Wiesmann, CH
Bruno Wiesmann, Inkwil CH
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20080249532 | Securing device to secure fixation devices to bone portions - The present invention discloses a securing device that is used to secure a fixation device to two bone portions to promote healing between the two bone portions. The bone portions commonly include a skull bone portion and a skull bone flap or implant, and the fixation device is commonly a cranial clamp. The securing device provides for securing the fixation device in a uniform, single movement as opposed to currently available products. The securing device has two handles pivotably connected, and a gripping means moveably associated with one handle. As the handles are activated, the gripping means travels proximally along the one handle and grips an elongated section of the fixation device and exerts a tensioning force along the shaft of the elongated section prior to the cutting means cutting the elongated shaft to secure the fixation device in place. | 10-09-2008 |
Bruno Wiesmann, Oberdorf CH
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20130310885 | Securing Device To Secure Fixation Devices To Bone Portions - The present invention discloses a securing device that is used to secure a fixation device to two bone portions to promote healing between the two bone portions. The bone portions commonly include a skull bone portion and a skull bone flap or implant, and the fixation device is commonly a cranial clamp. The securing device provides for securing the fixation device in a uniform, single movement as opposed to currently available products. The securing device has two handles pivotably connected, and a gripping means moveably associated with one handle. As the handles are activated, the gripping means travels proximally along the one handle and grips an elongated section of the fixation device and exerts a tensioning force along the shaft of the elongated section prior to the cutting means cutting the elongated shaft to secure the fixation device in place. | 11-21-2013 |
Christian Wiesmann, Bottmingen CH
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20100150919 | CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES - The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications. | 06-17-2010 |
20100210826 | HGF BETA CHAIN VARIANTS - The invention provides HGF/Met modulators comprising HGF having mutations in regions that affect HGF function, and antagonists that target said regions. The invention further provides methods of identifying, making and using these modulators. | 08-19-2010 |
20110165648 | Co-crystal structure of factor D and anti-factor D antibody - The present invention is directed towards the co-crystal structure of Factor D and an anti-Factor D antibody or an antigen binding fragment thereof. | 07-07-2011 |
20120321606 | CRYSTAL STRUCTURES AND METHODS USING SAME - The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of FGFR3 function, and the identification and uses of said modulators. | 12-20-2012 |
20120322989 | CRYSTAL STRUCTURES OF NEUROPILIN FRAGMENTS AND NEUROPILIN-ANTIBODY COMPLEXES - The invention provides crystal structures of neuropilin 1 (Nrp1) and neuropilin 2 (Nrp2) fragments alone and in complex with anti-neuropilin antibodies, and method for their use. The invention further provides anti-Nrp antibodies and methods for their therapeutic applications. | 12-20-2012 |
20130046078 | ANTI-FGFR3 ANTIBODIES AND METHODS USING SAME - The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies. | 02-21-2013 |
20130287776 | ANTI-FGFR3 ANTIBODIES AND METHODS USING SAME - The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies. | 10-31-2013 |
20140187754 | ANTI-FGFR3 ANTIBODIES AND METHODS USING SAME - The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies. | 07-03-2014 |
Christian Wiesmann, Bottmingen Schweiz CH
Patent application number | Description | Published |
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20100247531 | ANTI-FGFR3 ANTIBODIES AND METHODS USING SAME - The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies. | 09-30-2010 |
20100291114 | Crystal structures and methods using same - The present invention relates generally to the fields of molecular biology and growth factor regulation. More specifically, the invention concerns modulators of FGFR3 function, and the identification and uses of said modulators. | 11-18-2010 |
Dorothea Wiesmann, Oberrieden CH
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20150178637 | SYSTEM RECOMMENDATIONS BASED ON INCIDENT ANALYSIS - In one embodiment, a computer-implemented method includes obtaining incident data related to a plurality of servers, including a first server. Configuration data is obtained for each of the plurality of servers. The configuration data includes information about a set of one or more configuration items of the first server. A predictive modeler is trained to predict incident characteristics, based at least in part on the incident data and the configuration data. A modification is selected to the set of configuration items of the first server. Predicted incident characteristics of the first server are simulated, by a computer processor, based on the selected modifications. It is recommended that the selected modifications be made to the first server if predetermined criteria are met by the simulation. | 06-25-2015 |
Dorothea W. Wiesmann, Adliswil CH
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20080230696 | SURFACE TREATMENT AND SURFACE SCANNING - Provides surface treatment devices, surface scanning devices, methods of operating a surface treatment device and methods of operating a surface scanning device. An area within a medium comprises at least one sharpening location for sharpening a tip of a probe mechanically. The tip is conically shaped with a radius of an apex smaller than 100 nm. In the case of the surface treatment device the probe is designed for altering the surface of the medium. In the case of the surface scanning device the probe is designed for scanning the medium. The sharpening location is suited for sharpening the tip mechanically. For that purpose the probe and the medium are being moved relative to each other such that the tip is located in the sharpening location. Then the probe and/or the medium are moved relative to each other such, that the tip is mechanically sharpened. | 09-25-2008 |
20100265812 | Data storage device and method for operating a data storage system - A data storage device comprises a storage medium, at least one probe designed for creating indentation marks in the storage medium, a control unit designed for creating a control parameter (CTRL) acting on the probe resulting in the creation of one indentation mark. The control unit is further designed for modifying the control parameter (CTRL), if at least a given number of consecutive indentation marks with a given minimum distance between each other should be created. According to the method the control parameter (CTRL) is modified if at least a given number of consecutive marks with a given minimum distance between each other should be created. | 10-21-2010 |
Marion Wiesmann, Bottmingen CH
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20100130490 | CSF-1R INHIBITORS,COMPOSITIONS, AND METHODS OF USE - Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R. | 05-27-2010 |
20120225859 | PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS - Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases. | 09-06-2012 |