Patent application number | Description | Published |
20110173077 | Personalized Interactive Network Architecture - A system for personalizing interaction between a user communicating over at least one communication channel and a provider of information/products/services, the user having a communication device for communication over the channel with the provider, the system comprising a channel interface for interfacing with the channel, an information/product/service interface for interfacing with an information/product/service provider; and a knowledge management system coupled to the channel and information/product/service interface, the knowledge management system comprising a knowledge management repository storing information concerning the user, the information obtained from interaction with the user over the channel including current interactions between the user and the knowledge management system, and further storing information concerning a plurality of information/products/services to offer to the user, and a personalization engine for making a decision as to which of the plurality of information/product/services to present to the user over the communication channel based on the stored information in the knowledge management repository. | 07-14-2011 |
20120150659 | Personalized Interactive Network with Multiple Channels Coupled to Integrated Knowledge Management system - Systems and methods are disclosed for personalizing interaction between an information/service/product provider using a knowledge management (KM) system that tracks data exchanged between users and the provider over multiple communication channels. User requests to an information/service/product provider can made via multiple different channels, such as by using ATMs, PDAs, cell phones, computers accessing web sites or other Web Devices, Voice Response Units (VRUs), and others. User requests submitted over these multiple channels are routed into an integrated KM system that services these requests and selects personalized offers and/or personalized content and/or personalized format presentation to be provided to the users | 06-14-2012 |
20130151349 | Personalized Interactive Network with Knowledge Management System - Systems and methods are disclosed for personalizing interaction between an information/service/product provider using a knowledge management (KM) system that tracks data exchanged between users and the provider over multiple communication channels. User requests to an information/service/product provider can made via multiple different channels, such as by using ATMs, PDAs, cell phones, computers accessing web sites or other Web Devices, Voice Response Units (VRUs), and others. User requests submitted over these multiple channels are routed into an integrated KM system that services these requests. The user requests are serviced in such a manner that they are personalized in multiple aspects to enrich the user's experience. | 06-13-2013 |
20130246189 | Personalized Interactive Network for Delivery of Information Including Targetted Offers for Goods and Services - Systems and methods personalize interaction between a central server system, a plurality of consumers, and a plurality of providers of information regarding products and services of potential interest. For each consumer, a plurality potential offers may be generated for various products and/or services. The system may generate a list of personalized offers for each consumer corresponding to various products and/or services to promote to that consumer. When a consumer interacts with the central server system, a response results in the delivery of responsive content as well as personalized offer content. Consumers can interact with the system over a variety of communication channels and user devices, including ATMs, PDAs, cell phones, computers accessing web sites or other Web Devices, Voice Response Units (VRUs), and others. | 09-19-2013 |
20130346246 | PERSONALIZED INTERACTIVE NETWORK WITH SOCIAL MARKETING PERSONALIZED OFFERS - Systems and methods are disclosed for personalizing interaction between an information/service/product provider using a knowledge management (KM) system that tracks data exchanged between users and the provider over multiple communication channels. User requests to an information/service/product provider can made via multiple different channels, such as by using ATMs, PDAs, cell phones, computers accessing web sites or other Web Devices, Voice Response Units (VRUs), and others. User requests submitted over these multiple channels are routed into an integrated KM system that services these requests and selects personalized offers and/or personalized content and/or personalized format presentation to be provided to the users. | 12-26-2013 |
20140012683 | Personalized Interactive Network for Debt Management - Systems and methods are disclosed for personalizing interaction between an information/service/product provider using a debt management system that tracks data exchanged between users and the provider over multiple communication channels. User requests to an information/service/product provider can made via multiple different channels, such as by using ATMs, PDAs, cell phones, computers accessing web sites or other Web Devices, Voice Response Units (VRUs), and others. User requests submitted over these multiple channels are routed into an integrated debt management system that services these requests and selects personalized offers and/or personalized content and/or personalized format presentation to be provided to the users. | 01-09-2014 |
Patent application number | Description | Published |
20080301022 | Real-Time Core Integration Method and System - Embodiments include a system, or platform, and method allowing financial institutions (FIs) to have access to an account opening platform that is capable of completing every aspect of the account opening approval process for the FI, and that is also capable of interfacing with their respective core systems (regardless of type or protocol) for receiving account opening requests from customers. Account opening requests may encounter permanent or temporary errors. When temporary errors are encountered, the account opening request is placed in a queue and automatically retried until the error is resolved. The account opening platform performs real-time integration with a variety of core systems such that approved new accounts are immediately “boarded” to the FI's core. In an embodiment, the platform is a plug-and-play” architecture such that adding the ability to communicate with new or different cores requires minimal effort. For example, no recoding of basic FMS software is required, but only coding of a plug-in module for a specific FI. | 12-04-2008 |
20080301023 | Multi-Channel and Cross-Channel Account Opening - Embodiments as described herein include methods and a system for multi-channel and cross-channel account opening. An applicant may start an account opening process in one channel and move to one or more other channels without any application data being lost. A financial management system (FMS) provides a single account opening platform for multiple financial institutions (FIs) such that an application to open an account is handled by the FMS platform using shared resources among channels, and applying rules specified by each FI. | 12-04-2008 |
20090024505 | Global Risk Administration Method and System - Embodiments of a Global Risk Administration (GRA) method and system include a GRA tool that assists an institution with various decision making processes by enabling the institution to customize the GRA tool to generate decisions based on information input by the institution or a customer of the institution. The GRA tool further accesses third party data sources for the purpose of verifying information and gathering additional information to be used in generating decisions. The data sources are selectable by the institution as an aspect of the customization in an embodiment. In an embodiment, the institution is a financial institution (FI), and customizing the GRA tool involves an FI user assigning attribution rules using, wherein attribution rules comprise characteristics of applicants for financial accounts. The user further creates one or more decision classes using the UI, wherein one or more attribution rules place an applicant in a decision class; and the user creates business rules, wherein a business rule determines a manner in which the GRA module interprets data from the third party data sources. | 01-22-2009 |
20120271743 | Global Risk Administration Method and System - Embodiments of a Global Risk Administration (GRA) method and system include a GRA tool that assists an institution with various decision making processes by enabling the institution to customize the GRA tool to generate decisions based on information input by the institution or a customer of the institution. In an embodiment, the institution is a financial institution (FI), and customizing the GRA tool involves an FI user assigning attribution rules using, wherein attribution rules comprise characteristics of applicants for financial accounts. The user further creates one or more decision classes using the UI, wherein one or more attribution rules place an applicant in a decision class; and the user creates business rules, wherein a business rule determines a manner in which the GRA module interprets data from the third party data sources. | 10-25-2012 |
Patent application number | Description | Published |
20120201541 | ROUTING, WAVELENGTH ASSIGNMENT, AND SPECTRUM ALLOCATION IN WAVELENGTH CONVERTIBLE FLEXIBLE OPTICAL WAVELENGTH-DIVISION MULTIPLEXING NETWORKS - There is provided a method in a wavelength convertible flexible optical wavelength-division multiplexing (WC-FWDM) network. The network has a plurality of optical nodes interconnected by a plurality of optical fibers. The network is for providing an overall spectrum divisible into a set of consecutive wavelength slots. At least one optical node has at least one wavelength converter for wavelength conversion. The method includes determining a channel route through the network commencing at a source node and ceasing at a destination node. The determined channel route is selectively tunable responsive to selected ones of a plurality of routing methods. The routing methods are so selected responsive to a routing policy having one or more objectives of minimization of channel blocking, minimization of a number of wavelength converters used in the network, and minimization of physical distance traversed by a channel, and minimization of operating wavelengths of a channel. | 08-09-2012 |
20120213517 | OPTICAL-LAYER TRAFFIC GROOMING IN FLEXIBLE OPTICAL NETWORKS - Methods and systems for optical signal grooming that include providing one or more input signals, each having one or more modulated subcarriers, to a grooming processor; and grooming the input signals at a subcarrier level with the grooming processor to produce one or more output signals by arranging the modulated subcarriers in the output signals according to a grooming operation such that the modulated subcarriers are not demodulated or decoded prior to grooming. | 08-23-2012 |
20120213523 | OPTICAL-LAYER TRAFFIC GROOMING AT AN OFDM SUBCARRIER LEVEL WITH PHOTODETECTION CONVERSION OF AN INPUT OPTICAL OFDM TO AN ELECTRICAL SIGNAL - A method for optical layer traffic grooming includes receiving at least two optical input signals into respective optical receivers, each optical receiver having a photodetector for converting the respective optical input signal into a respective electrical signal; a grooming processor responsive to the electrical signals, the grooming processor being a radio frequency RF processor for processing the electrical signals at a subcarrier level to produce an RF orthogonal frequency division multiplexing signal OFDM signal; and modulating the groomed RF OFDM signal at a transmitter for conversion of the groomed RF OFDM into an optical signal. | 08-23-2012 |
20150043915 | PROVISIONING TIME-VARYING TRAFFIC IN SOFTWARE-DEFINED FLEXIBLE GRID TRANSPORT NETWORKS - A method is provided for provisioning time-varying traffic demands in an optical transport software-defined network. The method includes pre-provisioning an amount of bandwidth for best effort traffic. The method further includes iteratively applying, using a processor, an iterative simulated annealing-based traffic provisioning procedure to determine candidate bandwidths for the best effort traffic in a set of iterations. The method also includes selecting a particular candidate bandwidth that has a corresponding blocking value lower than a given blocking requirement β and that requires a minimum amount of spectrum as compared to other candidate bandwidths. The iteratively applying step includes varying the amount of bandwidth for best effort traffic in each iteration to determine the candidate bandwidths. The iteratively applying step further includes varying an amount of shared bandwidth between neighboring channels, out of the amount of bandwidth for best effort traffic, in each iteration, to further determine the candidate bandwidths. | 02-12-2015 |
Patent application number | Description | Published |
20100247608 | PHARMACEUTICAL COMPOSITIONS COMPRISING HGH FOR ORAL DELIVERY - The present invention relates to dosage forms of human growth hormone, the use of an absorption enhancer to allow absorption of human growth hormone into the systemic circulation in a biologically active form, in particular after oral administration, as well as the use of oral dosage forms comprising human growth hormone and an absorption enhancer for the treatment of human growth hormone deficiencies and disorders associated therewith. | 09-30-2010 |
20100286100 | Method and composition to improve absorption of therapeutic agents - A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the crystals upon co-milling. The blend is then compressed to form tablets that have an enhanced dissolution profile for the medicinally active ingredient. | 11-11-2010 |
20120244218 | Calcium supplement - An oral dosage form for administration to an animal comprising a biologically utilizable form of calcium and a extended release system that maintains the calcium level in the animal's bloodstream at a substantially beneficial level for a defined period of time. | 09-27-2012 |
20130122098 | Method and composition to improve absorption of therapeutic agents - A tablet with an enhanced dissolution profile for a medicinally active ingredient such as aspirin and methods for making the tablet. The tablet comprises a blend of crystals of the medicinally active ingredient and a dissolution aid such as sodium or calcium carbonate or bicarbonate that coats the crystals upon co-milling. The blend is then compressed to form tablets that have an enhanced dissolution profile for the medicinally active ingredient. | 05-16-2013 |
Patent application number | Description | Published |
20090173890 | Detector for a UV false positive of radiation sensitive devices - Disclosed is a detector for monitoring a UV false positive from genuine X-ray positive of color developing radiation sensitive devices. A layer which can be scratched off and is opaque to undesired radiation but transparent to X-ray is printed on the sensor. If the sensor displays a signal (i.e., develops color), whether it is genuine or false positive can be confirmed by scratching off the opaque layer. If the signal is a genuine positive, the whole sensor will be uniformly exposed/colored including the area under the opaque layer. If it is a false positive, the area under the scratched off layer will be of lighter color than the rest of the sensor. | 07-09-2009 |
20090301382 | Monitoring System Based on Etching of Metals - Compositions, devices and processes related to etching of a very thin layer or fine particles of a metal are disclosed for monitoring a variety of parameters, such as time, temperature, time-temperature, thawing, freezing, microwave, humidity, ionizing radiation, sterilization and chemicals. These devices have capabilities of producing a long and sharp induction period of an irreversible visual change. The devices are composed of an indicator comprising a very thin layer of a metal (e.g., polyester film having an extremely thin, e.g., about one hundred Angstroms layer of aluminum) and an activator, e.g., a reactant, such as water, water vapor, an acid, a base, oxidizing agent or their precursors, which is capable of reacting with the said indicator. The indicator retains its opacity and metallic luster, e.g., silvery white, mirror like finish of aluminum layer for a long time. The activator destroys the indicator layer including the naturally formed oxide layer. The indicator layer does not have a matrix/binder. As the device becomes transparent from being highly opaque, any color, message or image printed under it become visible at a pre-determined time, thus making the device self reading. A sealing tape or large label made from an activator and an indicator can be used for sealing boxes and monitoring self-life of perishables inside it. Ink formulations composed of a metal powder and a proper activator can be used for monitoring several sterilization processes, such as sterilization with steam. When water is used as an activator, a thin layer of metals, such as that of aluminum can be used as steam sterilization or humidity indicator. The process can also be used for making patterns, printing plates, electronic circuits and RFIDs (radio frequency identification devices). | 12-10-2009 |
20100043694 | Tamper evident indicating devices - A variety of indicators, e.g., time, temperature, time-temperature, freeze, thaw and sterilization are reported and used for monitoring quality of perishables. However, these indicators are tamperable, e.g., an indicator can be opened, removed, repositioned, exchanged or replaced. Disclosed are tamper evident time, temperature, time-temperature, freeze, thaw, sterilization and like indicating devices. If an indicator is tampered, it will be either destroyed or will provide a visual indication or a message, such as “VOID” or “TAMPERED”. | 02-25-2010 |
20120235062 | DEVICE AND A PROCESS FOR MASS MONITORING OF RADIATION EXPOSURE - A radiation detection device with at least one self indicating radiation sensor and at least one machine readable sensor. | 09-20-2012 |
20120244623 | TAMPER EVIDENT INDICATING DEVICES - A variety of indicators, e.g., time, temperature, time-temperature, freeze, thaw and sterilization are reported and used for monitoring quality of perishables. However, these indicators are tamperable, e.g., an indicator can be opened, removed, repositioned, exchanged or replaced. Disclosed are tamper evident time, temperature, time-temperature, freeze, thaw, sterilization and like indicating devices. If an indicator is tampered, it will be either destroyed or will provide a visual indication or a message, such as “VOID” or “TAMPERED”. | 09-27-2012 |
20130068155 | FREEZE, THAW AND REFREEZE INDICATORS BASED ON RAPID REACTIONS IN THE SOLID STATE - A freeze indicator, which is preferably a self-activating freeze indicator. The freeze indicator has a substrate with a freeze indicator composition coated thereon wherein the freeze indicator has a liquid diacetylene; and a catalyst or catalyst precursor and a protective cover. | 03-21-2013 |
Patent application number | Description | Published |
20100174048 | Processes for Preparing a Polypeptide - The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceutically acceptable salt thereof. | 07-08-2010 |
20100234272 | Processes for Preparing a Polypeptide - The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceutically acceptable salt thereof. | 09-16-2010 |
20100234566 | Processes for Preparing a Polypeptide - The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceuticaly acceptable salt thereof. | 09-16-2010 |
Patent application number | Description | Published |
20090156711 | HEMOSTATIC DEVICE - A hemostatic device comprising (i) a carrier comprising at least one component selected from the group consisting of hydroxypropyl methylcellulose phthalate, hydroxypropyl methylcellulose acetate succinate, cellulose acetate phthalate; polyvinylacetate phthalate, cellulose acetate phthalate, acetaldehyde dimethylcellulose acetate, polymethacrylate-based polymers, and derivatives, salts, copolymers or combinations thereof; and (ii) thrombin | 06-18-2009 |
20090318843 | SURGICAL BARRIERS HAVING ADHESION INHIBITING PROPERTIES - An adhesion inhibiting surgical barrier. The surgical barrier includes a wound-facing polymeric coating comprising an enteric polymer; and at least one flexible substrate, the at least one flexible substrate having at least one exterior surface, wherein the polymeric coating is applied to the at least one flexible substrate to substantially cover the at least one exterior surface thereof. A method of inhibiting the formation of adhesions in a patient who has undergone a surgical procedure and a method of repairing a gastric or duodenal perforation are also described herein. | 12-24-2009 |
20140093549 | Surgical Barriers Having Adhesion Inhibiting Properties - An adhesion inhibiting surgical barrier. The surgical barrier includes a wound-facing polymeric coating comprising an enteric polymer; and at least one flexible substrate, the at least one flexible substrate having at least one exterior surface, wherein the polymeric coating is applied to the at least one flexible substrate to substantially cover the at least one exterior surface thereof. A method of inhibiting the formation of adhesions in a patient who has undergone a surgical procedure and a method of repairing a gastric or duodenal perforation are also described herein. | 04-03-2014 |
Patent application number | Description | Published |
20120045041 | RINGBACK TONE MANAGEMENT FOR CONTACTS ACROSS COMMUNICATION ACCESS SYSTEMS - Ringback tone management devices, systems, and methods for supporting contacts across communication access systems are provided herein. Embodiments in the detailed description include ringback tone management devices, systems, and methods for contacts across a communication access system. As an example, the communication access system may be an enterprise access system. The embodiments provided herein allow a plurality of different client devices in the communication access system, each associated with a particular set of incoming caller identifiers, to receive a desired ringback tone. In this manner, as an example, a consistent ringback tone can be provided to the incoming caller for calls received from any of the incoming caller's communication devices based upon an incoming caller identifier. The communication access system may further include devices, systems, and methods for managing ringback tones. | 02-23-2012 |
20120045048 | RINGTONE MANAGEMENT FOR CONTACTS ACROSS COMMUNICATION ACCESS SYSTEMS - Ringtone management devices, systems, and methods for supporting contacts across communication access systems are provided herein. In one embodiment, the communication access system may be an enterprise access system. The communication access system can allow a plurality of different client devices in the enterprise access system, each associated with a particular set of incoming caller identifiers, to all be rung with an outgoing ringtone that identifies the incoming caller. In this manner, a user is provided with a consistent ringtone at each of the user's devices that identifies a particular incoming caller. | 02-23-2012 |
20130308770 | RINGBACK TONE MANAGEMENT FOR CONTACTS ACROSS COMMUNICATION ACCESS SYSTEMS - Ringback tone management devices, systems, and methods for supporting contacts across communication access systems are provided herein. Embodiments in the detailed description include ringback tone management devices, systems, and methods for contacts across a communication access system. As an example, the communication access system may be an enterprise access system. The embodiments provided herein allow a plurality of different client devices in the communication access system, each associated with a particular set of incoming caller identifiers, to receive a desired ringback tone. In this manner, as an example, a consistent ringback tone can be provided to the incoming caller for calls received from any of the incoming caller's communication devices based upon an incoming caller identifier. The communication access system may further include devices, systems, and methods for managing ringback tones. | 11-21-2013 |
Patent application number | Description | Published |
20100330158 | PROTEIN-ASSISTED DRUG DELIVERY SYSTEM FOR THE TARGETED ADMINISTRATION OF ACTIVE AGENTS - The present invention provides a composition and prodrug for targeted drug delivery to the central nervous system of a patient. The inventive composition and prodrug include a pharmaceutically acceptable active agent and at least one protein selected from the group consisting of a fimbrial adhesin protein, a membrane protein, and combinations thereof. The inventive compositions and prodrugs of the present invention selectively target the blood-brain barrier and deliver hydrophilic and lipophilic active agents of varying sizes to the central nervous system. | 12-30-2010 |
20110166214 | METHODS AND COMPOSITIONS FOR DELIVERY OF TAXANES IN STABLE OIL-IN-WATER EMULSIONS - The present invention provides methods and compositions for delivery of taxanes in stable oil-in-water emulsion. The inventive emulsion formulation includes an oil phase, aqueous and emulsifier phases. The oil portion includes all or substantial amount of taxane, vegetable oil and medium chain triglycerides; aqueous phase includes an emulsion stabilizer; emulsifier phase reduces the surface tension between oil and aqueous phases to produce a stable oil-in-water emulsion. The inventive compositions produce minimal side effects upon administration. | 07-07-2011 |
20110230441 | STABLE BORTEZOMIB FORMULATIONS - Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base. | 09-22-2011 |
20120172808 | Stable Bortezomib Formulations - Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base. | 07-05-2012 |
20120322762 | Stable Bortezomib Formulations - Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base. | 12-20-2012 |
20120322763 | Stable Bortezomib Formulations - Multi-dose formulations for bortezomib are presented in which bortezomib has significantly improved stability. Especially preferred formulations include those in which bortezomib is in a liquid form suitable for injection, wherein the solvent system predominantly comprises propylene glycol. In other preferred aspects, bortezomib is present as a Lewis donor-acceptor complex with a hetero-bifunctional Lewis base. | 12-20-2012 |
Patent application number | Description | Published |
20100174048 | Processes for Preparing a Polypeptide - The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceutically acceptable salt thereof. | 07-08-2010 |
20100234272 | Processes for Preparing a Polypeptide - The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceutically acceptable salt thereof. | 09-16-2010 |
20100234566 | Processes for Preparing a Polypeptide - The present invention relates to an improved process for preparing a polypeptide or pharmaceutically acceptable salt thereof comprising L-tyrosine, L-alanine, L-glutamate, and L-lysine. The polypeptide or pharmaceutically acceptable salt thereof is preferably glatiramer acetate. The process comprises: (a) polymerizing a mixture of N-carboxyanhydride of L-tyrosine, N-carboxyanhydride of L-alanine, N-carboxyanhydride of a protected L-glutamate and N-carboxyanhydride of a protected L-lysine, in a polar aprotic solvent in the presence of an initiator, to form a protected polypeptide; (b) admixing an acid with the protected polypeptide formed in Step (a) and a solvent, to form a product; and (c) admixing a substance selected from the group consisting of an alkali or alkaline earth metal hydroxide, a carbonate, a hydrogencarbonate, and mixtures thereof, with the product formed in Step (b), and a solvent or a mixture of a solvent and water, to form a deprotected polypeptide or a pharmaceuticaly acceptable salt thereof. | 09-16-2010 |
20130115253 | Sustained Release Suspension Preparation For Dextromethorphan - A stabilized pharmaceutical composition comprises a drug-resin complex wherein the resin has been treated with an alkaline material prior to the formation of the drug-resin complex. The drug-resin complex may further be impregnated with an alkalizing agent, L-methionine, an antioxidant agent, or a combination thereof, or be coated with a diffusion barrier. A method of preparation of the pharmaceutical composition is provided. | 05-09-2013 |
20140275260 | Preparation Of Stable Pharmaceutical Dosage Forms - The invention provides a process for preparing stable, high API content, solid pharmaceutical dosage forms by direct compression or dry granulation, characterized in that the pharmaceutical tablets rapidly disintegrate in water or other aqueous solutions to produce a clear or almost clear solution. Also provided is a pharmaceutical carglumic acid tablet, which has improved manufacturing, dissolution, and stability properties, and is less expensive to produce, compared to the equivalent commercial product. | 09-18-2014 |
20150080532 | Process For The Preparation Of Colesevelam Hydrochloride - A novel process of manufacturing colesevelam hydrochloride including the steps of alkylating polyallylamine with n-decylbromide and 6-bromohexyl trimethyl ammonium bromide, followed by cross-linking the alkylated polyallylamine with epichlorohydrin in an aqueous medium, and adding a suitable chloride ion source to obtain colesevelam hydrochloride. | 03-19-2015 |
20150087681 | Bendamustine HCL Stable Lyophilized Formulations - The present invention provides a lyophilized bendamustine hydrochloride (HCL) pharmaceutical composition. The present invention further provides methods of producing the lyophilized bendamustine HCL composition from a composition including bendamustine HCL, mannitol, formic acid, and water. The pharmaceutical formulation can be used for any disease that is sensitive to treatment with bendamustine, such as neoplastic diseases. | 03-26-2015 |
Patent application number | Description | Published |
20090036306 | Insecticidal Substituted Benzylamino Heterocyclic and Heteroaryl Derivatives - Certain substituted benzylamino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (1): wherein R, R1, R2, R3, and R4 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (1), and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present. | 02-05-2009 |
20090209422 | Insecticidal Substituted Aminoalkyl Heterocyclic and Heteroaryl Derivatives - Certain substituted aminoalkyl heteroaryl and heterocyclyl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein R, R | 08-20-2009 |
20100137385 | Insecticidal Substituted Amino Heterocyclic and Heteroaryl Derivatives - Certain substituted amino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I): wherein R, R | 06-03-2010 |
20110065710 | Insecticidal N-(Heteroarylalkyl)Alkanediamine Derivatives - Certain noel N-(heteroarylalkyl)alkanediamine derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula I: wherein Ar, a, r, R, R | 03-17-2011 |
Patent application number | Description | Published |
20110282689 | PROSPECTIVE MANAGEMENT SYSTEM FOR MEDICAL BENEFIT PRESCRIPTIONS - The present invention provides an interactive, electronic, knowledge-based ordering process for specialty/biotech pharmaceuticals (medically coded drugs) which results in less waste, improved procedural efficiencies, and greater cost savings than the current ordering systems. The knowledge-base of the system is based on the health plan's clinical policies as well as the status of the patient and their entitled benefits with the health plan, and it is applied in an interactive manner through a web-enabled system which provides a real-time, prospective examination and control over requests for authorization to dispense the medically coded drugs. The system also includes a feedback loop from the specialty pharmacies to provide information on the medicines that have actually been dispensed. The system also provides to the patient, educational material and adherence reminders to affect therapeutic outcomes. | 11-17-2011 |
20110282690 | PROSPECTIVE MANAGEMENT PROCESS FOR MEDICAL BENEFIT PRESCRIPTIONS - The present invention provides an interactive, electronic, knowledge-based ordering process for specialty/biotech pharmaceuticals (medically coded drugs) which results in less waste, improved procedural efficiencies, and greater cost savings than the current ordering systems. The knowledge-base of the system is based on the health plan's clinical policies as well as the status of the patient and their entitled benefits with the health plan, and it is applied in an interactive manner through a web-enabled system which provides a real-time, prospective examination and control over requests for authorization to dispense the medically coded drugs. The system also includes a feedback loop from the specialty pharmacies to provide information on the medicines that have actually been dispensed. The system also provides to the patient, educational material and adherence reminders to affect therapeutic outcomes. | 11-17-2011 |
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20080206173 | NAIL COMPOSITIONS IN POWDERED FORM - A process for making up nails involving the steps of: (a) providing a first composition, in powder form, containing: (i) at least one colorant, in powder form; (ii) optionally, at least one film-forming polymer, in powder form; and (iii) optionally, at least one plasticizer; (b) providing a second composition containing: (iv) at least one solvent; (v) at least one film-forming polymer chosen from nitrocellulose, cellulose acetate butyrate, and mixtures thereof; and (vi) at least one plasticizer; (c) depositing the first composition onto a nail surface; and (d) applying the second composition over-top of the first composition. | 08-28-2008 |
20110280818 | COMPOSITIONS CONTAINING HYPERBRANCHED POLYOL AND TACKIFIER - The invention relates to a composition, especially a cosmetic composition, comprising at least one hyperbranched polyol and at least one tackifier, as well as to methods of using such compositions. | 11-17-2011 |
20120171142 | COMPOSITIONS CONTAINING A MICRONIZED WAX - The invention relates to a composition comprising at least one oil-dispersible micronized wax which, if desired, can be processed at room temperature. | 07-05-2012 |
20130243715 | COMPOSITIONS CONTAINING ACRYLIC THICKENER AND OIL - The invention relates to a composition, especially a cosmetic composition, comprising at least one acrylic thickener, water and at least one oil, as well as methods of using such compositions. | 09-19-2013 |
20140308232 | COMPOSITIONS CONTAINING A SILICON RESIN AND A TACKIFYING AGENT - The invention relates to a composition, especially a cosmetic composition, comprising at least one silicon resin comprising at least one T unit and at least one tackifying agent, as well as to methods of using such compositions. | 10-16-2014 |
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20120141588 | DENTIFRICE COMPOSITIONS CONTAINING CALCIUM SILICATE AND A BASIC AMINO ACID - An oral care composition includes an effective amount of a basic amino acid in free or salt form; and an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits. | 06-07-2012 |
20130251772 | Dentifrice Compositions Containing Calcium Silicate - An oral care composition includes an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits. | 09-26-2013 |
20130263395 | Non-Aqueous Oral Care Composition Containing Dental Occlusion Actives - A oral care composition includes: (a) a hydrophilic film-forming polymer; and (b) a hydrophobic carrier, wherein the hydrophilic film-forming polymer is a film-forming polymer effective to occlude dentinal tubules and the oral care composition contains 0-10 wt. % water. The hydrophilic film-forming polymer is preferably GANTREZ S. The hydrophobic carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the oral care composition such that the hydrophilic film-forming polymer occludes dentinal tubules. A toothbrush includes: a handle; a head mounted to the handle, the head comprising an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and a gelatin capsule containing the oral care composition positioned on the head. | 10-10-2013 |
20130269132 | Gelatin Encapsulated Oral Care Composition Containing Dental Occlusion Actives, Hydrophobic Viscosity Modifier and Oil Carrier - A oral care composition includes: (a) a guanidine active; (b) a film-forming polymer; (c) a hydrophobic viscosity modifier in an amount sufficient to provide the oral care composition with a particle settling time greater than 20 minutes; and (d) an oil carrier. The guanidine active is preferably L-arginine. The film-forming polymer is preferably GANTREZ. The hydrophobic viscosity modifier is preferably a gelled mineral oil. The oil carrier is preferably a vegetable oil. A method of cleaning teeth includes applying to the teeth the oral care composition such that the oral care composition cleans the teeth. A oral care implement includes: a handle; a head mounted to the handle, the head having an outer surface and a plurality of tooth cleaning elements extending outwardly from the outer surface; and a gelatin capsule containing the oral care composition positioned on the head. | 10-17-2013 |
20140341820 | ORAL CARE COMPOSITIONS - Described herein are compositions comprising zirconium amino acid complexes suspended in a hydrophobic carrier; and methods of making and using the same. | 11-20-2014 |
20140348760 | ORAL CARE COMPOSITIONS - Described herein are oral care compositions comprising (i) a magnesium alkali metal silicate complex clay, and (ii) an orally acceptable anionic polymer, in a dentifrice base, which compositions are useful for alleviating dental sensitivity. Also provided for, are methods of making and using the compositions described herein. | 11-27-2014 |
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20100204996 | METHOD AND SYSTEM FOR DYNAMIC RANGE CONTROL IN AN AUDIO PROCESSING SYSTEM - Methods and systems for dynamic range control in an audio processing system are disclosed and may include controlling a dynamic range of an audio signal by expanding the dynamic range utilizing a dynamic expander, and dividing the audio signal into a plurality of frequency bands. Each of the bands may be individually compressed utilizing a multi-band compressor. A sum of the individually compressed frequency bands may be compressed utilizing a full-band compressor. The audio signal may be filtered utilizing a pre-emphasis filter, such as an infinite impulse response filter and may be divided into frequency bands utilizing one or more finite impulse response filters and/or delay modules. The dynamic expander may include adaptive thresholds and an envelope detector. Each of the frequency bands may be compressed utilizing syllabic compression in the multi-band compressor. The compressed sum of compressed plurality of bands may be processed utilizing an audio CODEC. | 08-12-2010 |
20100303228 | METHOD AND SYSTEM FOR A DUAL ECHO CANCELLER - Methods and systems for a dual echo canceller (EC) are disclosed and may include cancelling echo in utilizing a dual echo canceller, wherein said dual echo canceller includes an active echo canceller and an adaptive echo canceller. Filter coefficients may be copied from the adaptive echo canceller to the active echo canceller for the cancellation, based on whether said adaptive echo canceller has converged. The coefficients may be copied utilizing copy logic, which may comprise divergence detection and/or echo path change detection. The coefficients may be reset to default settings utilizing the copy logic. The coefficients may be calculated utilizing normalized block least mean squares (NBLMS), and may be calculated when the NBLMS is enabled by update logic. The coefficients may be calculated utilizing linear predictive coefficient (LPC) filtered uplink and downlink signals. | 12-02-2010 |
20100304679 | Method and System For Echo Estimation and Cancellation - Methods and systems for echo estimation and cancellation are disclosed and may include estimating combined echo return loss and echo return loss enhancement (ERL+ERLE). A subband gain vector may be calculated utilizing non-linear processing, subband analysis, and the estimated ERL+ERLE to mitigate residual echo. ERL+ERLE may be estimated by averaging a difference in DL and UL signals. A maximum value of ERL+ERLE may be determined over a period of time. A non-linear distortion adjustment factor may be estimated for ERL+ERLE. An ERL+ERLE estimation error may be calibrated specific to the wireless device. The estimating of ERL+ERLE may be suspended briefly after a transition in the DL or UL signals. Comfort noise may be added to mask the residual echo, which may be mitigated following a dual echo canceller. The estimating may be suspended when the DL signal is not present. A noise level may be included in the gain calculation. | 12-02-2010 |
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20110110932 | COMBINATION TREATMENT FOR OCULAR DISEASES - The invention provides compositions and methods for treating ocular disorders, such as angiogenesis-associated disorders, by administering a combination of an inhibitor of VEGF activity and an inhibitor of α | 05-12-2011 |
20120100136 | METHODS FOR TREATING OR PREVENTING OPHTHALMOLOGICAL DISEASES - This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an effective amount of a PDGF antagonist and a VEGF antagonist to a mammal in need thereof. | 04-26-2012 |
20140179621 | Methods for Treating or Preventing Ophthalmological Diseases - This invention relates to methods and compositions useful for the treatment or prevention of an ophthalmological disease, comprising administration of an effective amount of a PDGF antagonist and a VEGF antagonist to a mammal in need thereof. | 06-26-2014 |
20150017163 | Methods for Treating or Preventing Ophthalmological Conditions - The present invention relates to methods for treating and preventing ophthalmological disease and disorders, comprising administering Antagonist A or another pharmaceutically acceptable salt thereof, optionally in combination with another treatment, to a subject in need thereof. The present invention also relates to methods for treating and preventing ophthalmological disease and disorders, comprising administering an anti-C5 agent (e.g., ARC1905), optionally in combination with another treatment, to a subject in need thereof. | 01-15-2015 |
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20110255397 | SYSTEMS AND METHODS OF IMPROVING THE QUALITY OF VOIP COMMUNICATIONS - Methods of addressing problems in a voice over Internet protocol (VOIP) telephony system include collecting data on network events, analyzing the data, and taking corrective action when possible. If an IP telephony device is registering with the VOIP telephony system more frequently than necessary, which can indicate the IP telephony device is unnecessarily jumping between proxy services, the IP telephony device is instructed to re-initialize itself. If an IP telephony device sends two successive stay alive registration messages to a proxy server from different ports of a router, which can indicate that a router pinhole is closing between stay alive messages, then the IP telephony device is instructed to send stay alive registration messages more frequently. If data packet statistics indicate that an IP telephony device is experiencing a jitter problem, the IP telephony device is instructed to increase the size of a data buffer for incoming data packets. If data packet statistics indicate that an IP telephony device is experiencing an enduring bandwidth problem or an enduring data packet loss problem, the IP telephony device is instructed to adopt a new encoding algorithm with greater data compression. | 10-20-2011 |
20150063347 | SYSTEMS AND METHODS OF IMPROVING THE QUALITY OF VOIP COMMUNICATIONS - Methods of addressing problems in a voice over Internet protocol (VOIP) telephony system include collecting data on network events, analyzing the data, and taking corrective action when possible. If an IP telephony device is registering with the VOIP telephony system more frequently than necessary, which can indicate the IP telephony device is unnecessarily jumping between proxy services, the IP telephony device is instructed to re-initialize itself. If an IP telephony device sends two successive stay alive registration messages to a proxy server from different ports of a router, which can indicate that a router pinhole is closing between stay alive messages, then the IP telephony device is instructed to send stay alive registration messages more frequently. If data packet statistics indicate that an IP telephony device is experiencing a jitter problem, the IP telephony device is instructed to increase the size of a data buffer for incoming data packets. | 03-05-2015 |