Wakefield, US
Alexander Wakefield, Fort Lauderdale, FL US
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20140282315 | GRAPHICAL VIEW AND DEBUG FOR COVERAGE-POINT NEGATIVE HINT - The present invention provides a graphical view of this connected network that allows the user to navigate throughout a network. The graph view consists of a series of nodes that correspond to a set of test, testbench, design or coverage items in the simulation. Various nodes in the network are colored or shaped differently to represent either test, class, stimulus, testbench, design or coverage points. The graph may be drawn so that all items that occur at the same time are lined up in the same horizontal or vertical region, to give the user an intuitive view of time going left to right or top to bottom. | 09-18-2014 |
Brandan Wakefield, Phoenix, AZ US
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20100254807 | TURBINE ROTOR SEAL PLATE WITH INTEGRAL FLOW DISCOURAGER - A seal plate for a turbine engine is provided. The turbine engine has a central axis. The seal plate comprises a forward face extending radially from the central axis. The forward face comprises a flat portion extending circumferentially around the central axis, and a front flow discourager coupled to the flat portion and extending outward from the flat portion. | 10-07-2010 |
20120148406 | TURBINE ROTOR DISKS AND TURBINE ASSEMBLIES - A turbine rotor disk is provided. The turbine rotor disk includes a hub, a ring attached to the hub, the ring including a plurality of posts extending radially outwardly and disposed around a circumference of the ring, each post including a first radially-extending face, a second radially-extending face, and a blade attachment surface extending axially between the first and second radially-extending faces, a main cooling air feed channel formed in each post and extending from the first radially-extending face toward the second radially-extending face, and a plurality of ancillary jet openings formed in each post and extending from the main cooling air feed channel to the blade attachment surface. | 06-14-2012 |
20150075178 | GAS TURBINE ENGINES WITH TURBINE ROTOR BLADES HAVING IMPROVED PLATFORM EDGES - A turbine rotor blade is provided. The turbine rotor blade includes a root, a platform coupled to the root, and an airfoil extending from the platform. The platform has a leading edge, a trailing edge, a suction side edge, and a pressure side edge. The pressure side edge includes a first concave portion. | 03-19-2015 |
Brian D. Wakefield, Vernon Hills, IL US
Patent application number | Description | Published |
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20090163464 | BENZOTHIAZOLE AND BENZOOXAZOLE DERIVATIVES AND METHODS OF USE - Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions of compounds of formula (I), methods for using such compounds and compositions, and a process for preparing the compounds. | 06-25-2009 |
20090203690 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS - The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, | 08-13-2009 |
20090253678 | MACROCYCLIC PYRIMIDINE DERIVATIVES - Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described herein. | 10-08-2009 |
20100016344 | AMINO HETEROCYCLIC LINKED PYRIMIDINE DERIVATIVES - Macrocyclic benzofused pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions and disorders using such compounds and compositions are described herein. | 01-21-2010 |
20120164070 | BENZOTHIAZOLE AND BENZOOXAZOLE DERIVATIVES AND METHODS OF USE - Compounds of formula (I) | 06-28-2012 |
20140343066 | 5-SUBSTITUTED INDAZOLES AS KINASE INHIBITORS - The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, | 11-20-2014 |
20150218102 | 6-HETEROARYLOXY- OR 6-ARYLOXY-QUINOLINE-2-CARBOXAMIDES AND METHOD OF USE - Compounds of formula (I) | 08-06-2015 |
Brian David Wakefield, Skokie, IL US
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20090170913 | NOVEL MCH RECEPTOR ANTAGONISTS - The present invention relates to a melanin concentrating hormone antagonist compound of formula (I); wherein Ar | 07-02-2009 |
Buddy Wakefield, Seattle, WA US
Patent application number | Description | Published |
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20110250579 | DRIVEN WHEEL ENERGY AND ENTERTAINMENT DEVICE - Disclosed is a system based on an animal habitat for the purpose of teaching and entertaining children while familiarizing them with the field of energy generation, storage, transmission, energy consumption and a complete energy cycle. The present invention combines a small animal, enclosure, exercise wheel and plants, with a generator and light source to build a complete energy cycle. Additional features benefit the child by powering a toy, electronic game or cell phone while learning how several energy transformations are used to deliver electrical power. Accessories that add supplemental wind and solar power sources also add educational opportunities for the child. | 10-13-2011 |
Darren Wakefield, Fitchburg, WI US
Patent application number | Description | Published |
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20130190484 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages - The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate. | 07-25-2013 |
20130281658 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 10-24-2013 |
Darren H. Wakefield, Fitchburg, WI US
Patent application number | Description | Published |
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20080269450 | Endosomolytic Poly-Beta-Aminoester Polymers - The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation. | 10-30-2008 |
20080281041 | Reversibly Masked Polymers - The present invention is directed to reversibly inactivation of membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation. | 11-13-2008 |
20080281044 | Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers - The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation. | 11-13-2008 |
20080287628 | Endosomolytic Poly(Vinyl Ether) Polymers - The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation. | 11-20-2008 |
20080287630 | Endosomolytic Poly(Acrylate) Polymers - The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation. | 11-20-2008 |
20090023890 | Membrane Active Heteropolymers - The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation. | 01-22-2009 |
20090048410 | Membrane Active Heteropolymers - The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in vivo delivery. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation. | 02-19-2009 |
20110207799 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 08-25-2011 |
20120157509 | GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers. | 06-21-2012 |
20120165393 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 06-28-2012 |
20120172412 | In Vivo Polynucleotide Delivery Conjugates Having Enzyme Sensitive Linkages - The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate. | 07-05-2012 |
20120230938 | Polyconjugates for In Vivo Delivery of Polynucleotides - The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation. | 09-13-2012 |
20130121954 | Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery - The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness. | 05-16-2013 |
20130245091 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 09-19-2013 |
20130317079 | Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery - The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness. | 11-28-2013 |
20150104408 | Poly(acrylate) Polymers for In Vivo Nucleic Acid Delivery - The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness. | 04-16-2015 |
20150110732 | Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery - The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness. | 04-23-2015 |
20150202298 | Compositions for Targeted Delivery of siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted delivery polymers. Delivery polymers provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery polymers. | 07-23-2015 |
20150283256 | Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery - The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness. | 10-08-2015 |
20150352221 | Peptide-Based In Vivo siRNA Delivery System - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides. | 12-10-2015 |
20150361427 | Compositions and Methods for Inhibiting Gene Expression of Alpha-1 AntiTrypsin - The invention relates to a RNA interference triggers for inhibiting the expression of an AAT gene through the mechanism of RNA interference. The invention also relates to a pharmaceutical composition comprising the AAT RNAi trigger together with an excipient capable of improving delivery of the RNAi trigger to a liver cell in vivo. Delivery of the AAT RNAi trigger to liver cells in vivo provides for inhibition of AAT gene expression and treatment of alpha 1-antitrypsin deficiency and associated diseases. | 12-17-2015 |
20160102120 | Galactose Cluster-Pharmacokinetic Modulator Targeting Moiety for siRNA - The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co-targeted delivery polymers. | 04-14-2016 |
David L. Wakefield, Loves Park, IL US
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20120141316 | GEAR ROOT GEOMETRY FOR INCREASED CARRYOVER VOLUME - A gear includes a gear root defined by a stretched root blended into an involute tooth profile curve within a True Involute Form diameter. | 06-07-2012 |
20130184114 | CARRIER FOR PLANETARY GEAR SYSTEM - A planetary gear system includes a sun gear rotatable about an axis. Planetary gears are circumferentially arranged about and intermesh with the sun gear and peripherally with a ring gear. Each of the planetary gears is supported by a journal bearing arranged in a bore in a carrier wall. A carrier supports the journal bearings and is configured to rotate about the axis and carry the planetary gears. The carrier wall supports the journal bearings and has spaced apart lateral surfaces. A scupper is arranged between the lateral surfaces and provides an inlet in one of the lateral surfaces, in this example facing the sun gear. The inlet has a first circumferential dimension, and a passage fluidly interconnects the scupper to one of the journal bearings via the bore. The passage has a second circumferential dimension less than the first circumferential dimension. | 07-18-2013 |
20140314595 | Reservoir Vent and Thermal Stabilization Orifice - A reservoir includes first and second chambers, and a piston having first and second ends disposed in the first and second chambers, respectively. The first and second ends isolate a first area from a second area within the first and second chambers. The first area of the first chamber is in fluid communication with a high pressure fluid source and the second area of the first chamber is in fluid communication with a low pressure fluid source. An orifice is formed in the first end and is configured to allow fluid communication between the upper and lower areas of the first chamber. A pumping system and an aircraft are also disclosed. | 10-23-2014 |
20140345699 | VENT VALVE - A vent valve according to an exemplary aspect of the present disclosure includes, among other things, a sensing sleeve defining a sensing chamber and a vent channel for venting fluid out of the sensing chamber. A sensing piston is moveable within the sensing chamber between an open position and a closed position. The sensing piston allows flow of the fluid into the vent channel during movement of the sensing piston between the open and closed positions. | 11-27-2014 |
David W. Wakefield, Houston, TX US
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20080302106 | INTEGRATION OF COAL FIRED STEAM PLANTS WITH INTEGRATED GASIFICATION COMBINED CYCLE POWER PLANTS - A method of improving the output and efficiency of a pulverized coal plant by integration with an Integrated Gasification Combined Cycle (IGCC) plant. | 12-11-2008 |
20100050515 | Pressurized Gasification Apparatus to Convert Coal or Other Carbonaceous Material to Gas While Producing a Minimum Amount of Tar - An apparatus for the gasification of coal or other carbonaceous material is provided for operation at an elevated pressure of at least 30 psia, preferably, between 30 psia and 150 psia. Coal or other carbonaceous material passes downwards through two interconnected sections of a gasifier. In the upper section the coal is dried and partially devolatalized and so converted into a char before it passes into the lower section where it is converted, by reaction with steam and air, into ash and a gaseous mixture of carbon monoxide, hydrogen, carbon dioxide, methane, ethane, ethylene, hydrogen sulphide, carbonyl sulphide and small amounts of ammonia and phenols. The coal, ultimately converted to ash, exits the gasifier through a flanged semi-spherical containment section that has an integrated rotating grate, which collects and disposes of the ash and through which pass the air and steam used as reactants in the gasifier. | 03-04-2010 |
20110232088 | INTEGRATION OF COAL FIRED STEAM PLANTS WITH INTEGRATED GASIFICATION COMBINED CYCLE POWER PLANTS - A method of improving the output and efficiency of a pulverized coal plant by integration with an integrated gasification combined cycle plant. Specifically, embodiments of the invention provide improvements in the performance of an existing coal steam turbine electrical generating plant by the addition of coal gasifiers, a gas turbine and a heat recovery steam generator. | 09-29-2011 |
20120285176 | INTEGRATION OF COAL FIRED STEAM PLANTS WITH INTEGRATED GASIFICATION COMBINED CYCLE POWER PLANTS - A method of improving the output and efficiency of a pulverized coal plant by integration with a gas turbine and a Heat Recovery Steam Generator. Specifically, embodiments of the invention provide improvements in the performance of an existing coal steam turbine electricity generating plant by the addition of coal gasifiers, a gas turbine and a heat recovery steam generator. | 11-15-2012 |
Douglas A. Wakefield, Worcester, MA US
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20120175938 | Roadway Grinding/Cutting Apparatus and Monitoring System - A roadway grinding system is disclosed and can include a frame and a first cutting blade disposed within the frame. The first cutting blade can include a core. Further, a plurality of abrasive segments can be spaced apart from each other on the core. A first sensor can be disposed on the frame and can be configured to detect blade wear as a change in the distance between an outermost circumference of the first cutting blade and a predetermined distance. | 07-12-2012 |
Franz Antonio Wakefield, Miami, FL US
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20140317559 | METHOD, SYSTEM, APPARATUS, AND TANGIBLE PORTABLE INTERACTIVE ELECTRONIC DEVICE STORAGE MEDIUM; THAT PROCESSES CUSTOM PROGRAMS AND DATA FOR A USER BY CREATING, DISPLAYING, STORING, MODIFYING, PERFORMING ADAPTIVE LEARNING ROUTINES, AND MULTITASKING; UTILIZING CASCADE WINDOWS ON AN ELECTRONIC SCREEN DISPLAY IN A MOBILE ELECTRONIC INTERCATIVE DEVICE GUI (GRAPHICAL USER INTERFACE) SYSTEM - The instant invention comprises an apparatus, system, method, and tangible interactive mobile device storage medium, for creating, displaying, storing, modifying, performing adaptive learning routines, and multitasking; utilizing Cascade Windows™ on a display in an interactive mobile device GUI (Graphical User Interface) system; where the Cascade Windows created and displayed by The Cascade Software™ Technology Invention arranges the active interface of various mobile smartphone/device systems into adjustable dimension windows opened on the mobile device screen simultaneously so that multitasking is more efficient and effortless. This process and option of cascading various system and/or application windows simultaneously, creates a powerful tool for the user and a culminating technical effect that allows the user to go back in time, and view on the display various screen configurations ranked high in importance by the user and the machine, which occurred over a specific time interval in the past. | 10-23-2014 |
Gary C. Wakefield, Slippery Rock, PA US
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20120018668 | Compositions and Methods for Anti-Icing/De-Icing - Methods are provided which minimize loss of an anti-icing/de-icing composition from a surface. This is accomplished by adhering the anti-icing/de-icing composition to a surface using a film-forming polymeric composition. Methods are also provided for preventing snow accumulation and/or ice formation on a surface, delaying ice and/or snow formation on a surface, extending the life of an anti-icing/de-icing composition on a surface, surface anti-icing, and surface de-icing. These methods include the application of a film-forming polymeric composition and the anti-icing/de-icing composition to the surface. Desirably, the anti-icing/de-icing composition is a reagent which reduces the freezing point of water. | 01-26-2012 |
Gregory Wakefield, Ann Arbor, MI US
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20100280307 | USING A GENETIC ALGORITHM IN MIXED MODE DEVICE - Apparatus and method for at least partially fitting a medical implant system to a recipient is described. The medical implant system is configured to provide electrical stimulation and at least one other mode of stimulation to the recipient. These apparatuses and methods comprise executing a genetic algorithm to select a set of parameter values for the medical implant system. This genetic algorithm may comprise generating successive generations of child populations and then providing a determined set of parameter values to the medical implant system for use in providing stimulation to the recipient. | 11-04-2010 |
Gregory H. Wakefield, Ann Arbor, MI US
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20100152813 | USING A GENETIC ALGORITHM TO FIT A MEDICAL IMPLANT SYSTEM TO A PATIENT - Apparatus and method for at least partially fitting a medical implant system to a patient is described. These apparatuses and methods comprise executing a genetic algorithm to select a set of parameter values for the medical implant system. This genetic algorithm may comprise executing a tabu search wherein value sets that are determined to be bad are added to a tabu list that may be consulted to exclude tabu value sets from successive generations of the genetic algorithm. | 06-17-2010 |
20110060383 | USING A GENETIC ALGORITHM EMPLOYING DYNAMIC MUTATION - Apparatus and method for at least partially fitting a medical implant system to a patient is described. These apparatuses and methods comprise using a dynamic mutation rate. This genetic algorithm may comprise generating successive generations of child populations. In executing the genetic algorithm, children may undergo mutations based on a mutation rate. This mutation rate may be dynamic and be based on the characteristics of the children in the generation. Additionally, values may be frozen during execution of the genetic algorithm if the likelihood that the value has converged on a particular value exceeds a threshold. | 03-10-2011 |
20130103113 | USING A GENETIC ALGORITHM TO FIT A MEDICAL IMPLANT SYSTEM TO A PATIENT - Apparatus and method for at least partially fitting a medical implant system to a patient is described. These apparatuses and methods comprise executing a genetic algorithm to select a set of parameter values for the medical implant system. This genetic algorithm may comprise executing a tabu search wherein value sets that are determined to be bad are added to a tabu list that may be consulted to exclude tabu value sets from successive generations of the genetic algorithm. | 04-25-2013 |
I. Nelson Wakefield, Cary, NC US
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20090312060 | SYSTEM AND METHOD FOR INDICATING DATA TRANSFER RATE - An electronic device provides a user with a direct and intuitive indication of achieved data transfer rates. In one embodiment, a vibrator is controlled to provide a tactile indication of upload and/or download speeds. Other embodiments relate to visual and/or audio indications of data transfer speed. Combinations of these indicators are also described. | 12-17-2009 |
Ivan N. Wakefield, Cary, NC US
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20090129693 | SYSTEM AND METHOD FOR GENERATING A PHOTOGRAPH WITH VARIABLE IMAGE QUALITY - A method and system of quality management for a digital photograph includes using multi-zone autofocus information to generate an image file that has a high-quality portion and a low-quality portion. In one approach, captured image data is processed so that a portion of the image data corresponding to an area different than a focus zone is lower in quality than image data corresponding to an area inside the focus zone. In another approach, sensor resolution responsiveness is set higher for a sensor area corresponding to a focus zone than sensor resolution responsiveness in an area different than the sensor area corresponding to the focus zone. | 05-21-2009 |
James Wakefield, Brookline, MA US
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20110009343 | MODULATORS OF AMYLOID AGGREGATION - Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural β amyloid peptides (β-AP). In a preferred embodiment, the β amyloid modulator compounds of the invention are comprised of an Aβ aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural β amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural β-AP aggregation when the natural β-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed. | 01-13-2011 |
Jeffrey A. Wakefield, Big Lake, MN US
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20140352813 | SYSTEM AND METHODS FOR CONTROL AND MONITORING OF A FIELD DEVICE - A method of collecting data in a field device includes receiving indications of variables for which data is collected, receiving indications of trigger events to trigger collection of data, receiving threshold values associated with each of the trigger events, monitoring the trigger events, and initiating data collection when at least one of the trigger events crosses one the threshold values associated with the corresponding trigger event. A method of tuning a PID controller in a field device includes setting a limited range for selecting a value for a control parameter of the PID controller, selecting the value of the control parameter, wherein the selected value is constrained to be within the limited range, transmitting the selected value to the field device, obtaining, from the field device, a measurement of a response of the field device to a setpoint change, and displaying the obtained response measurements to a user. | 12-04-2014 |
Jeffrey Allen Wakefield, Big Lake, MN US
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20140352408 | SYSTEM AND METHOD FOR DIAGNOSING A FIELD DEVICE - A diagnostic system and method for a pressure regulator in a process plant is provided. The diagnostic apparatus includes a processor operatively coupled to the pressure regulator; a memory operatively coupled to the processor; and a sensor operatively coupled to an inlet valve of the pressure regulator, an exhaust valve of the pressure regulator, and the processor. A diagnostic module is stored in the memory, and when executed by the processor, presents a diagnostic tool at a user interface. | 12-04-2014 |
John Wakefield, Birmingham, AL US
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20140213639 | Optimization of Vectors for Effective Delivery and Expression of Genetic Content - Lentiviral vectors, plates, kits and methods are provided that permit improved efficiency for selection of a promoter sequence for use in a lentiviral application. Through various embodiments of the present invention, a researcher may first evaluate and then choose in a modular fashion, a vector comprising a promoter that is effective for expression in a particular cell line or type. | 07-31-2014 |
John K. Wakefield, Birmingham, AL US
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20120083035 | Modified Cell Lines for Increasing Lentiviral Titers - The present disclosure provides a method of modifying cells in order to enhance lentiviral titers, cell lines that are modified and modifying reagents. By mediating individual genes and combination thereof, lentiviral titers may be increased. | 04-05-2012 |
20130217121 | Modified Cell Lines for Increasing Lentiviral Titers - The present disclosure provides a method of modifying cells in order to enhance lentiviral titers, cell lines that are modified and modifying reagents. By mediating individual genes and combination thereof, lentiviral titers may be increased. | 08-22-2013 |
John K. Wakefield, Houston, TX US
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20150068739 | Wellbore Completion for Methane Hydrate Production with Real Time Feedback of Borehole Integrity Using Fiber Optic Cable - In producing methane a bottom hole assembly the borehole may enlarge due to shifting sands in an unconsolidated formation as the methane is produced. The enlargement of the borehole can be sensed in real time such as by using a fiber optic cable. In response to such information parts of the bottom hole assembly near the washout can be isolated or the bottom hole assembly in the vicinity of the washout can be fortified with inserts from the surface to minimize damage from erosion caused by higher velocities resulting from borehole washouts. | 03-12-2015 |
Jonathan Wakefield, Shumway, IL US
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20140197206 | Dispenser - A dispenser for animal feed or other granular material in which the material is dispensed as a mound, includes a dispenser body with a container having an outlet for discharging material by gravity feed onto a surface, a shelf or other moveable member beneath the outlet that travels vertically relative to the container to vary the gap between the container outlet and the surface, and an actuator to permit adjustment of the moveable member. The actuator uses frictional force to retain the moveable member in a selected position, which can be adjusted by overcoming the frictional force. | 07-17-2014 |
Joshua Benjamin Wakefield, Durham, NC US
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20140282106 | SYSTEMS AND METHODS FOR GESTURE-BASED SHARING OF DATA BETWEEN SEPARATE ELECTRONIC DEVICES - Described herein are various embodiments of systems, methods, and apparatus that allow a user to share data, such as one or more files from within an application with one or more other (not necessarily co-located) computing devices using a gesture-based sharing function. In a particular example, systems, methods, and apparatus described herein may be used to share graphical representations of chemical structures within a chemical structure rendering application between two or more user devices. By offering a user a quick and visually intuitive option for sharing a file with other user(s) without exiting a current application, the systems, methods, and apparatus described herein provide efficient and engaging tools for sharing work product in real time between two or more users. | 09-18-2014 |
Kenneth Wakefield, Dallas, TX US
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20130133590 | ATTACHMENT FOR FENCE SYSTEM AND METHOD OF USE - An attachment and method for a fence system to prevent a pet from escaping a fenced comprising at least one first support member adapted to be attached substantially horizontally to at least a portion of the fence system, a plurality of second support members adapted to be attached substantially vertically to the at least one first support member, and a plurality of inserts adapted to be received within the plurality of second support members. Each of the plurality of inserts is capable of extending out of a lower portion of the each of the plurality of second support members upon digging the fenced area by the pet animal such that the extended plurality of inserts block the dug area to prevent the pet animal from escaping the fenced area. | 05-30-2013 |
Paul C. Wakefield, Lehigh Acres, FL US
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20160096397 | Thermochromic Bathtub Shower Sheet Toy - Thermochromic Bathtub Shower Sheet Toy invention is laminated sheets with enclosed thermochromic illustrations which are placed in a shower/bath tub. The invention has an illustrated printed insert, which illustrations are covered by opaque thermochromic ink. That thermochromic ink clarifies as a temperature of about 75 degrees F. As the child splashes warm bath water on the laminated illustration, the thermochromic ink covering clarifies, and the entertaining illustration is revealed. This entertains and educates the child receiving the bath. | 04-07-2016 |
Robin Wakefield, Seattle, WA US
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20130080444 | Chart Recommendations - Chart recommendations may be provided. First, a summary of a dataset may be determined and each column and row in the dataset, based on the summary, may be classified into classifications. Next, based upon the classifications of each column and row in the dataset, the dataset may be mapped to a plurality of chart types. Each of the plurality of chart types may then be ranked. | 03-28-2013 |
20130091413 | Rich Data Label Formatting - Rich data label formatting may be provided. A rich data label may be created for at least one data point associated with a visualization. The data label may be formatted and displayed on the visualization. In response to determining that the change event has occurred on the visualization, the display of the formatted label may be updated according to the change event. | 04-11-2013 |
20130093782 | Color Selection and Chart Styles - Color selection may be provided. First, a selection of a target object may be received and a color selection mode may be entered. Then a color preview may be provided in response to entering the color selection mode. Next, a color selection may be received in response to providing the color preview. A color of a property of the selected target object may then be set to the received color selection. | 04-18-2013 |
20130097177 | SUGGESTING ALTERNATE DATA MAPPINGS FOR CHARTS - Data mapping alternatives for creating a visual representation of a set of data are presented. A set of data is identified for analysis. The identified set of data and properties associated with the identified set of data are analyzed. Based on the analysis, data mapping alternatives for the identified set of data are determined. The determined data mapping alternatives for the identified set of data are ranked. The determined data mapping alternatives are presented in an order according to the ranking of the determined data mapping alternatives. | 04-18-2013 |
20150212981 | PROVIDING PRINT VIEW OF DOCUMENT FOR EDITING IN WEB-BASED APPLICATION - Technologies are generally provided for enabling the viewing and editing the printed output of a document consistently in web-based application while a printed output of the document looks the same across different browsers as well as desktop client applications. A print view of a document handled by a server hosting the web-based application may be generated at the server, updated as edits are made to the document, and provided to a requesting browser or desktop client application such that the print view is consistent across multiple browsers and the client application. | 07-30-2015 |
20160026695 | SUGGESTING ALTERNATE DATA MAPPINGS FOR CHARTS - Data mapping alternatives for creating a visual representation of a set of data are presented. A set of data is identified for analysis. The identified set of data and properties associated with the identified set of data are analyzed. Based on the analysis, data mapping alternatives for the identified set of data are determined The determined data mapping alternatives for the identified set of data are ranked. The determined data mapping alternatives are presented in an order according to the ranking of the determined data mapping alternatives. | 01-28-2016 |
20160103796 | Rich Formatting for a Data Label Associated with a Data Point - Rich formatting may be provided for rich data labels. A rich data label may be created for at least one data point associated with a visualization. The data label may be formatted and displayed on the visualization. The rich data label may bind to a particular data point rather than adhering to conventional index-based anchor logic where a data label is bound to the index of a data point. Accordingly, in response to determining that the location of the data point has changed in the visualization, the location of the rich data label is automatically adjusted to remain attached to its original data point. | 04-14-2016 |
Scott Wakefield, Andover, MA US
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20140248795 | Electric Plug System - An electric plug system includes a stabilizing base constructed to stand on a horizontal floor surface, a vertical support element supported by and extending from the base and defining a vertical axis, and an electrical socket block coupled to a top portion of the vertical support element and supported thereby. The electrical socket block has a plurality of electrical sockets constructed to receive the plugs of the devices. Also, the system includes an electrical wire extending from the horizontal electrical socket block, down the vertical support element, and along or through the base and there-beyond, the electrical wire terminating in an electrical plug constructed to plug into the wall or floor electrical outlet. The system can include a device holder removably attached to the vertical support element. The base can include a first base portion and a second base portion removably attached to one another. | 09-04-2014 |
Scott H. Wakefield, Andover, MA US
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20150217337 | VESSEL AND PUMPING APPARATUS FOR CLEANING A SCRUBBING ARTICLE - A scrubbing article cleaning device may include a hollow vessel capable of retaining liquid and having an open top, a pumping apparatus having a handle connected to a top end of a pole portion, wherein said pole portion includes at least one segment of perforated pipe, and a plunger assembly connected to said pole portion, wherein said plunger assembly may include one or more perforated disks and one or more filter media. | 08-06-2015 |
20150286296 | ADJUSTABLE POINTING DEVICE - Methods and apparatus provide for an adjustable pointing device. The adjustable pointing device includes a base and an adjustable arm connecting a portion of the base with an input control portion. The input control portion includes at least one input control. A first end of the adjustable arm, which is distal from the base, allows for and independently maintains changes to various orientations of the input control portion. In other words, after the user adjusts the input control portion to be set at a new orientation, the first end of the adjustable arm maintains the input control portion at the new orientation as the user interacts with the adjustable pointing device. In addition, a second end of the adjustable arm, proximal to the base, also allows for and independently maintains changes in a distance between the input control portion and the base itself. | 10-08-2015 |
Stephen Wakefield, Hobe Sound, FL US
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20080295383 | Fishing pole tender system - A fishing pole tender system for temporary attachment to a horizontal support structure, such as a bench seat provided on a boat. The tender system includes a generally rigid frame having a top sized to extend over the support structure, the top having a first end and a second end. A first side depends perpendicularly from the first end of the top. A second side depends perpendicularly from the second end of the top, and has a first section that is parallel with the first side, and a second section that is inclined inwardly towards the first side, with the first section sized to extend over a vertical depth of the support structure such that the second section extends at least partially underneath the support structure. A fishing pole holder is secured to the first side, formed of a hollow sleeve having a notch therein for receiving a fishing reel. | 12-04-2008 |
Steve Wakefield, Billerica, MA US
Steven B. Wakefield, Billerica, MA US
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20110032678 | NANO-TUBE THERMAL INTERFACE STRUCTURE - A structure, comprising: a semiconductor structure having an electrically and thermally conductive layer disposed on one surface of the semiconductor structure; an electrically and thermally conductive heat sink; a electrically and thermally conductive carrier layer; a plurality of electrically and thermally nano-tubes, a first portion of the plurality of nano-tubes having proximal ends disposed on a first surface of the carrier layer and a second portion of the plurality of nano-tubes having proximal ends disposed on an opposite surface of the carrier layer; and a plurality of electrically and thermally conductive heat conductive tips disposed on distal ends of the plurality of nano-tubes, the plurality of heat conductive tips on the first portion of the plurality of nano-tubes being attached to the conductive layer, the plurality of heat conductive tips on the second portion of the plurality of nano-tubes being attached to the heat sink. | 02-10-2011 |
20120094484 | NANO-TUBE THERMAL INTERFACE STRUCTURE - A structure, comprising: a semiconductor structure having an electrically and thermally conductive layer disposed on one surface of the semiconductor structure; an electrically and thermally conductive heat sink; a electrically and thermally conductive carrier layer; a plurality of electrically and thermally nano-tubes, a first portion of the plurality of nano-tubes having proximal ends disposed on a first surface of the carrier layer and a second portion of the plurality of nano-tubes having proximal ends disposed on an opposite surface of the carrier layer; and a plurality of electrically and thermally conductive heat conductive tips disposed on distal ends of the plurality of nano-tubes, the plurality of heat conductive tips on the first portion of the plurality of nano-tubes being attached to the conductive layer, the plurality of heat conductive tips on the second portion of the plurality of nano-tubes being attached to the heat sink. | 04-19-2012 |
Theodore D. Wakefield, Vermillion, OH US
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20080269959 | METHOD AND APPARATUS FOR REPROGRAMMING A PROGRAMMED CONTROLLER OF A POWER DRIVEN WHEELCHAIR - Apparatus for reprogramming a programmed controller of a power driven wheelchair comprises: a reprogrammable, non-volatile memory programmed with a plurality of programs executable by the controller to operate the wheelchair, the non-volatile memory disposed at the wheelchair and coupled to the wheelchair controller; a general-purpose computer programmed to reprogram the non-volatile memory while disposed at the wheelchair, the programmed computer for storing main programs for use in reprogramming the non-volatile memory, the programmed computer being coupleable to the wheelchair controller for accommodating an exchange of data therebetween; and wherein the wheelchair controller being operative to communicate with the programmed computer to reprogram the non-volatile memory with the main programs while the non-volatile memory is disposed at the wheelchair. Methods for reprogramming the non-volatile memory are also disclosed. | 10-30-2008 |
William Wakefield, Waterford, MI US
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20130154224 | AXLE SUSPENSION SYSTEM - An axle suspension system for a vehicle. The axle suspension system may include an axle having an exterior surface and an axle wrap. The axle wrap may include a wrap portion, a cam bracket, and an actuator bracket. The wrap portion may engage the exterior surface. The cam bracket and actuator bracket may be spaced apart and may extend from the wrap portion. | 06-20-2013 |