Patent application number | Description | Published |
20100247498 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO - A method of delivering a gene product to a recipient, the method comprises (a) providing a micro-organ explant expressing at least one recombinant gene product, the micro-organ explant comprising a population of cells, the micro-organ explant maintaining a microarchitecture and a three dimensional structure of an organ from which it is obtained and at the same time having dimensions selected so as to allow diffusion of adequate nutrients and gases to cells in the micro-organ explant and diffusion of cellular waste out of the micro-organ explant so as to minimize cellular toxicity and concomitant death due to insufficient nutrition and accumulation of the to waste in the micro-organ explant, at least some of the cells of the population of cells of the micro-organ explant expressing at least one recombinant gene product; and (b) implanting the micro-organ explant in the recipient. | 09-30-2010 |
20110287071 | METHODS OF GENERATING TISSUE USING DEVITALIZED, ACELLULAR SCAFFOLD MATRICES DERIVED FROM MICRO-ORGANS - A composition of matter is provided comprising a devitalized, acellular tissue-derived scaffold seeded with differentiated cells, particularly pancreatic islet cells, wherein the cells can maintain cell-specific function or structure in culture on the scaffold. Methods of generating same and uses thereof are also provided. | 11-24-2011 |
20120003194 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO - Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation. | 01-05-2012 |
20120003195 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO - Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the to present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation. | 01-05-2012 |
20120004642 | IN VITRO MICRO-ORGANS, AND USES RELATED THERETO - Micro-organ cultures which include isolated populations of cells having specific characteristics are described. Salient features of the subject micro-organ cultures include the ability to be maintained in culture for relatively long periods of time, as well as the preservation of an organ microarchitecture which facilitates, for example, cell-cell and cell-matrix interactions analogous to those occurring in the source organ. The micro-organ cultures of the invention can be used in methods for delivering gene products to recipient subjects, for identifying cell proliferative and cell differentiating agents, and identification and isolation of progenitor and stem cells. In addition, the micro-organ cultures of the present invention can be used in methods for identifying inhibitors of cell proliferation, cell differentiation and viral infectivity. In other embodiments, the micro-organ cultures can be used for transplantation. | 01-05-2012 |
Patent application number | Description | Published |
20110093610 | Methods and Apparatus for Obtaining Content With Reduced Access Times - A method and apparatus for obtaining content with reduces round trip times is provided. The method may comprise transmitting, from a device, a primary content item request to a proxy server to obtain a primary content item using a first protocol, receiving the primary content item from the remote proxy using the first protocol, generating one or more secondary content item requests for one or more secondary content items associated with the primary content item, transmitting the one or more secondary content item requests to the proxy server using a second protocol, wherein the second protocol decouples the one or more secondary content item requests from an acknowledgement of receipt of the one or more secondary content item requests, and receiving at least one of the one or more secondary content items from the proxy server using the second protocol. | 04-21-2011 |
20120290253 | APPARATUS AND METHODS FOR HEIGHT DETERMINATION - A method for determining a height (i.e., elevation above ground level) at which a communication device having an electronic processor and a sensor is located may include obtaining a reference height of a first location, the reference height being a known height relative to ground level, the reference height having a corresponding reference pressure; obtaining, with the sensor, a pressure measurement at a second location; and calculating, with the electronic processor, a height at the second location based on the pressure measurement, the reference height, and the reference pressure. The height may also be based on temperature data, location data, motion data, and/or the like. | 11-15-2012 |