Ley
Arthur N. Ley, Kingston CA
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20090117600 | Detection of biological molecules by differential partitioning of enzyme substrates and products - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 05-07-2009 |
20130217041 | DETECTION OF BIOLOGICAL MOLECULES BY DIFFERENTIAL PARTITIONING OF ENZYME SUBSTRATES AND PRODUCTS - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 08-22-2013 |
20140295403 | DETECTION OF BIOLOGICAL MOLECULES BY DIFFERENTIAL PARTITIONING OF ENZYME SUBSTRATES AND PRODUCTS - This invention relates to a method and apparatus for detecting a biological molecule associated with enzyme activity in a sample. The invention is applicable to detecting a microorganism associated with an enzyme in a sample such as water, food, soil, or a biological sample. According to a preferred embodiment of the method of the invention, a sample containing an enzyme of interest or a microorganism associated with the enzyme is combined with a suitable substrate, and a fluorescent product of the enzyme-substrate reaction is selectively detected. The fluorescent product is detected with a partitioning element or optical probe/partitioning element of the invention. In one embodiment the partitioning element provides for partitioning of only the fluorescent product molecule into the probe. The invention also provides an automated system for monitoring for biological contamination of water or other samples. | 10-02-2014 |
Deborah Ley, Plan-Les-Ouates CH
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20150361451 | Enhanced Transgene Expression and Processing - Disclosed are constructs and methods for expressing DNAs of interest in particular in non-primate eukaryotic host cells that display advantages with regard quantity and quality of expression including high stability of expression and, if appropriate, transport of the expression product out of the cell. | 12-17-2015 |
John Martin Ley, Brentwood GB
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20090232166 | ELECTRO-OPTIC DEFLECTOR - An electro-optic deflector | 09-17-2009 |
Kim Michael Ley, Bristol GB
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20080272237 | Aircraft Auxiliary Fuel Tank System and Method - One or more main aircraft fuel tanks are provided with one or more fuel gauges arranged to provide a measure of the amount of fuel in said one or more main fuel tanks. One or more auxiliary fuel tanks are also provided. The aircraft uses fuel during a first phase of fuel consumption, upon commencement of which phase the auxiliary fuel tanks hold fuel. After the first phase said one or more auxiliary fuel tanks are empty and a second phase commences. During the first phase, an indication of the amount of fuel carried by the aircraft is provided by means of summing (i) the amount of fuel in the main fuel tanks as measured by said one or more fuel gauges and (ii) the amount of fuel remaining in said one or more auxiliary fuel tanks as calculated using a measure relating to the fuel consumption rate. During the second phase of fuel consumption, an indication of the amount of fuel carried by the aircraft is provided on the basis of the amount of fuel measured by said one or more fuel gauges. | 11-06-2008 |
Stephen Ley, London GB
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20110149248 | METHOD AND SYSTEM FOR FILMING - This invention concerns a method of filming a subjected to be projected as a Pepper's Ghost image. The method may comprise filming a subject under a lighting arrangement having one or more front lights for illuminating a front of a subject and one or more backlights. The lights may be controlled such that the total brightness of the one or more front lights, as measured of the subject, is less than or approximately the same as the total brightness of the one or more backlights, as measured at the subject. The subject may be located directly above one or more floor lights such the subject is illuminated from below by the one or more floor lights. The lights may comprise one or more LEDs. A drop-off distance of the front lights may be less than a distance between the front lights and a backscreen. The invention further concerns a lighting control system comprising an input device for receiving inputs on characteristics of the subject to be filmed and a controller arranged to determine from the inputs a required configuration for the lamps and send control signals to at least one of the lamps to cause the lamps to adjust to the required configuration. The lighting system may comprise a controller connected to a data link providing data on a lighting environment at a location where the film of the subject is being projected as a Pepper's Ghost image, the controller controlling the lamps to adjust configuration during filming in response to data on changes in the lighting environment. | 06-23-2011 |
20150227028 | Method and System for Filming - This invention concerns a method of filming a subjected to be projected as a Pepper's Ghost image. The method may comprise filming a subject under a lighting arrangement having one or more front lights for illuminating a front of a subject and one or more backlights. The lights may be controlled such that the total brightness of the one or more front lights, as measured of the subject, is less than or approximately the same as the total brightness of the one or more backlights, as measured at the subject. The subject may be located directly above one or more floor lights such the subject is illuminated from below by the one or more floor lights. The lights may comprise one or more LEDs. A drop-off distance of the front lights may be less than a distance between the front lights and a backscreen. The invention further concerns a lighting control system comprising an input device for receiving inputs on characteristics of the subject to be filmed and a controller arranged to determine from the inputs a required configuration for the lamps and send control signals to at least one of the lamps to cause the lamps to adjust to the required configuration. The lighting system may comprise a controller connected to a data link providing data on a lighting environment at a location where the film of the subject is being projected as a Pepper's Ghost image, the controller controlling the lamps to adjust configuration during filming in response to data on changes in the lighting environment. | 08-13-2015 |
Steven Ley, London GB
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20080199469 | Regulation and function of TPL-2 - The invention relates to the use of ABIN2 to stabilise TPL-2, and a ternary complex formed between ABIN2, TPL-2 and p105, as well as assays for compounds capable of modulating the interaction between ABIN2 and TPL-2 and/or p105 and use of such compounds in the treatment of inflammatory conditions. | 08-21-2008 |
Steven Victor Ley, Cambridge GB
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20100249233 | COMPOUND AND USE THEREOF IN THE TREATMENT OF AMYLOIDOSIS - The present invention relates to compounds of formula (I) for stabilizing the tetrameric form of transthyretin, compounds for use in the treatment or prevention of amyloidosis, and agents and medicaments comprising such compounds. | 09-30-2010 |