Ana
Ana Aguilera Barreto, Ciudad De La Habana CU
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20090304628 | STABILIZED PHARMACEUTICAL FORMULATIONS THAT CONTAIN THE INTERFERONS GAMMA AND ALPHA IN SYNERGISTIC PROPORTIONS - The present invention is related to stable pharmaceutical formulations to be applied by parenteral (liquids or freeze-dried), or topic way (gel, unguent or cream) that contain different quantities of the recombinant interferons gamma and alpha in synergistic proportions for the treatment of pathological events that contemplate the malignant or benign not-physiological growth of cells in tissue or organs. | 12-10-2009 |
Ana Alatorre, San Diego, CA US
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20110195170 | COMPOSITIONS COMPRISING SWEETNESS ENHANCERS AND METHODS OF MAKING THEM - The present invention provides solid and liquid compositions comprising 5-(neopentyloxy)-1H-benzo[c][1,2,6]thiadiazin-4-amino-2,2-dioxide or 3-(4-amino-2,2-dioxide-1H-benzo[c][1,2,6]thiadiazin-5-yloxy)-2′,2′-dimethyl-N-propylpropanamide, and methods of making the compositions by spray drying and spin melting. The present invention also provides ingestible compositions comprising compositions of the present invention and methods of making such foods. | 08-11-2011 |
Ana Antoran Martin, Zaragoza ES
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20100230916 | STACKABLE SHOPPING BASKET - The invention relates to a shopping basket in self service stores and/or supermarkets, of the type of those which can be stacked and incorporate rolling means ( | 09-16-2010 |
Ana Aranzabe Garcia, Eibar-Guipuzcoa ES
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20100068782 | METHOD FOR THE SURFACE TREATMENT OF SOLID SUBSTRATES - The invention relates to a process for the chemical modification of a surface of a support, in which said surface contains available hydroxyl groups and lacks metals or metallic alloys. According to the invention, the surface is treated with orthophosphoric acid. The surface thus treated can be used to immobilize biomolecules, cellular membranes, liposomes, cells or tissue sections. The invention is suitable for use in biotechnology, proteomics, genomics, pharmacology and histology in order to carry out studies on immobilized products. | 03-18-2010 |
Ana Armenta Lopez Vicuna, Madrid ES
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20110320207 | CODING, MODIFICATION AND SYNTHESIS OF SPEECH SEGMENTS - The invention relates to a method for speech signal analysis, modification and synthesis comprising a phase for the location of analysis windows by means of an iterative process for the determination of the phase of the first sinusoidal component and comparison between the phase value of said component and a predetermined value, a phase for the selection of analysis frames corresponding to an allophone and readjustment of the duration and the fundamental frequency according to certain thresholds and a phase for the generation of synthetic speech from synthesis frames taking the information of the closest analysis frame as spectral information of the synthesis frame and taking as many synthesis frames as periods that the synthetic signal has. The method allows a coherent location of the analysis windows within the periods of the signal and the exact generation of the synthesis instants in a manner synchronous with the fundamental period. | 12-29-2011 |
Ana Arreguin, Laval CA
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20080251097 | DENTAL PEN - A device comprising a body, a head and a tail, a material squeezed out from the body exiting the body and feeding a housing of the head, one wall of the housing being provided with apertures, allowing the material squeezed out from the body to further reach a toothbrush mounted on this wall of the housing. The tail acts as a dental floss dispenser. | 10-16-2008 |
Ana Aznar-Meyer, Parsippany, NJ US
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20120055597 | Waste Receptacle Cover - Waste receptacle covers may be used to cover the waste receptacle to limit the unsightliness of the receptacle, to identify the receptacle, and/or to protect the receptacles. A waste receptacle cover may be formed from a variety of materials. For example, the cover may be formed from weather (e.g., UV, moisture, temperature) and/or abrasion (e.g., cut, tear) resistant materials. The cover may be made of a material that is mold and/or mildew resistant or inhibitive. The cover may be made of a material that is odor absorbing or odor blocking. The cover may be polyester, a polyester-blend, nylon, other synthetic materials, or some combination thereof and may include recycled material (e.g., plastic), renewable/sustainable material (e.g., bamboo) and/or spandex fabric or spandex blend. | 03-08-2012 |
Ana Balevic, Munchen DE
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20090055753 | Method and arrangement for supporting a user and a user group - In one aspect a method for supporting a user in a user group, where the user has a mobile information appliance available, and where a user profile with user-specific preferences is input into a database by the user or for the user is provided. In this case, the user is assigned to at least one subgroup of the user group on the basis of the user profile, and the members of the subgroup are displayed to the user by means of the information appliance. A further important aspect is the option of writing and publishing experience reports, with other users being able to rate these reports and the prospect of advantages being held out to the author on the basis of the ratings. | 02-26-2009 |
Ana Blanco Toribio, Madrid ES
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20100120124 | SYSTEMS, METHODS AND MICRORGANISMS FOR ANTIBODY PRODUCTION WITH TYPE III SECRETION SYSTEM - Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to prepare pharmaceutical compositions for the treatment of human or veterinary diseases. | 05-13-2010 |
Ana Borisavljevic, Pleasanton, CA US
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20120043818 | Switching Circuits For Extracting Power From An Electric Power Source And Associated Methods - An electric power system includes N electric power sources and N switching circuits, where N in an integer greater than one. Each switching circuit includes an input port electrically coupled to a respective one of the N electric power sources, an output port, and a first switching device adapted to switch between its conductive and non-conductive states to transfer power from the input port to the output port. The output ports of the N switching circuits are electrically coupled in series and to a load to establish an output circuit. Each of the N switching circuits uses an interconnection inductance of the output circuit as a primary energy storage inductance of the switching circuit. | 02-23-2012 |
20120043823 | Switching Circuits For Extracting Power From An Electric Power Source And Associated Methods - A switching circuit for extracting power from an electric power source includes ( | 02-23-2012 |
20120044014 | Switching Circuits For Extracting Power From An Electric Power Source And Associated Methods - An integrated circuit chip includes a first input port, a first output port, and first and second transistors electrically coupled in series across the first input port. The second transistor is also electrically coupled across the first output port and is adapted to provide a path for current flowing through the first output port when the first transistor is in its non-conductive state. The integrated circuit chip additionally includes first driver circuitry for driving gates of the first and second transistors to cause the transistors to switch between their conductive and non-conductive states. The integrated circuit chip further includes first controller circuitry for controlling the first driver circuitry such that the first and second transistors switch between their conductive and non-conductive states to at least substantially maximize an amount of electric power extracted from an electric power source electrically coupled to the first input port. | 02-23-2012 |
20140375134 | Switching Circuits For Extracting Power From An Electric Power Source And Associated Methods - An electric power system includes N electric power sources and N switching circuits, where N is an integer greater than one. Each switching circuit includes an input port electrically coupled to a respective one of the N electric power sources, an output port, and a first switching device adapted to switch between its conductive and non-conductive states to transfer power from the input port to the output port. The output ports of the N switching circuits are electrically coupled in series and to a load to establish an output circuit. Each of the N switching circuits uses an interconnection inductance of the output circuit as a primary energy storage inductance of the switching circuit. | 12-25-2014 |
Ana Borisavljevic, Marina Del Rey, CA US
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20080211440 | MEASUREMENT OF SPEED AND DIRECTION OF COASTING PERMANENT MAGNET SYNCHRONOUS MOTOR - A method for determining the speed of rotation of an unpowered, coasting electric motor, driven, when powered, by an electronic inverter, and without activating switches of the inverter. The steps include determining an electrical frequency of a back emf signal generated at a terminal of the motor or switching node of the inverter when the motor is coasting and determining the mechanical motor frequency and thus speed of rotation by dividing the electrical frequency by the number of motor pole pairs. | 09-04-2008 |
Ana Calle Martin, Madrid ES
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20090021727 | DEVICE AND METHOD FOR DETECTING CHANGES IN THE REFRACTIVE INDEX OF A DIELECTRIC MEDIUM - The device for detecting changes in the refractive index of a dielectric medium comprises: at least one metallic layer ( | 01-22-2009 |
Ana Casas Infantes, Fraga (huesca) ES
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20100031452 | AZO DYES - The present invention relates to azo dyes, in particular azo dyes of Formula (I) or (II), a tautomer, a quaternary amine, or a salt thereof, | 02-11-2010 |
Ana Castro Morera, Tres Cantos (madrid) ES
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20100240692 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds. | 09-23-2010 |
20110306631 | TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER - The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition or cancer, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition or cancer, and a pharmaceutical composition comprising the compounds. | 12-15-2011 |
20140011835 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or prophylaxis of a neurodegenerative or hematological disease or condition, their use as a medicament, especially for treating a neurodegenerative or hematological disease or condition, and a pharmaceutical composition comprising the compounds. | 01-09-2014 |
Ana De Bettencourt-Dias, Reno, NV US
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20090281290 | Pyridine-bis (oxazoline)("pybox") moiety as a chelator and sensitizer for lanthanide Ion (Ln (III)) luminescence - This invention relates to novel Ln(III) complexes of pybox, and methods of making the same. The present invention also relates to a method of use of pybox as a chelating moiety and sensitizer for Ln(III) ion luminescence. Derivatives of pybox and methods of making the same are also provided. | 11-12-2009 |
Ana Deletic, Victoria AU
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20110166848 | METHOD AND SYSTEM FOR MODELLING WATER TREATMENT AND HARVESTING - A method of modelling a water harvesting and treatment system, the method comprising: receiving modelling data, the modelling data comprising a plurality of parameters relating to intended application of the water harvesting and treatment system; accessing rainfall data for a geographic region for a predetermined historical period, the rainfall data comprising data for a plurality of predetermined time increments over the historical period; and generating a model of the water harvesting and treatment system based on the rainfall data and the modelling data. | 07-07-2011 |
Ana De Prado Gonzalez, Madrid ES
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20100160340 | PROTEIN KINASE INHIBITORS - The present invention provides a compound of formula (I): | 06-24-2010 |
Ana De Vera, Basel CH
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20110124605 | Use of an S1P Receptor Agonist - The present invention relates to new uses of S1P receptor modulator or agonist such as fingolimod, for reducing or delaying the progression of cerebral atrophy. | 05-26-2011 |
20120264719 | DOSAGE REGIMEN OF AN S1P RECEPTOR MODULATOR - S1P receptor modulators are administered following a dosage regimen providing a positive benefit-risk profile. | 10-18-2012 |
20130253066 | Use of an S1P Receptor Agonist - The present invention relates to new uses of S1P receptor modulator or agonist such as fingolimod, for reducing or delaying the progression of cerebral atrophy. | 09-26-2013 |
20140187516 | DOSAGE REGIMEN OF AN S1P RECEPTOR MODULATOR - S1P receptor modulators are administered following a dosage regimen providing a positive benefit-risk profile. | 07-03-2014 |
Ana Diaz Blázquez, Tres Cantos ES
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20110190164 | CHIMERIC FUSION PROTEINS AND VIRUS LIKE PARTICLES FROM BIRNAVIRUS VP2 - The field of the invention refers to chimeric Virus Like Particles (VLP) derived from Birnavirus chimeric VP2 protein. In particular, the invention refers to chimeric VP2 fusion proteins which incorporate insertions and/or substitutions with one or more amino acids or particular peptide of interest while maintaining the capacity to assemble in the form of VLP. The invention identifies particular insertion and/or substitutions sites within VP2 P loop regions and outside said P loop regions. The invention also incorporates methods for the identification of preferred insertion and substitution sites within VP2 for the incorporation of particular amino acids and peptides of interest. The resulting chimeric VLP are of interest in the design of therapeutic and prophylactic vaccines as well as in the design of drug delivery systems, carriers for DNA and RNA in gene therapy, as targeted agents, in the development of antitoxins, and as diagnostic reagents. | 08-04-2011 |
Ana Díez Rodríguez, Madrid ES
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20100267732 | Prognostic Molecular Markers for ET-743 Treatment - The present invention relates to the use of ecteinascidin 743 in human patients having certain molecular markers profile which has been associated with the outcome of ET-743 chemotherapy. In particular, the invention relates to the use of ecteinascidin 743 in patients having high expression levels of XPG mRNA or protein and/or having a “wild type” genotype for Asp1104His SNP of XPG gene. | 10-21-2010 |
Ana Díez Rodríguez, Madrid ES
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20100267732 | Prognostic Molecular Markers for ET-743 Treatment - The present invention relates to the use of ecteinascidin 743 in human patients having certain molecular markers profile which has been associated with the outcome of ET-743 chemotherapy. In particular, the invention relates to the use of ecteinascidin 743 in patients having high expression levels of XPG mRNA or protein and/or having a “wild type” genotype for Asp1104His SNP of XPG gene. | 10-21-2010 |
Ana Downing-Mason, Las Vegas, NV US
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20120064980 | INTRA-OFFICE REGULATORY COMPLIANCE TESTING SYSTEM - A regulatory compliance testing system permits a gaming machine ( | 03-15-2012 |
Ana Dvoredsky, Woodinville, WA US
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20090234719 | METHOD TO DETERMINE INDIVIDUAL WORK EFFECTIVENESS - A method to determine individual work effectiveness for a given event so that the user can determine whether the individual can continue to work. Event is defined as a situation where the individual's work effectiveness comes into question. | 09-17-2009 |
Ana Fidantsef, Davis, CA US
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20080268526 | Methods for producing secreted polypeptides - The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a second nucleotide sequence encoding the polypeptide, wherein the first nucleotide sequence is foreign to the second nucleotide sequence and the 3′ end of the first nucleotide sequence is immediately upstream of the initiator codon of the second nucleotide sequence. The present invention also relates to the isolated signal peptide sequences and to constructs, vectors, and fungal host cells comprising the signal peptide sequences operably linked to nucleotide sequences encoding polypeptides. | 10-30-2008 |
20090053765 | Variants of Beta-Glucosidase - The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 02-26-2009 |
20100099146 | Variants of Beta-Glucosidases - The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences. | 04-22-2010 |
20120122191 | Methods For Producing Secreted Polypeptides - The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a nucleic acid construct comprising a first nucleotide sequence encoding a signal peptide operably linked to a second nucleotide sequence encoding the polypeptide, wherein the first nucleotide sequence is foreign to the second nucleotide sequence and the 3′ end of the first nucleotide sequence is immediately upstream of the initiator codon of the second nucleotide sequence. The present invention also relates to the isolated signal peptide sequences and to constructs, vectors, and fungal host cells comprising the signal peptide sequences operably linked to nucleotide sequences encoding polypeptides. | 05-17-2012 |
Ana Forgiarini, Merida VE
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20090008091 | Single Phase Microemulsions and In Situ Microemulsions for Cleaning Formation Damage - Single phase microemulsions (SPMEs) and in situ-formed microemulsions may be used to clean up and remove non-polar materials from reservoir production zones of oil and gas wells. This clean up occurs by solubilization of the non-polar material into the microemulsion when the treatment fluid contacts the non-polar material. An in situ microemulsion may be formed when one or more surfactant and a polar phase (e.g. water or brine), and eventually some small amount of organic phase, contacts the reservoir formation and solubilizes the non-polar material encountered in the porous media. The microemulsions are effective for removing the formation damage caused by non-polar materials which include, but are not necessarily limited to oil-based mud, synthetic-based mud, paraffins, asphaltenes, emulsions, slugs, and combinations thereof. | 01-08-2009 |
20090183877 | Mesophase Fluids with Extended Chain Surfactants for Downhole Treatments - Mesophase fluids may be pre-formed or formed in situ and may be used downhole for various treatments including, but not limited to, cleaning up and removing non-polar materials from reservoir production zones, removing wellbore damage, releasing stuck pipe, components in spacers and pills and the like in oil and gas wells. These treatments involve solubilization of the non-polar material into the emulsion when the treatment fluid contacts non-polar materials. These mesophase fluids use extended chain surfactants having propoxylated/ethoxylated spacer arms. The extended chain surfactants are intramolecular mixtures containing hydrophilic and lipophilic portions. They attain high solubilization in the mesophase fluids (e.g. single phase microemulsions), are in some instances insensitive to temperature and are useful for a wide variety of oil types. | 07-23-2009 |
20120241220 | Dendritic Surfactants and Extended Surfactants for Drilling Fluid Formulations - Modified surfactants may be added to an oil-based drilling fluid where the modified surfactant is selected from the group consisting of an extended surfactant, a dendritic surfactant, a dendritic extended surfactant, and combinations thereof. These oil-based drilling fluids may be used for drilling a well through a subterranean reservoir, while circulating the oil-based drilling fluid through the wellbore. The oil-based drilling fluid may include at least modified surfactant, at least one non-polar continuous phase, and at least one polar non-continuous phase. The modified surfactant may have propoxylated/ethoxylated spacer arms extensions. The modified surfactant may have intramolecular mixtures containing hydrophilic and lipophilic portions. They attain high solubilization in the oil-based drilling fluid and may be, in some instances, insensitive to temperature making them useful for a wide variety of oil types. | 09-27-2012 |
20150087563 | FLUID FORMULATIONS FOR CLEANING OIL-BASED OR SYNTHETIC OIL-BASED MUD FILTER CAKES - A treatment composition may contact an oil-based mud (OBM) filter cake formed over at least part of a wellbore for incorporating more oil and/or filter cake particles into the treatment composition as compared to an otherwise identical filter cake absent the treatment composition. The treatment composition may include, but is not limited to, a surfactant, an aqueous-based fluid, an agent, an optional second acid, and combinations thereof. The agent may be or include long chain alcohols, phenol derivatives, fatty esters, a first acid, and combinations thereof. The first acid may be or include citric acid, oleic acid, tartaric acid, stearic acid, linoleic acid, linolenic acid, aromatic dicarboxylic acids, oxalic acid, malonic acid, succinic acid, glutaric acid, boric acid, adipic acid, a diacid, a triacid, a tetraacid, and combinations thereof. | 03-26-2015 |
Ana Fucs, Rio De Janeiro BR
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20110184950 | SYSTEM FOR CREATIVE IMAGE NAVIGATION AND EXPLORATION - A system and method for assisting a user in navigation of an image dataset are disclosed. The method includes receiving a user's text query, retrieving images responsive to the query from an image dataset, providing for receiving the user's selection of a first feature selected from a set of available first features via a graphical user interface, providing for receiving the user's selection of a second feature selected from a set of available second features different from the first features via the graphical user interface, and displaying at least some of the retrieved images on the graphical user interface. The displayed images are arranged, e.g., grouped, according to levels and/or combinations of levels of the user-selected first and second features. | 07-28-2011 |
20120099784 | CHROMATIC MATCHING GAME - A system and method for image retrieval formulated as a game are disclosed. The method includes receiving a user's image category selection, retrieving an image responsive to the user's image category selection from an associated image database, and displaying the retrieved image and a set of candidate color palettes to the user. The set of candidate color palettes includes a correct palette and at least one incorrect palette. The method further includes providing for a user to attempt to identify the correct palette by selecting at least one of the displayed candidate color palettes and, with a computer processor, generating a score based on the user's at least one selection and outputting the score. | 04-26-2012 |
Ana Fucs, Meylan FR
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20100313124 | MANIPULATION OF DISPLAYED OBJECTS BY VIRTUAL MAGNETISM - A computer implemented tactile user interface (TUI) and a method of manipulating objects with a virtual magnet are provided. The TUI includes a display comprising a touch-screen. The display is configured for displaying a set of graphic objects, each graphic object representing a respective one of a set of items, such as documents, e.g., text documents or images. A virtual magnet is caused to move on the display, in response to touching on the touch-screen, e.g., by dragging a finger or other implement across. The magnet is associated with a particular function command such that a subset of the graphic objects exhibits a response to the virtual magnet (e.g., is caused to move, relative to the virtual magnet or exhibits another visible response), each graphic object in the subset moving or otherwise responding as a function of an attribute of the underlying item represented by the graphic object. | 12-09-2010 |
Ana Fuertes Huerta, Madrid ES
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20090124686 | GSK-3 INHIBITORS - The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthase kinase 3β, GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus. | 05-14-2009 |
20090192204 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS - The present invention relates to the use of N-(2-thiazolyl)-amide derivatives of formula (I) for the treatment and/or prophylaxis of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, especially neurodegenerative diseases, such as Alzheimer's disease, or non-insulin dependent diabetes mellitus. | 07-30-2009 |
20090221647 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES AS GSK-3 INHIBITORS - The present invention relates to the use of N-(2-thiazolyl)-amide derivatives of formula (I), for the treatment and/or prophylaxis of a disease in which glycogen synthase kinase 3 (GSK-3) is involved, especially neurodegenerative diseases, such as Alzheimer's disease, or non-insulin dependent diabetes mellitus. | 09-03-2009 |
20110144148 | ACETYLCHOLINESTERASE DUAL INHIBITORS - The invention provides compounds of formula: | 06-16-2011 |
Ana Garcia Quintana, Barcelona ES
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20100331261 | USE OF ALPHA-1-ANTITRYPSIN FOR THE PREPARATION OF DRUGS FOR THE TREATMENT OF CHRONIC FATIGUE SYNDROME - The present invention relates to the use of alpha-1-antitrypsin for the preparation of effective drugs for the treatment of chronic fatigue syndrome. In addition, the present invention relates to the use of plasma or other therapeutic forms with an alpha-1-antitrypsin content sufficient to obtain a dose of 6 mg or more of alpha-1-antitrypsin per kg of body weight at a frequency of between 1 and 31 days. | 12-30-2010 |
Ana Gavaldá Escudé, Sant Cugat Del Valles ES
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20100234469 | New Crystals Of A Benzoylbenzeneacetamide Derivative - The invention relates to 2-amino-3-benzoylbenzeneacetamide, i.e. nepafenac, crystals having reduced chargeability, to processes for the preparation thereof, and to the use thereof for preparing pharmaceutical formulations. | 09-16-2010 |
Ana Gavaldá Escudé, Sant Cugat Del Valles ES
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20100234469 | New Crystals Of A Benzoylbenzeneacetamide Derivative - The invention relates to 2-amino-3-benzoylbenzeneacetamide, i.e. nepafenac, crystals having reduced chargeability, to processes for the preparation thereof, and to the use thereof for preparing pharmaceutical formulations. | 09-16-2010 |
20120111098 | 2- ACETAMIDE - The invention relates to 2-{2-amino-3-[hydroxy(phenyl)methyl]phenyl}acetamide, a process for its preparation, and its use as a reference marker and reference standard for analyzing the purity of nepafenac. | 05-10-2012 |
Ana Gavalda I Escude, Barcelona ES
Ana Gonzalez Buenrostro, San Mateo, CA US
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20110319378 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I, | 12-29-2011 |
20140235629 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, | 08-21-2014 |
20140315895 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER - The present invention provides MDM2 inhibitor compounds of Formula I, | 10-23-2014 |
Ana Gutierrez Moraga, Santiago CL
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20110195034 | AGENT FOR CUTANEOUS PHOTOPROTECTION AGAINST UVA/UVB RAYS - This invention describes a new agent for cutaneous photoprotection against UVA (I and II) and UVB radiation that contains an aqueous extract obtained from a plant in the Gramineae family from the Antarctic Continent ( | 08-11-2011 |
Ana Gutierrez-Suarez, Madrid ES
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20080210393 | Mediator-Enzyme System for Controlling Pitch Deposits in Pulp and Paper Production - The invention relates to the use of mediator-enzyme system, which is characterised in that the enzyme comprises a laccase-type enzyme and the mediator comprises a chemical compound which acts as a redox intermediate in the enzymatic oxidation, for the elimination of lipophilic compounds (including, among others, sterols that are free and conjugated in the form of esters and glycosides, triglycerides, fatty alcohols and resin acids) which cause deposits in the product, the machinery and the circuits during the production of pulp and paper (both from hardwood and softwood and non-woody plants). The treatment eliminates up to 100% of the aforementioned lipophilic compounds, depending on the material treated, and, in this way, improves the quality of the pulp obtained, the operation of the industrial installations and the characteristics of the end product. | 09-04-2008 |
Ana Henneberke, Amsterdam NL
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20090105947 | Computer System and Method for Providing Warnings to a User for Completing Tasks From the Task List - A computer system is disclosed, including a processor unit, arranged to communicate with a memory and a positioning device, the memory including a map database and a task list, the task list including at least one task, where at least one of the at least one task has a location indicator associated therewith. The positioning device is arranged to provide information about a position. In at least one embodiment, the computer system is arranged to compute an estimated travel parameter from a current position to a location indicator associated with one of the at least one task using the map database, to compare the estimated travel parameter to a threshold value, and to generate a warning signal if the computed estimated travel parameter is smaller than the threshold value. | 04-23-2009 |
Ana Herrán Fuertes, Stuttgart DE
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20100137972 | SINTERED MOULDED BODY - A sintered molded body consisting of a material that contains aluminum oxide with chromium doping, zirconium oxide with Y-stabilization and strontium aluminates with variable Cr-doping, which is particularly suitable for medical applications. | 06-03-2010 |
20100152018 | CERAMIC MATERIAL - Hardness, ageing resistance, wetting behavior in relating to water and high thermal conductivity are known characteristics of sintered molded bodies consisting of aluminum oxide; high strength and a high resistance to cracking, i.e., damage tolerance are known characteristics of sintered molded bodies consisting of zirconium oxide. These properties are combined in a material having a large fraction of aluminum oxide, zirconium oxide and optionally strontium aluminate. | 06-17-2010 |
Ana Herrán Fuertes, Stuttgart DE
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20100137972 | SINTERED MOULDED BODY - A sintered molded body consisting of a material that contains aluminum oxide with chromium doping, zirconium oxide with Y-stabilization and strontium aluminates with variable Cr-doping, which is particularly suitable for medical applications. | 06-03-2010 |
20100152018 | CERAMIC MATERIAL - Hardness, ageing resistance, wetting behavior in relating to water and high thermal conductivity are known characteristics of sintered molded bodies consisting of aluminum oxide; high strength and a high resistance to cracking, i.e., damage tolerance are known characteristics of sintered molded bodies consisting of zirconium oxide. These properties are combined in a material having a large fraction of aluminum oxide, zirconium oxide and optionally strontium aluminate. | 06-17-2010 |
20120142237 | SINTERED MOULDED - A sintered molded body consisting of a material that contains aluminum oxide with chromium doping, zirconium oxide with Y-stabilization and strontium aluminates with variable Cr-doping, which is particularly suitable for medial application. | 06-07-2012 |
Ana Huarte Amezqueta, Sarriguren (navarra) ES
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20110156389 | WIND TURBINE CONTROL METHOD - The present disclosure relates to a method for controlling a wind turbine of the type including a rotor, a generator, a frequency converter, a control unit and means for connecting to a wind farm grid, using means for receiving a local voltage reference value (V | 06-30-2011 |
Ana Jaklenec, Cambridge, MA US
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20110280912 | DEGRADABLE POLYMER NANOSTRUCTURE MATERIALS - This invention relates generally to composites comprising a plurality of nanostructures, and methods of making the same. In some embodiments, the composites further comprise a polymer. In some embodiments, the composites may have desirable properties such as, for example, biodegradability, biocompatibility, and/or high tensile strength. In one embodiment, the plurality of nanostructures comprises carbon nanotubes, and the polymer comprises a poly(beta-amino ester). Various methods are provided for preparing the composites. For example, the polymer and the plurality of nanostructures may, in some embodiments, be combined in a layer-by-layer process to form the composite. High throughput methods for preparing composites having different compositions also are provided for screening composites for desirable properties. | 11-17-2011 |
Ana Jimenez Araujo, Sevilla ES
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20120046368 | METHOD FOR PURIFYING 3,4-DIHYDROXYPHENYLGLYCOL (DHPG) FROM PLANT PRODUCTS - Process for purifying 3,4-dihydroxyphenylglycol (DHPG) from any part of the plant, from the products or by-products derived from olive trees or any other vegetable product of the families Oleaceae, Orobanchaceae, Plantaginaceae, Compositae, Lamiaceae, Acanthaceae and/or Scrophulariaceae, and which comprises 1 or more steps wherein the initial product is introduced into at least one ion-exchange resin column, and in potentially subsequent steps the product eluted in the preceding column is introduced into an ion-exchange resin and/or a non-ionic adsorption resin column. Moreover, it relates to the DHPG extract obtainable by means of the process disclosed and to the applications thereof. | 02-23-2012 |
Ana Kljuic, New York, NY US
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20110300088 | WATER-INSOLUBLE REACTION PRODUCT OF A POLYAMINE AND AN OIL-SOLUBLE POLAR MODIFIED POLYMER - The invention relates to a water-insoluble reaction product of an oil-soluble polar modified polymer and a polyamine. | 12-08-2011 |
20120258055 | MINERAL SUNSCREEN COMPOSITION AND PROCESS FOR PROTECTING SKIN FROM PHOTODAMAGE AND AGING - The present invention is directed to a composition and method for protecting a keratinous substrate from harmful UV rays by applying onto the substrate a composition containing: (a) at least one oil phase thickening agent chosen from an activated clay; (b) at least one substantially solid form dispersing aid; (c) at least one non-volatile solvent; (d) at least one inorganic sunscreen active; (e) at least one emulsifier; (f) at least one volatile solvent; and (g) water, and wherein (a) and (b) are present in the composition in a ratio by weight ranging from greater than 1:4 to less than 1:10. | 10-11-2012 |
20130136701 | COSMETIC OIL MOUSSE COMPOSITION - An anhydrous oil foam composition containing: (a) at least one liquid oil; (b) at least one surfactant chosen from polyglyceryl-2 laurate; (c) at least one UV filter; and (d) a propellant, wherein the composition is waterless and is capable of imparting UV protection onto a target keratinous substrate. | 05-30-2013 |
20130142740 | SUNSCREEN COMPOSITIONS CONTAINING A NOVEL PRESERVATIVE SYSTEM - The present invention is directed to a sunscreen composition containing a novel preservative system for inhibiting micro-organisms comprising (a) at least one aromatic carboxylic acid, or salt thereof; (b) from about 0.01% to about 1% by weight of at least one at least one aromatic alcohol; (c) at least one sunscreen active; and (d) a cosmetically acceptable carrier. | 06-06-2013 |
Ana Krtolica, San Francisco, CA US
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20090305404 | Methods and compositions relating to blastomere-derived human embryonic stem cells - The invention provides methods for producing human embryonic stem cells from blastomeres with reduced or no animal cells or products, including no serum regardless of source and including xeno-free conditions, without compromising derivation efficiency. | 12-10-2009 |
20100162416 | Multi-stage stem cell carcinogenesis - The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics. | 06-24-2010 |
Ana Kwokal, Zagreb HR
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20100113527 | CRYSTALLINE FORMS OF DEXLANSOPRAZOLE - Provided are crystalline forms of dexLansoprazole, as well as processes for the preparation thereof. | 05-06-2010 |
20130079360 | RALTEGRAVIR SALTS AND CRYSTALLINE FORMS THEREOF - The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium. | 03-28-2013 |
20130096147 | Raltegravir Salts and Crystalline Forms Thereof - The present invention includes new salts of Raltegravir and crystalline forms thereof, pharmaceutical compositions containing the salts or crystalline forms, methods of using the salts or crystalline forms or the compositions to treat HIV infection or to prepare medicament for treating HIV infection, and a process for preparing Raltegravir potassium. | 04-18-2013 |
Ana Lazuen-Garay, Belfast GB
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20090143595 | Use of grinding in chemical synthesis - A process for the preparation of a multi-dimensional microporous metal-organic compound comprising the steps of providing a first reactant which includes at least one metal in ionic form, providing a second reactant which includes a bridging organic ligand, grinding the first and second reactants together, wholly or substantially in the absence of solvent. | 06-04-2009 |
Ana Martínez García, Madrid ES
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20100304384 | METHOD OF IDENTIFYING COMPOUNDS THAT INDUCE OR INHIBIT ENDOPLASMIC RETICULUM STRESS OR OXIDATIVE STRESS - The present invention generally relates to a method for the identification of compounds for the treatment of neurodegenerative diseases. Said method is based on a cell model for neurodegeneration useful for the identification of potentially useful compounds for the treatment or the prevention of a neurodegenerative disease associated with deficient expression of the DDIT3 gene, also known as CHOP. | 12-02-2010 |
Ana Martínez García, Madrid ES
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20100304384 | METHOD OF IDENTIFYING COMPOUNDS THAT INDUCE OR INHIBIT ENDOPLASMIC RETICULUM STRESS OR OXIDATIVE STRESS - The present invention generally relates to a method for the identification of compounds for the treatment of neurodegenerative diseases. Said method is based on a cell model for neurodegeneration useful for the identification of potentially useful compounds for the treatment or the prevention of a neurodegenerative disease associated with deficient expression of the DDIT3 gene, also known as CHOP. | 12-02-2010 |
Ana Martinez Gil, Tres Cantos (madrid) ES
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20100240692 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds. | 09-23-2010 |
20140011835 | [1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES - The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or prophylaxis of a neurodegenerative or hematological disease or condition, their use as a medicament, especially for treating a neurodegenerative or hematological disease or condition, and a pharmaceutical composition comprising the compounds. | 01-09-2014 |
Ana Martínez Gil, Tres Cantos (madrid) ES
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20110213000 | N-(2-THIAZOLYL)-AMIDE DERIVATIVES FOR THE TREATMENT OF OBESITY, DIABETES AND CARDIOVASCULAR DISEASES - The invention relates to the use of a compound of formula (I): | 09-01-2011 |
Ana Martínez Gil, Madrid ES
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20120129877 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES - The present invention relates to the use of a series of quinazoline-derived compounds to produce a medicament for the treatment and/or prevention of neurological and/or neurodegenerative diseases, such as Parkinson's disease or Alzheimer's disease. The present invention also relates to a method for the treatment and/prevention of neurological and/neurodegenerative diseases comprising the administration of a therapeutically effective amount of said compounds. | 05-24-2012 |
20120225879 | SUBSTITUTED 5-IMINO-1,2,4-THIADIAZOLES THAT CAN BE USED TO TREAT NEURODEGENERATIVE DISEASES - The present invention is based on the use of a broad family of 5-imino-1,2,4-thiadiazoles as potential new drugs for the treatment of diseases in which PDE7 inhibition is important, specially inflammatory diseases, autoimmune and neurodegenerative disorders. On the other hand, compounds of the 5-imino-1,2,4-thiadiazole family are here described, as well as their synthetic procedures, and they may have great application as drug or drug candidates. | 09-06-2012 |
Ana Martin-Herranz, Madrid ES
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20090149522 | Method of preserving a customised composition - The invention concerns a process for producing a preserved customised consumer composition, preferably from a Vending machine, wherein a plurality of ingredient streams are mixed together in predefined relative amounts, characterised in that At least two streams consist of water and preservative only, at least two of which having different concentrations of preservative. The Invention permits the final preservative mix to be independently variable to the formation. | 06-11-2009 |
Ana Martin-Villalba, Heidelberg DE
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20100322922 | Neutralization of CD95 Activity Blocks Invasion of glioblastoma Cells In Vivo - The present invention relates to methods for treating an individual with high grade glioblastoma multiforme by preventing or disrupting the binding of CD95 to its ligand, CD95L, in vivo, whereupon that neutralization of CD95 activity reduces undesirable glial cell migration and invasion into body tissue. | 12-23-2010 |
20110189194 | USE OF CD95 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISORDERS - The present invention refers to the use of an inhibitor of the CD95/CD95L system for the prevention and/or treatment of an inflammatory disorder or for the prevention and/or treatment of an inflammatory process in a neuronal disorder, particularly in a CNS disorder. | 08-04-2011 |
20110300113 | Death Receptor CD95 Controls Neurogenesis of Adult Neural Stem Cells in Vivo and in Vitro - The present invention relates to the activation of the CD95L/CD95 system for inducing neuronal differentiation in vitro and in vivo and the use of CD95L compositions to effect differentiation. | 12-08-2011 |
Ana Minatti, Woodland Hills, CA US
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20110251190 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I | 10-13-2011 |
Ana Munoz Munoz, Leioa-Vizcaya ES
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20090312376 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES - The invention relates to a compound of formula (I): | 12-17-2009 |
20100305164 | 5-(4-METHANESULFONYL-PHENYL)-THIAZOLE DERIVATIVES FOR THE TREATMENT OF ACUTE AND CHRONIC INFLAMMATORY DISEASES - A compound of formula (I): | 12-02-2010 |
Ana Navarro Arévalo, Cadiz ES
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20090298895 | USE OF THIOPROLINE IN BODY WEIGHT REDUCTION TREATMENTS - The invention relates to thioproline, pharmaceutically acceptable salts and/or prodrugs thereof that can be used as anorexia-inducing agents in both therapeutic and cosmetic treatments to reduce body weight. | 12-03-2009 |
Ana Navarro Arévalo, Cadiz ES
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20090298895 | USE OF THIOPROLINE IN BODY WEIGHT REDUCTION TREATMENTS - The invention relates to thioproline, pharmaceutically acceptable salts and/or prodrugs thereof that can be used as anorexia-inducing agents in both therapeutic and cosmetic treatments to reduce body weight. | 12-03-2009 |
Ana Navarro Gonzalo, Valencia ES
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20100137855 | APPLICATOR DEVICE FOR ABLATION BY RADIOFREQUENCY OF BIOLOGICAL TISSUES - An applicator device ( | 06-03-2010 |
Ana Orea Garcia, Madrid ES
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20110307546 | Method and Device for Handling of Connections between a Client and a Server via a Communication Network - A method is described for handling of connections between a client ( | 12-15-2011 |
Ana Ospina Martinez, Madrid ES
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20090252831 | PROCESS FOR MANUFACTURING A FERMENTED MILK - The invention relates to a manufacturing process of stirred or drinking fermented milk or fresh cheese comprising a smoothing step after fermentation wherein said smoothing step is performed by a ring-shaped rotor-stator mixer, each ring of the rotor and the stator being provided with radial slots having a given width, and adjusting the rotational speed to adjust the peripheral velocity. | 10-08-2009 |
Ana Pereda-Lopez, Mundelein, IL US
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20090214515 | METHODS OF PREPARATION OF RECOMBINANT FORMS OF HUMAN BETA-AMYLOID PROTEIN AND USES OF THESE PROTEINS - The subject invention relates to the cloning, expression and isolation of recombinant forms of beta-amyloid protein containing a N-terminal methionine (or one or more amino acids) as well as to methods of using this recombinant protein in the production of therapeutic antibodies, in the identification of therapeutic small molecules, and in the performance of diagnostic assays. | 08-27-2009 |
Ana Pérez Castillo, Madrid ES
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20120129877 | USE OF QUINAZOLINE DERIVATIVES FOR NEURODEGENERATIVE DISEASES - The present invention relates to the use of a series of quinazoline-derived compounds to produce a medicament for the treatment and/or prevention of neurological and/or neurodegenerative diseases, such as Parkinson's disease or Alzheimer's disease. The present invention also relates to a method for the treatment and/prevention of neurological and/neurodegenerative diseases comprising the administration of a therapeutically effective amount of said compounds. | 05-24-2012 |
Ana Quiros Del Bosque, Madrid ES
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20100048464 | Bioactive peptides identified in enzymatic hydrolyzates of milk caseins and method of obtaining same - The invention relates to the production of bioactive products that are derived from milk proteins for the production of bioactive milk products derived from milk proteins, particularly caseins. The 16 inventive peptides can be obtained chemically, biotechnologically or by means of enzymatic treatment from proteins containing same and give rise to peptides with an antimicrobial activity, an in vitro angiotensin converter inhibitor activity and/or antihypertensive activity and/or antioxidant activity. Said nutraceutical products are suitable for use in the food and pharmaceutical industries, both in the form of a hydrolyzate or bioactive peptides. | 02-25-2010 |
Ana Racoveanu, Melrose, MA US
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20110319643 | Synthesis of an Azido Energetic Alcohol - A method of forming an azido energetic alcohol includes converting an energetic diol to a cyclic sulfite, oxidizing the cyclic sulfite to a cyclic sulfate, and opening the cyclic sulfate. The cyclic sulfate is opened, followed by hydrolysis, to form an azido energetic alcohol. | 12-29-2011 |
Ana Ramirez De Molina, Madrid ES
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20090304575 | IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY - The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression. | 12-10-2009 |
20100068302 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER - The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent or a death receptor ligand and uses thereof for the treatment of cancer. | 03-18-2010 |
20110250179 | METHODS FOR TREATMENT AND DIAGNOSIS OF CANCER - The present invention relates to methods for the treatment of cancer based on the induction of the choline kinase beta (hereinafter ChoKβ) activity as well as to methods for the design of personalized therapies and for determining the response of an agent capable of inducing choline kinase beta (hereinafter ChoKβ) for the treatment of cancer as well as to methods for determining the prognosis of a patient based on the determination of the ChoKβ expression levels as well as based on the determination of the relationship between the ChoKβ and ChoKα expression levels. Finally, the invention relates to methods for determining the response of a patient who suffers from cancer to ChoKα-inhibiting agents based on the determination of the PEMT and/or ChoKβ expression levels. | 10-13-2011 |
20110256241 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER - The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and a chemotherapeutic agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and a death receptor ligand and uses thereof for the treatment of cancer. | 10-20-2011 |
20110269948 | Method for Identifying Compounds for Cancer Therapy - The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression. | 11-03-2011 |
20120040021 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER - The invention relates to compositions comprising an acid ceramidase inhibitor and a choline kinase inhibitor as well as to the uses thereof for the treatment of cancer. The invention also relates to methods for the selection of an individualised therapy of a cancer patient based on the detection of the acid ceramidase levels. Moreover, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent and uses thereof for the treatment of cancer. Finally, the invention also relates to compositions comprising a choline kinase inhibitor and an alkylating agent or a death receptor ligand and uses thereof for the treatment of cancer. | 02-16-2012 |
20140023657 | IN VITRO METHOD FOR IDENTIFYING COMPOUNDS FOR CANCER THERAPY - The present invention relates to an in vitro method for identifying and evaluating compounds useful in the treatment of different types of cancer, especially lung, breast, colorectal and bladder cancer in an individual, for determining the stage or severity of said cancer in the individual, or for monitoring the effect of the therapy administered to an individual having said cancer; to finding, identifying, developing and evaluating the efficacy of compounds for the therapy of said cancer, for the purpose of developing new medicinal products; as well as to agents inhibiting the expression and/or activity of the choline kinase alpha protein and/or the effects of this expression. | 01-23-2014 |
Ana Redondo Puntonet, Moncada (valencia) ES
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20110119788 | METHOD FOR GENERATING RESISTANCE AGAINST CITRUS DISEASES CAUSED BY INSECTS, FUNGI, OOMYCETES, BACTERIA OR NEMATODES - The invention consists in modifying the levels of accumulation and emission of monoterpenes and sesquiterpenes in citrus as a mechanism to achieve systemic resistance against pathogens or repellency against pests. The alteration of the content of d-limonene and other terpenes is achieved by genetic transformation via the introduction of a gene that encodes an enzyme with d-limonene synthase activity, from a citrus fruit or plant or from another living organism, in antisense or RNAi (RNA interference) configuration. Genetic modification is achieved either by | 05-19-2011 |
Ana Rodriguez Baixauli, Moncada (valencia) ES
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20110119788 | METHOD FOR GENERATING RESISTANCE AGAINST CITRUS DISEASES CAUSED BY INSECTS, FUNGI, OOMYCETES, BACTERIA OR NEMATODES - The invention consists in modifying the levels of accumulation and emission of monoterpenes and sesquiterpenes in citrus as a mechanism to achieve systemic resistance against pathogens or repellency against pests. The alteration of the content of d-limonene and other terpenes is achieved by genetic transformation via the introduction of a gene that encodes an enzyme with d-limonene synthase activity, from a citrus fruit or plant or from another living organism, in antisense or RNAi (RNA interference) configuration. Genetic modification is achieved either by | 05-19-2011 |
Ana Ryuu, Kanagawa JP
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20110129568 | Process For Producing Fermented Milk And Fermented Milk - Provided is a process for producing fermented milk which makes it possible to effectively prevent increases in acidity in the fermented milk during transportation and storage, and also makes it possible to produce fermented milk with a good flavour. Bacteriocin-producing lactic acid bacteria and/or a culture or fermentation product thereof are/is added to a yoghurt mix. The bacteriocin-producing lactic acid bacteria are then killed. Lactic acid bacteria different from the bacteriocin-producing lactic acid bacteria are then added as a starter. It is thus possible to incorporate bacteriocin in yoghurt without directly adding bacteriocin. Since the bacteriocin-producing lactic acid bacteria are killed, intensification of the flavour of cheese, for example, can be prevented, and it is possible to produce fermented milk with a good flavour. | 06-02-2011 |
Ana Sousa-Herves, Santiago De Compostela ES
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20120003322 | PH-SENSITIVE DENDRITIC POLYMERIC MICELLES - The present invention relates to a pH-sensitive PIC (polyion complex) type polymeric micelle formed by electrostatic interaction between a dendritic block copolymer and another polymer of opposite charge. The presence of a dendritic block copolymer confers high stability to the micelles in physiological conditions, while in the acid medium of tumor tissues (pH 6.5) or cell compartments, such as the endosome/lysosome (pH 5.0-5.5), the micelles tend to become destabilized, being able to selectively release drugs or macromolecules encapsulated therein. The micelles are characterized by high stability against ionic strength, dilution and temperature. They can further be lyophilized and conserved in solid state. | 01-05-2012 |
20120269895 | DENDRITIC PIC MICELLES WITH BIOACTIVE PROTEINS - A polyion Complex (PIC) polymeric micelle is formed by interaction between a bioactive protein and a dendritic block copolymer of opposite charge. The conventional low stability of PIC micelles with bioactive proteins vis-à-vis ionic strength is offset by the stability provided by the dendritic block. The overall process for preparing the micelles is facilitated by the simplicity of the drendritic block copolymer synthesis. | 10-25-2012 |
Ana Valdes, Oxford GB
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20080269277 | Pyrrolopyridine-2-Carboxylic Acid Hydrazides - Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, hyperglycemia, hypercholesterolemia, hyperinsulinemia, hyperlipidemia, hypertension, atherosclerosis or tissue ischemia e.g. myocardial ischemia, or as cardioprotectants or inhibitors of abnormal cell growth. | 10-30-2008 |
Ana Viguera Sancho, Alfortville FR
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20110030434 | METHOD FOR ULTRASOUND SHOT-BLASTING OF TURBOMACHINE PARTS - The present invention relates to a method for ultrasound shot-blasting by means of a cloud of balls set in motion through contact with a sonotrode having one metallic surface including an area of difficult access. It is characterized in that the surface is that of a hook ( | 02-10-2011 |
Ana Vinuales Martinez, Gipuzkoa ES
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20120083043 | TEMPERATURE-TIME INDICATOR SYSTEM BASED ON IRREVERSIBLE COLOR CHANGES, AND CORRESPONDING METHOD - The present invention relates to a temperature-time indicator system which allows monitoring the maintenance of the cold chain in frozen or refrigerated substances based on irreversible color changes, comprising a layer with a solution of ascorbic acid and a layer with a solution of at least one base, wherein the solution of ascorbic acid does not mix with the solution of at least one base unless the temperature reaches a pre-determined threshold. The invention also relates to a method using said system. | 04-05-2012 |
Ana Viso Cabrera, Elgoibar ES
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20100000273 | PROGRAMMABLE ELECTRONIC LOCK - A programmable electronic lock with a closing tongue is actuated with an actuating mechanism formed by a mobile knob acting as a button joined to the closing tongue. Actuation of the mobile knob generates a movement of the closing tongue and closure of the lock. Recovery of the mobile knob to its initial position generates an opening of the lock. Furthermore, an electronics board is activated with a transponder key and controls operation of the lock by deactivating and subsequently activating a blocking mechanism formed by a motor that actuates a punch via a gear mechanism. When the punch is in a blocking position it is located against the actuating mechanism. When the punch is in an unblocking position, it is separated from the actuating mechanism and allows the movement of the closing tongue by unblocking the actuating mechanism. | 01-07-2010 |
20100000274 | ELECTRONIC BLOCKING MODULE FOR CLOSING SYSTEMS - The invention relates to an electronic blocking module for closing systems with a casing ( | 01-07-2010 |
Ana Viso Cabrera, Elgoibar (gipuzkoa) ES
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20090107192 | PROGRAMMABLE ELECTRONICALLY CLOSING LOCK WITH TURN KNOB - Programmable electronically closing lock, with knob of the type which incorporates programmed electronic elements which make possible bidirectional communication between lock and key without contact between the two is disclosed. It consists of an electronic board ( | 04-30-2009 |