Patent application number | Description | Published |
20080294351 | METHOD FOR PREDICTING SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE, A PREDICTOR FOR SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE AND A PREDICTING PROGRAM FOR PREDICTING SECONDARY STRUCTURE OF NUCLEIC ACID SEQUENCE - An exemplary object of the present invention is to provide method, predictor and predicting program for predicting secondary structure of nucleic acid sequence capable of evaluating not only overall similarity and but also localized similarity of secondary structure of nucleic acid sequence. A method according to an exemplary aspect of the present invention includes the steps of: | 11-27-2008 |
20100235155 | METHOD FOR PREDICTING SECONDARY STRUCTURE OF RNA, AN APPARATUS FOR PREDICTING AND A PREDICTING PROGRAM - The present invention is to provide a method for predicting secondary structure of RNA capable of predicting the secondary structure which has been difficult to predict the secondary structure including pseudonot structure, and an apparatus for predicting secondary structure of RNA using the method for predicting. The method for predicting secondary structure of RNA according to the present invention is characterized in that: | 09-16-2010 |
20120083418 | METHOD FOR DESIGNING PRIMERS FOR SELEX METHOD, METHOD FOR PRODUCING THE PRIMERS, METHOD FOR PRODUCING APTAMERS, SYSTEM FOR DESIGNING THE PRIMERS, AND COMPUTER PROGRAM AND RECORDING MEDIUM FOR DESIGNING THE PRIMERS - A method for designing primers, being capable of efficiently designing primers for a SELEX method is provided. The method for designing primers of the present invention includes the steps of: (S | 04-05-2012 |
20130022967 | NUCLEIC ACID MOLECULE HAVING AFFINITY TO RODENT-DERIVED IgG ANTIBODY, BINDER, DETECTION REAGENT, AND DETECTION KIT - The invention provides a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the invention includes the binder for a rodent-derived IgG antibody of the invention. The detection kit for detecting a rodent-derived IgG antibody of the invention includes the detection reagent for detecting a rodent-derived IgG antibody of the invention. | 01-24-2013 |
20130158884 | METHOD FOR IDENTIFYING NUCLEOTIDE SEQUENCE, METHOD FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, APPARATUS FOR IDENTIFYING NUCLEOTIDE SEQUENCE, APPARATUS FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, PROGRAM FOR IDENTIFYING NUCLEOTIDE SEQUENCE, AND PROGRAM FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE - The object of the present invention is to provide a method for identifying a nucleotide sequence necessary for expressing affinity for a target substance with respect to a nucleotide sequence of a nucleic acid molecule such as an aptamer having such affinity for the target substance, based on similarity between nucleotide sequences and an evaluated value of the affinity of the nucleotide sequence, and a method for predicting a secondary structure of the nucleic acid molecule including the identified nucleotide sequence. The method of present invention includes the steps of extracting a single-stranded region by excluding based capable of forming a stem structure from the nucleotide sequence of the nucleic acid molecule; and searching a motif sequence from the single-stranded region, based on an evaluated value of the affinity. | 06-20-2013 |
20140128589 | METHOD FOR EVALUATING REDOX ACTIVITY OF NUCLEIC ACID MOLECULE AND NUCLEIC ACID MOLECULE HAVING REDOX ACTIVITY - The present invention provides a novel technique by which the redox activity of a nucleic acid molecule can be evaluated. An evaluation method of the present invention includes: a detection step of electrochemically detecting a redox reaction to a substrate, the redox reaction being catalyzed by a nucleic acid molecule to be evaluated, using a device that electrochemically detects a redox reaction; and an evaluation step of evaluating redox activity of the nucleic acid molecule from a result of the detection of the redox reaction. As the device, a device in which a base provided with a detection portion is included, the detection portion. | 05-08-2014 |
20140370618 | NUCLEIC ACID MOLECULE HAVING BINDING AFFINITY TO RODENT-DERIVED IGG ANTIBODY, BINDER, DETECTION REAGENT, AND DETECTION KIT - The present invention is to provide a nucleic acid molecule having a binding affinity to a rodent-derived IgG antibody, which can be prepared easier than an antibody and has a binding affinity equivalent or superior to that of an antibody, a binder using the nucleic acid molecule, a detection reagent, and a detection kit. The nucleic acid molecule of the present invention has a binding affinity to a rodent-derived IgG antibody and has a dissociation constant of 1 μM or less. The binder for a rodent-derived IgG antibody of the present invention includes the nucleic acid molecule of the present invention. The detection reagent for detecting a rodent-derived IgG antibody of the present invention includes the binder for a rodent-derived IgG antibody of the present invention. The detection kit for detecting a rodent-derived IgG antibody of the present invention includes the detection reagent for detecting a rodent-derived IgG antibody of the present invention. | 12-18-2014 |
20150056720 | DEVICE AND METHOD FOR ANALYZING TARGET - The present invention provides a novel sensor for detecting a target. The nucleic acid sensor of the present invention includes a nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to a target. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (S | 02-26-2015 |
20150086980 | DEVICE AND METHOD FOR ANALYZING STREPTAVIDIN - The present invention provides a novel sensor for detecting streptavidin (SA). The nucleic acid sensor for analyzing SA of the present invention includes the following nucleic acid element that includes a catalyst nucleic acid molecule (D) that exerts a catalytic function and a binding nucleic acid molecule (A) that binds to SA. The nucleic acid element is a double-stranded nucleic acid element including a first strand and a second strand. The first strand (ss1) includes the binding nucleic acid molecule (A), a loop-forming sequence (L1), and the catalyst nucleic acid molecule (D) linked in this order. The second strand (ss2) includes a stem-forming sequence (S | 03-26-2015 |
Patent application number | Description | Published |
20100185397 | METHOD FOR IDENTIFYING NUCLEOTIDE SEQUENCE, METHOD FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, APPARATUS FOR IDENTIFYING NUCLEOTIDE SEQUENCE, APPARATUS FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, PROGRAM FOR IDENTIFYING NUCLEOTIDE SEQUENCE, AND PROGRAM FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE - It is intended to provide a method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules such as aptamers having the affinity for the target substance based on a homology of the respective nucleotide sequences and an evaluation value related to the affinity of the nucleotide sequences, and a method for predicting a secondary structure of a nucleic acid molecule containing the identified nucleotide sequence. The method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules having such an affinity is characterized by comprising the steps of: extracting a single-strand region from the nucleotide sequences of nucleic acid molecules by excluding nucleotides capable of forming a stem structure; and searching a motif sequence based on an evaluation value of the affinity from the single-strand region. | 07-22-2010 |
20100216650 | METHOD OF PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE, APPARATUS FOR PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE, AND PROGRAM FOR PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE - The object of the present invention is to provide a method of predicting a higher-order structure of a nucleic acid sequence typified by a G quartet structure, and an apparatus and a program that execute the method. The method according to the present invention relates to a method of predicting a nucleic acid higher-order structure that predicts a higher-order structure of a nucleic acid sequence, the method, including the steps of: extracting bases capable of forming a higher-order structure as a higher-order structure candidate from said nucleic acid sequence; extracting bases capable of forming a stem structure as a stem structure candidate from said nucleic acid sequence; and searching an optimal combinatorial structure based on the higher-order structure candidate and the stem structure candidate. | 08-26-2010 |
20110125681 | FEATURE EXTRACTION METHOD, FEATURE EXTRACTION APPARATUS, AND FEATURE EXTRACTION PROGRAM - Provided are a feature extraction method of creating a feature vector for objectively evaluating the sequence of aptamer on the basis of the biological features and a feature extraction apparatus and a feature extraction program for performing the method. The feature extraction method according to the present invention includes a step of predicting a secondary structure of a base sequence applied and a step of creating a feature vector based on a predicted secondary structure of the sequence. | 05-26-2011 |
20120003749 | NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE - The present invention relates to a nucleic acid molecule capable of binding to a 2,4,6-trinitrophenyl skeleton, a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton using the nucleic acid molecule, use of the nucleic acid molecule for detecting a compound having the 2,4,6-trinitrophenyl skeleton, and a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton. | 01-05-2012 |
20120129720 | APTAMER THAT RECOGNIZES PEPTIDE - An aptamer capable of binding to a histidine peptide is provided. A nucleic acid used as the aptamer capable of binding to a histidine peptide is any of the following nucleic acids (a) to (d): (a) a nucleic acid having a base sequence represented by SEQ ID NO: 17: GGUN | 05-24-2012 |
20120202195 | NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME - The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element | 08-09-2012 |
20120208867 | HMGB1 BINDING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF - A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10 | 08-16-2012 |
20130102480 | PREDICTION DEVICE, PREDICTION METHOD, PROGRAM, AND RECORDING MEDIUM - The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention | 04-25-2013 |
20130123350 | NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO c-MET AND USE THEREOF - The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2). | 05-16-2013 |
20130273530 | ANALYTICAL DEVICE AND ANALYTICAL METHOD - The present invention provides a technique capable of simply analyzing a target to be analyzed. An analytical device of the present invention includes a basal plate; a nucleic acid element; and a detection section of detecting a signal. The nucleic acid element and the detection section are arranged on the basal plate. The nucleic acid element includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule is a nucleic acid molecule capable of binding to a target. The second nucleic acid molecule is a nucleic acid molecule capable of binding to streptavidin. When the target does not bind to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is inactivated. When the target binds to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is activated. The detection section detects binding between the second nucleic acid molecule and the streptavidin. The target is bound to the first nucleic acid molecule, so that the streptavidin is bound to the second nucleic acid molecule. Thus, the target can be analyzed through detecting the binding between the second nucleic acid molecule and the streptavidin using the detection device. | 10-17-2013 |
Patent application number | Description | Published |
20120092379 | SENSING DATA DISPLAY APPARATUS AND SENSING DATA PROCESSING SYSTEM - It is provided a sensing data display apparatus which displays a sensing data with regard to a human, the sensing data display apparatus comprising: a receiving module for receiving a data indicating a physical amount detected by a sensor terminal mounted by the human; a sensing data storing module for storing the data indicating the physical amount; an information creating module for creating a piece of information related to the sensor terminal from the data stored to the sensing data storing module; a display module for displaying the piece of information; and a viewer detecting module for detecting a viewer who locates at a vicinity of the sensing display apparatus. The display module displays the piece of information related to a piece of information of the viewer detected by the viewer detecting module. | 04-19-2012 |
20130053086 | INFORMATION PROCESSING SYSTEM, MANAGEMENT SERVER AND INFORMATION PROCESSING METHOD - An information processing system including plural terminals, a base station to communicate with the terminals, and a management server coupled via a network to the base station, in which each terminal includes a behavioral information sensor to acquire behavioral information on the person wearing the terminal, and the management server retains the predefined relations among the persons within the organization, receives and retains the behavioral information from each terminal, calculates the behavioral characteristic quantity showing behavioral characteristics of each person relative to other persons based on the behavioral information, sums the calculated behavioral characteristic quantities for each of the defined relations between the person and the other persons, and when information showing changes in the still non-implemented defined relations is acquired, estimates the behavioral characteristic quantity of the person after changing the defined relation according to the acquired information, based on the acquired information and the behavioral characteristic quantity. | 02-28-2013 |