Zhenquan
Zhenquan Jai, Blacksburg, VA US
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20100261783 | CRUCIFEROUS 3H-1,2-DITHIOLE-3-THIONE (D3T) AND METHODS OF PROTECTING AGAINST CELL INJURY - Astrocytes possess important roles in maintaining normal brain function and providing trophic support to the neurons. They also suffer a range of toxic insults, being a chief target of prooxidants such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+), 6-hydroxydopamine (6-OHDA), 4-hydroxy-2-nonenal (HNE), and acrolein. Recently, we have observed that the cellular antioxidants and phase 2 enzymes can be upregulated by 3H-1,2-dithiole-3-thione (D3T), a nutraceutical found in cruciferous vegetables, against many prooxidants in human neuroblastoma cell lines (SH-SY5Y). However, the regulation of the above cellular factors by D3T in astrocytes and their role in ameliorating the neurotoxic effects of the above neurotoxins have not been investigated. In this study, we show that incubation of human primary astrocytes with micromolar concentrations (5-100 IM) of D3T for 24 h resulted in significant increases in the levels of reduced glutathione (GSH), glutathione reductase (GR), and the phase 2 enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). D3T treatment also caused time-dependent increases in mRNA expression of the gamma-glutamylcysteine ligase catalytic subunit (GCLC), GR, and of NQO1 in these cells. Pretreatment of astrocytes with D3T was found to afford remarkable protection against the neurocytotoxicity elicited by MPTP, MPP+, 6-OHDA, HNE and acrolein. Taken together, this study demonstrates for the first time that in human astrocytes, the cruciferous nutraceutical D3T potently induces the cellular GSH system and the phase 2 enzyme NQO1, which is accompanied by dramatically increased resistance of these cells to the damage induced by various neurotoxicants. The results of this study may have important implications for the development of novel neuroprotective strategies. | 10-14-2010 |
Zhenquan Li, Dongying City CN
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20110178257 | NOVEL OIL DISPLACEMENT AGENT AND PROCESS FOR PREPARING THE SAME - The present invention relates to a new type of oil displacement agent and the process for preparing the same. The oil displacement agent is formed of a polyaclylamide-based polymer characterized by a partly crosslinked and partly branched structure, wherein said polyacrylamide-based polymer is obtained by aqueous copolymerization of acrylamide and N,N-dimethylaminoethyl methacrylate as a functional monomer, in the presence of a redox initiator system. | 07-21-2011 |
Zhenquan Shen, Guangdong CN
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20130338435 | METHOD FOR MANUFACTURING VISIBLE PUNCTURE OUTFIT FOR DISPOSABLE LAPAROSCOPE AND PUNCTURE OUTFIT USING THE METHOD - This invention discloses a method for manufacturing a disposable endoscopic puncture outfit for laparoscopy operations. The manufacturing method comprises the following steps: 1) preparing a camera shooting module; 2) preparing a puncture needle; 3) preparing a positioning puncture casing pipe; 4) mounting the camera shooting module on the puncture needle; 5) inserting the puncture needle in the positioning puncture casing pipe, and making a transparent cover slightly extend out of the positioning puncture casing pipe. This invention also discloses a puncture outfit made with a method for manufacturing a disposable endoscopic puncture outfit for laparoscopy operations. The manufacturing method provided by this invention has a simple process, is easy to implement, and has high production efficiency. The puncture outfit provided by this invention has a reasonable structure, can be used for visible surgical procedures through the camera shooting module, and can effectively improve the safety of the puncture surgery and reduce the medical negligence. Moreover, the operation becomes simple in a visible state, relies less on the skill of a surgeon, and the accuracy and success rate of the surgery can be increased. | 12-19-2013 |
Zhenquan Wang, Tieling City CN
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20120004065 | ELECTRIC GENERATOR UNIT - An electric generator unit comprises a front flywheel, a back flywheel, a gear accelerating assembly, a planetary decelerating assembly, a middle shaft and a tail shaft. The electric generator unit forms the effect of energy increasing by degrees based on the nonlinear coupling theory and the assembly of mass, acceleration and lever. When a small driving force is continuously given from the outside, the electric generator unit can achieve energy increasing by degrees. | 01-05-2012 |