Patent application number | Description | Published |
20100221119 | Helicopter Rotor Yoke and Method of Making Same - A rotor yoke includes a blade attachment portion, a mast attachment portion, and an intermediate portion extending between the blade attachment portion and the mast attachment portion. The intermediate portion, the blade attachment portion, and the mast attachment portion define an optional inner edge, such that the inner edge, if present, defines an opening. The rotor yoke further includes a peripheral, outer edge extending about the blade attachment portion, the intermediate portion, and the mast attachment portion. At least one of the outer edge and the inner edge, if present, includes a reduced thickness portion exhibiting a thickness that is less than a thickness of an adjacent portion of the rotor yoke. | 09-02-2010 |
20100266416 | Rotor Blade and Method of Making Same - A helicopter rotor blade includes a structural composite skin defining a cavity therein; a composite spar disposed within the cavity and adhesively bonded to the skin, a portion of the spar exhibiting a C-shape in cross section; and a foam core disposed within the cavity and adhesively bonded to the skin. The structural composite skin forms an external, closed box structure configured to transmit mechanical loads encountered by the rotor blade. | 10-21-2010 |
Patent application number | Description | Published |
20110206513 | Drive Mechanisms For Variable Diameter Rotor Systems - A rotor hub assembly includes a rotor hub for supporting a telescoping rotor blade having an outboard section; and a drive mechanism associated with the telescoping rotor blade, the drive mechanism including: a motor; a spool driven by the motor; and a strap wound on the spool, the strap coupled to the outboard section of the telescoping rotor blade. | 08-25-2011 |
20130078100 | LOW OFFSET HINGELESS ROTOR WITH PITCH CHANGE BEARINGS - A hub assembly for a tilt rotor includes a yoke having a plurality of yoke arms located substantially orthogonal to a central axis of the hub assembly. An inboard pitch change bearing assembly substantially surrounds a yoke arm of the plurality of yoke arms. An outboard pitch change bearing assembly is located at the yoke arm. The inboard pitch change bearing assembly and the outboard pitch change bearing assembly are operably connectable with a rotor blade to allow pitch change of the rotor blade relative to the yoke about a pitch change axis. | 03-28-2013 |
20150125299 | COUNTER-ROTATING ROTOR SYSTEM WITH STATIONARY STANDPIPE - A rotor system includes a first rotor located at a rotor axis that imparts a first axial load and a first moment, and a first shaft connected to the first rotor at the axis. A first bearing connects a gearbox to the first shaft, transferring the first axial load from the first shaft to the gearbox. A second rotor located at the axis imparts a second axial load and a second moment. A second shaft is connected to the second rotor at the axis, the second shaft coaxial with the first rotor. A second bearing connects the gearbox to the second shaft, transferring the second axial load from the second shaft to the gearbox. A nonrotating standpipe is located at the axis radially between the first shaft and the second shaft. An intershaft bearing located at the standpipe reacts the first and second moments using the first and second bearings. | 05-07-2015 |
20150139799 | COUNTER-ROTATING ROTOR SYSTEM WITH STATIC MAST - A coaxial, dual rotor system includes a first rotor assembly positioned at a rotor axis. A first rotor quill shaft is operably connected to the first rotor assembly at the rotor axis to drive rotation of the first rotor assembly about the rotor axis. A nonrotating static mast extends along the rotor axis through the first rotor quill shaft. A second rotor assembly is positioned at the rotor axis. A second rotor quill shaft is operably connected to the second rotor assembly to drive rotation of the second rotor assembly about the rotor axis. The second rotor quill shaft is coaxial with the first rotor quill shaft and disposed inside of the static mast. A second rotor bearing is positioned between the second rotor assembly and the static mast to transfer loads from the second rotor assembly to the static mast. | 05-21-2015 |
20150298803 | ADJUSTABLE SCISSOR CONTROL LINK - A control link disposed to transfer rotor shaft rotation from an elongate element rotatable with a shaft to a rotatable element is provided and includes a structure terminating at a first end thereof as a mating element, which is securable to the elongate element such that the elongate element is rotatable about an axis defined through the mating element and such that a moment reaction in opposition to structure rotation about the elongate element is generated and a rod coupled to the rotatable element being and configured to be coupled to a second end of the structure at variable distances relative to the rotatable element. | 10-22-2015 |
Patent application number | Description | Published |
20130157261 | Compositions and Methods for Quantitative Histology, Calibration of Images in Fluorescence Microscopy, and ddTUNEL Analyses - Disclosed are compositions and methods for quantitation and calibration of images in fluorescence microscopy. Also provided are tissue phantoms that contain known amount(s) of fluorophore standard(s), as well as components and diagnostic kits containing the same for use in various histological analyses. In certain embodiments, three distinct nucleic-acid based assays provide improvements over conventional TUNEL methods to facilitate precise quantitation of a variety of nucleic acids obtained from a biological sample. | 06-20-2013 |
20140154269 | TARGETED NANOVECTORS AND THEIR USE FOR TREATMENT OF BRAIN TUMORS - In some embodiments, the invention pertains to therapeutic compositions for treating a brain tumor. Such therapeutic compositions generally comprise: (1) a nanovector; (2) an active agent associated with the nanovector with activity against brain tumor cells; and (3) a targeting agent associated with the nanovector with recognition activity for a marker of the brain tumor cells. In some embodiments, the active agent and the targeting agent are non-covalently associated with the nanovector. Additional embodiments of the present invention pertain to methods of treating a brain tumor in a subject (e.g., a human being) by administering the aforementioned therapeutic compositions to the subject. Further embodiments of the present disclosure pertain to methods of formulating therapeutic compositions for treating a brain tumor in a subject in a personalized manner. | 06-05-2014 |
20140323513 | Chemotherapeutic Compositions and Methods for Treating Human Gliomas - Disclosed are compound for targeting chemotherapeutic agents to mammalian mitochondria. Also disclosed are monoamine oxidase-specific compositions, and methods of using them for the selective therapy of mammalian cancers, and in particular, in the treatment of human gliomas. Also disclosed are methods employing the novel targeted chemotherapeutics with one or more conventional anti-cancer therapies, including, for example, radiotherapy, or multi-drug regimens. | 10-30-2014 |
20150216975 | NANOVECTOR BASED DRUG DELIVERY SYSTEM FOR OVERCOMING DRUG RESISTANCE - Various embodiments of the present invention provide therapeutic compositions for specifically targeting tumor cells. In some embodiments, the therapeutic compositions generally include: (1) a plurality of nanovectors; (2) one or more active agents associated with the nanovectors, where the one or more active agents have activity against the tumor cells; (3) one or more active agent enhancers associated with the nanovectors; and (4) one or more targeting agents associated with the nanovectors, where the one or more targeting agents have recognition activity for one or more markers of the tumor cells. Additional embodiments of the present invention pertain to methods of targeting tumor cells in a subject by administering one or more of the aforementioned therapeutic compositions to the subject. Further embodiments of the present invention pertain to methods of formulating the aforementioned therapeutic compositions for targeting tumor cells in a subject in a personalized manner. | 08-06-2015 |
Patent application number | Description | Published |
20090068738 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES - The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). | 03-12-2009 |
20110213123 | COMPOSITIONS AND METHODS FOR MODIFICATION OF BIOMOLECULES - The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). | 09-01-2011 |
20130344527 | Compositions and Methods for Modification of Biomolecules - The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids). | 12-26-2013 |
Patent application number | Description | Published |
20090150486 | SYSTEM AND METHOD FOR DELIVERING REMOTELY STORED APPLICATIONS AND INFORMATION - A method and system are disclosed for delivering interactive links for presenting applications and second information at a client computer from remote sources in a network-configured computer processing system. In one embodiment, the method includes retrieving over a first communication connection, in response to a request of a client computer, informational content having computer program code embedded therein, and executing the embedded computer program code for establishing a second communication connection to an application server. The method further includes retrieving over the second communication connection first information including presentational information for presenting the application and the second information. The method also includes presenting the application and the second information based upon the presentational information, and storing on the client computer an interactive link for selectively re-establishing the second communication connection to the application server for retrieving the first information and presenting the application and the second information on an as-needed basis. Preferably, the storing of the interactive link includes downloading a graphical representation of the interactive link and storing a file containing information representing an operating environment of the client computer and a network address of the application server. | 06-11-2009 |
20130024499 | SYSTEM AND METHOD FOR DELIVERING REMOTELY STORED APPLICATIONS AND INFORMATION - The computerized method and apparatus for mobile device interactivity includes hosting a network application on a server. The method and apparatus further includes receiving, at the application on the server, an event message from a mobile application executing on a mobile device, the application having executable code embedded therein for communicating with the network information for presenting a user interface for the network application on the mobile device, the event message reporting an action taken via the user interface. The method and apparatus further including executing application logic within the network application to generate data values based on the action reported in the event message and mobile device information and sending to the mobile device an update message with at least some of the generated data values and instructions for use by the executable code to present the data values within the user interface at the mobile device. | 01-24-2013 |
20140310333 | SYSTEM AND METHOD FOR DELIVERING REMOTELY STORED APPLICATIONS AND INFORMATION - The present invention includes computerized method and apparatus for user interactivity with a network application executing on a server. The method and apparatus includes receiving, via a wireless network, an event message from a mobile device, the event message representing an input from a user interface on the mobile device where the user interface is executing based on a mobile application. The method and apparatus further includes generating data values based on the input in the event message and information relating to the mobile device. Moreover, the method and apparatus includes sending an update message to the mobile device based on the data values for updating a display of the mobile device. | 10-16-2014 |
Patent application number | Description | Published |
20090117207 | Methods and compositions for treatment of poison-caused pathology - A method of treating a poison-caused pathology in an individual subject is described which includes administering a pharmaceutical composition including a therapeutically effective amount of a chloride current modulator, a therapeutically effective amount of an exogenous oxygen carrier, or a combination of a therapeutically effective amount of a chloride current modulator and a therapeutically effective amount of an exogenous oxygen carrier, to an individual subject exposed to a poison. Optionally, an inventive method further includes administering a therapeutic agent to inhibit poison-caused pathology. A composition according to the invention is described which includes a therapeutically effective amount of a chloride current modulator, a therapeutically effective amount of an exogenous oxygen carrier, or a combination of a therapeutically effective amount of a chloride current modulator and a therapeutically effective amount of an exogenous oxygen carrier. Further included in one embodiment is a therapeutic agent to inhibit poison-caused pathology. | 05-07-2009 |
20100168030 | Methods and compositions for treatment of organophosphate-caused pathology - A method of treating an organophosphate toxin-caused cardiac abnormality is described which includes administering a pharmaceutical composition including a therapeutically effective amount of a chloride current modulator to an individual subject having a cardiac abnormality caused by intoxication with an organophosphate toxin. The chloride current modulator is effective to modulate a chloride conductance and thereby reduce a symptom or sign of an organophosphate toxin-caused cardiac abnormality, thus treating the toxin-caused cardiac abnormality. Optionally, included is administering a therapeutic agent to inhibit an organophosphate toxin-caused distortion of the action potential of myocytes, support restoration of usual intracellular ionic concentrations, and support an increase in cardiac contractility. A composition according to the invention is described which includes a chloride current modulator; and a therapeutic agent to inhibit an organophosphate toxin-induced distortion of the action potential of myocytes, support restoration of usual intracellular ionic concentrations, and support an increase in cardiac contractility. | 07-01-2010 |
20120164738 | DETECTION OF SMALL LIGANDS WITH METMYOGLOBIN - The invention relates to methods and compositions for the rapid detection of small ligands, such as cyanide, carbon monoxide or azide, in small quantities. Specifically, metmyoglobin is used to bind small ligands which yield a product with a characteristic absorbance spectrum that is detectable and quantifiable. Also disclosed is a kit for detecting small ligands with metmyoglobin, which is portable and provides for practice of the invention without the use of harsh solvents or chemical reagents. | 06-28-2012 |