Patent application number | Description | Published |
20080299642 | VECTORS WITH MODIFIED PROTEASE-DEPENDENT TROPISM - The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo. | 12-04-2008 |
20100297732 | VECTORS WITH MODIFIED PROTEASE-DEPENDENT TROPISM - The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modified to be cleaved by different proteases, were produced. In cells transfected with these vectors, the genomic RNA present in the vectors is replicated, and cell fusogenic infection spreads to neighboring cells depending on the presence of other proteases; however, no viral particles are released. The vectors of this invention, encoding the F proteins which are cleaved by proteases whose activity is enhanced in cancer, show cancer growth suppressive effect in vivo. | 11-25-2010 |
Patent application number | Description | Published |
20090030023 | PYRIMIDINE COMPOUNDS AND MEDICINAL COMPOSITION THEREOF - A compound represented by the following formula (I), a salt, or a solvate thereof: | 01-29-2009 |
20090292120 | BENZIMIDAZOLE COMPOUNDS HAVING GASTRIC ACID SECRETION INHIBITORY ACTION - The present invention provides a compound that has superior gastric acid secretion inhibitory action, ample long-lasting gastric acid secretion inhibitory action, and is able to maintain intragastric pH at a high level for an extended period of time, making it useful as a therapeutic or prophylactic agent for diseases or symptoms caused by gastric acid, as well as an active form of this compound (form to which the compound is converted in the body following administration thereof) in the form of a compound represented by general formula (1a) (wherein R2 represents a group represented by formula (I) or the like, and R1, R3, W1 and X | 11-26-2009 |
20100022778 | PROCESS FOR PRODUCTION OF SULFINYLBENZIMIDAZOLE COMPOUNDS OR SALTS THEREOF - It is an object of the present invention to provide a process for the production on an industrial scale of a compound (1) or a salt thereof. There is provided a process for the production of compound (1) represented by the formula or a salt thereof: (wherein R1 and R3 independently represents a hydrogen atom or a methyl group), the process comprising the steps of: (a) reacting together a compound (3T) represented by the formula: (wherein X1 represents a leaving group, and R1 and R3 are defined as above) and (2,2-dimethyl-1,3-dioxan-5-yl)methanol represented by the formula or a salt thereof: so as to produce a compound (2T) represented by the formula (wherein R1 and R3 are defined as above); and (b) reacting the compound represented by above formula (2T) with an oxidizing agent. | 01-28-2010 |
20110009624 | BENZIMIDAZOLE COMPOUNDS HAVING GASTRIC ACID SECRETION INHIBITORY ACTION - The present invention provides a compound that has superior gastric acid secretion inhibitory action, ample long-lasting gastric acid secretion inhibitory action, and is able to maintain intragastric pH at a high level for an extended period of time, making it useful as a therapeutic or prophylactic agent for diseases or symptoms caused by gastric acid, as well as an active form of this compound (form to which the compound is converted in the body following administration thereof) in the form of a compound represented by general formula (1a) (wherein R2 represents a group represented by formula (I) or the like, and R1, R3, W1 and X | 01-13-2011 |
Patent application number | Description | Published |
20100291363 | ELECTROPHOTOGRAPHIC RECORDING SHEET AND RECORDED MATERIAL - An electrophotographic recording sheet having, on a water-resistant support, a toner-receiving layer containing a liphophilic polymer antistatic agent with a specific surface resistivity of from 1×10 | 11-18-2010 |
20110143104 | ELECTROSTATIC ADSORBABLE SHEET - An electrostatic adsorbable sheet (iii), which has a long-lasting adsorbability not easily affected by humidity, secures good ink adhesiveness, and does not generate troubles in a printing process, is provided. The electrostatic adsorbable sheet (iii) comprises a laminate of a label layer (i) containing a resin film layer (A) and a recording layer (D) on one surface of the resin film layer (A), and a peelable sheet layer (ii) containing a peelable layer (B) and a support layer (C), in which the label layer (i) and the peelable sheet layer (ii) are laminated so that the resin film layer (A) and the peelable layer (B) contact with each other. The peeling strength between the label layer (i) and the peelable sheet layer (ii) is from 1 to 50 g/cm, and the label layer (i) peeled from the peelable sheet layer (ii) is electrostatically adsorbable to an object to be attached. | 06-16-2011 |
20120177907 | ENERGY CONVERSION FILM - An energy conversion film, which can hold a larger amount of charges by pores in the inside of the film and has high energy conversion performances, is provided, by obtaining a porous resin film with a high expansion ratio without adopting an expansion treatment with a high-pressure gas by forming a thermoplastic resin stretched film having a specified structure. The energy conversion film includes a core layer (A) having specified pores and composed of a thermoplastic resin stretched film including a thermoplastic resin and at least one of an inorganic powder and an organic filler. | 07-12-2012 |
20130164471 | READILY REMOVABLE FILM, LABEL FOR IN-MOLD MOLDING, MOLDED RESIN ARTICLE HAVING LABEL ATTACHED THERETO, WALLPAPER, GLUE LABEL, AND CONTAINER HAVING LABEL ATTACHED THERETO - A readily removable film containing a substrate layer (A) and a readily removable layer (B), wherein the substrate layer (A) contains a thermoplastic resin, the readily removable layer (B) contains from 30 to 60% by weight of a mixture of a crystalline polypropylene resin having a degree of crystallinity of at least 65% and a thermoplastic resin immiscible with the crystalline polypropylene resin, and from 40 to 70% by weight of a fine powder, in which the thermoplastic resin immiscible with the crystalline polypropylene resin is blended in a ratio of from 105 to 300 parts by weight relative to 100 parts by weight of the crystalline polypropylene resin, and the readily removable layer (B) is stretched at least monoaxially. | 06-27-2013 |
20140137935 | BACK SHEET FOR SOLAR CELLS, AND SOLAR CELL USING SAME - A solar-cell back sheet comprising a laminate of an adhesive layer ( | 05-22-2014 |
20150375477 | READILY REMOVABLE FILM, LABEL FOR IN-MOLD MOLDING, MOLDED RESIN ARTICLE HAVING LABEL ATTACHED THERETO, WALLPAPER, GLUE LABEL, AND CONTAINER HAVING LABEL ATTACHED THERETO - A readily removable film containing a substrate layer (A) and a readily removable layer (B), wherein the substrate layer (A) contains a thermoplastic resin, the readily removable layer (B) contains from 30 to 60% by weight of a mixture of a crystalline polypropylene resin having a degree of crystallinity of at least 65% and a thermoplastic resin immiscible with the crystalline polypropylene resin, and from 40 to 70% by weight of a fine powder, in which the thermoplastic resin immiscible with the crystalline polypropylene resin is blended in a ratio of from 105 to 300 parts by weight relative to 100 parts by weight of the crystalline polypropylene resin, and the readily removable layer (B) is stretched at least monoaxially. | 12-31-2015 |