Patent application number | Description | Published |
20100033788 | MICROMIRROR AND FABRICATION METHOD FOR PRODUCING MICROMIRROR - A high-fill-factor and large-aperture tip-tilt micromirror array is disclosed. Electrothermal actuation can be used to obtain a large scan range, and the actuation engine can be hidden underneath the mirror plate for high fill factor. In one embodiment, inverted-series-connected (ISC) bimorph actuators can be used to achieve tilt and piston scanning. Embodiments can be used to implement optical phased array technology for steering active and passive electro-optical systems based on MEMS mirrors. | 02-11-2010 |
20100307150 | ELECTROTHERMAL MICROACTUATOR FOR LARGE VERTICAL DISPLACEMENT WITHOUT TILT OR LATERAL SHIFT - A microactuator for displacing a platform vertically with respect to a substrate includes a first rigid frame, a first flexible bimorph beam connecting the first frame to the substrate, a second rigid frame, a second flexible bimorph beam connecting the second frame to the first frame, and a third flexible bimorph beam connecting a platform to the second frame. Activation of the first, second, and third flexible bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A microactuator assembly includes a substrate, a plurality of first rigid frames, a plurality of first flexible bimorph beams, a plurality of second rigid frames, a plurality of second flexible bimorph beams, a platform, and a plurality of third flexible bimorph beams. Activation of the first, second, and third bimorph beams allows vertical displacement of the platform with respect to the substrate, with negligible lateral shift. A further embodiment with four identical such microactuators oriented at four sides of the platform, can achieve 1D or 2D angular scanning of the mirror plate by the activation of 1 or 2 adjacent microactuators. | 12-09-2010 |
20110139990 | MEMS-BASED FTIR SPECTROMETER - A MEMS-based Fourier Transform (FT) spectrometer is provided. According to an embodiment, the MEMS-based FT spectrometer is an FT infrared (FTIR) spectrometer. The FT spectrometer can include a beam splitter positioned to receive an incoming beam from a light source and split the incoming beam into a first sub-beam and a second sub-beam, a fixed mirror positioned to receive the first sub-beam from the beam splitter, a scanning MEMS mirror positioned to receive the second sub-beam from the beam splitter, and a photodetector, wherein a reflected first sub-beam from the fixed mirror and a reflected second sub-beam from the scanning MEMS mirror recombine at the beam splitter and become directed to the photodetector. According to one embodiment, the photodetector is a MEMS-based IR detector. In addition, the MEMS-based IR detector can be an un-cooled IR detector having a capacitive sensing structure. | 06-16-2011 |
Patent application number | Description | Published |
20080200349 | MICRODEVICES HAVING A PREFERENTIAL AXIS OF MAGNETIZATION AND USES THEREOF - This invention relates generally to the field of moiety or molecule isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 08-21-2008 |
20080206757 | METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE - The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention includes a debulking step that uses a microfabricated filters for filtering fluid samples and the enriched rare cells can be used in a downstream process such as identifies, characterizes or even grown in culture or used in other ways. The invention also include a method of determining the aggressiveness of the tumor or of the number or proportion of cancer cells in the enriched sample by detecting the presence or amount of telomerase activity or telomerase nucleic acid or telomerase expression after enrichment of rare cells. This invention further provides an efficient and rapid method to specifically remove red blood cells as well as white blood cells from a biological sample containing at least one of each of red blood cells and white blood cells, resulting in the enrichment of rare target cells including circulating tumor cells (CTC), stromal cells, mesenchymal cells, endothelial cells, fetal cells, stem cells, non-hematopoietic cells etc from a blood sample. The method is based upon combination of immuno-microparticles (antibody coated microparticles) and density-based separation. The final enriched target cells can be subjected to a variety of analysis and manipulations, such as flowcytometry, PCR, immunofluorescence, immunocytochemistry, image analysis, enzymatic assays, gene expression profiling analysis, efficacy tests of therapeutics, culturing of enriched rare cells, and therapeutic use of enriched rare cells. In addition, depleted plasma protein and white blood cells can be optionally recovered, and subjected to other analysis such as inflammation studies, gene expression profiling, etc. | 08-28-2008 |
20080286750 | APPARATUS INCLUDING ION TRANSPORT DETECTING STRUCTURES AND METHODS OF USE - The present invention recognizes that the determination of ion transport function or properties using direct detection methods, such as whole cell recording or single channel recording, are preferable to methods that utilize indirect detection methods, such as FRET based detection system. The present invention provides biochips and other fluidic components and methods of use that allow for the direct analysis of ion transport function or properties using microfabricated structures that can allow for automated detection of ion transport function or properties. These biochips and fluidic components and methods of use thereof are particularly appropriate for automating the detection of ion transport function or properties, particularly for screening purposes. | 11-20-2008 |
20090209029 | HIGH-DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS - The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips. | 08-20-2009 |
20100260984 | MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME - This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 10-14-2010 |
20120228386 | MICRODEVICES CONTAINING PHOTORECOGNIZABLE CODING PATTERNS AND METHODS OF USING AND PRODUCING THE SAME - This invention relates generally to the field of moiety or molecule analysis, isolation, detection and manipulation and library synthesis. In particular, the invention provides a microdevice, which microdevice comprises: a) a substrate; and b) a photorecognizable coding pattern on said substrate. Preferably, the microdevice does not comprise an anodized metal surface layer. Methods and kits for isolating, detecting and manipulating moieties, and synthesizing libraries using the microdevices are also provided. The invention further provides two-dimensional optical encoders and uses thereof. In certain embodiments, the invention provides a microdevice, which microdevice comprises: a) a magnetizable substance; and b) a photorecognizable coding pattern, wherein said microdevice has a preferential axis of magnetization. Systems and methods for isolating, detecting and manipulating moieties and synthesizing libraries using the microdevices are also provided. | 09-13-2012 |
20130266490 | HIGH-DENSITY ION TRANSPORT MEASUREMENT BIOCHIP DEVICES AND METHODS - The present invention includes biochips for the measurement of cellular ion channels and methods of use and manufacture. The biochips of the present invention have enhanced sealing capabilities provided in part by chemically modifying the surface of the biochip surface or substrate or by exposure to an ionized gas. The present invention also includes novel cartridges for biochips. | 10-10-2013 |
20140073536 | METHODS AND COMPOSITIONS FOR DETECTING NON-HEMATOPOIETIC CELLS FROM A BLOOD SAMPLE - The present invention recognizes that diagnosis and prognosis of many conditions can depend on the enrichment of rare cells, especially tumor cells, from a complex fluid sample such as a blood sample. In particular, the present invention is directed to methods and compositions for detecting a non-hematopoietic cell, e.g., a non-hematopoietic tumor cell, in a blood sample via, inter alia, removing red blood cells (RBCs) from a blood sample using a non-centrifugation procedure, removing white blood cells (WBCs) from said blood sample to enrich a non-hematopoietic cell, if any, from said blood sample; and assessing the presence, absence and/or amount of said enriched non-hematopoietic cell. | 03-13-2014 |
20140087358 | METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE - The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention includes a debulking step that uses a microfabricated filters for filtering fluid samples and the enriched rare cells can be used in a downstream process such as identifies, characterizes or even grown in culture or used in other ways. The invention also include a method of determining the aggressiveness of the tumor or of the number or proportion of cancer cells in the enriched sample by detecting the presence or amount of telomerase activity or telomerase nucleic acid or telomerase expression after enrichment of rare cells. This invention further provides an efficient and rapid method to specifically remove red blood cells as well as white blood cells from a biological sample. | 03-27-2014 |
20150079677 | METHODS AND COMPOSITIONS FOR SEPARATING RARE CELLS FROM FLUID SAMPLES - The present invention includes methods of enriching rare cells, such as cancer cells, from biological samples, such as blood samples. The methods include performing at least one debulking step on a blood sample and selectively removing at least one type undesirable component from the blood sample to obtain a blood sample that is enriched in a rare cell of interest. In some embodiments magnetic beads coupled to specific binding members are used to selectively removed components. | 03-19-2015 |
20150185184 | METHODS AND COMPOSITIONS FOR SEPARATING OR ENRICHING BLOOD CELLS - The present invention provides a filtration chamber comprising a microfabricated filter enclosed in a housing, wherein the surface of said filter and/or the inner surface of said housing are modified by vapor deposition, sublimation, vapor-phase surface reaction, or particle sputtering to produce a uniform coating; and a method for separating cells of a fluid sample, comprising: a) dispensing a fluid sample into the filtration chamber disclosed herein; and b) providing fluid flow of the fluid sample through the filtration chamber, wherein components of the fluid sample flow through or are retained by the filter based on the size, shape, or deformability of the components. | 07-02-2015 |
Patent application number | Description | Published |
20090070248 | METHOD, SYSTEM AND SERVER FOR CHARGING A PREPAID ACCOUNT - The present invention relates to prepaid services in the communication field. A method for charging a prepaid account includes: delivering the available traffic to the NAS based on the available balance of an account shared by the user and other users in response to a successful authentication of a user's access request; and delivering the available traffic to the NAS based on the available balance of the account shared by the user and other users in response to a receipt of an Accounting-Request-Interim message from the NAS. The solution provided by the invention may deliver the available traffic to a user every accounting period so that an account can be used by multiple users concurrently, whereas overdraft does not occur. The present invention also provides a system and an AAA server for charging a prepaid account. | 03-12-2009 |
20140098345 | OPHTHALMIC OPTICAL COHERENCE TOMOGRAPHY SYSTEM AND METHOD FOR QUICK SWITCHING TO REALIZE ANTERIOR AND POSTERIOR EYE SEGMENTS IMAGING - It is provided an ophthalmic optical coherence tomography system in the invention, the system comprising: an OCT interferometer primary module and a sample arm module, wherein the OCT interferometer primary module comprises an OCT light source, a fiber coupler, a reference arm, a detection module, an X-direction scanning unit, and a Y-direction scanning unit; the sample arm module comprises an anterior eye segment imaging module and a posterior eye segment imaging module; the Y-direction scanning unit is rotatable; when the Y-direction scanning unit is at a first rotation angle, the Y-direction scanning unit reflects the light received by the X-direction scanning unit into the anterior eye segment imaging module; and when the Y-direction scanning unit is at a second rotation angle, the Y-direction scanning unit reflects the light received by the X-direction scanning unit into the posterior eye segment imaging module. It is further provided a method for quick switching to realize anterior and posterior eye segments imaging in the invention, in which imaging at one time and quick switching for locations at different depths can be realized, and on this basis, the eye axial length can be measured accurately. | 04-10-2014 |
20140123079 | DRAWING CONTROL METHOD, APPARATUS, AND MOBILE TERMINAL - In a drawing control method and a terminal provided in the embodiments, a gesture track input by a user is detected, then first attribute information about the gesture track is acquired, and then the gesture track is recognized according to a preset rule and the first attribute information about the gesture track, so as to acquire second attribute information about the gesture track, and finally the gesture track is presented according to the second attribute information about the gesture track; in this manner, part of feature information required for presenting the track is carried in the first attribute information about the gesture track, and therefore, it is avoided that the user frequently manually switches all kinds of options to implement the input of the gesture track, thereby solving a problem of the complexity in drawing operations. | 05-01-2014 |
20150213108 | MULTIDIMENSIONAL DATA PROCESS METHOD AND DEVICE THEREOF - A multidimensional data process method and device thereof are disclosed in the present embodiments. The method comprises: obtaining attribute information in dimension information and hierarchical relationship information of respective attributes in a data service, and generating a recursive topology; and the recursive topology comprises an attribute composition set and recursive paths of respective attribute compositions in the attribute composition set; confirming attribute compositions for querying in the attribute composition set; confirming attribute compositions for fixing in the attribute composition set according to the attribute compositions for querying; fixing the attribute compositions for fixing to form fixed attribute compositions and obtaining index data in accordance with the fixed attribute compositions; recursing index data in accordance with the attribute compositions for querying. The present invention is applied to the multidimensional data analysis. | 07-30-2015 |
20150245764 | SUBJECTIVE EYE REFRACTOMETER AND REFRACTOMETRY METHOD - A subjective eye refractometer includes an imaging lens and a target, the front surface of the cornea of a testee is located at a focal point of the imaging lens, the target and an eye of the testee are respectively located on two sides of the imaging lens along an optical axis of the imaging lens, and the target can move forward and backward along the optical axis by means of setting, and the subjective eye refractometer is marked with a value D | 09-03-2015 |
20150365545 | Picture Outputting Method and Apparatus - A picture outputting method and apparatus are provided, where the method may include collecting photographing data by using a camera, parsing the collected photographing data to obtain a first attribute parameter, where the first attribute parameter includes the number of faces and a location of a face on a screen, matching the parsed-out first attribute parameter to a second attribute parameter of one or more pre-stored photographic pose recommendation pictures, and when a photographic pose recommendation picture is found, outputting the photographic pose recommendation picture, so that a user adjusts a photographic pose according to the photographic pose recommendation picture, where a second attribute parameter of the photographic pose recommendation picture and the first attribute parameter meet a preset matching result. Therefore, a superb photographic pose recommendation picture is output for a user. | 12-17-2015 |