomb structure. The mold for manufacturing the cored slab comprises a female mold and multiple male molds which are provided in the female mold. The male molds include polygonal cylinders capable of melting, dissolving, or vaporizing. A clearance exists between at least one pair of adjacent polygonal cylinders. The mold for manufacturing the solid slab is provided with a male mold main-body of polygonal cylinders which share the same shape and amount as the polygonal grids. The male mold main-body, which is made of one of the functional materials including sound insulating materials, flame retardant materials, and thermal insulating materials, is located in the frame-like female mold having a bottom plate. Clearances are provided between the adjacent male mold bodies. A casting method is adopted when manufacturing the slabs. | 08-16-2012 |
20150311710 | A time based global optimization dispatching method - The invention discloses a global optimization and dispatching method based on time scales. The time scale based global optimization and dispatching method disclosed herein, relies on a target value system and a dispatch model. The global optimization and dispatching method depends on the results from a variety of subtopics. The methods provide adjustment and optimization in accordance with the time scales that are given in the sub goal of each sub topic: long-term, mid-long-term, short-term, ultra short term and real time optimization. Smart distribution grid can improve operational efficiency, integrated application of new elements in the distribution network of distribution energy network, micro grid, energy storage device and non-linear loads. This invention is fully adapted to the smart grid trends, with a good prospective. | 10-29-2015 |
Patent application number | Description | Published |
20140207057 | INFUSION PUMP AND METHOD TO ENHANCE LONG TERM MEDICATION DELIVERY ACCURACY - An infusion pump is provided for pumping fluid though an administration set at a constant flow rate. The pump includes a pumping mechanism for pumping fluid and operates at a pulse frequency, and a controller controls the pulse frequency. Additionally, the pump has one or more sensors configured for measuring at least one characteristic value relating to a status of the infusion pump. The controller is configured for causing the pumping mechanism to operate at a first pulse frequency, and the one or more sensors measure the characteristic value intermittently. When the measured characteristic value meets a threshold value, the controller causes the pumping mechanism to operate at a second pulse frequency different from the first pulse frequency. | 07-24-2014 |
20150023808 | INFUSION PUMP INCLUDING REVERSE LOADING PROTECTION - An infusion pump for transferring fluid through tubing of an administration set connected to the pump, where the pump includes a housing and a pumping mechanism mounted to the housing. The pumping mechanism includes a plurality of pumping fingers, a motor for sequentially, reciprocally moving the plurality of pumping fingers, and an occlusion sensor configured to detect reverse loading of the tubing to the pumping mechanism. In operation, the occlusion sensor causes at least one of a triggering of an alarm and prevention of the operation of the pumping mechanism when the sensor detects that the administration set tubing is reverse loaded to the pumping mechanism. | 01-22-2015 |
20150238690 | INFUSION PUMP AND METHOD TO ENHANCE LONG TERM MEDICATION DELIVERY ACCURACY - An infusion pump is provided for pumping fluid though an administration set at a constant flow rate. The pump includes a pumping mechanism for pumping fluid and operates at a pulse frequency, and a controller controls the pulse frequency. Additionally, the pump has one or more sensors configured for measuring at least one characteristic value relating to a status of the infusion pump. The controller is configured for causing the pumping mechanism to operate at a first pulse frequency, and the one or more sensors measure the characteristic value. When the measured characteristic value meets a threshold value, the controller causes the pumping mechanism to operate at a second pulse frequency different from the first pulse frequency. | 08-27-2015 |