Patent application number | Description | Published |
20120021998 | Cancer Diagnosis and Treatment Methods of Use - The present invention relates to a method for treating a subject suffering from growth of AR-containing tumor cells, comprising administrating the subject an effective amount of DDB2. The present invention also relates to a kit for the diagnosis of cancer. | 01-26-2012 |
20120065122 | Pharmaceutical Composition and Method for Modulating Slow Myosin - The present invention directed to a method for modulating the expression level of slow myosin comprising administering to a subject in need thereof a therapeutically effective amount of nuclear receptor interaction protein (NRIP) modulator and calmodulin, and a pharmaceutically acceptable carrier. | 03-15-2012 |
20130081148 | NRIP KNOCKOUT MICE AND USES THEREOF - The present invention directs to a transgenic NRIP knockout mouse, the genome of which is manipulated to comprise a disruption of a nuclear receptor interaction protein (NRIP) gene, wherein the NRIP gene is disrupted by deletion of exon 2, the mouse exhibits a phenotype comprising abnormal muscular function. The present invention also directs to a method for making a transgenic NRIP knockout mouse whose genome comprises a homozygous disruption of the NRIP gene, the mouse exhibits abnormal muscular function. | 03-28-2013 |
20130178410 | METHODS FOR MODULATING SLOW MYOSIN - The present invention provides a method for modulating an expression level of a gene encoding slow myosin in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of a nuclear receptor interaction protein (NRIP) and a pharmaceutically acceptable carrier. The present invention also provides a method for modulating an expression level of a gene encoding slow myosin in a subject in need thereof, comprising administering to said subject a pharmaceutically effective amount of an expression vector comprising a gene encoding a nuclear receptor interaction protein (NRIP) and a pharmaceutically acceptable carrier. In a preferred embodiment, the expression vector is an adenoviral vector. | 07-11-2013 |
20130184224 | METHODS FOR INHIBITING TUMOR GROWTH - The present invention provides a method for inhibiting androgen receptor (AR)-containing tumor cell growth in a subject in need thereof, comprising administrating to said subject a pharmaceutically effective amount of a damaged-DNA binding protein 2 (DDB2) and a pharmaceutically acceptable carrier. The present invention also provides a method for inhibiting androgen receptor (AR)-containing tumor cell growth in a subject in need thereof, comprising administrating to said subject a pharmaceutically effective amount of an expression vector comprising a gene encoding a damaged-DNA binding protein 2 (DDB2) and a pharmaceutically acceptable carrier. In a preferred embodiment, the expression vector is a plasmid vector. | 07-18-2013 |
20150226750 | NRIP AS A BIOMARKER OF ABNORMAL FUNCTION OF MOTOR NEURONS - The present invention provides a method for evaluating physiological state of motor neurons in a subject. The method comprises detecting an expression level of a nuclear receptor interaction protein (NRIP) in a biological sample from the subject; and comparing the expression level of the NRIP to a control value for NRIP; wherein detecting a decrease of the expression level of the NRIP in the biological sample from the subject as compared to the control value for NRIP indicates an abnormal function of the motor neurons of the subject | 08-13-2015 |
Patent application number | Description | Published |
20100282880 | Paper Shredder Control System Responsive to Touch-Sensitive Element - The invention is directed to a touch-sensitive paper shredder control system. The touching feature is implemented through a series of electronic circuits, taking input from a conductive touch panel on the shredder feed throat, processing the signal, and through a motor driving circuit, stopping the mechanical parts of the shredder. The system has a touch detection circuit unit, which contains a bioelectricity controlled switching circuit to sense the conductive touch panel. The bioelectricity controlled switching circuit is configured to trigger a ground switching circuit in the touch detection circuit unit which outputs to a multifunction control circuit unit. The control circuit unit then takes care of the remaining protection issues. The touching device for paper shredders protects humans and other living beings including pets from injuries through automatic and real time monitoring. The complete control process is both safe and sensitive. | 11-11-2010 |
20110024535 | Safety Inlet Apparatus for a Paper Feed Opening of a Shredder - Safety inlet apparatus for a shredder paper feed opening includes upper cover, safety cover, paper feed passage block, and elastic member. A safety cover end section covers the shredder paper feed opening, and rotatably couples to the upper cover. Paper feed passage block is positioned between shredder paper feed opening and elastic member, and the safety cover pivots to the upper cover. Paper feed passage block is slidably arranged on the upper cover near shredder paper feed opening, connecting to the safety cover second end section. Elastic member ends respectively connect to the upper cover inner wall and the paper feed passage block. Paper feed passage block may be fixed to, or integrated with, the second end section, or may limit a stud on the second end section. | 02-03-2011 |
20110039483 | Apparatus and Composition for Sharpening a Paper Shredder Blade, and Preparation Process Therefor - Composition, apparatus, and methods of composition and apparatus manufacture, for sharpening a paper shredder blade. Composition includes grinding powder, thickening agent, and additive. The thickening agent may be a white oil, an animal oil, an vegetable oil, or a stearine wax. The additive may be an antirust powder, an antiwear powder, an antistatic powder, or an antioxidation powder. The grinding composition is dispensed into a polyethylene film, and sealed to form the grinding apparatus, as a grinding sheet or a grinding packet. A method for forming a grinding sheet includes selecting the constituent materials for a grinding composition; stirring the constituent grinding composition materials; heating the constituent materials to melting; mixing the constituent materials, while melting and intermixing; cooling and packaging the grinding composition to form a grinding sheet or packet. | 02-17-2011 |
20110072876 | New-Type Thin Shredder Blade Having Blade Points without Steps, Blade Sets and Manufacturing Method Thereof - The present invention provides a new-type thin shredder blade having blade points without steps, comprising at least one blade body and at least one cutting part that is located on the periphery of the blade body and includes a blade point, wherein the cutting part further comprises a protrusion which protrudes from the cutting part and includes a top, a inclined plane extends between the top and the blade point, and an acute angle is formed by the inclined plane and the blade body, preferably, the inclined plane is an inverted triangle, the cutting part further includes a first hemline and a second hemline extending respectively from the blade body and intersecting to the 10 blade point, a first plane extends between the top and the first hemline and intersects with the inclined plane, the blade body includes at least one large protrusion which protrudes in the same direction as the protrusion, the blade sets formed by the above-mentioned new-type thin blades and the manufacturing method of the above-mentioned new-type thin blades are also provided, with the blade sets formed by the new-type thin shredder blade having blade points without steps of the present invention, the shredder can reduce the production cost and the energy consumption greatly, while meet the same cutting requirement of the common shredder entirely. | 03-31-2011 |
20110133008 | PERMITTIVITY-BASED PAPER SHREDDER CONTROL SYSTEM - The invention is directed to a permittivity-based paper shredder control system. The touching feature is implemented through a series of electronic circuits, taking input from a conductive touch panel on the shredder feed throat, processing the signal, and through a motor driving circuit, stopping the mechanical parts of the shredder. The system has a touch detection circuit unit, which contains a bioelectricity controlled switching circuit to sense the conductive touch panel. The bioelectricity controlled switching circuit is configured to trigger a ground switching circuit in the touch detection circuit unit which outputs to a multifunction bioshield controller. The bioshield controller then takes care of the remaining protection issues. The touching device for paper shredders protects humans and other living beings including pets from injuries through automatic and real time monitoring. The complete control process is both safe and sensitive. | 06-09-2011 |
20110316356 | PAPER SHREDDER CONTROL SYSTEM RESPONSIVE TO TOUCH-SENSITIVE ELEMENT - The invention is directed to a touch-sensitive paper shredder control system. The touching feature is implemented through a series of electronic circuits, taking input from a conductive touch panel on the shredder feed throat, processing the signal, and through a motor driving circuit, stopping the mechanical parts of the shredder. The system has a touch detection circuit unit, which contains a bioelectricity controlled switching circuit to sense the conductive touch panel. The bioelectricity controlled switching circuit is configured to trigger a ground switching circuit in the touch detection circuit unit which outputs to a multifunction control circuit unit. The control circuit unit then takes care of the remaining protection issues. The touching device for paper shredders protects humans and other living beings including pets from injuries through automatic and real time monitoring. The complete control process is both safe and sensitive. | 12-29-2011 |
20130099040 | GROOVED INCISOR SHREDDER CUTTING BLADE SET AND METHOD - A grooved incisor blade set for paper shredders is disclosed. A blade includes a crown, a groove juxtaposed with the crown, and a center hole for a cutting arbor, where the crown and the groove define a relief channel. A stair-shaped, U-shaped or V-shaped blade assembly is described. In one embodiment, a notched grooved incisor blade having notches proximate to the central hole comes in contact with a mating grooved incisor blade also having a central hole. Force is applied to the mating blade to displace some of the body of the mating blade into the notches, affixing the blades together. A method for forming shredder cutting blades includes providing a strip of metal, forming a crown in the strip of metal, forming a relief groove juxtaposed to the crown in the strip of metal, thereby forming a relief channel, and trimming the grooved incisor blade of excess metal. | 04-25-2013 |
20130227893 | APPARATUS AND COMPOSITION FOR SHARPENING A PAPER SHREDDER BLADE, AND PREPARATION PROCESS THEREFOR - Composition, apparatus, and methods of composition and apparatus manufacture, for sharpening a paper shredder blade. Composition includes grinding powder, thickening agent, and additive. The thickening agent may be a white oil, an animal oil, an vegetable oil, or a stearine wax. The additive may be an antirust powder, an antiwear powder, an antistatic powder, or an antioxidation powder. The grinding composition is dispensed into a polyethylene film, and sealed to form the grinding apparatus, as a grinding sheet or a grinding packet. A method for forming a grinding sheet includes selecting the constituent materials for a grinding composition; stirring the constituent grinding composition materials; heating the constituent materials to melting; mixing the constituent materials, while melting and intermixing; cooling and packaging the grinding composition to form a grinding sheet or packet. | 09-05-2013 |
20130227894 | APPARATUS AND COMPOSITION FOR SHARPENING A PAPER SHREDDER BLADE, AND PREPARATION PROCESS THEREFOR - Composition, apparatus, and methods of composition and apparatus manufacture, for sharpening a paper shredder blade. Composition includes grinding powder, thickening agent, and additive. The thickening agent may be a white oil, an animal oil, an vegetable oil, or a stearine wax. The additive may be an antirust powder, an antiwear powder, an antistatic powder, or an antioxidation powder. The grinding composition is dispensed into a polyethylene film, and sealed to form the grinding apparatus, as a grinding sheet or a grinding packet. A method for forming a grinding sheet includes selecting the constituent materials for a grinding composition; stirring the constituent grinding composition materials; heating the constituent materials to melting; mixing the constituent materials, while melting and intermixing; cooling and packaging the grinding composition to form a grinding sheet or packet. | 09-05-2013 |
20140084093 | SAFETY SHREDDER - A safety inlet apparatus for a paper feed opening of a shredder, with cutting cylinders including an upper casing having a feed end with a safety dam with upper and lower indices. An angled plate means set apart from the upper casing forms the paper feed opening. A safety plate with a distal index end is provided, which is formed to traverse the feed opening from the angled plate to the safety dam. Also included is a pivot, and a power control switch. The pivot is configured to facilitate traversal of the safety plate distal index from the angled plate to the safety dam. The power limit switch is on the upper casing, apart from the pivot member. The traversal of the safety plate distal index end to the safety dam lower index causes the power control switch to stop comminution. A buckle bit plate provides open and closed detents. | 03-27-2014 |
20150273477 | GROOVED INCISOR SHREDDER CUTTING BLADE SET AND METHOD - A grooved incisor blade set for paper shredders is disclosed. A blade includes a crown, a groove juxtaposed with the crown, and a center hole for a cutting arbor, where the crown and the groove define a relief channel. A stair-shaped, U-shaped or V-shaped blade assembly is described. In one embodiment, a notched grooved incisor blade having notches proximate to the central hole comes in contact with a mating grooved incisor blade also having a central hole. Force is applied to the mating blade to displace some of the body of the mating blade into the notches, affixing the blades together. A method for forming shredder cutting blades includes providing a strip of metal, forming a crown in the strip of metal, forming a relief groove juxtaposed to the crown in the strip of metal, thereby forming a relief channel, and trimming the grooved incisor blade of excess metal. | 10-01-2015 |