Peale
David Peale, San Diego, CA US
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20150135917 | SECTIONING VOLUME SAMPLES - A microtome includes a blade located at an end of a trough that defines a cavity for holding a liquid; a sample block in which the at least one sample is suspended, the sample block is moveable relative to the blade such that when the sample block is passed across the blade a section is cut from the sample block; a plate that includes a support frame that defines an opening, and a transparent film extending across the opening, the transparent film being transparent to electrons, a grasper being configured to receive and retain the plate, wherein the grasper is moveable relative to the blade; and a pusher section that lacks the sample pusher section. | 05-21-2015 |
David R. Peale, San Diego, CA US
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20080198385 | Integrated Visible Pilot Beam for Non-Visible Optical Waveguide Devices - In one embodiment, a radiation based analysis system comprises a first radiation source to generate first radiation having a wavelength outside the visible spectrum, a second radiation source to generate second radiation having a wavelength within the visible spectrum, and a waveguide coupler to couple a portion of the first radiation and a portion of the second radiation into a combined radiation beam such that the first radiation and the second radiation follow a path that is substantially coaxial. | 08-21-2008 |
20090067797 | OPTICAL WAVEGUIDE RADIATION CONTROL - An integrated optical planar waveguide chip comprising materials and structures such as substrates, adhesives, capping materials, and waveguide structures which are absorbing at the wavelength of the working radiation. | 03-12-2009 |
20110122398 | Integrated Visible Pilot Beam for Non-Visible Optical Waveguide Devices - In one embodiment, a radiation based analysis system comprises a first radiation source to generate first radiation having a wavelength outside the visible spectrum, a second radiation source to generate second radiation having a wavelength within the visible spectrum, and a waveguide coupler to couple a portion of the first radiation and a portion of the second radiation into a combined radiation beam such that the first radiation and the second radiation follow a path that is substantially coaxial. | 05-26-2011 |
Franklin Peale, San Carlos, CA US
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20080305106 | Novel Gene Disruptions, Composition and Methods Relating Thereto - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO256, PRO34421, PRO334, PRO770, PRO983, PRO1009, PRO1107, PRO1158, PRO1250, PRO1317, PRO4334, PRO4395, PRO49192, PRO9799, PRO21175, PRO19837, PRO21331, PRO23949, PRO697 or PRO1480 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. | 12-11-2008 |
20110173708 | NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. | 07-14-2011 |
20120272341 | NOVEL GENE DISRUPTIONS, COMPOSITIONS AND METHODS RELATING THERETO - The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO226, PRO257, PRO268, PRO290, PRO36006, PRO363, PRO365, PRO382, PRO444, PRO705, PRO1071, PRO1125, PRO1134, PRO1155, PRO1281, PRO1343, PRO1379, PRO1380, PRO1387, PRO1419, PRO1433, PRO1474, PRO1550, PRO1571, PRO1572, PRO1759, PRO1904, PRO35193, PRO4341, PRO4348, PRO4369, PRO4381, PRO4407, PRO4425, PRO4985, PRO4989, PRO5737, PRO5800, PRO5993, PRO6017, PRO7174, PRO9744, PRO9821, PRO9852, PRO9873, PRO10196, PRO34778, PRO20233, PRO21956, PRO57290, PRO38465, PRO38683 or PRO85161 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. | 10-25-2012 |
Franklin V. Peale, San Carlos, CA US
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20080247951 | ANTI-ROBO4 ANTIBODIES AND USES THEREFOR - The invention provides anti-Robo4 antibodies, and compositions comprising the antibodies and methods of using these antibodies, including diagnostic and therapeutic methods. | 10-09-2008 |
Robert Peale, Winter Park, FL US
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20150109606 | PLASMONIC PHOTOTRANSISTOR - A plasmonic phototransistor includes a photon to surface-plasmon-polariton (SPP) transducer including and an optical coupling structure configured to receive incident light and an electrically conducting layer having a first and a second surface. The second surface is on the optical coupling structure and the first surface generates SPPs responsive to the incident light. A gate dielectric layer is on the first surface. A two dimensional (2D) electrically conductive material is on the gate dielectric layer having electrical properties sensitive to electromagnetic fields of the SPP. Source and drain contacts are on the 2D electrically conductive material. Dynamic electric fields of the SPPs reach the 2D electrically conductive material that are operable to electric field-induce modulation of an electrical conductance of the 2D electrically conductive material which is sensed from the source and drain contacts. | 04-23-2015 |
Robert E. Peale, Winter Park, FL US
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20150070698 | QUANTUM CASCADE LASER WITH AUTONOMOUSLY ALIGNED EXTERNAL CAVITY AND RELATED METHODS - A quantum cascade laser (QCL) may include a QCL crystal having an emitting facet, and an active region adjacent the emitting facet, the emitting facet for providing an electromagnetic beam. The QCL may include an optical cavity comprising a mirror being external to the QCL crystal, and for redirecting the electromagnetic beam into the active region of the QCL crystal to provide optical feedback, and a driver circuit for driving the QCL crystal with a constant current. The QCL may include a controller coupled to the optical cavity and for dynamically and autonomously aligning the optical cavity based upon an error signal from the QCL crystal to maintain stable the optical feedback into the active region of the QCL crystal. | 03-12-2015 |
William Barrows Peale, Berkeley, CA US
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20100010870 | System and Method for Tuning Demand Coefficients - The present invention relates to a system and method for tuning demand coefficients. Transaction data for product categories is received from a store(s). Price elasticity and uncertainty values are selected for the product categories. This transaction data may be seeded with generic price elasticity and uncertainty values. Product categories where the transaction history is not sufficient enough to generate accurate demand coefficients may be identified. Tuning parameters for a product category are estimated using price elasticity and uncertainty values. The tuning parameters include price elasticity mean and price elasticity standard deviation. A modified likelihood function is generated by applying a normally distributed price elasticity term. The modified likelihood function may then be solved for its maxima, thereby generating tuned demand coefficients which may be output to a pricing optimization system for product price setting, and/or may be stored for later product categories. New sales data may be received from the store(s). This data may be used to retrain the tuned demand coefficients. | 01-14-2010 |
20110131079 | System and Method for Modeling by Customer Segments - The present invention relates to a system and method for the system and method for modeling demand by consumer segments. In some embodiments a segment data organizer may receive transaction data. Transaction data may include transaction logs (T logs) from point of sales records from a retailer. These transaction logs, for the most part, include identification information for each transaction. The segment data organizer may also receive customer identification data which includes groupings of customers by consumer segments. The identification information within the transaction logs may be cross referenced by the customer identification data in order to generate groupings of transactions belonging to consumers in each segment. The organizer may then also aggregate the transaction logs by location, time series and product. The aggregated data may be supplied to an econometric engine capable of generating elasticity coefficients for each set of aggregate data. These coefficients may be stored or utilized to generate optimized pricing, lifts, and demand models. | 06-02-2011 |