Patent application number | Description | Published |
20100144558 | SYSTEMS AND METHODS FOR BIODOSIMETRY WITH BIOCHIP USING GENE EXPRESSION SIGNATURES - Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures. | 06-10-2010 |
20100221726 | RELATING TO DEVICES - A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues. | 09-02-2010 |
20100267092 | COMPONENTS - A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels. | 10-21-2010 |
20110100101 | PERFORMANCE - Instruments, devices and methods of analysis are provided which fully integrate a significant number of process steps in a continuous operation. Accurate positioning and full contact between components is also provided by the relative movement the designs allow. An effect interface between a low cost disposable cartridge or device and the instrument to process it is also detailed. | 05-05-2011 |
20110287407 | INTEGRATED METHODS AND SYSTEMS FOR PROCESSING A MOLECULAR PROFILE - An automated and integrated matching of a biological specimen to an individual, can include a collector having substrate materials and configured to selectively collect and release at least one bio-molecular species from a biological specimen; a self-contained mobile automated testing instrument configured to receive the biological specimen and further configured to generate, store and output a molecular profile of the at least one predetermined bio-molecular species; a processor based system communicatively coupled to the self-contained mobile automated testing instrument and configured to receive the molecular profile; and wherein the processor based system is configured to provide a quantitative comparative analysis and report of the molecular profile with a selected molecular profile. In one approach, at least one predetermined bio-molecular species and stored pre-selected molecular profile is for a predetermined sequence of interest, such as a DNA-profile as defined by a Combined DNA Index System (CODIS) system. | 11-24-2011 |
20110287524 | METHODS AND SYSTEMS FOR PREDICTIVE DESIGN OF STRUCTURES BASED ON ORGANIC MODELS - A method and system to predict a design of an article of manufacture, which can include the steps of introducing a biological organism into a test environment to activate at least one molecular component of the biological organism representing at least one set of genetic characters of the biological organism; monitoring for change in at least one expression phenomenon pattern in response to the test environment; translating the monitored change in the at least one expression phenomenon pattern into a molecular data profile; interrogating the molecular data profile against a stored database to generate an information pattern of a phenotype correlated to the molecular data profile; and translating the information pattern of the phenotype into a correlated design component of the article of manufacture. | 11-24-2011 |
20120034601 | Porous Materials for Biological Sample Collection - Methods, apparatuses, and systems for collecting samples using hybrid porous materials that include an organic material and an inorganic material. A method for sample collection includes contacting a hybrid porous material and a biological sample to the porous material. The hybrid porous material includes an inorganic material and an organic material. The method includes placing the porous material with the attached sample in a liquid medium, wherein the sample is separated from the porous material in the liquid medium to form a separated sample, and collecting the separated sample in the medium. | 02-09-2012 |
20120082985 | Sensing And Identifying Biological Samples On Microfluidic Devices - A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction. | 04-05-2012 |
20130073221 | SYSTEMS AND METHODS FOR IDENTIFICATION OF FLUID AND SUBSTRATE COMPOSITION OR PHYSICO-CHEMICAL PROPERTIES - Techniques for identifying a composition of a target fluid using a set of vectors representing known residue patterns for a two or more fluids including said target fluid is provided. An exemplary method includes storing one or more digital measurements of residue for the target fluid, extracting one or more descriptive features from the measurements; and processing descriptive features to identify the composition of the target fluid. The processing includes using a machine learning algorithm trained with data linking residue morphology to fluid composition. A distance between a vector representing said one or more descriptive features and said set of vectors representing known residue patterns is determined, and a residue is assigned to one or more of the known residue patterns. | 03-21-2013 |
20130130365 | DEVICES - A method of analysis, instrument for analysis and device for use in such an instrument are provided, which perform a number of processes need to reach a useful result in the context of a wide variety of samples. The sequence of those processes being optimised. A device, instrument using the device and method of use are also provided which offer reliable performance of a heating based process, with minimal condensation and/or sample loss issues. | 05-23-2013 |
20130135618 | ANALYSIS - Analysis methods and apparatus are provided for inspecting a channel, such as a capillary electrophoresis channel, in a device. Configuration and alignment systems are provided, together with optical systems and temperature control. | 05-30-2013 |
20130137103 | ANALYSIS - A method of analysing a sample includes providing a first part of the sample and a second part of the sample. A first analysis is conducted on the first part of the sample and the results of the first analysis are considered. A second analysis is conducted on the second part of the sample, the second analysis being conducted according to a procedure using a value for each of one or more characteristics of the procedure. The consideration of the results of the first analysis is used to determine whether the value for one or more of the characteristics of the procedure is changed to a different value. The second analysis is started before the results of the first analysis are obtained. | 05-30-2013 |
20130138354 | ANALYSIS - A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position. | 05-30-2013 |
20130205563 | METHODS AND SYSTEMS FOR CONNECTING DISLIKE SHAPED ARTICLES - A secure and integrated matching of a consumer product box of dissimilar shapes and characteristics to a receiving holder from a moving environmental surroundings, can include a connector configured to selectively connect and position at least one wall from said the box to link with the receiving holder. In a preferred embodiment, the present method and apparatus is suitable for holding a tissue box of any shape in a cup holder of any shape in a vehicle, for example a car. | 08-15-2013 |
20130323737 | METHOD AND SYSTEM FOR ANALYZING A SAMPLE - A method and system for analysing a sample are provided, wherein one or more process steps and/or sample processors are provided separately from the instrument, for instance a sample receiving step and sample preparation step and sample extraction step and sample retention step and/or purification step and washing step and elution step, and one or more process steps and/or sample processors provided by the instrument as an integrated set, the one or more process steps and/or sample processors provided by the instrument including a sample receiving step and amplification step and denaturing step and investigation step and detection step and results analysis step and results output step. Other combinations of the split in location of the steps are possible. The optimisation of the split allows the accurate processing by a cartridge based instrument of the sample, whilst fully interfacing with a variety of sample collection and/or preparation approaches. | 12-05-2013 |
20140017676 | BIOLOGIC SAMPLE COLLECTION DEVICES AND METHODS OF PRODUCTION AND USE THEREOF - Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA). | 01-16-2014 |
20140162262 | Method and Device for Generating a Tunable Array of Fluid Gradients - Provided herein are devices and methods for generating microfluidic gradients, including an array of unique microfluidic gradients within an array of microchannels. Fluids within conduits are mixed in an intersection region to generate a mixed flow stream in a source reservoir channel that provides a gradient that varies with axial distance from the intersection region. Microchannels having an inlet connected to the source reservoir channel are configured to provide a microfluidic gradient in the microchannel. An outlet end of the microchannel is connected to a sink reservoir channel. By varying the ratio of fluid flow rates from the fluid conduits, the microchannel gradients are tuned. In this manner, a large number of unique gradients or array of microfluidic gradients is provided, wherein the gradient can be any number of physical or chemical parameters, including concentrations and physical fluid properties. | 06-12-2014 |
20140178938 | COMPONENTS - A method and device structure are provided which enable an archive sample to be collected and detached relative to a device within which a series of processes, such as PCR are being provided. A chamber structure and method of use are provided in which a controlled and precise volume is obtained by control of the relative resistance to flow through various channels. | 06-26-2014 |
20140186841 | SENSING AND IDENTIFYING BIOLOGICAL SAMPLES ON MICROFLUIDIC DEVICES - A method, system, and apparatus for analysis of a biological sample includes receiving the sample, wherein the sample includes deoxyribonucleic acid (DNA), lysing the sample to obtain access to the DNA included in the sample, purifying the DNA in the sample to isolate the DNA from other components in the sample, amplifying the DNA, separating fragments of the amplified DNA, detecting the separated fragments using laser induced fluorescence, based on the detecting, generating a profile of the DNA in the received sample, comparing the generated profile with profiles of DNA stored in a database, and upon determining that the generated profile matches one of the stored profiles, identifying the source from which the stored profile was obtained, wherein the receiving, lysing, purifying, amplifying, and detecting are performed on corresponding portions of a microfluidic device, and wherein transporting the sample and the DNA to the portions of the microfluidic device and enabling the lysing, purifying, amplifying, separating, detecting, generating, comparing, and identifying are performed automatically without user interaction. | 07-03-2014 |
20140220585 | BIOLOGIC SAMPLE COLLECTION DEVICES AND METHODS OF PRODUCTION AND USE THEREOF - Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA). | 08-07-2014 |
20150047413 | ANALYSIS - A method of verifying the performance of a size standard, formed of a plurality of size standard elements, used in a nucleic acid analysis method is provided. The verification is achieved by introducing the size standard to an analysis stage and performing a size based separation on the size standard. The size based separation defines an experimental position for each size standard element. A comparison is made as to whether or not the experimental position for the size standard element corresponds with expected position. The comparison allows a decision to be made on whether or not to use the size standard, which is dependent upon whether or not the experimental position of the size standard element corresponds with the expected position. | 02-19-2015 |
20150072413 | CELL CULTURE APPARATUS AND CULTURE METHODS USING SAME - Cell culture apparatus comprising at least two adjacent cell cultivation channels separated by a permeable or semipermeable membrane, wherein at least one channel, for the majority of its length, has a cross sectional area of no more than 1 mm | 03-12-2015 |
20150221048 | Method and system for matching a gear and travel storage for processing a transaction in an on-demand service system - A matching of a traveler's gear and vehicle when engaging into an electronic transaction of on demand services, preferably for transportation. In a preferred embodiment, the present method and apparatus is suitable for assessing remotely from a digital image, the physical properties of a travel gear, for example its shape, size and weight dimensions or texture, in order to match the geometric parameters of the container storage of a vehicle, for example the trunk of an automobile, listed in a database of an electronic transportation service, in order to optimize the conditions of transportation, such as cost reduction and energy fuel efficiency, for improving the quality of the traveler's experience. | 08-06-2015 |
20150228033 | PORTRAYING AN INDIVIDUAL THROUGH USE OF ARTIFACTS FOR SOCIAL NETWORKING AND PLAYING - A method and apparatus platform for portraying a first individual relating to engaging in social activities, such as networking and/or playing, with at least a second individual, through using artifacts, preferably an image and/or an art work, that can be displayed at a physical or virtual exhibit, whose elements of said artwork can be extracted or described by the individuals for identifying or defining some personal and/or psychological attributes that can translate, pattern or portrait unique characters of the individuals, for example with the purpose of interacting, communicating, playing, gaming, entertaining, initiating courtship or intimate relationship, networking or trading. | 08-13-2015 |
20150238958 | MICROFLUIDIC DEVICE FOR BIOLOGICAL SAMPLE PREPARATION - The present invention provides a microfluidic device for preparing or extracting a biological sample from a solid material and methods for using the same. The microfluidic device of the invention automates the biological sample extraction from a solid material, thereby significantly reducing the possibility of contamination, human error and a potential variability of the sample that is obtained by different technicians. | 08-27-2015 |