Michèle
Michèle Besenval, Paris FR
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20120004294 | ANTITUMOR COMBINATION COMBINING AVE8062 AND DOCETAXEL - The invention relates to a sequential antitumor combination of AVE8062, or a salt thereof, and docetaxel, characterized in that AVE8062 is administered to a patient in a dose of 10 to 50 mg/m2, and then, on a different day of the week, preferably after a 24-hour interval, docetaxel is administered in a dose of 50 to 120 mg/m2. | 01-05-2012 |
Michèle Besenval, Paris FR
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20120004294 | ANTITUMOR COMBINATION COMBINING AVE8062 AND DOCETAXEL - The invention relates to a sequential antitumor combination of AVE8062, or a salt thereof, and docetaxel, characterized in that AVE8062 is administered to a patient in a dose of 10 to 50 mg/m2, and then, on a different day of the week, preferably after a 24-hour interval, docetaxel is administered in a dose of 50 to 120 mg/m2. | 01-05-2012 |
Michèle Beunache, La Haie Traversaine FR
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20120006921 | Working Vessel Including a Removable Collar and Electric Household Appliance for Culinary Preparation Equipped with Such a Vessel - Working vessel for an electric household appliance for culinary preparation including a removable collar ( | 01-12-2012 |
Michèle Bois-Choussy, Fontenay Aux Roses FR
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20090171080 | Intermediate and Process of Preparation of Ecteinascidin Such as Ecteinascidines-583,597 Using Such Intermediate - The present invention concerns an intermediate of the following formula (I) in which R | 07-02-2009 |
Michèle Bois-Choussy, Fontenay Aux Roses FR
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20090171080 | Intermediate and Process of Preparation of Ecteinascidin Such as Ecteinascidines-583,597 Using Such Intermediate - The present invention concerns an intermediate of the following formula (I) in which R | 07-02-2009 |
Michèle Boisdron-Celle, Saint Leger Des Bois FR
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20110177092 | INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFIRI TREATMENT - The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFIRI regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFIRI or similar treatment cycle is optimized using the decision algorithm according to the invention. | 07-21-2011 |
20110246079 | INDIVIDUAL 5-FLUOROURACILE DOSE OPTIMIZATION IN FOLFOX TREATMENT - The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5-FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5-FU plasmatic concentration measured during the previous 5-FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5-FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention. | 10-06-2011 |
Michèle Cristau, St Aunes FR
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20110003943 | Supported Oxidation Reactants, Process for their Preparation and Uses Thereof - The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O) | 01-06-2011 |
Michèle Cristau, Visp CH
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20140094567 | Diketopiperazine Forming Dipeptidyl Linker - The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. | 04-03-2014 |
Michèle Cristau, Agarn CH
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20140343227 | Diketopiperazine Forming Dipeptidyl Linker - The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragmcnt; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. | 11-20-2014 |
Michèle Cristau, St Aunes FR
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20110003943 | Supported Oxidation Reactants, Process for their Preparation and Uses Thereof - The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O) | 01-06-2011 |
Michèle Eymard Du Vernet, Paris FR
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20100255045 | COMPOSITION FOR PHOTODYNAMIC SKIN TREATMENT - The invention relates to a composition for photodynamic therapy. The composition of the invention, in the form of a gel or a cross-linked hydrogel, includes a chlorophyll photosensitising substance or a derivative thereof, in particular chlorophyllin optionally associated with an additional ingredient such as an alpha- or beta-hydroxy acid, a depigmentation or lightening agent, and/or an antioxidant. The invention can be used in the treatment of skin aging signs and in skin regeneration. | 10-07-2010 |
Michèle Eymard Du Vernet, Paris FR
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20100255045 | COMPOSITION FOR PHOTODYNAMIC SKIN TREATMENT - The invention relates to a composition for photodynamic therapy. The composition of the invention, in the form of a gel or a cross-linked hydrogel, includes a chlorophyll photosensitising substance or a derivative thereof, in particular chlorophyllin optionally associated with an additional ingredient such as an alpha- or beta-hydroxy acid, a depigmentation or lightening agent, and/or an antioxidant. The invention can be used in the treatment of skin aging signs and in skin regeneration. | 10-07-2010 |
Michèle Ranson, Paris FR
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20090299053 | Product Resulting From the Grafting of Fatty Chains to Ulvans and Use of Said Product as a Surfactant - The invention relates to a product resulting from the grafting, by esterification or transesterification, onto at least a part of the hydroxyl functions of an ulvan-type polysaccharide in the form of an acid or in the form of a mono- or divalent salt, in particular a sodium salt, of fatty chains or of mixtures of fatty chains containing 8 to 28 carbon atoms, said fatty chains being saturated or unsaturated, and linear or branched. | 12-03-2009 |
Michèle Reigner, Morges CH
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20110009525 | ENAMEL - The invention relates to a translucent or transparent, coloured enamel that contains metal nanoparticles that lost their natural tendency to aggregate with each other, and having a colour essentially provided by the reflection of light. The nanoparticles have lost their natural capability to aggregate with each other due to the application of a coating, or because they have been functionalised electrostatically or using highly sterically hindered entities or using hydrophilic entities located at the surface thereof. The nanoparticles may be gold nanoparticles that impart an intense and deep red to said enamel. | 01-13-2011 |
Michèle Reigner, Morges CH
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20110009525 | ENAMEL - The invention relates to a translucent or transparent, coloured enamel that contains metal nanoparticles that lost their natural tendency to aggregate with each other, and having a colour essentially provided by the reflection of light. The nanoparticles have lost their natural capability to aggregate with each other due to the application of a coating, or because they have been functionalised electrostatically or using highly sterically hindered entities or using hydrophilic entities located at the surface thereof. The nanoparticles may be gold nanoparticles that impart an intense and deep red to said enamel. | 01-13-2011 |
20120114522 | GRAY GOLD ALLOY FREE OF NICKEL AND COPPER - The present invention relates to a white gold alloy free of nickel and copper having a hardness that is suitable in particular for watchmakers and jewellers. Said alloy consists of (in wt %): more than 75% of Au; more than 18% to less than 24% of Pd; more than 1% to less than 6% of at least one element selected from among Mn, Hf, Nb, Pt, Ta, V, Zn and Zr; optionally, no more than 0.5% of at least one element selected from among Si, Ga and Ti; and optionally, no more than 0.2% of at least one element selected from among Ru, Ir and Re. The invention also relates to a method for preparing said alloy. | 05-10-2012 |
Michèle Resche-Rignon, Paris FR
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20090298799 | Methods of Treating Osteoporosis and Secondary Hyperparathyroidism Using 20-Methyl, Gemini Vitamin D3 Compounds - The invention provides for methods of using 20-methyl Gemini vitamin D | 12-03-2009 |
Michèle Resche-Rignon, Paris FR
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20090298799 | Methods of Treating Osteoporosis and Secondary Hyperparathyroidism Using 20-Methyl, Gemini Vitamin D3 Compounds - The invention provides for methods of using 20-methyl Gemini vitamin D | 12-03-2009 |
Michèle Rosenzwajg, Paris FR
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20140004080 | USE OF LOW DOSE IL-2 FOR TREATING AUTOIMMUNE - RELATED OR INFLAMMATORY DISORDERS | 01-02-2014 |