Megan M.
Megan M. Barber, Parrish, FL US
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20160116482 | Target Binding Molecules Identified by Kinetic Target-Guided Synthesis - Methods of identifying target binding molecules by target guided synthesis are provided. The methods include providing two or more fragments capable of reacting to form the target binding molecule and mixing the fragments with the target. The methods can be used to identify target binding molecules that bind targets such as proteins or nucleic acids, including those that bind shallow binding pockets on the surface of such targets. The methods are applied to the Bcl-XL and Mcl-1 proteins from the Bcl-2 family of proteins. Using thio acid and sulfonyl azide fragments capable of reacting through sulfo-click chemistry, new acyl sulfonamides are identified that bind one or both of the Bcl-XL and Mcl-1 proteins. Pharmaceutical formulations of these target binding molecules are also provided. | 04-28-2016 |
Megan M. Crask, Livermore, CA US
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20150232955 | Method for Measuring Cell-Free Virus Particles From Dried Blood Spots - Methods for the measuring cell-free nucleic acids and/or virus particles from dried blood spots are described. The methods can include the steps of rehydrating a dried blood sample, optionally fixing cells present in the rehydrated dried blood sample, eluting cell-free virus particles from the rehydrated dried blood sample, separating the cell-free viruses from any cell debris that may be present in the rehydrated dried blood sample by way of a filter, and measuring cell-free virus particles by a viral particle quantification technique. | 08-20-2015 |
Megan M. Illick, Gaithersburg, MD US
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20100261640 | SOLUBLE AND MEMBRANE ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS - The invention discloses compositions comprising soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins. This invention further relates to diagnostic and preventative methods using these compositions. Preventative methods include preparation of vaccines, as well as factors (e.g. small molecules) that inhibit LASV infectivity. Further, the invention relates to diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses. | 10-14-2010 |
20140377740 | SOLUBLE AND MEMBRANE-ANCHORED FORMS OF LASSA VIRUS SUBUNIT PROTEINS - Soluble and membrane-anchored forms of Lassa virus (LASV) glycoprotein 1 (GP1), glycoprotein 2 (GP2), the glycoprotein precursor (GPC), the nucleocapsid protein (NP), and the nucleic acids encoding these proteins are disclosed, as well as diagnostic and preventative methods using these compositions. Also disclosed are methods including preparation of vaccines, factors (e.g. small molecules) that inhibit LASV infectivity, and diagnostic and therapeutic antibodies including neutralizing antibodies for the prevention and treatment of infection by LASV and other arenaviruses. | 12-25-2014 |
Megan M. Isaak, Plainsboro, NJ US
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20130325337 | LOGO-ENABLED INTERACTIVE MAP INTEGRATING SOCIAL NETWORKING APPLICATIONS - A logo-enabled interactive map integrating social networking applications is provided. The interactive map may be configured to help end users discover and share information (e.g., events, deals, news occurrences, etc.) associated with a plurality of venues. | 12-05-2013 |
20130325818 | LOGO-ENABLED INTERACTIVE MAP INTEGRATING SOCIAL NETWORKING APPLICATIONS - A logo-enabled interactive map integrating social networking applications is provided. The interactive map may be configured to help end users discover and share information (e.g., events, deals, news occurrences, etc.) associated with a plurality of venues. | 12-05-2013 |
20130325894 | LOGO-ENABLED INTERACTIVE MAP INTEGRATING SOCIAL NETWORKING APPLICATIONS - A logo-enabled interactive map integrating social networking applications is provided. The interactive map may be configured to help end users discover and share information (e.g., events, deals, news occurrences, etc.) associated with a plurality of venues. | 12-05-2013 |
20130326365 | LOGO-ENABLED INTERACTIVE MAP INTEGRATING SOCIAL NETWORKING APPLICATIONS - A logo-enabled interactive map integrating social networking applications is provided. The interactive map may be configured to help end users discover and share information (e.g., events, deals, news occurrences, etc.) associated with a plurality of venues. | 12-05-2013 |
20160042486 | LOGO-ENABLED INTERACTIVE MAP INTEGRATING SOCIAL NETWORKING APPLICATIONS - A logo-enabled interactive map integrating social networking applications is provided. The interactive map may be configured to help end users discover and share information (e.g., events, deals, news occurrences, etc.) associated with a plurality of venues. | 02-11-2016 |
Megan M. Lantry, Redmond, WA US
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20130095102 | DIMERIC FUSION PROTEINS AND RELATED COMPOSITIONS AND METHODS - Compositions and methods relating to soluble dimeric proteins are disclosed. The dimeric proteins comprise first and second polypeptide fusions linked via a dimerizing domain, each polypeptide fusion comprising first and second monomer domains corresponding to a cytokine or an extracellular domain of a cell-surface receptor. The monomer domains may be positioned amino terminal and carboxyl terminal to the dimerizing domain. Alternatively, the monomer domains may be positioned in tandem, either carboxyl terminal or amino terminal to the dimerizing domain. The dimeric proteins are useful in methods for therapy, diagnosis, and research. | 04-18-2013 |
Megan M. Mekarski, East Amherst, NY US
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20120277614 | High-Frequency Oscillatory Ventilation Monitoring Method and System - A method of monitoring high frequency oscillatory ventilation (HFOV) wherein the oscillatory movement of the chest wall of an individual is measured. An average amplitude is determined and compared to a pre-determined baseline amplitude, which is established by using the average amplitude at a particular instant of time. If the variance between the average amplitude and the baseline meets and/or exceeds a pre-determined threshold above or below the baseline value, an operator is alerted. | 11-01-2012 |
Megan M. Suhoski, Nuangola, PA US
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20110262467 | Novel Artificial Antigen Presenting Cells and Uses Therefor - The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit. | 10-27-2011 |
20140212446 | Novel Artificial Antigen Presenting Cells and Uses Thereof - The invention relates to novel artificial antigen presenting cells (aAPCs). The aAPC comprises at least one stimulatory ligand and at least one co-stimulatory ligand where the ligands each specifically bind with a cognate molecule on a T cell of interest, thereby mediating expansion of the T cell. The aAPC of the invention can further comprise additional molecules useful for expanding a T cell of interest. The aAPC of the invention can be used as an “off the shelf” APC that can be readily designed to expand a T cell of interest. Also, the aAPC of the invention can be used identify the stimulatory, co-stimulatory, and any other factors that mediate growth and expansion of a T cell of interest. Thus, the present invention provides powerful tools for development of novel therapeutics where activation and expansion of a T cell can provide a benefit. | 07-31-2014 |