Smith, San Diego
Allen Smith, San Diego, CA US
Allen W. Smith, San Diego, CA US
Patent application number | Description | Published |
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20100251283 | SYSTEM AND MEHOD FOR PROVIDING INTERACTIVE CONTENT - A system and method for providing interactive content are disclosed. In one embodiment, the method comprises receiving, in a vehicle via a wireless broadcast, audiovisual content and user-requestable content, rendering the audiovisual content, receiving user input indicative of request for the user-requestable content, and rendering, in response to receiving the user input, the user-requestable content. The user-requestable content can include, but is not limited to, additional audiovisual content, climate control data, and navigation data. | 09-30-2010 |
20100262336 | SYSTEM AND METHOD FOR GENERATING AND RENDERING MULTIMEDIA DATA INCLUDING ENVIRONMENTAL METADATA - A system and method for generating and rendering multimedia data including environmental data is disclosed. In one embodiment, a system for rendering content in a vehicle is disclosed, the system comprising a receiver configure to receive, via a wireless broadcast, audiovisual content and an environmental event associated with a subset of the audiovisual content and a vehicular electronic system configured to render the audiovisual content and alter an environmental parameter in accordance with the environmental event when the associated subset of the audiovisual content is rendered. | 10-14-2010 |
20110154390 | DYNAMIC LIVE CONTENT PROMOTER FOR DIGITAL BROADCAST TV - Methods and devices for alerting users to live programming on digital television broadcast receiver devices provide an on-screen object revealing a content item broadcast in an overhead flow portion of a broadcast signal. Information regarding programs available on other channels or content flows may be presented in a portion of the display screen. A variety of user touch gestures may be recognized on a touchscreen-equipped digital television receiver to enable users to respond to promotion messages. Users may use touch gestures to request a next promotion message, request further details regarding a promotion, discontinue promotion displays, and select a promoted program. Digital broadcast television systems may be configured to transmit promotion messages within the overhead flow in response to developments in broadcast content, special messages received from content providers, and the programs currently being broadcast. | 06-23-2011 |
20110166932 | SYSTEM AND METHOD OF PROVIDING CONTENT BASED ON USER INTERACTION - Methods and systems provide for displaying advertisement items on mobile devices in response to user selections. Advertisement items may be transmitted to mobile devices ahead of an insertion point and stored in memory. While displaying a content item, mobile devices may display a list of alternatives related advertisement content and prompt the user to select one. Mobile devices may determine an advertisement content item to display at the insertion point based on a received user input or lack of an input. In a further embodiment, mobile devices report displayed advertisement items to a service, such as the distributor, content provider, or a third party. In a further embodiment, the selection of alternative advertisement items to present to the user is made based upon weighting values associated with each advertisement item. Such weighting values may be adjusted when advertisement items are displayed or listed in a user interface display. | 07-07-2011 |
Andrew R. Smith, San Diego, CA US
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20140162003 | PYROPHORIC SHEET - A pyrophoric sheet that comprises oxidizable iron, non-combustible fibers, stiction-reducing coating where the sheet has a water content<2%. | 06-12-2014 |
Andrew Tombras Smith, San Diego, CA US
Patent application number | Description | Published |
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20130073114 | DRIVER IDENTIFICATION BASED ON FACE DATA - A system for identifying a driver comprises an image capturing device, a processor, and a memory. The image is captured during vehicle operation and of an expected driver location. The processor is configured to detect a face of a driver in the image, determine a set of face data from the image, and identify the driver based at least in part on the set of face data. The memory is coupled to the processor and configured to provide the processor with instructions. | 03-21-2013 |
20140324281 | DRIVER IDENTIFICATION BASED ON FACE DATA - A system for identifying a driver comprises an image capturing device, a processor, and a memory. The image is captured during vehicle operation and of an expected driver location. The processor is configured to detect a face of a driver in the image, determine a set of face data from the image, and identify the driver based at least in part on the set of face data. The memory is coupled to the processor and configured to provide the processor with instructions. | 10-30-2014 |
Brian M. Smith, San Diego, CA US
Patent application number | Description | Published |
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20080255137 | N-Biaryl and N-Arylheteroaryl 2-Substituted Piperazine Derivatives as Modulators of the 5ht2c Receptor Useful for the Treatment of Disorders Related Thereto - The present invention relates to certain N-biaryl and N-arylheteroaryl 2-substituted piperazine derivatives of Formula (Ia) that are modulators of the 5HT2C receptor. Accordingly, compounds of the present invention are useful for the treatment of 5HT2C receptor associated diseases or disorders, such as, obesity, Alzheimer Disease, erectile dysfunction and related disorders. | 10-16-2008 |
20090197868 | 5ht2c receptor modulator compositions and methods of use - The present invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist. In addition, the invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist having Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof. These compositions are useful in pharmaceutical compositions whose use includes the treatment of obesity. | 08-06-2009 |
20100004264 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT | 01-07-2010 |
20100240653 | BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - The present invention relates to certain biphenyl sulfonamide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3-receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like. | 09-23-2010 |
20100331312 | MODULATORS OF THE HISTAMINE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Amide derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the histamine H3 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of histamine H3-associated disorders, such as cognitive disorders, epilepsy, brain trauma, depression, obesity, disorders of sleep and wakefulness such as excessive daytime sleepiness, narcolepsy, shift-work sleep disorder, drowsiness as a side effect from a medication, maintenance of vigilance to aid in the completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease, pain and the like. | 12-30-2010 |
20110319451 | 5-Ht6 Receptor and Modulators Thereof for the Treatment of Insulin-Related Disorders - The present invention relates to a method for identifying a glycemic stabilizing compound, by: a) contacting a candidate compound with a 5-HT | 12-29-2011 |
20130217677 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS AND METHODS OF USE - The present invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist. In addition, the invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist having Formula (I): or a pharmaceutically acceptable salt, solvate or hydrate thereof. These compositions are useful in pharmaceutical compositions whose use includes the treatment of obesity. | 08-22-2013 |
20130217700 | PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO - Pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the serotonin 5HT | 08-22-2013 |
20150087634 | 5HT2C RECEPTOR MODULATOR COMPOSITIONS - The present invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist. In addition, the invention relates to a composition comprising phentermine and a selective 5HT-2C receptor agonist having Formula (I): | 03-26-2015 |
Brian S. Smith, San Diego, CA US
Patent application number | Description | Published |
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20140061076 | GOLF BAG WITH STRAP-RECEIVING CHANNEL - A golf bag having an internal strap channel is disclosed herein. The strap channel is affixed to a top collar, is located proximate a rear portion of the golf bag body, and extends from one side to the other side of the bag body. In some embodiments, the strap channel includes a center portion and two openings, which may further include rims made of rubber or another lightweight polymeric material. | 03-06-2014 |
Christine Smith, San Diego, CA US
Patent application number | Description | Published |
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20090247463 | POLYMER-BASED SUSTAINED RELEASE DEVICE - This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. | 10-01-2009 |
20100191182 | Mixing Tool - The present invention provides devices and methods for mixing a formulation containing two or more constituents, such as a drug product and a diluent. The devices have a chamber for securing a container of the drug product. Various embodiments are presented. In one embodiment the device has two or more sides connected by a hinge, the two or more sides defining the chamber between them, and a handle for grasping and manipulating the device. In another embodiment the device has a housing with two or more side bars defining the chamber, the container being visible from outside the housing between the side bars and having a stopping element at the distal end, and a handle having two arms for grasping. | 07-29-2010 |
20120296309 | MIXING TOOL - The present invention provides devices and methods for mixing a formulation containing two or more constituents, such as a drug product and a diluent. The devices have a chamber for securing a container of the drug product. Various embodiments are presented. In one embodiment the device has two or more sides connected by a hinge, the two or more sides defining the chamber between them, and a handle for grasping and manipulating the device. In another embodiment the device has a housing with two or more side bars defining the chamber, the container being visible from outside the housing between the side bars and having a stopping element at the distal end, and a handle having two arms for grasping. | 11-22-2012 |
20130130977 | POLYMER-BASED SUSTAINED RELEASE DEVICE - This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. | 05-23-2013 |
Christine M. Smith, San Diego, CA US
Patent application number | Description | Published |
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20090035253 | Poly(lactide-Co-glycolide) based sustained release microcapsules comprising a polypeptide and a sugar - This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar. | 02-05-2009 |
Christophen Ronald Smith, San Diego, CA US
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20080214622 | Substituted Triazole Derivatives As Oxytocin Antagonists - The present invention relates to a class of substituted triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.). | 09-04-2008 |
Christopher Ronald Smith, San Diego, CA US
Patent application number | Description | Published |
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20090156594 | HETEROCYCLIC KINASE MODULATORS - The present disclosure provides heterocyclic protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity. | 06-18-2009 |
20090258855 | BICYCLIC TRIAZOLES AS PROTEIN KINASE MODULATORS - The present disclosure provides bicyclic triazole protein kinase modulators and methods of using these compounds to treat diseases mediated by kinase activity. | 10-15-2009 |
20100063064 | Substituted Triazole Derivatives As Oxytocin Antagonists - The present invention relates to a class of substituted 1,2,4-triazoles of formula (I) with activity as oxytocin antagonists, uses thereof, processes for the preparation thereof and compositions containing said inhibitors. These inhibitors have utility in a variety of therapeutic areas including sexual dysfunction, particularly premature ejaculation (P.E.). | 03-11-2010 |
20100120739 | TRIAZOLOPYRIDAZINE PROTEIN KINASE MODULATORS - The present disclosure relates to triazolopyridazine protein kinase modulators of Formula (I), methods of using these compounds to treat diseases mediated by kinase activity. | 05-13-2010 |
Conrad Smith, San Diego, CA US
Patent application number | Description | Published |
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20120314650 | Quality of Service, Battery Lifetime, and Latency in Wireless Communication Devices - Embodiments for processing media over Internet Protocol (IP) packets in a wireless device are provided. Embodiments enable downlink and uplink media over IP flows within the wireless device that reduce the load on the application processor (AP) of the wireless device. In an embodiment, media over IP flows bypass the AP entirely allowing the AP to enter a power saving mode during media over IP sessions. This results in increased battery lifetime and reduced power consumption of the wireless device. In addition, the media over IP session quality is improved by the reduced latency resulting from bypassing the AP. | 12-13-2012 |
Dan Smith, San Diego, CA US
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20090169571 | SELECTED MA MOTIFS TO INCLUDE CELL DEATH AND/OR APOPTOSIS - The present application is directed to the use of dsRNA and/or ssRNA for the purpose of inducing apoptosis or cell death in proliferating cells. Specifically, low molecular weight and high molecular weight dsRNA and ssRNA are shown to induce apoptosis and/or cell death in proliferating cells, to arrest proliferation of transformed cells or tumor cells and to cause rapid induction of the cytokine TNF-alpha and/or also induce production of IL-12 which directs a Th-1 response. | 07-02-2009 |
20110274705 | METHODS AND COMPOSITIONS TO GENERATE AND CONTROL THE EFFECTOR PROFILE OF T CELLS BY SIMULTANEOUS LOADING AND ACTIVATION OF SELECTED SUBSETS OF ANTIGEN PRESENTING CELLS - The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-γ, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process. | 11-10-2011 |
20120189645 | Compositions and methods to treat and control tumors - The present application is directed to non-coding RNA motifs that are used in conjunction with an antigen or without an antigen to induce, enhance or modulate an immune response that compromises a B cell and a T cell component. | 07-26-2012 |
Daniel Thomas Smith, San Diego, CA US
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20090043747 | Remote segmentation system and method - Remote segmentation is a process by which segmentation data is collected from a third party and applied to an existing database. In a preferred embodiment of remote segmentation, a definition is added that makes the local system aware of all the possible segmentation dimensions in a way that is presentable to the user as well as transmittable to a third party (in house or other company) which processes the segment and returns the result. | 02-12-2009 |
Danny Ferrel Smith, San Diego, CA US
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20100218508 | System for supporting and servicing a gas turbine engine - A power system includes a gas turbine engine, which may include a gear box. The gear box may include a pipe connection configured to receive a removable pipe. The power system may also include a moveable support configured to fasten to the pipe connection to at least partially support the gear box. | 09-02-2010 |
20130219733 | SHAFT ALIGNMENT TOOL - An alignment tool is disclosed for aligning a first shaft assembly and a second shaft assembly to be connected by a coupling device. The alignment tool includes: a housing assembly having a first end and a second end, and a front plate assembly coupled to the first end of the housing assembly. The front plate assembly forms a cavity within the housing, and the front plate assembly has a stationary support housing disposed within the cavity and aligned with the first shaft assembly in the radial direction. The alignment tool also includes a core assembly having a rotatable core shaft disposed within the support housing of the front plate assembly and aligned with the first shaft assembly in the radial direction, the core assembly configured to receive an alignment device for aligning the first shaft assembly and the second shaft assembly in the radial direction. | 08-29-2013 |
Darren Smith, San Diego, CA US
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20100321590 | System and Method for Reducing Intra-Channel Interference - The present invention provides a method for determining a local oscillator frequency for a baseband converter, comprising obtaining characteristics of a channel comprising a plurality of radio signals at corresponding radio frequencies; using the channel characteristics to select a local oscillator frequency to use in baseband conversion of the plurality of radio signals of the channel to form a first baseband converted signal and a second baseband converted signal; and programming a local oscillator to operate the selected local oscillator frequency; wherein the local oscillator frequency is selected such that an image rejection ratio of the baseband converted second signal to an image of the baseband converted first signal is above a predetermined threshold. | 12-23-2010 |
David L. Smith, San Diego, CA US
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20130179199 | SYSTEMS AND METHODS FOR GRANTING ACCESS TO DIGITAL CONTENT USING ELECTRONIC TICKETS AND TICKET TOKENS - Systems and methods for granting access to digital content using electronic tickets and ticket tokens in accordance with embodiments of the invention are disclosed. One embodiment includes a processor, and memory configured to store an electronic ticket, and a ticket token. In addition, the processor is configured to authenticate a merchant server, receive a request for a ticket token for a specific piece of content from the merchant server, generate a ticket token that expires after a predetermined time period, associate the ticket token with an electronic ticket, send the ticket token to the merchant server for delivery to a user device, receive a request to access the identified piece of digital content from the user device, where the request includes the ticket token, send the electronic ticket and access information to the user device, and expire the ticket token. | 07-11-2013 |
20130179992 | SYSTEMS AND METHODS FOR ACCESSING DIGITAL CONTENT USING ELECTRONIC TICKETS AND TICKET TOKENS - Systems and methods for accessing digital content using electronic tickets and ticket tokens in accordance with embodiments of the invention are disclosed. In one embodiment, a user device includes a processor, a network interface, and memory configured to store an electronic ticket, and a ticket token, and the processor is configured by an application to send a request for digital content, receive a ticket token from a merchant server, wherein the ticket token is generated by a DRM server and associated with an electronic ticket that enables playback of the requested digital content, send the ticket token to a DRM server, receive an electronic ticket that enables playback of requested digital content, request the digital content associated with the electronic ticket, and play back the requested digital content using the electronic ticket. | 07-11-2013 |
David Wayne Smith, San Diego, CA US
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20140346838 | Bicycle Backrest - The device is a backrest for a bicycle that consists of three main parts. The backrest: a padded rectangular shaped device that attaches horizontally to a thick walled vertical post, that transverses downward at a 55° angle and is coupled with a thick walled cylindrical mounting bracket. The mounting bracket has a cylinder that accepts the seatpost of a bicycle, attaching the whole assembly to the frame. | 11-27-2014 |
Deborah M. Smith, San Diego, CA US
Patent application number | Description | Published |
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20090075970 | Thieno-and furo-pyrimidine modulators of the histamine H4 receptor - Thieno- and furo-pyrimidine compounds are described, which are useful as H | 03-19-2009 |
20110160451 | 2-Aminopyrimidine modulators of the histamine H4 receptor - 2-Aminopyrimidine compounds are described, which are useful as H | 06-30-2011 |
20110160452 | 2-Aminopyrimidine modulators of the histamine H4 receptor - 2-Aminopyrimidine compounds are described, which are useful as H | 06-30-2011 |
20110218338 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - 2-Aminopyrimidine compounds are described, which are useful as H | 09-08-2011 |
20120208793 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - Thieno- and furo-pyrimidine compounds are described, which are useful as H | 08-16-2012 |
20120214792 | THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - Thieno- and furo-pyrimidine compounds are described, which are useful as H | 08-23-2012 |
20120238544 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - Thieno- and furo-pyrimidine compounds are described, which are useful as H | 09-20-2012 |
20120270855 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - Thieno- and furo-pyrimidine compounds are described, which are useful as H | 10-25-2012 |
20130158258 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - 2-Aminopyrimidine compounds are described, which are useful as H | 06-20-2013 |
20130158259 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR - 2-Aminopyrimidine compounds are described, which are useful as H | 06-20-2013 |
Deborah Margaret Smith, San Diego, CA US
Patent application number | Description | Published |
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20110092481 | QUINOLINE OR ISOQUINOLINE SUBSTITUTED P2X7 ANTAGONISTS - The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I) | 04-21-2011 |
Derek M. Smith, San Diego, CA US
Patent application number | Description | Published |
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20090174569 | Plug-In Network Appliance - A plug-in network appliance is disclosed. In one aspect, a network appliance performs a bridge between two wireless communication formats. In another aspect, a network appliance is deployed to perform position location services. In another aspect, a mesh network comprising one or more network appliances is deployed. A mesh network comprising one or more network appliances may be deployed to perform position location services. A plug-in form factor is described. A network appliance may convert power received from a plug in a first format to power in a second format for powering various components. A network appliance may connect with a wireless network and/or a network connected through a plug. A plug-in network appliance may connect to a weight-bearing outlet. Various other aspects are also presented. | 07-09-2009 |
20100052991 | Wireless Position Location And Tracking System - Techniques for accurate position location and tracking suitable for a wide range of facilities in variable environments are disclosed. In one aspect, a system for position location comprises a plurality of sensors (e.g. a network monitor, an environment sensor) for generating measurements of a plurality of sources, a plurality of objects or tags, each object generating measurements of the plurality of sources, and a processor for receiving the measurements and generating a position location for one or more objects in accordance with the received measurements. In another aspect, a position engine comprises a mapped space of a physical environment, and a processor for updating the mapped space in response to received measurements. The position engine may receive second measurements from an object within the physical environment, and generate a position location estimate for the object from the received second measurements and the mapped space. | 03-04-2010 |
20100073235 | Wireless Position Location And Tracking System - Techniques for accurate position location and tracking suitable for a wide range of facilities in variable environments are disclosed. In one aspect, a system for position location comprises a plurality of sensors (e.g. a network monitor, an environment sensor) for generating measurements of a plurality of sources, a plurality of objects or tags, each object generating measurements of the plurality of sources, and a processor for receiving the measurements and generating a position location for one or more objects in accordance with the received measurements. In another aspect, a position engine comprises a mapped space of a physical environment, and a processor for updating the mapped space in response to received measurements. The position engine may receive second measurements from an object within the physical environment, and generate a position location estimate for the object from the received second measurements and the mapped space. | 03-25-2010 |
20100090901 | Wireless Position Location And Tracking System - Techniques for accurate position location and tracking suitable for a wide range of facilities in variable environments are disclosed. In one aspect, a system for position location comprises a plurality of sensors (e.g. a network monitor, an environment sensor) for generating measurements of a plurality of sources, a plurality of objects or tags, each object generating measurements of the plurality of sources, and a processor for receiving the measurements and generating a position location for one or more objects in accordance with the received measurements. In another aspect, a position engine comprises a mapped space of a physical environment, and a processor for updating the mapped space in response to received measurements. The position engine may receive second measurements from an object within the physical environment, and generate a position location estimate for the object from the received second measurements and the mapped space. | 04-15-2010 |
Derek Matthew Smith, San Diego, CA US
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20090302782 | SYSTEMS AND METHODS FOR RULES BASED, AUTOMATED LIGHTING CONTROL - A lighting control system comprising a plurality of intelligent switches designed to replace a conventional light switch, each of the intelligent switches including a receiver configured to receive communication signals that include rules based instructions for controlling one or more lighting circuits; a circuit interrupter configured to control the amount of current flowing to a lighting circuit; a memory configured to store the rules based instructions; and a processor coupled with the receiver, memory, and circuit interrupter, the processor configured to control the operation of the circuit interrupter based on the rules based instructions stored in memory. | 12-10-2009 |
20130093333 | SYSTEMS AND METHODS FOR RULES BASED, AUTOMATED LIGHTING CONTROL - A lighting control system comprising a plurality of intelligent switches designed to replace a conventional light switch, each of the intelligent switches including a receiver configured to receive communication signals that include rules based instructions for controlling one or more lighting circuits; a circuit interrupter configured to control the amount of current flowing to a lighting circuit; a memory configured to store the rules based instructions; and a processor coupled with the receiver, memory, and circuit interrupter, the processor configured to control the operation of the circuit interrupter based on the rules based instructions stored in memory. | 04-18-2013 |
Douglas Gillette Smith, San Diego, CA US
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20100041035 | IDENTIFICATION OF CENTROMERE SEQUENCES AND USES THEREFOR - Provided herein are methods for identifying centromeres and centromeres identified by such methods. Centromeres of organisms such as algae, fungi, and protists can be used, for example, for constructing artificial chromosomes and cells containing such artificial chromosomes. | 02-18-2010 |
Earnest Smith, San Diego, CA US
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20090133077 | Methods and systems of displaying advertisement or other information and content via mobile platforms - The methods and systems of the present invention are particularly adaptable as additions in the form of displaying means, such as monitors, that can works in conjunction with any type of motor vehicle including cars, box trucks, boats, ships, yachts, trains, recreational vehicles, motorcycles, tractor trailer trucks, or motor scooters. The methods of the present invention can be combined as an addition to any part of the motor vehicle in order to turn the motor vehicle into a mobile displaying platform for displaying advertisements or other information. | 05-21-2009 |
20120069136 | METHODS AND SYSTEMS OF DISPLAYING ADVERTISEMENT OR OTHER INFORMATION AND CONTENT VIA NON-MOBILE PLATFORMS - The present invention is directed towards an audio/video based interactive system that includes; a) one or more non-mobile structures including one or more non-mobile surfaces; and b) one or more video displays including one or more receiving means and one or more speakers, the one or more video displays being able to wireless transmission or by way of hardwire transmission receive and display content, the one or more video displays being directly mounted on the one or more non-mobile surfaces outwardly and away from the one or more non-mobile structures for viewing from the outside of the one or more non-mobile structures; and c) at least one call center able to generate and broadcast the content via one or more transmission means to the one or more video displays. The present invention also includes the capability to receive and send live content, including full video conferencing. | 03-22-2012 |
Elizabeth Smith, San Diego, CA US
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20090061942 | WIRELESS COMMUNICATION DEVICE - A system that incorporates teachings of the present disclosure may include, for example, a wireless communication device including a housing assembly formed from a first section that is rotatably coupled about an axis to a second section such that the first and second sections are movable between a closed position in which a first side of the first section is aligned with and in close proximity to a first side of the second section. The wireless communication device can also include a first display screen positioned in the first section and a second display screen positioned in the second section. The first and second display screens can be configured to display images. The wireless communication device can also include a keypad including keys on the first and second sections, thereby creating a foldable keypad rotatable about the axis between the first and second sections. Additional embodiments are disclosed. | 03-05-2009 |
20100067676 | System and Method of Providing Number Identification in an Intelligent Telephone Network - In a particular embodiment, a method of managing calls to a toll-free telephone number is disclosed. The method includes modifying a calling party identification (ID) privacy indicator associated with a received telephone call directed to a toll-free number. The calling party ID privacy indicator is modified based at least in part on a day that the telephone call is received. | 03-18-2010 |
Eric D. Smith, San Diego, CA US
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20120044672 | Solar-Powered Lighting System - An improved, solar-controlled light device with a circuit-control having a phototransistor, a variable resistor, and a first transistor connected to a storage unit, to a solar cell, and to a current-control. The variable resistor can be set to permit the device to turn on at pre-set ambient light levels. The current-control has a transformer, a second resistor, and a second transistor, connected at one end of the current-control to a light and at another end connected to the circuit-control, wherein the current-control senses the amount of power and boosts the power as needed to a sufficient level to power the lights. | 02-23-2012 |
Eric Michael Smith, San Diego, CA US
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20090060924 | ANTI-SCLEROSTIN ANTIBODIES - Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject. | 03-05-2009 |
20090202986 | METHODS OF OPTIMIZING ANTIBODY VARIABLE REGION BINDING AFFINITY - The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the optimized heteromeric variable region binding fragments. | 08-13-2009 |
20090239258 | Anti-IL-6 Antibody Nucleic Acid Molecules and Methods - Anti-IL-6 antibody nucleic acids, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 09-24-2009 |
20100221263 | Anti-Sclerostin Antibodies - Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject. | 09-02-2010 |
20110081355 | Methods of Diagnosing and Treating Conditions Using Anti-IL-6 Antibodies - Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus, chronic obstructive pulmonary disease, and renal cell carcinoma. | 04-07-2011 |
20110250205 | ANTI-SCLEROSTIN ANTIBODIES - Humanized and chimeric antibodies are provided that specifically bind human sclerostin and are characterized as having high affinity and strong neutralizing properties. The antibodies of the invention are useful for increasing bone mass, bone mineral density and bone strength and for the treatment of various disorders, e.g., osteoporosis, in human subject. | 10-13-2011 |
20120045453 | Anti-IL-6 Antibodies, Compositions, Methods and Uses - An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 02-23-2012 |
20130017208 | Anti-IL-6 Antibodies, Compositions, Methods and Uses - An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 01-17-2013 |
20140099311 | Anti-IL-6 Antibodies, Compositions, Methods and Uses - An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. | 04-10-2014 |
Garrett Smith, San Diego, CA US
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20120010599 | INORGANICALLY SURFACE-MODIFIED POLYMERS AND METHODS FOR MAKING AND USING THEM - In alternative embodiments, the invention provides articles of manufacture comprising biocompatible nanostructures comprising PolyEther EtherKetone (PEEK) surface-modified (surface-nanopatterned) to exhibit nanostructured surfaces that promote osseointegration and bone-bonding for, e.g., joint (e.g., knee, hip and shoulder) replacements, bone or tooth reconstruction and/or implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as primary or ancillary drug delivery devices. In alternative embodiments, the invention provides biocompatible nanostructures that promote osseointegration and bone-bonding for enhanced cell and bone growth and e.g., for in vitro and in vivo testing, restorative and reconstruction procedures, implants and therapeutics. | 01-12-2012 |
Gary W. Smith, San Diego, CA US
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20110076913 | Animated interactive figure and system - A system and subsystems include a server for determining the identity of a media program being received which will provide stimuli to an interactive figure. The system, and the subsystem as well as programmed media which, when executed on a processor, will operate the interactive figure, the system, and subsystems. A master library of sound patterns, preferably housed in a server, provides a reference for a recognition routine to identify, e.g., a particular television show. A control signal library stores commands each corresponding to a distinctive value. The commands initiate actions, e.g., motion, speech, or other response, by operating means in the interactive figure. The server may “push,” or transmit information to a user computer which transmits to and which may receive intelligence from the interactive figure. | 03-31-2011 |
20120185254 | INTERACTIVE FIGURINE IN A COMMUNICATIONS SYSTEM INCORPORATING SELECTIVE CONTENT DELIVERY - In a system, an interactive figurine delivers messages to a user in one of a number of forms. A server operation system includes processing capability which may individually couple content or may customize messages to a particular user of the interactive figurines. The interactive figurine contains an embedded circuit consisting of a receiver comprising a detector circuit tuned to at least one preselected frequency, a decoder to provide information indicative of intelligence and signals sent to the receiver, and a decoder circuit to provide actionable output signals indicative of information transmitted to the receiver. The server operation system may include a subscriber database and administration routines for customizing of messages and for directing messages. A user station intermediate the interactive figurine and the server module may be used to provide parental control or other control. | 07-19-2012 |
George Joseph Smith, San Diego, CA US
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20140004142 | PCSK9 VACCINE | 01-02-2014 |
Gordon W. Smith, San Diego, CA US
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20090294605 | FLAT PANEL TV STAND PROVIDING FLOATING APPEARANCE - A TV stand for a flat panel TV includes a base with plural shelves and a translucent frame on the top shelf A rear support holds the TV juxtaposed with the translucent frame with the bottom of the TV above the top shelf, so that the TV appears as though it is floating above the top shelf. | 12-03-2009 |
20120092855 | FLAT PANEL TV STAND PROVIDING FLOATING APPEARANCE - A TV stand for a flat panel TV includes a base with plural shelves and a translucent frame on the top shelf. A rear support holds the TV juxtaposed with the translucent frame with the bottom of the TV above the top shelf, so that the TV appears as though it is floating above the top shelf. | 04-19-2012 |
Hejira La Shon Smith, San Diego, CA US
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20100227525 | Book with removable objects - A book with removable objects comprising a plurality of card board sheets printed on both sides, cut to form removable insert, folded, and bound together as page(s), allowing for printed material to be visible in the insert cavity once the removable insert is extracted. | 09-09-2010 |
Jeff Smith, San Diego, CA US
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20110091560 | COMPOSITIONS OF NANOPARTICLES AND METHODS OF MAKING THE SAME - Disclosed herein are compositions of nanoparticles. In some embodiments, the nanoparticles are Janus particles, where each particle includes a first component and second component that are exposed to the surface of the particle. Also, disclosed are methods and systems for making a composition of nanoparticles. Finally, a method of treating a mammal by administering a composition of nanoparticles is disclosed. | 04-21-2011 |
20110311616 | TARGETING TUMOR ASSOCIATED MACROPHAGES USING BISPHOSPHONATE-LOADED PARTICLES - Provided herein are compositions including particles that comprise a bisphosphonate compound and a tumor specific targeting peptide or peptidomimetic. Also provided herein are methods of reducing tumor associated macrophages and methods of treating cancer with said compositions. | 12-22-2011 |
Jeffery Smith, San Diego, CA US
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20150045552 | 5HT2C RECEPTOR MODULATORS - The present invention relates to novel compounds of Formula (I): | 02-12-2015 |
Jeffrey M. Smith, San Diego, CA US
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20120065184 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. | 03-15-2012 |
20130331397 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS - The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated TRK kinase activity. | 12-12-2013 |
Jeffrey P. Smith, San Diego, CA US
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20110011908 | Quick fill adaptor for a fluid container - In a quick fill fluid container an adaptor for receiving a hollow container having a cavity or a reservoir for receiving fluids, preferable water but may be any other kind of fluids which refreshes the user or provides nourishment, reasonably necessary to refresh the user. The adaptor has a generally streamlined shape which mounts on to the container, which is typically supported in generally available cages or other mounting devices attached to a bicycle frame or other structure. A hollow extraction tube is provided for the adaptor which extends through the adaptor and into the container for withdrawal of the fluid by the user and preferably includes a mouth piece with a normally closed bite valve which is operated by the user to open the valve to extract water from the container. The adaptor has an intake port which may be disposed at many selected angles to the longitudinal axis of the adaptor base to provide a quick fill capability even while underway, The intake tube of the adaptor may be rotated to dispose the intake port to an infinite number of angles to receive the fluid dispensing apparatus such as a readily available capped water bottle or container. | 01-20-2011 |
Jeffrey Thomas Smith, San Diego, CA US
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20110121922 | FLEXIBLE INTERCONNECT CABLE FOR AN ELECTRONIC ASSEMBLY - A high speed flexible interconnect cable for an electronic assembly includes a number of conductive layers and a number of dielectric layers. Conductive signal traces, located on the conductive layers, combine with the dielectric layers to form one or more high speed electrical transmission line structures. The cable can be coupled to electronic components using a variety of connection techniques. The cable can also be terminated with any number of known or standardized connector packages. | 05-26-2011 |
Jennifer Smith, San Diego, CA US
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20140147481 | ANTI-INFLAMMATORY AND QUORUM SENSING INHIBITION COMPOUNDS AND METHODS OF MAKING AND USING THEM - The invention provides novel compositions based on a structure designated as “Honaucin A”, including Honaucin A variants and analogs, and pharmaceutical compositions, liposomes and nanoparticles comprising them, and methods of making and using them. In one embodiment these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used to ameliorate (including to treat or prevent) inflammation. In one embodiment, these Honaucin A compounds, and variants and analogs thereof are used as bacterial quorumsensing inhibitors. Accordingly, in alternative embodiments the compositions of the invention are used as anti-bacterial agents. | 05-29-2014 |
Joel Smith, San Diego, CA US
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20100131024 | ELECTROTHERAPY ORTHOPEDIC DEVICE - An electrotherapy orthopedic device including an electronic capsule and an orthopedic device, together providing a means to supply electrotherapy to damaged bones and tissue or promoting bone ingrowth to the device. A pre-programmed microprocessor delivers an optimal electrotherapy treatment regime, wherein a sequence of pulses form a plurality of waveforms available for specific clinical needs. A waveform, its pulse frequency, pulse width, duration and intensity (in sum, “Waveform Parameters”) are pre-programmed into the microprocessor based on the optimal treatment regimen for any particular disorder. | 05-27-2010 |
20150105779 | Combined Intramedullary and Extramedullary Surgical Aiming System And Method - A surgical aiming system is disclosed comprising a one or more fixation plates, an aiming assembly, a one or more nails and a plurality of screws. Said aiming assembly comprising a channeling assembly and a plurality of channels. Said one or more fixation plates comprising a plurality of plate apertures capable of receiving a portion of said plurality of screws. Said plurality of channels in said aiming assembly are capable of aligning a portion of said plurality of screws with said plurality of plate apertures in a first fixation plate. Said plurality of channels receive and align said plurality of screws as they are secured to said first bone. Said first fixation plate being extramedullary attached to a portion of said surface of said first bone; and said plurality of channels of said aiming assembly being aligned to identify a one or more intramedullary locations within said first bone. | 04-16-2015 |
John J. Smith, San Diego, CA US
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20130262510 | QUERY DERIVED COMMUNICATION MECHANISM FOR COMMUNICATION BETWEEN RELATIONAL DATABASES AND OBJECT-BASED COMPUTING ENVIRONMENTS AND SYSTEMS - Techniques for providing communication mechanisms between object-based and relational database systems are disclosed. A communication mechanism (e.g., a Web service) can be effectively derived from one or more query statements (e.g., SQL statements) based on a mapping to the objects of the object-based system. The communication mechanism can be generated in a Top-Down or Contract-First approach based on definitions and/or metadata needed to effectively construct the communication mechanism. | 10-03-2013 |
Jonathan Smith, San Diego, CA US
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20150157703 | METHOD OF RAPIDLY PRODUCING IMPROVED VACCINES FOR ANIMALS - A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal. | 06-11-2015 |
Jonathan Fowler Smith, San Diego, CA US
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20130064839 | METHOD OF RAPIDLY PRODUCING IMPROVED VACCINES FOR ANIMALS - A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal. | 03-14-2013 |
20130122025 | METHOD OF RAPIDLY PRODUCING IMPROVED VACCINES FOR ANIMALS - A method of quickly producing a vaccine for a biotype of pathogenic microorganism is described, where a nucleic acid molecule or fragment thereof is obtained from a biological sample from an animal exposed to the microorganism, a protective molecule is prepared based on the nucleic acid molecule of interest or fragment thereof, and administered to an animal which has been or is as risk of being exposed to the microorganism. A protective response to the biotype of the microorganism is obtained in the animal. | 05-16-2013 |
Kenneth Smith, San Diego, CA US
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20090277164 | BURNER ASSEMBLEY FOR PARTICULATE TRAP REGENERATION - An exhaust treatment system is provided. The system may include a particulate trap configured to remove one or more types of particulate matter from an exhaust flow, the exhaust flow including at least a portion of a totality of exhaust gases produced by an engine. The system may further include a burner assembly configured to increase a temperature of gases in the exhaust flow at a location upstream from the particulate trap. The burner assembly may include an exhaust inlet oriented in a direction along a first axis and configured to direct the exhaust flow into the burner assembly and an exhaust outlet oriented in a direction along a second axis at an angle relative to the first axis, the exhaust outlet being configured to direct the exhaust flow out of the burner assembly toward the particulate trap. The burner assembly may also include a fuel injector having a longitudinal axis in substantial alignment with the second axis. In addition, the burner assembly may include a cylindrical combustion chamber member defining a combustion chamber, having a longitudinal axis in substantial alignment with the longitudinal axis of the fuel injector, and configured to house a flame that is fueled by the fuel injector within the combustion chamber. The burner assembly may further include an exhaust flow distribution member configured to substantially evenly distribute exhaust about the combustion chamber member and in a heat exchange relation to the combustion chamber member. | 11-12-2009 |
Kenneth O. Smith, San Diego, CA US
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20080280238 | LOW SWIRL INJECTOR AND METHOD FOR LOW-NOX COMBUSTOR - A fuel injector and a combustor including a fuel injector that enables a combustor to burn a lean fuel/oxider gas mixture while providing low emissions of oxides of nitrogen (NO | 11-13-2008 |
20130125548 | FLOW CONDITIONER FOR FUEL INJECTOR FOR COMBUSTOR AND METHOD FOR LOW-NOx COMBUSTOR - An injector for a gas turbine combustor including a catalyst coated surface forming a passage for feed gas flow and a channel for oxidant gas flow establishing an axial gas flow through a flow conditioner disposed at least partially within an inner wall of the injector. The flow conditioner includes a length with an interior passage opening into upstream and downstream ends for passage of the axial gas flow. An interior diameter of the interior passage smoothly reduces and then increases from upstream to downstream ends. | 05-23-2013 |
Kenneth Owen Smith, San Diego, CA US
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20100115954 | Gas turbine fuel injector with a rich catalyst - A fuel injector for a gas turbine engine may include a pilot assembly extending along a longitudinal axis. The pilot assembly may be configured to direct a pilot fuel-air mixture to a combustor of the gas turbine engine. The fuel injector may also include a rich catalyst module circumferentially disposed about the pilot assembly. The catalyst module may be configured to simultaneously direct a stream of compressed air and a stream of first fuel-air mixture therethrough without intermixing. The fuel injector may also include a post mix zone disposed downstream of the catalyst module. The post mix zone may be configured to mix the compressed air and the first fuel air mixture to create a main fuel-air mixture. The fuel injector may further include an air swirler disposed downstream of the post mix zone. The air swirler may be configured to direct the main fuel-air mixture to the combustor without intermixing with the pilot fuel-air mixture. | 05-13-2010 |
Kent Smith, San Diego, CA US
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20110054366 | THERAPEUTIC PRESSURE SYSTEM - A therapeutic pressure system includes a sealed actuator housing containing an electrolyte and one or more polymer actuators that actuate via movement of electrolyte components into, out of around or within the polymer matrix of the polymer actuators. The system also includes an actuator support structure for the polymer actuators, working and counter electrodes in working contact with the actuators, circuitry for connecting the electrodes to a power source, and a controller between the power source and the electrodes to control the electrical current to the electrodes. The system is particularly useful for use in a hospital bed. | 03-03-2011 |
Larry R. Smith, San Diego, CA US
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20090069256 | Enhancing protein expression - Modified polynucleotide compositions providing enhanced gene expression and methods for preparing said compositions are disclosed. Methods of using the compositions, such as in screening assays, diagnostic tools, kits, etc. and for prevention and/or treatment of diseases and disorders are also disclosed. | 03-12-2009 |
20130005028 | Activation of RIG-I Pathway - The disclosed invention relates to nucleic acid molecules and compositions thereof for stimulating or enhancing an immune response in a subject. Methods for the use of the molecules and compositions, including administration of the molecules or compositions to a subject to facilitate an immune response to a vector encoded antigen are also described. | 01-03-2013 |
Lawrence D. Smith, San Diego, CA US
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20140268615 | TWO-STAGE POWER DELIVERY ARCHITECTURE - A two-stage power delivery network includes a voltage regulator and an interposer. The interposer includes a packaging substrate having an embedded inductor. The embedded inductor includes a set of traces and a set of through substrate vias at opposing ends of the traces. The interposer is coupled to the voltage regulator. The two-stage power delivery network also includes a semiconductor die supported by the packaging substrate. The two-stage power delivery network also includes a capacitor that is supported by the packaging substrate. The capacitor is operable to provide a decoupling capacitance associated with the semiconductor die and a capacitance to reduce a switching noise of the voltage regulator. | 09-18-2014 |
Matt Smith, San Diego, CA US
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20120203822 | APPARATUS AND METHODS FOR CONTROLLED BANDWIDTH RECLAMATION - Apparatus and methods for control of bandwidth reclamation in a content distribution network. In one embodiment, the invention provides a network operator or subscriber with the ability to disable or otherwise control reclamation in a switched digital video (SDV) network. A controller uses rules in determining whether to reclaim bandwidth. These rules designate certain carriers, content, devices and/or subscribers as high priority (or protected from reclamation). In one variant, the rules determine which subscribers are queried (“pinged”) in order to evaluate whether delivered content is actually being utilized by these subscribers. Alternatively, selected ones of the devices are configured so as to generate an automatic response to any ping messages. In another variant, the rules for disabling bandwidth reclamation are entered via user interaction with an application running on a client device and in communication with the controller via a network proxy, or with the SDV server directly. | 08-09-2012 |
Nichola D. Smith, San Diego, CA US
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20150133481 | CRYSTALLINE FORMS OF AN ANDROGEN RECEPTOR MODULATOR - Described herein are amorphous and crystalline forms of the androgen receptor modulator 4-[7-(6-cyano-5-trifluoromethylpyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]oct-5-yl]-2-fluoro-N-methylbenzamide. Also described are pharmaceutical compositions suitable for administration to a mammal that include the androgen receptor modulator, and methods of using the androgen receptor modulator, alone and in combination with other compounds, for treating diseases or conditions that are associated with androgen receptor activity. | 05-14-2015 |
Nicholas D. Smith, San Diego, CA US
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20090048308 | VLA-4 Antagonists - 4-Thio, 4-sulfinyl and 4-sulfonyl proline derivatives of the present invention are antagonists of the VLA-4 integrin and are useful in the treatment, prevention and suppression of diseases mediated by VLA-4-binding and cell adhesion and activation. Moreover, the compounds of the present invention demonstrate significant receptor occupancy of VLA-4 bearing cells after oral administration and are suitable for once-, twice-, or thrice-a-day oral administration. This invention also relates to compositions containing such compounds and methods of treatment using such compounds. | 02-19-2009 |
20090105124 | HETEROCYCLIC MODULATORS OF TGR5 - Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulation of TGR5 activity in a human or animal subject are also provided for the treatment diseases mediated by TGR5. | 04-23-2009 |
20090203903 | Thiazolyl mglur5 antagonists and methods for their use - The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts. | 08-13-2009 |
20110230526 | Thiazolyl Mglur5 Antagonists and Methods for Their Use - The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts. | 09-22-2011 |
20120071535 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 03-22-2012 |
20120289696 | THIAZOLYL MGLUR5 ANTAGONISTS AND METHODS FOR THEIR USE - The identification of a unique series of compounds which possesses special advantages in terms of drug-like properties due to their possessing advantageous properties in terms of potency and/or pharmacokinetic and/or selectivity and/or in vivo receptor occupancy properties. Specifically, the selection of a 1,3-thiazol-2-yl ring member linked by an ethynylene to the 3 position of a pyridyl ring or the 5 position of a pyrimidinyl ring, wherein the ring is substituted with selected substituents, results in a compound having superior drug-like properties. The invention includes pharmaceutically acceptable salt forms of these heterocyclic compounds, in particular chloride salts and trifluoroacetate salts. | 11-15-2012 |
20130012561 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 01-10-2013 |
20130116232 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 05-09-2013 |
20130116258 | ANDROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are androgen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon androgen receptors. | 05-09-2013 |
20130137746 | INDANE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 05-30-2013 |
20130231333 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 09-05-2013 |
20140107095 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 04-17-2014 |
20140199236 | ANDROGEN RECEPTOR MODULATOR AND USES THEREOF - Described herein is the androgen receptor modulator of formula (I) | 07-17-2014 |
20140364427 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 12-11-2014 |
20150105403 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF - Described herein are compounds that are estrogen receptor modulators. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such estrogen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions that are mediated or dependent upon estrogen receptors. | 04-16-2015 |
Nicole Smith, San Diego, CA US
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20100152207 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO - GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R | 06-17-2010 |
20120122891 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO - GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: | 05-17-2012 |
20140024665 | GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO - GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: | 01-23-2014 |
Peter A. Smith, San Diego, CA US
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20130281360 | BROAD SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGS - Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided. | 10-24-2013 |
20150045286 | BROAD SPECTRUM ANTIBIOTIC ARYLOMYCIN ANALOGS - Arylomycin analogs are provided, wherein the analogs can have broad spectrum bioactivity. Resistance to the antibiotic bioactivity of natural product arylomycin in a range of pathogenic bacterial species has been found to depend upon single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases), wherein the presence of a proline residue confers arylomycin resistance. Arylomycin analogs are provided herein that can overcome that resistance and provide for a broader spectrum of antibiotic bioactivity than can natural product arylomycins such as arylomycin A2. Methods for determining if a bacterial strain is susceptible to narrow spectrum arylomycin antibiotics, or if a broad spectrum analog is required for treatment, is provided. Pharmaceutical compositions and methods of treatment of bacterial infections, and methods of synthesis of arylomycin analogs, are provided. | 02-12-2015 |
Philip Smith, San Diego, CA US
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20120261515 | Platform and launch initiation system for secondary spacecraft for launch vehicle - A platform and launch initiation control system for secondary spacecraft for a launch vehicle includes an aluminum honeycomb core sandwiched between top and bottom structural aluminum skins and strengthened by a spider-like stiffener. Spool inserts for engaging the secondary spacecraft are arranged on the platform. A computer processor based auxiliary payload support unit (APSU) is provided on the platform and receives power and enable signals through a single cable from the LV to permit the APSU to control the release of the secondary spacecraft transparently to the LV without impacting LV operations. | 10-18-2012 |
20140131522 | PLATFORM AND LAUNCH INITIATION SYSTEM FOR SECONDARY SPACECRAFT FOR LAUNCH VEHICLE - A platform and launch initiation control system for secondary spacecraft for a launch vehicle includes an aluminum honeycomb core sandwiched between top and bottom structural aluminum skins and strengthened by a spider-like stiffener. Spool inserts for engaging the secondary spacecraft are arranged on the platform. A computer processor based auxiliary payload support unit (APSU) is provided on the platform and receives power and enable signals through a single cable from the LV to permit the APSU to control the release of the secondary spacecraft transparently to the LV without impacting LV operations. | 05-15-2014 |
Randall Smith, San Diego, CA US
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20130079232 | METHODS AND COMPOSITIONS FOR NUCLEIC ACID SEQUENCING - The present disclosure provides methods and systems for detecting multiple different nucleotides in a sample. In particular, the disclosure provides for detection of multiple different nucleotides in a sample utilizing fewer detection moieties than the number of nucleotides being detected and/or fewer imaging events than the number of nucleotides being detected. | 03-28-2013 |
20150031833 | FORMYLPYRROLE-BASED HETEROCYCLES FOR NUCLEIC ACID ATTACHMENT TO SUPPORTS - A compound has Formula I: | 01-29-2015 |
Rodger Smith, San Diego, CA US
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20100053021 | System, Method and Apparatus for Supporting and Concealing Radio Antennas - A multi-trunk antenna structure that includes a main trunk and a plurality of upper trunks is provided. The upper trunks extend upwardly at a desired angle from the main trunk and provide a desired girth of the structure near the top. A plurality of antennas are attached to desired upper trunks at a desired height above ground level. The antennas can be adjusted to a desire azimuth. The antenna structure can include branches so that it resembles a Eucalyptus tree, an Oak tree, or other type of tree. The trunks of the structure can provide raceways for antenna cabling. | 03-04-2010 |
Ryan Smith, San Diego, CA US
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20090109499 | Scanner Having Driven Member Tension - An apparatus in an example comprises a guide, a driven member, and a carriage. Tension in the driven member generates a moment that biases the carriage against the guide. | 04-30-2009 |
20090322017 | TORQUE LIMITER AND SHEET SEPARATING DEVICE HAVING A TORQUE LIMITER - A torque limiter may include a first member configured to rotate about a first axis and having a first contact surface. The torque limiter may include a second member configured to rotate about the first axis and including a first axially extending finger. The first finger may be radially biased so that a second contact surface defined by the first finger may contact the first contact surface with a normal force to define a predetermined torque value between the first and second members. When one of the first and second members is rotatably driven in a first rotational direction, the other of the first and second members may be rotatably driven in the first rotational direction unless a torque load greater than or equal to the predetermined torque value is applied to the other of the first and second members. | 12-31-2009 |
20110228356 | Image scan device - Image scan device, comprising a platen, and a carriage, the carriage comprising a scan head, and a support structure arranged to move the scan head with respect to the platen, wherein a resilient element is provided that is arranged to bias the scan head in the direction of the platen, and resilient element fully extends between the platen and the bottom of the carriage, as seen from a direction parallel to the platen. | 09-22-2011 |
Ryan C. Smith, San Diego, CA US
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20110105361 | MICROVESSELS, MICROPARTICLES, AND METHODS OF MANUFACTURING AND USING THE SAME - A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis. The method can include providing a plurality of encoded microvessels. The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels. | 05-05-2011 |
20140079923 | POLYMER COATINGS - The present disclosure relates to polymer coatings covalently attached to the surface of a substrate and the preparation of the polymer coatings, such as poly(N-(5-azidoacetamidylpentyl)acrylamide-co-acrylamide) (PAZAM), in the formation and manipulation of substrates, such as molecular arrays and flow cells. The present disclosure also relates to methods of preparing a substrate surface by using beads coated with a covalently attached polymer, such as PAZAM, and the method of determining a nucleotide sequence of a polynucleotide attached to a substrate surface described herein. | 03-20-2014 |
20140100123 | MICROVESSELS, MICROPARTICLES, AND METHODS OF MANUFACTURING AND USING THE SAME - A plurality of isolated microvessels including a plurality of encoded microvessels each having a microbody and a reservoir core. The microbody is configured to separate a biological or chemical substance in the reservoir core from an ambient environment surrounding the microbody. The microbody includes a transparent material that at least partially surrounds the reservoir core and facilitates detection of an optical characteristic of the substance within the reservoir core. The microbody of each microvessel includes an identifiable code that distinguishes individual microvessels of the plurality of encoded microvessels from each other. The plurality of isolated microvessels also includes a plurality of compartments each configured to separate individual microvessels of the plurality of encoded microvessels from each other. | 04-10-2014 |
Ryan Christopher Smith, San Diego, CA US
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20150031833 | FORMYLPYRROLE-BASED HETEROCYCLES FOR NUCLEIC ACID ATTACHMENT TO SUPPORTS - A compound has Formula I: | 01-29-2015 |
Ryan M. Smith, San Diego, CA US
Patent application number | Description | Published |
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20090034020 | ADJUSTING SCAN RATE WITHIN SCANNING DEVICE - A scanning device includes a scanning mechanism, a memory, a processing mechanism, and a scan rate adjustment mechanism. The scanning mechanism scans a media sheet having an image thereon at a variable scan rate, to yield raw data. The memory temporarily stores the raw data. The processing mechanism converts the raw data within the memory into processed data. The raw data is removed from the memory as the raw data is converted. The scan rate adjustment mechanism adjusts the variable scan rate, based on one or more of an amount of free space within the memory, a fill rate at which the raw data is filling the memory, and a removal rate at which the raw data is being removed from the memory, so that the memory does not become completely full. | 02-05-2009 |
20090079127 | Media pick system and method - A media pick system includes a media support, a pick roller, disposed above media support, configured to selectively contact and pick sheets of media disposed upon the media support, and clearance means, associated with the media support, for providing contact-free clearance around the pick roller during a media out condition. | 03-26-2009 |
20090278302 | Actuation Of Output Tray - One embodiment is an apparatus that has an input tray and an output tray. Commencement of a print job causes the output tray to move from a closed position to an open position. | 11-12-2009 |
20090283960 | SHEET FEEDER - A sheet feeder has a tray for receiving one or more media sheets. An arm is configured to pivot relative to the tray. A roller is rotatably coupled to the arm. A biasing device is coupled to the arm. The biasing device biases the arm to pivot toward the tray. | 11-19-2009 |
20090283964 | Systems And Methods For Orienting Media For Improved Scan Quality - Systems and methods systems and methods for orienting media for improved scan quality are disclosed. In an exemplary implementation, a method may include receiving a transparency media in a media holder, and guiding the transparency media into the media holder. The method may also include accepting the transparency media in the media holder only if the transparency media is oriented with an emulsion side facing toward an imaging surface. The method may also include self-ejecting the transparency media from the media holder if the transparency media is oriented with the emulsion side facing away from the imaging surface. | 11-19-2009 |
20100038847 | TRANSMISSION FOR AN AUTOMATIC DOCUMENT FEEDER - An automatic document feeder transmission includes a single electric motor mounted on a chassis. Motor actuates a power input gear that is rotatably mounted on the chassis and has gear teeth. A swing arm, rotatably mounted to the chassis, pivots about a swing arm pivot axis through an arc of travel. Arm has central and distal ends, the latter having gear teeth formed therein. Driving and driven pinions, each having mutually intermeshing gear teeth, are rotatably mounted to the arm. Driven pinion gear teeth also intermesh with power input gear teeth. A paper stop is rotatably mounted on the chassis. A catch, disposed on the arm, is selectively engageable with a wire spring disposed adjacent portion(s) of the travel arc, wherein arm rotation is selectively stopped in one direction and allowed in an opposite direction. Arm selectively switches between three discreet feeder modes and selectively actuates the paper stop. | 02-18-2010 |
20120236371 | SCANNER ASSEMBLY - A scanner assembly comprising the following components. A scan module having a first surface and configured to receive an image oriented along the first surface. A carriage having a thickness no thicker than a thickness of the scan module perpendicular to the first surface, the carriage configured to receive the scan module and to move the scan module in a direction of travel. A v-bearing coupled to the carriage proximate to one end of the carriage and protruding from the carriage in a direction perpendicular to the first surface. A scan base having a groove and configured to receive the v-bearing. A belt drive configured to move the v-bearing in the groove of the scan base. | 09-20-2012 |
20140047935 | APPARATUS FOR LOWERING AND RAISING A PICK ARM - An apparatus for lowering and raising a pick arm is disclosed herein. An example of the apparatus includes a shuttle assembly having a first direction of movement and a second direction of movement, and a lift assembly rotatably coupled to the shuttle assembly. The apparatus additionally includes a cam coupled to the lift assembly to transform rotary motion of the lift assembly into substantially linear motion that allows the pick arm to lower as a result of movement of the shuttle assembly in the first direction and that raises the pick arm as a result of movement of the shuttle assembly in the second direction. Other components and attributes of the apparatus are also disclosed herein, as are additionally examples of the apparatus. A method of lowering and raising the pick arm is further disclosed herein. | 02-20-2014 |
Scot T. Smith, San Diego, CA US
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20120162657 | Coherency Reduction for Bandwidth Measurement - A method includes directing a portion of a laser beam output from a laser along a secondary beam path toward a detector, the secondary beam path being distinct from a main beam path of the laser beam; generating a bandwidth selective interference pattern of the laser beam on the detector; detecting, at the detector, a width of a fringe within the interference pattern to thereby measure measuring a bandwidth of the laser beam; and homogenizing the laser beam traveling along the secondary beam path prior to generation of the bandwidth selective interference pattern. The homogenizing includes diffusing the laser beam; and introducing a time dependent, position dependent, or both time and position dependent random modulation to the wavefront of the laser beam to reduce fluctuations in the detected fringe width and to reduce the influence of spatial coherence of the laser beam on the detected interference pattern. | 06-28-2012 |
Scott Wendell Smith, San Diego, CA US
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20080274192 | Pharmaceutical Compositions Comprising an Amorphous Form of a Vegf-R-Inhibitor - A pharmaceutical composition comprising the compound 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-E-[2-(pyridin-2-yl)ethenyl]indazole, or a pharmaceutically acceptable salt or solvate thereof, in an amorphous form. | 11-06-2008 |
Sherry Smith, San Diego, CA US
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20090232041 | Method And System For Advertising Bluetooth Multicast Feature - Aspects of a method and system for advertising a Bluetooth multicast feature are provided. A master device may provide a multicast service to active slave devices during a Bluetooth piconet connection. A Bluetooth multicast packet addressed to a specific slave device may be transmitted over a point-to-point connection. The multicast packet may be decoded and acknowledged by each of the slave devices on the piconet. The master device may re-transmit the multicast packet addressed to the specific slave device over the same point-to-point connection when an acknowledgment or response indicating a reception of the multicast packet from each of active slave devices may not be detected. The point-to-point connection may be associated with a L2CAP channel identified by a determined unique channel identifier (M-CID). The point-to-point connection may be secured by assigning a common authentication key shared among the slaves of the piconet. | 09-17-2009 |
20110076949 | LOCATION SYSTEM FOR BLUETOOTH ENABLED DEVICES - A method, apparatus, and system for tracking and locating Bluetooth enabled devices is described. A network of Bluetooth sniffers can be used to rapidly locate lost devices and their owners. Wearable child devices maintain low power contact with parent devices until such time as a signal limit is reached, at which point the parent devices alarm. An optional network of fixed sniffing devices can be used to coordinate a search for lost child devices once an alert is issued to the system. | 03-31-2011 |
20130331029 | Near Field Communication Application Identification Routing In Card Emulation - A near field communications (NFC) device is disclosed that interacts with other NFC devices to exchange information and/or the data. The NFC device can include a plurality of secure elements each configured to store one or more card emulation instances. Each card emulation instance is associated with an application identification (AID) and a priority value. The NFC device can route communications between another NFC device and plurality of secure elements based on each card emulation instance's associated AID and priority value. | 12-12-2013 |
Sherry Wang Smith, San Diego, CA US
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20140087655 | SYSTEMS AND METHODS FOR DETERMINING WHETHER A COMPANION COMMUNICATION DEVICE IS BEYOND A PROXIMITY OF A PRIMARY COMMUNICATION DEVICE - Systems and methods for determining whether a companion communication device is beyond a proximity of a primary communication device are provided. In some aspects, a system includes an analysis module configured to determine whether a wireless transaction between the primary communication device and the companion communication device is at a conclusion. The system also includes a communications module configured to emit a sensing signal based on the determination of whether the transaction is at the conclusion. The sensing signal is insufficient to elicit a response from the companion communication device. The system also includes a detection module configured to detect a present parameter associated with the emitted sensing signal. The analysis module is configured to determine a parameter change between the present parameter and a reference parameter, and to determine whether the companion communication device is beyond the proximity of the primary communication device based on the parameter change. | 03-27-2014 |
Zachery Smith, San Diego, CA US
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20120058338 | SYSTEMS AND METHODS FOR PROTECTING CABLES AND OTHER STRUCTURAL MEMBERS - According to some embodiments, a cable protection system to at least partially shield a cable from heat, fire, an impact or other potentially harmful event or occurrence comprises a first encompassing member configured for placement around the cable or cable bundle, wherein a first void is defined between the first encompassing member and an outside of the cable or cable bundle. The system additionally includes a second encompassing member positioned around the first encompassing member, wherein a second void is defined between the first encompassing member and the second encompassing member. Further, the system comprises one or more fill materials positioned within the second void. In some embodiments, the fill material comprises vermiculite, ceramic and/or one or more other materials. The first void permits the cable protection system to be slidably moved relative to the cable or cable bundle. | 03-08-2012 |