Patent application number | Description | Published |
20100009364 | Methods for diagnosis, prognosis and methods of treatment - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 01-14-2010 |
20100204973 | Methods For Diagnosis, Prognosis And Treatment - An embodiment of the present invention is a method of generating a report based on an association metric. The method involves identifying node state data associated with a sample, and generating an association metric based on the node state data. | 08-12-2010 |
20100297676 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. | 11-25-2010 |
20110059861 | ANALYSIS OF CELL NETWORKS - The present invention provides an approach for the determination of activation state of a plurality of discrete cell populations and/or the state of one or more cellular networks in an individual. The status of a plurality of discrete cell populations and/or the state of one or more cellular networks can be correlated with the diagnosis, prognosis, choice or modification of treatment, and/or monitoring of a condition | 03-10-2011 |
20110104717 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 05-05-2011 |
20110262468 | Method for Monitoring Vaccine Response Using Single Cell Network Profiling - The present invention provides methods for determining safety and efficacy of a vaccine by monitoring cellular pathways prior to and after vaccine treatment using single cell network profiling | 10-27-2011 |
20110269154 | Methods for Diagnosis, Prognosis and Methods of Treatment - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 11-03-2011 |
20120157340 | PATHWAYS CHARACTERIZATION OF CELLS - The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations. | 06-21-2012 |
20130034862 | Methods for Diagnosis, Prognosis and Methods of Treatment - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 02-07-2013 |
20130096948 | METHODS FOR DIAGNOSIS, PROGNOSIS AND TREATMENT - An embodiment of the present invention is a method of generating a report based on an association metric. The method involves identifying node state data associated with a sample, and generating an association metric based on the node state data. | 04-18-2013 |
20130122524 | Methods for Diagnosis, Prognosis and Methods of Treatment - This invention is directed to methods and compositions for diagnosis, prognosis and for determining methods of treatment. The physiological status of a cell present in a sample (e.g. clinical sample) can be used in diagnosis or prognosis of a condition (e.g. Chronic Lymphocytic Leukemia), in patient selection for therapy, to monitor treatment and to modify or optimize therapeutic regimens. | 05-16-2013 |
20130129681 | METHODS FOR DIAGNOSING SOLID TUMORS - An embodiment of the present invention is useful for identifying tumor cells in bladder cancer washes, pleural effusions, biliary tumor cells and circulating tumor cells in whole blood. Subsequent analysis may identify therapeutic treatments based on a single cell analysis of activatable elements in cell signaling pathways. This analysis can be useful for diagnosis, prognosis, therapy selection and monitoring of solid tumor diseases. | 05-23-2013 |
20130130279 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 05-23-2013 |
20140017678 | PATHWAY CHARACTERIZATION OF CELLS - The present invention provides methods, compositions and kits for the characterization of cellular pathways in cells containing genetic alterations. | 01-16-2014 |
20140031308 | BENCHMARKS FOR NORMAL CELL IDENTIFICATION - Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample. | 01-30-2014 |
20140065633 | METHODS FOR DETERMINING THE EFFECTS OF COMPOUNDS ON JAK/STAT ACTIVITY - An embodiment of the present invention is a method for subjecting a hematopoetic cell to a JAK/STAT inhibitor, determining the activity of gain-of-function mutations of a Jak family kinase, determining the expression levels and activity of JAK/STAT regulatory proteins, correlating the expression levels and the activity of JAK/STAT regulatory proteins with the activity of gain-of-function mutations of a Jak family kinase and with a response to the JAK/STAT inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the JAK/STAT inhibitors or other compounds. | 03-06-2014 |
20140120122 | METHOD FOR MONITORING VACCINE RESPONSE USING SINGLE CELL NETWORK PROFILING - The present invention provides methods for determining safety and efficacy of a vaccine by monitoring cellular pathways prior to and after vaccine treatment using single cell network profiling | 05-01-2014 |
20140127716 | BENCHMARKS FOR NORMAL CELL IDENTIFICATION - Provided herein are methods, compositions, and kits for determining cell signaling profiles in normal cells and comparing the cell signaling profiles of normal cells to cell signaling profiles from a test sample. | 05-08-2014 |
20140147857 | METHODS FOR DIAGNOSIS PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 05-29-2014 |
20140199273 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell population. | 07-17-2014 |
20140255393 | COMPOSITIONS AND METHODS FOR AUTOIMMUNE DISEASE - Methods and compositions are described for categorizing and treating autoimmune disease, using single cell network profiling (SCNP), where activation levels of one or more activatable elements are determined in single cells, with or without modulation, to categorize or determine treatment for the autoimmune disease. | 09-11-2014 |
20150017119 | METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT - The present invention provides an approach for the determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of heterogeneity in a complex cell population based on activation states, expression markers and other criteria, and the identification of cellular subsets that exhibit correlated changes in activation within the cell population. Moreover, this approach allows the correlation of cellular activities or properties. In addition, the use of modulators of cellular activation allows for characterization of pathways and cell populations. Several exemplary diseases that can be analyzed using the invention include AML, MDS, and MPN. | 01-15-2015 |
Patent application number | Description | Published |
20080317730 | Compositions Useful for Recovering Original Trophism and Pigmentation, and for Stimulating Growth of the Integumentary Apparatus, Uses and Products Thereof - The present invention relates to compositions and products comprising at least one proteolytic enzyme adapted to promoting the restoration of original trophism of the integumentary apparatus, the original pigmentation and stimulating the growth thereof and, particularly, improving the viability of the pilifer follicles, even in scar tissue areas. | 12-25-2008 |
20090181007 | CULTURE MEDIUM AND PHARMACEUTICAL COMPOSITION FOR REGENERATING CARTILAGE TISSUE, A METHOD, USES AND PRODUCTS RELATED THERETO - A composition for in vitro use as a culture medium or in vivo use as a pharmaceutical composition or a medical device, capable of accelerating the differentiation of stem cells into cells with a chondrocytic phenotype and of restoring the original trophism of chondrocytes, is described. The composition comprises, in combination, at least one proteolytic enzyme, at least one growth factor and at least one from a sugar, an amino acid, a vitamin factor, a vitamin, a nucleotide and a nucleoside, in a physiologically acceptable carrier or diluent. A method of differentiating stem cells in cells having a chondrocytic phenotype, the cells obtained by the method and their uses, for example in human or animal cell therapy, for example by CBMP (Cellular Based Medicinal products) are also described. | 07-16-2009 |
20100092454 | NOVEL USE OF ANTIDEPRESSANT COMPOUNDS AND RELATED COMPOSITIONS - What is described is a use of an antidepressant compound, preferably belonging to the class of selective serotonin reuptake inhibitors (SSRI), for regenerating the integumentary system and/or for stimulating the growth, the original trophism and/or original pigmentation of the corresponding cutaneous appendages, particularly body hair and/or head hair, in mammals. For this purpose, the antidepressant can be formulated in a cosmetic preparation, a pharmaceutical composition, a medical device, or in the form of a culture medium, alone or in combination with a further active ingredient such as a proteolytic enzyme and/or a vitamin. | 04-15-2010 |
20100310544 | COMPOSITION COMPRISING CALCIUM IONS AND AT LEAST ONE PROTEOLYTIC ENZYME FOR USE IN THE IN VITRO AND IN VIVO REGENERATION OF CUTANEOUS AND CONNECTIVE TISSUES - The invention is based on the finding that calcium ions and proteolytic enzymes, particularly papain, act in a synergetic way in the regeneration of skin and connective tissues. Thus, such a combination of active principles can be used for the preparation of culture media for cutaneous and/or connective tissue biopsies, which allow for the maintenance of the biopsies under viable conditions for periods of over 6 months, even for over 3 years, as well as for the preparation of pharmaceutical compositions or medical devices for the treatment of diseases in which the regeneration of cutaneous and connective tissues is beneficial (for instance, injuries and wounds, keloids, paradontopathies, conjunctivitis, nasal and ear polyps, cellulite, human and animal dermatitis), and for the preparation of cosmetic compositions that in particular have an anti-ageing effect on the skin. | 12-09-2010 |
Patent application number | Description | Published |
20100243643 | DEVICE AND METHOD FOR PERFORMING A LOCALIZED INDUCTION HARDENING TREATMENT ON MECHANICAL COMPONENTS, SPECIFICALLY THRUST BLOCKS FOR LARGE-SIZED ROLLING BEARINGS - A device and method for induction hardening rolling tracks of thrust blocks of bearings, according to a required hardening profile. At least two inductors arranged in tandem are used within a track to be hardened, at a predetermined distance from a surface of the track and the thrust block is rotated with respect to the inductors, so as to make them cover the entire track, with a complete 360° turn; the inductors, at least one first pre-heating inductor and one at least heating inductor, are shaped so as to generate a first and a second magnetic fields, respectively, both having flux lines which are perpendicular to each other, and one of the two inductors is mounted on an orientable head so as to be able to arrange the two inductors oriented according to the curvature of the track. The mentioned predetermined distance of the inductors from the track is obtained by using a feeler to accurately detect the geometry of the track and which is introduced between the two inductors and then moved away during the heating steps which are performed sequentially in synchronism with the rotation of the thrust block, and by varying, in a final step, the electric power fed to at least one inductor. | 09-30-2010 |
20120297580 | METHOD AND DEVICE FOR OBTAINING A MULTICRYSTALLINE SEMICONDUCTOR MATERIAL, IN PARTICULAR SILICON - A device for obtaining multicrystalline silicon, including: at least one crucible, removably housed in a cup-shaped graphite container; a fluid-tight casing, including a fixed bottom half-shell and a vertically mobile top half-shell; a top induction coil, set facing, with interposition of a graphite plate, the crucible, a lateral induction coil and a bottom induction coil vertically mobile for varying the distance from the bottom wall; and means for a.c. electrical supply of the induction coils separately from one another; at least the lateral induction coil includes a plurality of plane turns set on top of one another, and means for selectively short-circuiting, supplying or not supplying the turns, all together or separately one or more at a time and for varying the frequency of supply thereof all together or separately one or more at a time. | 11-29-2012 |
20120304697 | DEVICE FOR OBTAINING A MULTICRYSTALLINE SEMICONDUCTOR MATERIAL, IN PARTICULAR SILICON, AND METHOD FOR CONTROLLING THE TEMPERATURE THEREIN - A device for obtaining multicrystalline silicon, including: at least one crucible made of quartz for the silicon, removably housed in a cup-shaped graphite container; a fluid-tight openable casing; a top induction coil, set facing, with interposition of a graphite plate, the crucible, a lateral induction coil, set around a side wall of the graphite container, and a bottom induction coil, set facing a bottom wall of the graphite container and vertically mobile for varying the distance from the bottom wall; and first means for a.c. electrical supply of the induction coils separately from one another, and second means for supply of a coolant within respective hollow turns of the induction coils; the bottom induction coil includes four spiral windings, arranged alongside one another; electrical switching means enable in use selective connection of the four windings to one another according to different configurations. | 12-06-2012 |